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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">MERS-CoV: address the knowledge gaps to move forward</title></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24856011</idno><idno type="pmc">7134689</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7134689</idno><idno type="RBID">PMC:7134689</idno><idno type="doi">10.1016/S0140-6736(14)60864-3</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000846</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000846</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">MERS-CoV: address the knowledge gaps to move forward</title></analytic><series><title level="j">Lancet (London, England)</title><idno type="ISSN">0140-6736</idno><idno type="eISSN">1474-547X</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="editorial"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lancet</journal-id><journal-id journal-id-type="iso-abbrev">Lancet</journal-id><journal-title-group><journal-title>Lancet (London, England)</journal-title></journal-title-group><issn pub-type="ppub">0140-6736</issn><issn pub-type="epub">1474-547X</issn><publisher><publisher-name>Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24856011</article-id><article-id pub-id-type="pmc">7134689</article-id><article-id pub-id-type="publisher-id">S0140-6736(14)60864-3</article-id><article-id pub-id-type="doi">10.1016/S0140-6736(14)60864-3</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>MERS-CoV: address the knowledge gaps to move forward</article-title></title-group><contrib-group><contrib contrib-type="author" id="au10"><name><surname>The Lancet</surname></name></contrib></contrib-group><pub-date pub-type="pmc-release"><day>23</day><month>5</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub" iso-8601-date="2014-05-30"><season>24-30 May</season><year>2014</year></pub-date><pub-date pub-type="epub"><day>23</day><month>5</month><year>2014</year></pub-date><volume>383</volume><issue>9931</issue><fpage>1782</fpage><lpage>1782</lpage><permissions><copyright-statement>Copyright © 2014 Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2014</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><related-article related-article-type="commentary-article" id="d32e199" ext-link-type="doi" xlink:href="10.1016/S0140-6736(14)60866-7"></related-article></article-meta></front><body><p id="para10">The first and second cases of Middle East respiratory syndrome coronavirus (MERS-CoV) infection in the USA were reported by the Indiana State Department of Health and the Florida Department of Health on May 1 and May 11, respectively, to the Centers for Disease Control and Prevention. These two cases, like all previous cases reported worldwide, have a Middle Eastern connection.</p><p id="para20">Person-to-person transmission of MERS-CoV has not been sustained, but the number of cases reported to WHO has been increasing. However, according to the <ext-link ext-link-type="uri" xlink:href="http://www.who.int/mediacentre/news/statements/2014/mers-20140514/en/" id="interrefs10">WHO Statement</ext-link> on the Fifth Meeting of the International Health Regulations Emergency Committee released on May 14, the conditions have not yet been met for a MERS-CoV public health emergency of international concern. More than 600 laboratory-confirmed cases have been reported to WHO so far. Alarmingly, Simon Cauchemez and colleagues <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/S1473-3099(13)70304-9" id="interrefs20">reported</ext-link> that at least 62% of asymptomatic cases had not been detected up to Aug 8, 2013.</p><p id="para30">Although severe acute respiratory syndrome (SARS) coronavirus and MERS-CoV have different infection sources, some of the lessons learnt from SARS since 2003 are relevant for the prevention of MERS-CoV transmission. All confirmed and probable cases of MERS-CoV infection should be notified to WHO. Health-care personnel should be taught or given refreshers on infection control practices to safeguard against nosocomial transmission. In a <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/S0140-6736(14)60852-7" id="interrefs30">Comment</ext-link>, Alimuddin Zumla and David Hui stress the importance of basic measures for infection control for curbing the increase in nosocomial infections.</p><p id="para40">Since the first case of MERS-CoV was reported in Saudi Arabia in September, 2012, much remains to be learnt about the virus. In 2013, Abdullah Assiri and colleagues <ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/S1473-3099(13)70204-4" id="interrefs40">pointed out</ext-link> major gaps in knowledge about the epidemiology, community prevalence, and clinical range of MERS-CoV. Questions that still need to be addressed include what are the optimum measures for infection control, what is the potential for person-to-person transmission, and what is the complete range of expression of disease? International collaboration is imperative to address the gaps in knowledge and apply the lessons learnt from past outbreaks to existing and emerging infectious diseases.</p><p id="para50"><fig id="f10"><graphic xlink:href="fx1_lrg"></graphic><permissions><copyright-statement>© 2014 Callista Images/Corbis</copyright-statement><copyright-year>2014</copyright-year><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></fig></p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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