20.083 Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A systematic literature review
Identifieur interne : 000582 ( Pmc/Corpus ); précédent : 000581; suivant : 00058320.083 Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A systematic literature review
Auteurs : P. Dawson ; S. MorseSource :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2016.
Url:
DOI: 10.1016/j.ijid.2016.11.310
PubMed: NONE
PubMed Central: 7128666
Links to Exploration step
PMC:7128666Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">20.083 Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A systematic literature review</title><author><name sortKey="Dawson, P" sort="Dawson, P" uniqKey="Dawson P" first="P." last="Dawson">P. Dawson</name><affiliation><nlm:aff id="aff0005">Columbia University, Epidemiology, New York, NEW YORK/US</nlm:aff></affiliation></author><author><name sortKey="Morse, S" sort="Morse, S" uniqKey="Morse S" first="S." last="Morse">S. Morse</name><affiliation><nlm:aff id="aff0010">Columbia University, New York, NY/US</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">7128666</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128666</idno><idno type="RBID">PMC:7128666</idno><idno type="doi">10.1016/j.ijid.2016.11.310</idno><idno type="pmid">NONE</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000582</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000582</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">20.083 Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A systematic literature review</title><author><name sortKey="Dawson, P" sort="Dawson, P" uniqKey="Dawson P" first="P." last="Dawson">P. Dawson</name><affiliation><nlm:aff id="aff0005">Columbia University, Epidemiology, New York, NEW YORK/US</nlm:aff></affiliation></author><author><name sortKey="Morse, S" sort="Morse, S" uniqKey="Morse S" first="S." last="Morse">S. Morse</name><affiliation><nlm:aff id="aff0010">Columbia University, New York, NY/US</nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader></TEI><pmc article-type="abstract"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Infect Dis</journal-id><journal-id journal-id-type="iso-abbrev">Int. J. Infect. Dis</journal-id><journal-title-group><journal-title>International Journal of Infectious Diseases</journal-title></journal-title-group><issn pub-type="ppub">1201-9712</issn><issn pub-type="epub">1878-3511</issn><publisher><publisher-name>Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">7128666</article-id><article-id pub-id-type="publisher-id">S1201-9712(16)31528-4</article-id><article-id pub-id-type="doi">10.1016/j.ijid.2016.11.310</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>20.083 Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A systematic literature review</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Dawson</surname><given-names>P.</given-names></name><xref rid="aff0005" ref-type="aff">a</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Morse</surname><given-names>S.</given-names></name><xref rid="aff0010" ref-type="aff">b</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Columbia University, Epidemiology, New York, NEW YORK/US</aff><aff id="aff0010"><label>b</label>Columbia University, New York, NY/US</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author.</corresp></author-notes><pub-date pub-type="pmc-release"><day>22</day><month>12</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>12</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>22</day><month>12</month><year>2016</year></pub-date><volume>53</volume><fpage>125</fpage><lpage>125</lpage><permissions><copyright-statement>Copyright © 2016 Published by Elsevier Ltd.</copyright-statement><copyright-year>2016</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions></article-meta></front><body><p id="par0005"><bold>Purpose:</bold> Since the detection of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) among humans in 2012, questions remain unanswered regarding the virus's origins; clinical, epidemiological, and virological characteristics; and potential therapeutics. A systematic literature review was conducted to synthesize current knowledge and identify critical knowledge gaps.</p><p id="par0010"><bold>Methods & Materials:</bold> We conducted a systematic review on MERS-CoV using PRISMA guidelines and identified 312 relevant, peer-reviewed publications from Embase, Google Scholar, and PubMed. Of these, 206 were selected for inclusion based on their contributions to four pre-defined themes (virology, epidemiology/clinical characteristics, origins/reservoirs, and therapeutics/prevention).</p><p id="par0015"><bold>Results:</bold> Virological research identified the functional human receptor (CD26/DPP4) and shed light on MERS-CoV's broad species tropism. A variety of molecular and serological assays have been developed for surveillance and research. The epidemiologic profile is incomplete, although initial data suggest values for the basic reproductive rate, proportion of primary cases, case fatality rate, and demographic and geographic distributions. There have been sustained outbreaks in Saudi Arabia and South Korea, and potential risks for infection include camel contact, nosocomial exposures, and close contact to active cases, but not Hajj pilgrimage. The primary mechanism of transmission in health care settings appears to be environmental contamination of medical devices and surfaces from respiratory secretions. MERS and MERS-like CoVs have been detected in bat species in numerous countries, and MERS-CoV is genetically similar to bat coronavirus HKU-4, which contains cell surface-expressed CD26/DPP4. Dromedary camels have demonstrated MERS-CoV seropositivity throughout the Middle East and Africa and there is preliminary evidence of camel-to-human MERS-CoV transmission events. Various potential therapeutic agents have been identified from high-throughput screening and other methods, but none have been clinically evaluated in human trials. At least one candidate vaccine has progressed to Phase I human trials.</p><p id="par0020"><bold>Conclusion:</bold> Although there has been substantial MERS-CoV research since 2012, significant knowledge gaps persist. Uncertainties remain about the zoonotic origin, clinical characteristics, risk factors for infection, asymptomatic transmission, effective therapeutics, and vaccine candidates. These areas merit urgent attention by the global community to better understand, detect, and control MERS-CoV using a unified One Health approach.</p></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000582 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000582 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:7128666
|texte= 20.083 Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A systematic literature review
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:NONE" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |