Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors
Identifieur interne : 000663 ( Pmc/Curation ); précédent : 000662; suivant : 000664Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1H)-one derivatives as potential MERS-CoV inhibitors
Auteurs : Ji Hye Yoon [Corée du Sud] ; Jun Young Lee [Corée du Sud] ; Jihye Lee [Corée du Sud] ; Young Sup Shin [Corée du Sud] ; Sangeun Jeon [Corée du Sud] ; Dong Eon Kim [Corée du Sud] ; Jung Sun Min [Corée du Sud] ; Jong Hwan Song [Corée du Sud] ; Seungtaek Kim [Corée du Sud] ; Sunoh Kwon [Corée du Sud] ; Young-Hee Jin [Corée du Sud] ; Min Seong Jang [Corée du Sud] ; Hyoung Rae Kim [Corée du Sud] ; Chul Min Park [Corée du Sud]Source :
- Bioorganic & Medicinal Chemistry Letters [ 0960-894X ] ; 2019.
Abstract
Url:
DOI: 10.1016/j.bmcl.2019.126727
PubMed: 31624041
PubMed Central: 7126094
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</author>
<author><name sortKey="Watson, S J" uniqKey="Watson S">S.J. Watson</name>
</author>
<author><name sortKey="Zumla, A I" uniqKey="Zumla A">A.I. Zumla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, R" uniqKey="Liang R">R. Liang</name>
</author>
<author><name sortKey="Wang, L" uniqKey="Wang L">L. Wang</name>
</author>
<author><name sortKey="Zhang, N" uniqKey="Zhang N">N. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, J F W" uniqKey="Chan J">J.F.W. Chan</name>
</author>
<author><name sortKey="Lau, S K P" uniqKey="Lau S">S.K.P. Lau</name>
</author>
<author><name sortKey="To, K K W" uniqKey="To K">K.K.W. To</name>
</author>
<author><name sortKey="Cheng, V C C" uniqKey="Cheng V">V.C.C. Cheng</name>
</author>
<author><name sortKey="Woo, P C Y" uniqKey="Woo P">P.C.Y. Woo</name>
</author>
<author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K.-Y. Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E. De Wit</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N. van Doremalen</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D. Falzarano</name>
</author>
<author><name sortKey="Munster, V J" uniqKey="Munster V">V.J. Munster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dyall, J" uniqKey="Dyall J">J. Dyall</name>
</author>
<author><name sortKey="Coleman, C M" uniqKey="Coleman C">C.M. Coleman</name>
</author>
<author><name sortKey="Hart, B J" uniqKey="Hart B">B.J. Hart</name>
</author>
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</author>
<author><name sortKey="Jochmans, D" uniqKey="Jochmans D">D. Jochmans</name>
</author>
<author><name sortKey="Posthuma, C C" uniqKey="Posthuma C">C.C. Posthuma</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, H J" uniqKey="Kim H">H.J. Kim</name>
</author>
<author><name sortKey="Kim, N" uniqKey="Kim N">N. Kim</name>
</author>
<author><name sortKey="Shum, D" uniqKey="Shum D">D. Shum</name>
</author>
<author><name sortKey="Huddar, S" uniqKey="Huddar S">S. Huddar</name>
</author>
<author><name sortKey="Park, C M" uniqKey="Park C">C.M. Park</name>
</author>
<author><name sortKey="Jang, S" uniqKey="Jang S">S. Jang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, D H" uniqKey="Kang D">D.-H. Kang</name>
</author>
<author><name sortKey="Jun, K Y" uniqKey="Jun K">K.-Y. Jun</name>
</author>
<author><name sortKey="Lee, J P" uniqKey="Lee J">J.P. Lee</name>
</author>
<author><name sortKey="Pak, C S" uniqKey="Pak C">C.S. Pak</name>
</author>
<author><name sortKey="Na, Y" uniqKey="Na Y">Y. Na</name>
</author>
<author><name sortKey="Kwon, Y" uniqKey="Kwon Y">Y. Kwon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharma, M C" uniqKey="Sharma M">M.C. Sharma</name>
</author>
<author><name sortKey="Sharma, S" uniqKey="Sharma S">S. Sharma</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Hwang, B H" uniqKey="Hwang B">B.H. Hwang</name>
</author>
<author><name sortKey="Park, S H" uniqKey="Park S">S.H. Park</name>
</author>
<author><name sortKey="Choi, E B" uniqKey="Choi E">E.B. Choi</name>
</author>
<author><name sortKey="Park, C S" uniqKey="Park C">C.S. Park</name>
</author>
<author><name sortKey="Lee, H K" uniqKey="Lee H">H.K. Lee</name>
</author>
</analytic>
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<article-id pub-id-type="pmc">7126094</article-id>
<article-id pub-id-type="publisher-id">S0960-894X(19)30685-7</article-id>
<article-id pub-id-type="doi">10.1016/j.bmcl.2019.126727</article-id>
<article-id pub-id-type="publisher-id">126727</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Synthesis and biological evaluation of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4(1<italic>H</italic>
)-one derivatives as potential MERS-CoV inhibitors</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au005"><name><surname>Yoon</surname>
