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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015</title>
<author><name sortKey="Wang, Wen Ling" sort="Wang, Wen Ling" uniqKey="Wang W" first="Wen Ling" last="Wang">Wen Ling Wang</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Hui Juan" sort="Wang, Hui Juan" uniqKey="Wang H" first="Hui Juan" last="Wang">Hui Juan Wang</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deng, Yao" sort="Deng, Yao" uniqKey="Deng Y" first="Yao" last="Deng">Yao Deng</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Song, Tie" sort="Song, Tie" uniqKey="Song T" first="Tie" last="Song">Tie Song</name>
<affiliation><nlm:aff id="aff2">Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lan, Jia Ming" sort="Lan, Jia Ming" uniqKey="Lan J" first="Jia Ming" last="Lan">Jia Ming Lan</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Gui Zhen" sort="Wu, Gui Zhen" uniqKey="Wu G" first="Gui Zhen" last="Wu">Gui Zhen Wu</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ke, Chang Wen" sort="Ke, Chang Wen" uniqKey="Ke C" first="Chang Wen" last="Ke">Chang Wen Ke</name>
<affiliation><nlm:aff id="aff2">Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tan, Wen Jie" sort="Tan, Wen Jie" uniqKey="Tan W" first="Wen Jie" last="Tan">Wen Jie Tan</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
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<idno type="pmid">27109133</idno>
<idno type="pmc">7135062</idno>
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<idno type="doi">10.3967/bes2016.027</idno>
<date when="2016">2016</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015</title>
<author><name sortKey="Wang, Wen Ling" sort="Wang, Wen Ling" uniqKey="Wang W" first="Wen Ling" last="Wang">Wen Ling Wang</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wang, Hui Juan" sort="Wang, Hui Juan" uniqKey="Wang H" first="Hui Juan" last="Wang">Hui Juan Wang</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Deng, Yao" sort="Deng, Yao" uniqKey="Deng Y" first="Yao" last="Deng">Yao Deng</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Song, Tie" sort="Song, Tie" uniqKey="Song T" first="Tie" last="Song">Tie Song</name>
<affiliation><nlm:aff id="aff2">Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lan, Jia Ming" sort="Lan, Jia Ming" uniqKey="Lan J" first="Jia Ming" last="Lan">Jia Ming Lan</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Wu, Gui Zhen" sort="Wu, Gui Zhen" uniqKey="Wu G" first="Gui Zhen" last="Wu">Gui Zhen Wu</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ke, Chang Wen" sort="Ke, Chang Wen" uniqKey="Ke C" first="Chang Wen" last="Ke">Chang Wen Ke</name>
<affiliation><nlm:aff id="aff2">Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tan, Wen Jie" sort="Tan, Wen Jie" uniqKey="Tan W" first="Wen Jie" last="Tan">Wen Jie Tan</name>
<affiliation><nlm:aff id="aff1">Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Biomedical and Environmental Sciences</title>
<idno type="ISSN">0895-3988</idno>
<idno type="eISSN">2214-0190</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p>The first imported Middle East respiratory syndrome (MERS) case in China was identified in May 2015. We determined the kinetics of antibody (IgG and IgM) and neutralizing antibodies against MERS-coronavirus (MERS-CoV) in this case before discharge. Moreover, no seroconversion was found among 53 close contacts by anti-MERS IgG antibody enzyme-linked immunosorbent assay (ELISA) of paired serum samples. These findings suggest that neither community nor nosocomial transmission of MERS-CoV occurred in China.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S Van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Liu, D" uniqKey="Liu D">D Liu</name>
</author>
<author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, J" uniqKey="Wu J">J Wu</name>
</author>
<author><name sortKey="Yi, L" uniqKey="Yi L">L Yi</name>
</author>
<author><name sortKey="Zou, L" uniqKey="Zou L">L Zou</name>
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</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Who" uniqKey="Who">WHO</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petersen, E" uniqKey="Petersen E">E Petersen</name>
</author>
<author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name>
</author>
<author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Da Guan, W" uniqKey="Da Guan W">W Da Guan</name>
</author>
<author><name sortKey="Mok, Ck" uniqKey="Mok C">CK Mok</name>
</author>
<author><name sortKey="Chen, Zl" uniqKey="Chen Z">ZL Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name>
</author>
<author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name>
</author>
<author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Breakwell, L" uniqKey="Breakwell L">L Breakwell</name>
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<author><name sortKey="Song, P" uniqKey="Song P">P Song</name>
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</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="letter"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Environ Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Biomed. Environ. Sci</journal-id>
