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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">African green monkey model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection</title><author><name sortKey="Nalca, A" sort="Nalca, A" uniqKey="Nalca A" first="A." last="Nalca">A. Nalca</name></author><author><name sortKey="Totura, A" sort="Totura, A" uniqKey="Totura A" first="A." last="Totura">A. Totura</name></author><author><name sortKey="Livingston, V" sort="Livingston, V" uniqKey="Livingston V" first="V." last="Livingston">V. Livingston</name></author><author><name sortKey="Frick, O" sort="Frick, O" uniqKey="Frick O" first="O." last="Frick">O. Frick</name></author><author><name sortKey="Dyer, D" sort="Dyer, D" uniqKey="Dyer D" first="D." last="Dyer">D. Dyer</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7129279</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7129279</idno><idno type="RBID">PMC:7129279</idno><idno type="doi">10.1016/j.ijid.2018.11.249</idno><idno type="pmid">NONE</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000586</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000586</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">African green monkey model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection</title><author><name sortKey="Nalca, A" sort="Nalca, A" uniqKey="Nalca A" first="A." last="Nalca">A. Nalca</name></author><author><name sortKey="Totura, A" sort="Totura, A" uniqKey="Totura A" first="A." last="Totura">A. Totura</name></author><author><name sortKey="Livingston, V" sort="Livingston, V" uniqKey="Livingston V" first="V." last="Livingston">V. Livingston</name></author><author><name sortKey="Frick, O" sort="Frick, O" uniqKey="Frick O" first="O." last="Frick">O. Frick</name></author><author><name sortKey="Dyer, D" sort="Dyer, D" uniqKey="Dyer D" first="D." last="Dyer">D. Dyer</name></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis</journal-id><journal-title-group><journal-title>International Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1201-9712</issn><issn pub-type="epub">1878-3511</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7129279</article-id><article-id pub-id-type="publisher-id">S1201-9712(18)34828-8</article-id><article-id pub-id-type="doi">10.1016/j.ijid.2018.11.249</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>African green monkey model of Middle East respiratory syndrome coronavirus (MERS-CoV) infection</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Nalca</surname><given-names>A.</given-names></name><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Totura</surname><given-names>A.</given-names></name></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Livingston</surname><given-names>V.</given-names></name></contrib><contrib contrib-type="author" id="aut0020"><name><surname>Frick</surname><given-names>O.</given-names></name></contrib><contrib contrib-type="author" id="aut0025"><name><surname>Dyer</surname><given-names>D.</given-names></name></contrib></contrib-group><aff id="aff0005">USAMRIID, Frederick/US</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author.</corresp></author-notes><pub-date pub-type="pmc-release"><day>30</day><month>1</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>2</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>1</month><year>2019</year></pub-date><volume>79</volume><fpage>99</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright © 2018 Published by Elsevier Ltd.</copyright-statement><copyright-year>2018</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="par0005"><bold>Purpose:</bold> Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a highly pathogenic zoonosis that emerged in 2012, causing lethal respiratory disease in approximately 35% of human cases. MERS-CoV continues to emerge on the Arabian Peninsula with the possibility of travel-exported cases to other regions of the world including prior confirmed cases in the Republic of Korea, the United States, England, France, and China. Currently, there are no specific countermeasures for MERS-CoV that have proven efficacious at ameliorating disease. Animal models that recapitulate severe MERS disease signs are needed to support development of therapeutics or vaccines to protect vulnerable populations.</p><p id="par0010"><bold>Methods & Materials:</bold> For initial development of a MERS-CoV primate model, twelve African green monkeys (AGMs) were exposed to 10<sup>3</sup>, 10<sup>4</sup>, or 10<sup>5</sup> PFU target doses of aerosolized MERS-CoV. Disease progression was followed with daily health observations, weights, body temperatures, blood and throat swab collection.</p><p id="par0015"><bold>Results:</bold> In this study, infection of the 10<sup>3</sup> PFU dose group was associated with minimal disease signs in AGMs, including lack of fever, lower viral titers and minimal clinical scores over 28 days of observation post-exposure to MERS-CoV. In contrast, the 10<sup>4</sup> PFU dose and especially the 10<sup>5</sup> PFU dose were associated with significantly more observable disease signs of MERS-CoV infection, although all AGMs survived for the 28 day duration of the study.</p><p id="par0020"><bold>Conclusion:</bold> Clinical symptoms of MERS in humans range from asymptomatic to severe respiratory syndrome and death. Severe cases of MERS present initially as fever, cough and shortness of breath, but progress to more severe respiratory symptoms including end-stage lung disease. Although biological factors including advanced age (>65 years) and comorbidities are associated with severe MERS disease in humans, few animal models exist that demonstrate biomarkers of severity in MERS-CoV infection as end-points for therapeutic testing. This study is the first to describe dose-dependent effects of highly pathogenic coronavirus infection of primates and uses a route of infection (aerosol) more relevant to MERS-CoV transmission in humans. Aerosol exposure of AGMs at higher doses may provide a lethal model of MERS in African green monkeys with potential utility in therapeutic development and viral pathogenesis studies.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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