<given-names>Ji Hye</given-names>
</name>
<xref rid="af005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au010"><name><surname>Lee</surname>
<given-names>Jun Young</given-names>
</name>
<xref rid="af005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au015"><name><surname>Lee</surname>
<given-names>Jihye</given-names>
</name>
<xref rid="af010" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au020"><name><surname>Shin</surname>
<given-names>Young Sup</given-names>
</name>
<xref rid="af005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au025"><name><surname>Jeon</surname>
<given-names>Sangeun</given-names>
</name>
<xref rid="af010" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au030"><name><surname>Kim</surname>
<given-names>Dong Eon</given-names>
</name>
<xref rid="af015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="au035"><name><surname>Min</surname>
<given-names>Jung Sun</given-names>
</name>
<xref rid="af015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="au040"><name><surname>Song</surname>
<given-names>Jong Hwan</given-names>
</name>
<xref rid="af005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au045"><name><surname>Kim</surname>
<given-names>Seungtaek</given-names>
</name>
<xref rid="af020" ref-type="aff">d</xref>
</contrib>
<contrib contrib-type="author" id="au050"><name><surname>Kwon</surname>
<given-names>Sunoh</given-names>
</name>
<xref rid="af015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="au055"><name><surname>Jin</surname>
<given-names>Young-hee</given-names>
</name>
<xref rid="af015" ref-type="aff">c</xref>
</contrib>
<contrib contrib-type="author" id="au060"><name><surname>Jang</surname>
<given-names>Min Seong</given-names>
</name>
<xref rid="af025" ref-type="aff">e</xref>
</contrib>
<contrib contrib-type="author" id="au065"><name><surname>Kim</surname>
<given-names>Hyoung Rae</given-names>
</name>
<xref rid="af005" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au070"><name><surname>Park</surname>
<given-names>Chul Min</given-names>
</name>
<xref rid="af005" ref-type="aff">a</xref>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff id="af005"><label>a</label>
Center for Convergent Research of Emerging Virus Infection (CEVI), Korea Research Institute of Chemical Technology, 141 Gajeong-ro, Yuseong-gu, Daejeon 34114, South Korea</aff>
<aff id="af010"><label>b</label>
Respiratory Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea</aff>
<aff id="af015"><label>c</label>
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, South Korea</aff>
<aff id="af020"><label>d</label>
Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do 13488, South Korea</aff>
<aff id="af025"><label>e</label>
Department of Non-Clinical Studies, Korea Institute of Toxicology, Yuseong-gu, Daejeon 34114, South Korea</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Corresponding author.</corresp>
</author-notes>
<pub-date pub-type="pmc-release"><day>9</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>1</day>
<month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>9</day>
<month>10</month>
<year>2019</year>
</pub-date>
<volume>29</volume>
<issue>23</issue>
<fpage>126727</fpage>
<lpage>126727</lpage>
<history><date date-type="received"><day>24</day>
<month>6</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>6</day>
<month>9</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>30</day>
<month>9</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 Elsevier Ltd. All rights reserved.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Elsevier Ltd</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract abstract-type="graphical" id="ab005"><title>Graphical abstract</title>
<fig id="f0020" position="anchor"><graphic xlink:href="ga1_lrg"></graphic>
</fig>
</abstract>
<abstract id="ab010"><p>3-Acyl-2-phenylamino-1,4-dihydroquinolin-4(1<italic>H</italic>
)-one derivatives were synthesized and evaluated to show high anti-MERS-CoV inhibitory activities. Among them, 6,8-difluoro-3-isobutyryl-2-((2,3,4-trifluorophenyl)amino)quinolin-4(1<italic>H</italic>
)-one (<bold>6u</bold>
) exhibits high inhibitory effect (IC<sub>50</sub>
= 86 nM) and low toxicity (CC<sub>50</sub>
> 25 μM). Moreover, it shows good metabolic stability, low hERG binding affinity, no cytotoxicity, and good <italic>in vivo</italic>
PK properties.</p>
</abstract>
<kwd-group id="kg005"><title>Keywords</title>
<kwd>MERS-CoV</kwd>
<kwd>RNA virus</kwd>
<kwd>3-Acyl-2-amino-1,4-dihydroquinolin-4(1<italic>H</italic>
)-ones</kwd>
<kwd>Inhibitor</kwd>
<kwd>SAR optimization</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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