<journal-title-group><journal-title>Biomedical and Environmental Sciences</journal-title>
</journal-title-group>
<issn pub-type="ppub">0895-3988</issn>
<issn pub-type="epub">2214-0190</issn>
<publisher><publisher-name>The Editorial Board of Biomedical and Environmental Sciences. Published by Elsevier (Singapore) Pte Ltd.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27109133</article-id>
<article-id pub-id-type="pmc">7135062</article-id>
<article-id pub-id-type="publisher-id">S0895-3988(16)30038-1</article-id>
<article-id pub-id-type="doi">10.3967/bes2016.027</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Serological Study of An Imported Case of Middle East Respiratory Syndrome and His Close Contacts in China, 2015</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au10a"><name><surname>WANG</surname>
<given-names>Wen Ling</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="fn1" ref-type="fn">⁁</xref>
</contrib>
<contrib contrib-type="author" id="au10b"><name><surname>WANG</surname>
<given-names>Hui Juan</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="fn1" ref-type="fn">⁁</xref>
</contrib>
<contrib contrib-type="author" id="au10"><name><surname>DENG</surname>
<given-names>Yao</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au20"><name><surname>SONG</surname>
<given-names>Tie</given-names>
</name>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au30"><name><surname>LAN</surname>
<given-names>Jia Ming</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au40"><name><surname>WU</surname>
<given-names>Gui Zhen</given-names>
</name>
<xref rid="aff1" ref-type="aff">a</xref>
</contrib>
<contrib contrib-type="author" id="au50"><name><surname>KE</surname>
<given-names>Chang Wen</given-names>
</name>
<xref rid="aff2" ref-type="aff">b</xref>
</contrib>
<contrib contrib-type="author" id="au60"><name><surname>TAN</surname>
<given-names>Wen Jie</given-names>
</name>
<email>tanwj28@163.com</email>
<xref rid="aff1" ref-type="aff">a</xref>
<xref rid="cor1" ref-type="corresp">#</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>a</label>
Key Laboratory of Medical Virology and Virus Disease, National Health and Family Planning Commission of the People's Republic of China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China</aff>
<aff id="aff2"><label>b</label>
Guangdong Provincial Center for Disease Control and Prevention, Guangzhou 511430, Guangdong, China</aff>
<author-notes><corresp id="cor1"><label>#</label>
Corresponding should be addressed to TAN Wen Jie, MD, PhD <email>tanwj28@163.com</email>
</corresp>
<fn id="fn1"><label>⁁</label>
<p id="cenpara20">WANG Wen Ling and WANG Hui Juan contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="pmc-release"><day>25</day>
<month>4</month>
<year>2016</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>3</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>25</day>
<month>4</month>
<year>2016</year>
</pub-date>
<volume>29</volume>
<issue>3</issue>
<fpage>219</fpage>
<lpage>223</lpage>
<history><date date-type="received"><day>23</day>
<month>12</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>2</day>
<month>3</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© 2016 The Editorial Board of Biomedical and Environmental Sciences</copyright-statement>
<copyright-year>2016</copyright-year>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract id="ceab10"><p>The first imported Middle East respiratory syndrome (MERS) case in China was identified in May 2015. We determined the kinetics of antibody (IgG and IgM) and neutralizing antibodies against MERS-coronavirus (MERS-CoV) in this case before discharge. Moreover, no seroconversion was found among 53 close contacts by anti-MERS IgG antibody enzyme-linked immunosorbent assay (ELISA) of paired serum samples. These findings suggest that neither community nor nosocomial transmission of MERS-CoV occurred in China.</p>
</abstract>
</article-meta>
</front>
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</ref>
<ref id="bib11"><label>11</label>
<element-citation publication-type="journal" id="sbref110"><person-group person-group-type="author"><name><surname>Gao</surname>
<given-names>J</given-names>
</name>
<name><surname>Song</surname>
<given-names>P</given-names>
</name>
</person-group>
<article-title>China upgrades surveillance and control measures of Middle East respiratory syndrome (MERS)</article-title>
<source>Biosci Trends</source>
<volume>9</volume>
<year>2015</year>
<fpage>203</fpage>
<lpage>204</lpage>
<pub-id pub-id-type="pmid">26063202</pub-id>
</element-citation>
</ref>
</ref-list>
<bio><p>Biographical notes of the first authors: WANG Wen Ling, female, born in 1973, PhD, Researcher, majoring in pathogen biology</p>
</bio>
<bio><p>WANG Hui Juan, female, born in 1972, Bachelor, Associate Chief Technician, majoring in pathogen biology.</p>
</bio>
<fn-group><fn id="d32e239"><p id="cenpara10">Funds from the <funding-source id="GS1">Nationl Health and Family Planning Commission of China</funding-source>
: grants 2014ZX10004-001 and 2013ZX10004601.</p>
</fn>
</fn-group>
</back>
</pmc>
</record>
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