From SARS to MERS: evidence and speculation
Identifieur interne : 000514 ( Pmc/Corpus ); précédent : 000513; suivant : 000515From SARS to MERS: evidence and speculation
Auteurs : Hainv Gao ; Hangping Yao ; Shigui Yang ; Lanjuan LiSource :
- Frontiers of Medicine [ 2095-0217 ] ; 2016.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths.Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.
Url:
DOI: 10.1007/s11684-016-0466-7
PubMed: 27726088
PubMed Central: 7088694
Links to Exploration step
PMC:7088694Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">From SARS to MERS: evidence and speculation</title><author><name sortKey="Gao, Hainv" sort="Gao, Hainv" uniqKey="Gao H" first="Hainv" last="Gao">Hainv Gao</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id institution-id-type="GRID">grid.13402.34</institution-id><institution>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine,</institution><institution>Zhejiang University,</institution></institution-wrap>Hangzhou, 310003 China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id institution-id-type="GRID">grid.13402.34</institution-id><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious 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Diseases,</institution></institution-wrap>Hangzhou, 310003 China</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27726088</idno><idno type="pmc">7088694</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088694</idno><idno type="RBID">PMC:7088694</idno><idno type="doi">10.1007/s11684-016-0466-7</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000514</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000514</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">From SARS to MERS: evidence and speculation</title><author><name sortKey="Gao, Hainv" sort="Gao, Hainv" uniqKey="Gao H" first="Hainv" last="Gao">Hainv Gao</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id 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institution-id-type="GRID">grid.13402.34</institution-id><institution>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine,</institution><institution>Zhejiang University,</institution></institution-wrap>Hangzhou, 310003 China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id institution-id-type="GRID">grid.13402.34</institution-id><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,</institution></institution-wrap>Hangzhou, 310003 China</nlm:aff></affiliation></author><author><name sortKey="Yang, Shigui" sort="Yang, Shigui" uniqKey="Yang S" first="Shigui" last="Yang">Shigui Yang</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id 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institution-id-type="GRID">grid.13402.34</institution-id><institution>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine,</institution><institution>Zhejiang University,</institution></institution-wrap>Hangzhou, 310003 China</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id institution-id-type="GRID">grid.13402.34</institution-id><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,</institution></institution-wrap>Hangzhou, 310003 China</nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers of Medicine</title><idno type="ISSN">2095-0217</idno><idno type="eISSN">2095-0225</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths.Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A H D" uniqKey="Zumla A">A H D Zumla</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name></author><author><name sortKey="Li, Ks" uniqKey="Li K">KS Li</name></author><author><name sortKey="Tsang, Ak" uniqKey="Tsang A">AK Tsang</name></author><author><name sortKey="Lam, Cs" uniqKey="Lam C">CS Lam</name></author><author><name sortKey="Ahmed, S" uniqKey="Ahmed S">S Ahmed</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fehr, Ar" uniqKey="Fehr A">AR Fehr</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author><author><name sortKey="El Kafrawy, Sa" uniqKey="El Kafrawy S">SA El-Kafrawy</name></author><author><name sortKey="Farraj, Sa" uniqKey="Farraj S">SA Farraj</name></author><author><name sortKey="Hassan, Am" uniqKey="Hassan A">AM Hassan</name></author><author><name sortKey="Al Saeed, Ms" uniqKey="Al Saeed M">MS Al-Saeed</name></author><author><name sortKey="Hashem, Am" uniqKey="Hashem A">AM Hashem</name></author><author><name sortKey="Madani, Ta" uniqKey="Madani T">TA Madani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name></author><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Mohran, K S" uniqKey="Mohran K">K S Mohran</name></author><author><name sortKey="Raj, V" uniqKey="Raj V">V Raj</name></author><author><name sortKey="Pas, Sd" uniqKey="Pas S">SD Pas</name></author><author><name sortKey="Voermans, J" uniqKey="Voermans J">J Voermans</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Godeke, Gj" uniqKey="Godeke G">GJ Godeke</name></author><author><name sortKey="Al Hajri, Mm" uniqKey="Al Hajri M">MM Al-Hajri</name></author><author><name sortKey="Alhajri, Fh" uniqKey="Alhajri F">FH Alhajri</name></author><author><name sortKey="Al Romaihi, He" uniqKey="Al Romaihi H">HE Al-Romaihi</name></author><author><name sortKey="Ghobashy, H" uniqKey="Ghobashy H">H Ghobashy</name></author><author><name sortKey="El Maghraby, Mm" uniqKey="El Maghraby M">MM El-Maghraby</name></author><author><name sortKey="El Sayed, A A" uniqKey="El Sayed A">A A El-Sayed</name></author><author><name sortKey="Thani, Mh" uniqKey="Thani M">MH Thani</name></author><author><name sortKey="Al Marri, S" uniqKey="Al Marri S">S Al-Marri</name></author><author><name sortKey="Koopmans, Mp" uniqKey="Koopmans M">MP Koopmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Sm" uniqKey="Chan S">SM Chan</name></author><author><name sortKey="Damdinjav, B" uniqKey="Damdinjav B">B Damdinjav</name></author><author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name></author><author><name sortKey="Chu, Dk" uniqKey="Chu D">DK Chu</name></author><author><name sortKey="Khishgee, B" uniqKey="Khishgee B">B Khishgee</name></author><author><name sortKey="Enkhbold, B" uniqKey="Enkhbold B">B Enkhbold</name></author><author><name sortKey="Poon, Ll" uniqKey="Poon L">LL Poon</name></author><author><name sortKey="Peiris, M" uniqKey="Peiris M">M Peiris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name></author><author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name></author><author><name sortKey="Jain, K" uniqKey="Jain K">K Jain</name></author><author><name sortKey="Zalmout, Is" uniqKey="Zalmout I">IS Zalmout</name></author><author><name sortKey="Jabado, Oj" uniqKey="Jabado O">OJ Jabado</name></author><author><name sortKey="Karesh, Wb" uniqKey="Karesh W">WB Karesh</name></author><author><name sortKey="Daszak, P" uniqKey="Daszak P">P Daszak</name></author><author><name sortKey="Mohammed, Ob" uniqKey="Mohammed O">OB Mohammed</name></author><author><name sortKey="Alagaili, An" uniqKey="Alagaili A">AN Alagaili</name></author><author><name sortKey="Lipkin, Wi" uniqKey="Lipkin W">WI Lipkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name></author><author><name sortKey="Provacia, Lb" uniqKey="Provacia L">LB Provacia</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Stittelaar, Kj" uniqKey="Stittelaar K">KJ Stittelaar</name></author><author><name sortKey="Getu, S" uniqKey="Getu S">S Getu</name></author><author><name sortKey="De Waal, L" uniqKey="De Waal L">L de Waal</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Van Amerongen, G" uniqKey="Van Amerongen G">G van Amerongen</name></author><author><name sortKey="Verjans, Gm" uniqKey="Verjans G">GM Verjans</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name></author><author><name sortKey="Miazgowicz, Kl" uniqKey="Miazgowicz K">KL Miazgowicz</name></author><author><name sortKey="Milne Price, S" uniqKey="Milne Price S">S Milne-Price</name></author><author><name sortKey="Bushmaker, T" uniqKey="Bushmaker T">T Bushmaker</name></author><author><name sortKey="Robertson, S" uniqKey="Robertson S">S Robertson</name></author><author><name sortKey="Scott, D" uniqKey="Scott D">D Scott</name></author><author><name sortKey="Kinne, J" uniqKey="Kinne J">J Kinne</name></author><author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name></author><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barlan, A" uniqKey="Barlan A">A Barlan</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Sarkar, Mk" uniqKey="Sarkar M">MK Sarkar</name></author><author><name sortKey="Li, K M" uniqKey="Li K">K M Li</name></author><author><name sortKey="Cray, P J" uniqKey="Cray P">P J Cray</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name></author><author><name sortKey="Baldwin, Hj" uniqKey="Baldwin H">HJ Baldwin</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Klose, Sm" uniqKey="Klose S">SM Klose</name></author><author><name sortKey="Owusu, M" uniqKey="Owusu M">M Owusu</name></author><author><name sortKey="Nkrumah, Ee" uniqKey="Nkrumah E">EE Nkrumah</name></author><author><name sortKey="Badu, Ek" uniqKey="Badu E">EK Badu</name></author><author><name sortKey="Anti, P" uniqKey="Anti P">P Anti</name></author><author><name sortKey="Agbenyega, O" uniqKey="Agbenyega O">O Agbenyega</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Oppong, S" uniqKey="Oppong S">S Oppong</name></author><author><name sortKey="Sarkodie, Ya" uniqKey="Sarkodie Y">YA Sarkodie</name></author><author><name sortKey="Kalko, Ek" uniqKey="Kalko E">EK Kalko</name></author><author><name sortKey="Lina, Ph" uniqKey="Lina P">PH Lina</name></author><author><name sortKey="Godlevska, Ev" uniqKey="Godlevska E">EV Godlevska</name></author><author><name sortKey="Reusken, C" uniqKey="Reusken C">C Reusken</name></author><author><name sortKey="Seebens, A" uniqKey="Seebens A">A Seebens</name></author><author><name sortKey="Gloza Rausch, F" uniqKey="Gloza Rausch F">F Gloza-Rausch</name></author><author><name sortKey="Vallo, P" uniqKey="Vallo P">P Vallo</name></author><author><name sortKey="Tschapka, M" uniqKey="Tschapka M">M Tschapka</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Drexler, Jf" uniqKey="Drexler J">JF Drexler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Tang, J" uniqKey="Tang J">J Tang</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name></author><author><name sortKey="Olival, Kj" uniqKey="Olival K">KJ Olival</name></author><author><name sortKey="Fagbo, Sf" uniqKey="Fagbo S">SF Fagbo</name></author><author><name sortKey="Kapoor, V" uniqKey="Kapoor V">V Kapoor</name></author><author><name sortKey="Epstein, Jh" uniqKey="Epstein J">JH Epstein</name></author><author><name sortKey="Alhakeem, R" uniqKey="Alhakeem R">R Alhakeem</name></author><author><name sortKey="Durosinloun, A A" uniqKey="Durosinloun A">A A Durosinloun</name></author><author><name sortKey="Asmari, M" uniqKey="Asmari M">M Asmari</name></author><author><name sortKey="Islam, A" uniqKey="Islam A">A Islam</name></author><author><name sortKey="Kapoor, A" uniqKey="Kapoor A">A Kapoor</name></author><author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name></author><author><name sortKey="Daszak, P A" uniqKey="Daszak P">P A Daszak</name></author><author><name sortKey="Rabeeah, Aa" uniqKey="Rabeeah A">AA Rabeeah</name></author><author><name sortKey="Lipkin, Wi" uniqKey="Lipkin W">WI Lipkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, D M M" uniqKey="Dekkers D">D M M Dekkers</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, Ja" uniqKey="Demmers J">JA Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Lambertz, Am" uniqKey="Lambertz A">AM Lambertz</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siu, Kl" uniqKey="Siu K">KL Siu</name></author><author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name></author><author><name sortKey="Kok, Kh" uniqKey="Kok K">KH Kok</name></author><author><name sortKey="Yuen, Ks" uniqKey="Yuen K">KS Yuen</name></author><author><name sortKey="Kew, C" uniqKey="Kew C">C Kew</name></author><author><name sortKey="Lui, Py" uniqKey="Lui P">PY Lui</name></author><author><name sortKey="Chan, Cp" uniqKey="Chan C">CP Chan</name></author><author><name sortKey="Tse, H" uniqKey="Tse H">H Tse</name></author><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Jin, Dy" uniqKey="Jin D">DY Jin</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Josset, L" uniqKey="Josset L">L Josset</name></author><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author><author><name sortKey="Gralinski, Le" uniqKey="Gralinski L">LE Gralinski</name></author><author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name></author><author><name sortKey="Sova, P" uniqKey="Sova P">P Sova</name></author><author><name sortKey="Carter, Vs" uniqKey="Carter V">VS Carter</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Katze, Mg" uniqKey="Katze M">MG Katze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Al Rabiah, Fa" uniqKey="Al Rabiah F">FA Al-Rabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al-Hajjar</name></author><author><name sortKey="Al Barrak, A" uniqKey="Al Barrak A">A Al-Barrak</name></author><author><name sortKey="Flemban, H" uniqKey="Flemban H">H Flemban</name></author><author><name sortKey="Al Nassir, Wn" uniqKey="Al Nassir W">WN Al-Nassir</name></author><author><name sortKey="Balkhy, H A" uniqKey="Balkhy H">H A- Balkhy</name></author><author><name sortKey="Hakeem, Rf" uniqKey="Hakeem R">RF Hakeem</name></author><author><name sortKey="Makhdoom, Hq" uniqKey="Makhdoom H">HQ Makhdoom</name></author><author><name sortKey="Zumla, Ai" uniqKey="Zumla A">AI Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Eckerle, I M M" uniqKey="Eckerle I">I M M Eckerle</name></author><author><name sortKey="Kallies, S" uniqKey="Kallies S">S Kallies</name></author><author><name sortKey="Gotthardt, Dn" uniqKey="Gotthardt D">DN Gotthardt</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saad, M" uniqKey="Saad M">M Saad</name></author><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A Bahloul</name></author><author><name sortKey="Elzein, F" uniqKey="Elzein F">F Elzein</name></author><author><name sortKey="Matin, Ma" uniqKey="Matin M">MA Matin</name></author><author><name sortKey="Selim, Ma" uniqKey="Selim M">MA Selim</name></author><author><name sortKey="Al Mutairi, M" uniqKey="Al Mutairi M">M Al Mutairi</name></author><author><name sortKey="Al Nakhli, D" uniqKey="Al Nakhli D">D Al Nakhli</name></author><author><name sortKey="Al Aidaroos, Ay" uniqKey="Al Aidaroos A">AY Al Aidaroos</name></author><author><name sortKey="Al Sherbeeni, N" uniqKey="Al Sherbeeni N">N Al Sherbeeni</name></author><author><name sortKey="Al Khashan, Hi" uniqKey="Al Khashan H">HI Al-Khashan</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Albarrak, Am" uniqKey="Albarrak A">AM Albarrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Makhdoom, Hq" uniqKey="Makhdoom H">HQ Makhdoom</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Alhakeem, Rf" uniqKey="Alhakeem R">RF Alhakeem</name></author><author><name sortKey="Alrabiah, Fa" uniqKey="Alrabiah F">FA AlRabiah</name></author><author><name sortKey="Al Hajjar, S" uniqKey="Al Hajjar S">S Al Hajjar</name></author><author><name sortKey="Albarrak, A" uniqKey="Albarrak A">A Albarrak</name></author><author><name sortKey="Flemban, H" uniqKey="Flemban H">H Flemban</name></author><author><name sortKey="Balkhy, H" uniqKey="Balkhy H">H Balkhy</name></author><author><name sortKey="Barry, M" uniqKey="Barry M">M Barry</name></author><author><name sortKey="Alhassan, S" uniqKey="Alhassan S">S Alhassan</name></author><author><name sortKey="Alsubaie, S" uniqKey="Alsubaie S">S Alsubaie</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name></author><author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name></author><author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name></author><author><name sortKey="Rha, B" uniqKey="Rha B">B Rha</name></author><author><name sortKey="Tohme, Ra" uniqKey="Tohme R">RA Tohme</name></author><author><name sortKey="Abedi, G A" uniqKey="Abedi G">G A Abedi</name></author><author><name sortKey="Nsour, M" uniqKey="Nsour M">M Nsour</name></author><author><name sortKey="Iblan, I" uniqKey="Iblan I">I Iblan</name></author><author><name sortKey="Jarour, N" uniqKey="Jarour N">N Jarour</name></author><author><name sortKey="Farag, Nh" uniqKey="Farag N">NH Farag</name></author><author><name sortKey="Haddadin, A" uniqKey="Haddadin A">A Haddadin</name></author><author><name sortKey="Al Sanouri, T" uniqKey="Al Sanouri T">T Al-Sanouri</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A Tamin</name></author><author><name sortKey="Harcourt, Jl" uniqKey="Harcourt J">JL Harcourt</name></author><author><name sortKey="Kuhar, Dt" uniqKey="Kuhar D">DT Kuhar</name></author><author><name sortKey="Swerdlow, Dl" uniqKey="Swerdlow D">DL Swerdlow</name></author><author><name sortKey="Erdman, Dd" uniqKey="Erdman D">DD Erdman</name></author><author><name sortKey="Pallansch, Ma" uniqKey="Pallansch M">MA Pallansch</name></author><author><name sortKey="Haynes, Lm" uniqKey="Haynes L">LM Haynes</name></author><author><name sortKey="Gerber, Si" uniqKey="Gerber S">SI Gerber</name></author><author><name sortKey="Sabri, N" uniqKey="Sabri N">N Sabri</name></author><author><name sortKey="Al Azhari, M" uniqKey="Al Azhari M">M Al Azhari</name></author><author><name sortKey="Khazali, H" uniqKey="Khazali H">H Khazali</name></author><author><name sortKey="Al Maayah, M" uniqKey="Al Maayah M">M Al Maayah</name></author><author><name sortKey="Bilbeisi, A" uniqKey="Bilbeisi A">A Bilbeisi</name></author><author><name sortKey="Dawood, N" uniqKey="Dawood N">N Dawood</name></author><author><name sortKey="Al Zubi, B" uniqKey="Al Zubi B">B Al Zubi</name></author><author><name sortKey="Meflih, J" uniqKey="Meflih J">J Meflih</name></author><author><name sortKey="Mounds, T" uniqKey="Mounds T">T Mounds</name></author><author><name sortKey="Fitzner, J" uniqKey="Fitzner J">J Fitzner</name></author><author><name sortKey="Eltom, A" uniqKey="Eltom A">A Eltom</name></author><author><name sortKey="Mafi, A" uniqKey="Mafi A">A Mafi</name></author><author><name sortKey="Miao, C" uniqKey="Miao C">C Miao</name></author><author><name sortKey="Caidi, H" uniqKey="Caidi H">H Caidi</name></author><author><name sortKey="Trivedi, S" uniqKey="Trivedi S">S Trivedi</name></author><author><name sortKey="Kamili, S" uniqKey="Kamili S">S Kamili</name></author><author><name sortKey="Hall, Aj" uniqKey="Hall A">AJ Hall</name></author><author><name sortKey="Curns, A" uniqKey="Curns A">A Curns</name></author><author><name sortKey="Moore, J" uniqKey="Moore J">J Moore</name></author><author><name sortKey="Pham, H" uniqKey="Pham H">H Pham</name></author><author><name sortKey="Zimmerman, C" uniqKey="Zimmerman C">C Zimmerman</name></author><author><name sortKey="Farnon, E" uniqKey="Farnon E">E Farnon</name></author><author><name sortKey="Giorgi, G" uniqKey="Giorgi G">G Giorgi</name></author><author><name sortKey="Gerber, R" uniqKey="Gerber R">R Gerber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name></author><author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name></author><author><name sortKey="Price, C A" uniqKey="Price C">C A Price</name></author><author><name sortKey="Rabeeah, Aa" uniqKey="Rabeeah A">AA Rabeeah</name></author><author><name sortKey="Cummings, Da" uniqKey="Cummings D">DA Cummings</name></author><author><name sortKey="Alabdullatif, Zn" uniqKey="Alabdullatif Z">ZN Alabdullatif</name></author><author><name sortKey="Assad, M" uniqKey="Assad M">M Assad</name></author><author><name sortKey="Almulhim, A" uniqKey="Almulhim A">A Almulhim</name></author><author><name sortKey="Makhdoom, H" uniqKey="Makhdoom H">H Makhdoom</name></author><author><name sortKey="Madani, H" uniqKey="Madani H">H Madani</name></author><author><name sortKey="Alhakeem, R" uniqKey="Alhakeem R">R Alhakeem</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name></author><author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name></author><author><name sortKey="Kellam, P" uniqKey="Kellam P">P Kellam</name></author><author><name sortKey="Zumla, A M Z K M C I Team" uniqKey="Zumla A">A M Z K M-C I Team Zumla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Hinedi, K" uniqKey="Hinedi K">K Hinedi</name></author><author><name sortKey="Ghandour, J" uniqKey="Ghandour J">J Ghandour</name></author><author><name sortKey="Khairalla, H" uniqKey="Khairalla H">H Khairalla</name></author><author><name sortKey="Musleh, S" uniqKey="Musleh S">S Musleh</name></author><author><name sortKey="Ujayli, A" uniqKey="Ujayli A">A Ujayli</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name></author><author><name sortKey="Arifi, Aa" uniqKey="Arifi A">AA Arifi</name></author><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name></author><author><name sortKey="Najm, H" uniqKey="Najm H">H Najm</name></author><author><name sortKey="Aldawood, As" uniqKey="Aldawood A">AS Aldawood</name></author><author><name sortKey="Ghabashi, A" uniqKey="Ghabashi A">A Ghabashi</name></author><author><name sortKey="Hawa, H" uniqKey="Hawa H">H Hawa</name></author><author><name sortKey="Alothman, A" uniqKey="Alothman A">A Alothman</name></author><author><name sortKey="Khaldi, A" uniqKey="Khaldi A">A Khaldi</name></author><author><name sortKey="Al Raiy, B" uniqKey="Al Raiy B">B Al Raiy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thabet, F" uniqKey="Thabet F">F Thabet</name></author><author><name sortKey="Chehab, M" uniqKey="Chehab M">M Chehab</name></author><author><name sortKey="Bafaqih, H" uniqKey="Bafaqih H">H Bafaqih</name></author><author><name sortKey="Al Mohaimeed, S" uniqKey="Al Mohaimeed S">S Al Mohaimeed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Denison, Mr" uniqKey="Denison M">MR Denison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bin Seo, Y" uniqKey="Bin Seo Y">Y Bin Seo</name></author><author><name sortKey="Heo, Jy" uniqKey="Heo J">JY Heo</name></author><author><name sortKey="Song, Ms" uniqKey="Song M">MS Song</name></author><author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name></author><author><name sortKey="Kim, Eh" uniqKey="Kim E">EH Kim</name></author><author><name sortKey="Park, Sj" uniqKey="Park S">SJ Park</name></author><author><name sortKey="Kwon, Hi" uniqKey="Kwon H">HI Kwon</name></author><author><name sortKey="Kim, Sm" uniqKey="Kim S">SM Kim</name></author><author><name sortKey="Kim, Yi" uniqKey="Kim Y">YI Kim</name></author><author><name sortKey="Si, Yj" uniqKey="Si Y">YJ Si</name></author><author><name sortKey="Lee, Iw" uniqKey="Lee I">IW Lee</name></author><author><name sortKey="Baek, Yh" uniqKey="Baek Y">YH Baek</name></author><author><name sortKey="Choi, Ws" uniqKey="Choi W">WS Choi</name></author><author><name sortKey="Min, J" uniqKey="Min J">J Min</name></author><author><name sortKey="Jeong, Hw" uniqKey="Jeong H">HW Jeong</name></author><author><name sortKey="Choi, Yk" uniqKey="Choi Y">YK Choi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hui, Ds" uniqKey="Hui D">DS Hui</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Wilde, Ah" uniqKey="De Wilde A">AH de Wilde</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Oudshoorn, D" uniqKey="Oudshoorn D">D Oudshoorn</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Van Nieuwkoop, S" uniqKey="Van Nieuwkoop S">S van Nieuwkoop</name></author><author><name sortKey="Limpens, Rw" uniqKey="Limpens R">RW Limpens</name></author><author><name sortKey="Posthuma, Cc" uniqKey="Posthuma C">CC Posthuma</name></author><author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name></author><author><name sortKey="Barcena, M" uniqKey="Barcena M">M Bárcena</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Van Den Hoogen, Bg" uniqKey="Van Den Hoogen B">BG van den Hoogen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author><author><name sortKey="Martellaro, C" uniqKey="Martellaro C">C Martellaro</name></author><author><name sortKey="Callison, J" uniqKey="Callison J">J Callison</name></author><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Omrani, As" uniqKey="Omrani A">AS Omrani</name></author><author><name sortKey="Saad, Mm" uniqKey="Saad M">MM Saad</name></author><author><name sortKey="Baig, K" uniqKey="Baig K">K Baig</name></author><author><name sortKey="Bahloul, A" uniqKey="Bahloul A">A Bahloul</name></author><author><name sortKey="Abdul Matin, M" uniqKey="Abdul Matin M">M Abdul-Matin</name></author><author><name sortKey="Alaidaroos, Ay" uniqKey="Alaidaroos A">AY Alaidaroos</name></author><author><name sortKey="Almakhlafi, Ga" uniqKey="Almakhlafi G">GA Almakhlafi</name></author><author><name sortKey="Albarrak, Mm" uniqKey="Albarrak M">MM Albarrak</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author><author><name sortKey="Albarrak, Am" uniqKey="Albarrak A">AM Albarrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Kao, Ry" uniqKey="Kao R">RY Kao</name></author><author><name sortKey="To, Kk" uniqKey="To K">KK To</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Li, Cp" uniqKey="Li C">CP Li</name></author><author><name sortKey="Li, Pt" uniqKey="Li P">PT Li</name></author><author><name sortKey="Dai, J" uniqKey="Dai J">J Dai</name></author><author><name sortKey="Mok, Fk" uniqKey="Mok F">FK Mok</name></author><author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name></author><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Murakami, A" uniqKey="Murakami A">A Murakami</name></author><author><name sortKey="Tamin, A M L" uniqKey="Tamin A">A M L Tamin</name></author><author><name sortKey="Wong, Sk" uniqKey="Wong S">SK Wong</name></author><author><name sortKey="Moore, Mj" uniqKey="Moore M">MJ Moore</name></author><author><name sortKey="Tallarico, As" uniqKey="Tallarico A">AS Tallarico</name></author><author><name sortKey="Olurinde, M" uniqKey="Olurinde M">M Olurinde</name></author><author><name sortKey="Choe, H" uniqKey="Choe H">H Choe</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author><author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ter Meulen, J" uniqKey="Ter Meulen J">J ter Meulen</name></author><author><name sortKey="Bakker, Ab" uniqKey="Bakker A">AB Bakker</name></author><author><name sortKey="Van Den Brink, En" uniqKey="Van Den Brink E">EN van den Brink</name></author><author><name sortKey="Weverling, Gj" uniqKey="Weverling G">GJ Weverling</name></author><author><name sortKey="Martina, Be" uniqKey="Martina B">BE Martina</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="De Kruif, J" uniqKey="De Kruif J">J de Kruif</name></author><author><name sortKey="Preiser, W" uniqKey="Preiser W">W Preiser</name></author><author><name sortKey="Spaan, W" uniqKey="Spaan W">W Spaan</name></author><author><name sortKey="Gelderblom, Hr" uniqKey="Gelderblom H">HR Gelderblom</name></author><author><name sortKey="Goudsmit, J" uniqKey="Goudsmit J">J Goudsmit</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Traggiai, E" uniqKey="Traggiai E">E Traggiai</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S Becker</name></author><author><name sortKey="Subbarao, K" uniqKey="Subbarao K">K Subbarao</name></author><author><name sortKey="Kolesnikova, L" uniqKey="Kolesnikova L">L Kolesnikova</name></author><author><name sortKey="Uematsu, Y" uniqKey="Uematsu Y">Y Uematsu</name></author><author><name sortKey="Gismondo, Mr" uniqKey="Gismondo M">MR Gismondo</name></author><author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name></author><author><name sortKey="Rappuoli, R" uniqKey="Rappuoli R">R Rappuoli</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Kou, Z" uniqKey="Kou Z">Z Kou</name></author><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="Tseng, Ct" uniqKey="Tseng C">CT Tseng</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Ju, Tw" uniqKey="Ju T">TW Ju</name></author><author><name sortKey="Prabakaran, P" uniqKey="Prabakaran P">P Prabakaran</name></author><author><name sortKey="Lau, Cc" uniqKey="Lau C">CC Lau</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Wang, L" uniqKey="Wang L">L Wang</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y Feng</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Zuo, T" uniqKey="Zuo T">T Zuo</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Poon, Km" uniqKey="Poon K">KM Poon</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Gao, F" uniqKey="Gao F">F Gao</name></author><author><name sortKey="Li, D" uniqKey="Li D">D Li</name></author><author><name sortKey="Wang, R" uniqKey="Wang R">R Wang</name></author><author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Xc" uniqKey="Tang X">XC Tang</name></author><author><name sortKey="Agnihothram, Ss" uniqKey="Agnihothram S">SS Agnihothram</name></author><author><name sortKey="Jiao, Y" uniqKey="Jiao Y">Y Jiao</name></author><author><name sortKey="Stanhope, J" uniqKey="Stanhope J">J Stanhope</name></author><author><name sortKey="Graham, Rl" uniqKey="Graham R">RL Graham</name></author><author><name sortKey="Peterson, Ec" uniqKey="Peterson E">EC Peterson</name></author><author><name sortKey="Avnir, Y" uniqKey="Avnir Y">Y Avnir</name></author><author><name sortKey="Tallarico, As" uniqKey="Tallarico A">AS Tallarico</name></author><author><name sortKey="Sheehan, J" uniqKey="Sheehan J">J Sheehan</name></author><author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ying, T" uniqKey="Ying T">T Ying</name></author><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Dimitrov, Ds" uniqKey="Dimitrov D">DS Dimitrov</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lu, L" uniqKey="Lu L">L Lu</name></author><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name></author><author><name sortKey="Zhu, Y" uniqKey="Zhu Y">Y Zhu</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Qin, L" uniqKey="Qin L">L Qin</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Chan, Jf" uniqKey="Chan J">JF Chan</name></author><author><name sortKey="Du, L" uniqKey="Du L">L Du</name></author><author><name sortKey="Yu, F" uniqKey="Yu F">F Yu</name></author><author><name sortKey="Ma, C" uniqKey="Ma C">C Ma</name></author><author><name sortKey="Ye, S" uniqKey="Ye S">S Ye</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Jiang, S" uniqKey="Jiang S">S Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borio, L" uniqKey="Borio L">L Borio</name></author><author><name sortKey="Cox, E" uniqKey="Cox E">E Cox</name></author><author><name sortKey="Lurie, N" uniqKey="Lurie N">N Lurie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A Volz</name></author><author><name sortKey="Wohlsein, P" uniqKey="Wohlsein P">P Wohlsein</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Schipper, D" uniqKey="Schipper D">D Schipper</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Okba, N" uniqKey="Okba N">N Okba</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R Fux</name></author><author><name sortKey="Bensaid, A" uniqKey="Bensaid A">A Bensaid</name></author><author><name sortKey="Solanes Foz, D" uniqKey="Solanes Foz D">D Solanes Foz</name></author><author><name sortKey="Kuiken, T" uniqKey="Kuiken T">T Kuiken</name></author><author><name sortKey="Baumg Rtner, W" uniqKey="Baumg Rtner W">W Baumgärtner</name></author><author><name sortKey="Segales, J" uniqKey="Segales J">J Segalés</name></author><author><name sortKey="Sutter, G" uniqKey="Sutter G">G Sutter</name></author><author><name sortKey="Osterhaus, Ad" uniqKey="Osterhaus A">AD Osterhaus</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Med</journal-id><journal-id journal-id-type="iso-abbrev">Front Med</journal-id><journal-title-group><journal-title>Frontiers of Medicine</journal-title></journal-title-group><issn pub-type="ppub">2095-0217</issn><issn pub-type="epub">2095-0225</issn><publisher><publisher-name>Higher Education Press</publisher-name><publisher-loc>Beijing</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27726088</article-id><article-id pub-id-type="pmc">7088694</article-id><article-id pub-id-type="publisher-id">466</article-id><article-id pub-id-type="doi">10.1007/s11684-016-0466-7</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>From SARS to MERS: evidence and speculation</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Gao</surname><given-names>Hainv</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yao</surname><given-names>Hangping</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Shigui</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Li</surname><given-names>Lanjuan</given-names></name><address><email>ljli@zju.edu.cn</email></address><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id institution-id-type="GRID">grid.13402.34</institution-id><institution>State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine,</institution><institution>Zhejiang University,</institution></institution-wrap>Hangzhou, 310003 China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1759 700X</institution-id><institution-id institution-id-type="GRID">grid.13402.34</institution-id><institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,</institution></institution-wrap>Hangzhou, 310003 China</aff></contrib-group><pub-date pub-type="epub"><day>23</day><month>12</month><year>2016</year></pub-date><pub-date pub-type="ppub"><year>2016</year></pub-date><volume>10</volume><issue>4</issue><fpage>377</fpage><lpage>382</lpage><history><date date-type="received"><day>9</day><month>8</month><year>2015</year></date><date date-type="accepted"><day>12</day><month>6</month><year>2016</year></date></history><permissions><copyright-statement>© Higher Education Press and Springer-Verlag Berlin Heidelberg 2016</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has spread to more than 1600 patients in 26 countries, resulting in over 600 deaths.Without a travel history, few clinical and radiological features can reliably differentiate MERS from SARS. But in real world, comparing with SARS, MERS presents more vaguely defined epidemiology, more severe symptoms, and higher case fatality rate. In this review, we summarize the recent findings in the field of MERS-CoV, especially its molecular virology, interspecies mechanisms, clinical features, antiviral therapies, and the further investigation into this disease. As a newly emerging virus, many questions are not fully answered, including the exact mode of transmission chain, geographical distribution, and animal origins. Furthermore, a new protocol needs to be launched to rapidly evaluate the effects of unproven antiviral drugs and vaccine to fasten the clinical application of new drugs.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>middle east respiratory syndrome</kwd><kwd>animal origin</kwd><kwd>cross-species transmission</kwd><kwd>monoclonal antibody</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Higher Education Press and Springer-Verlag Berlin Heidelberg 2016</meta-value></custom-meta></custom-meta-group></article-meta></front><back><ref-list id="Bib1"><title>References</title><ref id="CR1"><label>1.</label><mixed-citation publication-type="other">World Health Organization. Summary of probable SARS cases with onset of illness from 1 November 2002 to 31 July 2003[EB/OL]. 2004–04–21.http://www.who.int/csr/sars/country/table2004_04_21/en/ (Acessed July 27, 2015)</mixed-citation></ref><ref id="CR2"><label>2.</label><mixed-citation publication-type="other">World Health Organization. Middel East respiratory syndrome coronavirus (MERS-CoV) Saudi Arabia. http://www.who.int/csr/ don/23-march-2016-mers-saudi-arabia/en/(Acessed August 6, 2016)</mixed-citation></ref><ref id="CR3"><label>3.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zaki</surname><given-names>AM</given-names></name><name><surname>van Boheemen</surname><given-names>S</given-names></name><name><surname>Bestebroer</surname><given-names>TM</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name></person-group><article-title>Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia</article-title><source>N Engl J Med</source><year>2012</year><volume>367</volume><issue>19</issue><fpage>1814</fpage><lpage>1820</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa1211721</pub-id><pub-id pub-id-type="pmid">23075143</pub-id></element-citation></ref><ref id="CR4"><label>4.</label><mixed-citation publication-type="other">World Health Organization. Background and summary of novel coronavirus infection—as of 22 November 2013. 2013. http://www.who.int/ csr/disease/coronavirus_infections/Update12_ MERSCoV_update_22Nov13. Pdf (Acessed August 6, 2016)</mixed-citation></ref><ref id="CR5"><label>5.</label><mixed-citation publication-type="other">World Health Organization. Middle East respiratory syndrome coronavirus (MERS-CoV)—Republic of Korea. Geneva: WHO. 24 May 2015. http://www.who.int/csr/don/14-july-2015-mers-korea/ en/ (Accessed July 15 2015)</mixed-citation></ref><ref id="CR6"><label>6.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zumla</surname><given-names>A H D</given-names></name><name><surname>Perlman</surname><given-names>S</given-names></name></person-group><article-title>Middle East respiratory syndrome</article-title><source>Lancet</source><year>2015</year><volume>386</volume><issue>9997</issue><fpage>995</fpage><lpage>1007</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(15)60454-8</pub-id><pub-id pub-id-type="pmid">26049252</pub-id></element-citation></ref><ref id="CR7"><label>7.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lau</surname><given-names>SK</given-names></name><name><surname>Li</surname><given-names>KS</given-names></name><name><surname>Tsang</surname><given-names>AK</given-names></name><name><surname>Lam</surname><given-names>CS</given-names></name><name><surname>Ahmed</surname><given-names>S</given-names></name><name><surname>Chen</surname><given-names>H</given-names></name><name><surname>Chan</surname><given-names>KH</given-names></name><name><surname>Woo</surname><given-names>PC</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name></person-group><article-title>Genetic characterization of Betacoronavirus lineage C viruses in bats reveals marked sequence divergence in the spike protein of pipistrellus bat coronavirus HKU5 in Japanese pipistrelle: implications for the origin of the novel Middle East respiratory syndrome coronavirus</article-title><source>J Virol</source><year>2013</year><volume>87</volume><issue>15</issue><fpage>8638</fpage><lpage>8650</lpage><pub-id pub-id-type="doi">10.1128/JVI.01055-13</pub-id><pub-id pub-id-type="pmid">23720729</pub-id></element-citation></ref><ref id="CR8"><label>8.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fehr</surname><given-names>AR</given-names></name><name><surname>Perlman</surname><given-names>S</given-names></name></person-group><article-title>Coronaviruses: an overview of their replication and pathogenesis</article-title><source>Methods Mol Biol</source><year>2015</year><volume>1282</volume><fpage>1</fpage><lpage>23</lpage><pub-id pub-id-type="doi">10.1007/978-1-4939-2438-7_1</pub-id><pub-id pub-id-type="pmid">25720466</pub-id></element-citation></ref><ref id="CR9"><label>9.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Azhar</surname><given-names>EI</given-names></name><name><surname>El-Kafrawy</surname><given-names>SA</given-names></name><name><surname>Farraj</surname><given-names>SA</given-names></name><name><surname>Hassan</surname><given-names>AM</given-names></name><name><surname>Al-Saeed</surname><given-names>MS</given-names></name><name><surname>Hashem</surname><given-names>AM</given-names></name><name><surname>Madani</surname><given-names>TA</given-names></name></person-group><article-title>Evidence for camel-to-human transmission of MERS coronavirus</article-title><source>N Engl J Med</source><year>2014</year><volume>370</volume><issue>26</issue><fpage>2499</fpage><lpage>2505</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa1401505</pub-id><pub-id pub-id-type="pmid">24896817</pub-id></element-citation></ref><ref id="CR10"><label>10.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Farag</surname><given-names>EA</given-names></name><name><surname>Reusken</surname><given-names>CB</given-names></name><name><surname>Haagmans</surname><given-names>BL</given-names></name><name><surname>Mohran</surname><given-names>K S</given-names></name><name><surname>Raj</surname><given-names>V</given-names></name><name><surname>Pas</surname><given-names>SD</given-names></name><name><surname>Voermans</surname><given-names>J</given-names></name><name><surname>Smits</surname><given-names>SL</given-names></name><name><surname>Godeke</surname><given-names>GJ</given-names></name><name><surname>Al-Hajri</surname><given-names>MM</given-names></name><name><surname>Alhajri</surname><given-names>FH</given-names></name><name><surname>Al-Romaihi</surname><given-names>HE</given-names></name><name><surname>Ghobashy</surname><given-names>H</given-names></name><name><surname>El-Maghraby</surname><given-names>MM</given-names></name><name><surname>El-Sayed</surname><given-names>A A</given-names></name><name><surname>Thani</surname><given-names>MH</given-names></name><name><surname>Al-Marri</surname><given-names>S</given-names></name><name><surname>Koopmans</surname><given-names>MP</given-names></name></person-group><article-title>High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014</article-title><source>Infect Ecol Epidemiol</source><year>2015</year><volume>5</volume><fpage>28305</fpage><pub-id pub-id-type="doi">10.3402/iee.v5.28305</pub-id><pub-id pub-id-type="pmid">26183160</pub-id></element-citation></ref><ref id="CR11"><label>11.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>SM</given-names></name><name><surname>Damdinjav</surname><given-names>B</given-names></name><name><surname>Perera</surname><given-names>RA</given-names></name><name><surname>Chu</surname><given-names>DK</given-names></name><name><surname>Khishgee</surname><given-names>B</given-names></name><name><surname>Enkhbold</surname><given-names>B</given-names></name><name><surname>Poon</surname><given-names>LL</given-names></name><name><surname>Peiris</surname><given-names>M</given-names></name></person-group><article-title>Absence of MERS-Coronavirus in Bactrian Camels, Southern Mongolia, November 2014</article-title><source>Emerg Infect Dis</source><year>2015</year><volume>21</volume><issue>7</issue><fpage>1269</fpage><lpage>1271</lpage><pub-id pub-id-type="doi">10.3201/eid2107.150178</pub-id><pub-id pub-id-type="pmid">26080032</pub-id></element-citation></ref><ref id="CR12"><label>12.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Briese</surname><given-names>T</given-names></name><name><surname>Mishra</surname><given-names>N</given-names></name><name><surname>Jain</surname><given-names>K</given-names></name><name><surname>Zalmout</surname><given-names>IS</given-names></name><name><surname>Jabado</surname><given-names>OJ</given-names></name><name><surname>Karesh</surname><given-names>WB</given-names></name><name><surname>Daszak</surname><given-names>P</given-names></name><name><surname>Mohammed</surname><given-names>OB</given-names></name><name><surname>Alagaili</surname><given-names>AN</given-names></name><name><surname>Lipkin</surname><given-names>WI</given-names></name></person-group><article-title>Middle East respiratory syndrome coronavirus quasispecies that include homologues of human isolates revealed through whole-genome analysis and virus cultured from dromedary camels in Saudi Arabia</article-title><source>MBio</source><year>2014</year><volume>5</volume><issue>3</issue><fpage>e01146</fpage><lpage>e14</lpage><pub-id pub-id-type="doi">10.1128/mBio.01146-14</pub-id><pub-id pub-id-type="pmid">24781747</pub-id></element-citation></ref><ref id="CR13"><label>13.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haagmans</surname><given-names>BL</given-names></name><name><surname>van den Brand</surname><given-names>JM</given-names></name><name><surname>Provacia</surname><given-names>LB</given-names></name><name><surname>Raj</surname><given-names>VS</given-names></name><name><surname>Stittelaar</surname><given-names>KJ</given-names></name><name><surname>Getu</surname><given-names>S</given-names></name><name><surname>de Waal</surname><given-names>L</given-names></name><name><surname>Bestebroer</surname><given-names>TM</given-names></name><name><surname>van Amerongen</surname><given-names>G</given-names></name><name><surname>Verjans</surname><given-names>GM</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Smits</surname><given-names>SL</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name></person-group><article-title>Asymptomatic Middle East respiratory syndrome coronavirus infection in rabbits</article-title><source>J Virol</source><year>2015</year><volume>89</volume><issue>11</issue><fpage>6131</fpage><lpage>6135</lpage><pub-id pub-id-type="doi">10.1128/JVI.00661-15</pub-id><pub-id pub-id-type="pmid">25810539</pub-id></element-citation></ref><ref id="CR14"><label>14.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van Doremalen</surname><given-names>N</given-names></name><name><surname>Miazgowicz</surname><given-names>KL</given-names></name><name><surname>Milne-Price</surname><given-names>S</given-names></name><name><surname>Bushmaker</surname><given-names>T</given-names></name><name><surname>Robertson</surname><given-names>S</given-names></name><name><surname>Scott</surname><given-names>D</given-names></name><name><surname>Kinne</surname><given-names>J</given-names></name><name><surname>McLellan</surname><given-names>JS</given-names></name><name><surname>Zhu</surname><given-names>J</given-names></name><name><surname>Munster</surname><given-names>VJ</given-names></name></person-group><article-title>Host species restriction of Middle East respiratory syndrome coronavirus through its receptor, dipeptidyl peptidase 4</article-title><source>J Virol</source><year>2014</year><volume>88</volume><issue>16</issue><fpage>9220</fpage><lpage>9232</lpage><pub-id pub-id-type="doi">10.1128/JVI.00676-14</pub-id><pub-id pub-id-type="pmid">24899185</pub-id></element-citation></ref><ref id="CR15"><label>15.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barlan</surname><given-names>A</given-names></name><name><surname>Zhao</surname><given-names>J</given-names></name><name><surname>Sarkar</surname><given-names>MK</given-names></name><name><surname>Li</surname><given-names>K M</given-names></name><name><surname>Cray</surname><given-names>P J</given-names></name><name><surname>Perlman</surname><given-names>S</given-names></name><name><surname>Gallagher</surname><given-names>T</given-names></name></person-group><article-title>Receptor variation and susceptibility to Middle East respiratory syndrome coronavirus infection</article-title><source>J Virol</source><year>2014</year><volume>88</volume><issue>9</issue><fpage>4953</fpage><lpage>4961</lpage><pub-id pub-id-type="doi">10.1128/JVI.00161-14</pub-id><pub-id pub-id-type="pmid">24554656</pub-id></element-citation></ref><ref id="CR16"><label>16.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Annan</surname><given-names>A</given-names></name><name><surname>Baldwin</surname><given-names>HJ</given-names></name><name><surname>Corman</surname><given-names>VM</given-names></name><name><surname>Klose</surname><given-names>SM</given-names></name><name><surname>Owusu</surname><given-names>M</given-names></name><name><surname>Nkrumah</surname><given-names>EE</given-names></name><name><surname>Badu</surname><given-names>EK</given-names></name><name><surname>Anti</surname><given-names>P</given-names></name><name><surname>Agbenyega</surname><given-names>O</given-names></name><name><surname>Meyer</surname><given-names>B</given-names></name><name><surname>Oppong</surname><given-names>S</given-names></name><name><surname>Sarkodie</surname><given-names>YA</given-names></name><name><surname>Kalko</surname><given-names>EK</given-names></name><name><surname>Lina</surname><given-names>PH</given-names></name><name><surname>Godlevska</surname><given-names>EV</given-names></name><name><surname>Reusken</surname><given-names>C</given-names></name><name><surname>Seebens</surname><given-names>A</given-names></name><name><surname>Gloza-Rausch</surname><given-names>F</given-names></name><name><surname>Vallo</surname><given-names>P</given-names></name><name><surname>Tschapka</surname><given-names>M</given-names></name><name><surname>Drosten</surname><given-names>C</given-names></name><name><surname>Drexler</surname><given-names>JF</given-names></name></person-group><article-title>Human betacoronavirus 2c EMC/2012-related viruses in bats, Ghana and Europe</article-title><source>Emerg Infect Dis</source><year>2013</year><volume>19</volume><issue>3</issue><fpage>456</fpage><lpage>459</lpage><pub-id pub-id-type="doi">10.3201/eid1903.121503</pub-id><pub-id pub-id-type="pmid">23622767</pub-id></element-citation></ref><ref id="CR17"><label>17.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Yang</surname><given-names>Y</given-names></name><name><surname>Du</surname><given-names>L</given-names></name><name><surname>Liu</surname><given-names>C</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Ma</surname><given-names>C</given-names></name><name><surname>Tang</surname><given-names>J</given-names></name><name><surname>Baric</surname><given-names>RS</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Li</surname><given-names>F</given-names></name></person-group><article-title>Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus</article-title><source>Proc Natl Acad Sci USA</source><year>2014</year><volume>111</volume><issue>34</issue><fpage>12516</fpage><lpage>12521</lpage><pub-id pub-id-type="doi">10.1073/pnas.1405889111</pub-id><pub-id pub-id-type="pmid">25114257</pub-id></element-citation></ref><ref id="CR18"><label>18.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Memish</surname><given-names>ZA</given-names></name><name><surname>Mishra</surname><given-names>N</given-names></name><name><surname>Olival</surname><given-names>KJ</given-names></name><name><surname>Fagbo</surname><given-names>SF</given-names></name><name><surname>Kapoor</surname><given-names>V</given-names></name><name><surname>Epstein</surname><given-names>JH</given-names></name><name><surname>Alhakeem</surname><given-names>R</given-names></name><name><surname>Durosinloun</surname><given-names>A A</given-names></name><name><surname>Asmari</surname><given-names>M</given-names></name><name><surname>Islam</surname><given-names>A</given-names></name><name><surname>Kapoor</surname><given-names>A</given-names></name><name><surname>Briese</surname><given-names>T</given-names></name><name><surname>Daszak</surname><given-names>P A</given-names></name><name><surname>Rabeeah</surname><given-names>AA</given-names></name><name><surname>Lipkin</surname><given-names>WI</given-names></name></person-group><article-title>Middle East respiratory syndrome coronavirus in bats, Saudi Arabia</article-title><source>Emerg Infect Dis</source><year>2013</year><volume>19</volume><issue>11</issue><fpage>1819</fpage><lpage>1823</lpage><pub-id pub-id-type="doi">10.3201/eid1911.131172</pub-id><pub-id pub-id-type="pmid">24206838</pub-id></element-citation></ref><ref id="CR19"><label>19.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Raj</surname><given-names>VS</given-names></name><name><surname>Mou</surname><given-names>H</given-names></name><name><surname>Smits</surname><given-names>SL</given-names></name><name><surname>Dekkers</surname><given-names>D M M</given-names></name><name><surname>Dijkman</surname><given-names>R</given-names></name><name><surname>Muth</surname><given-names>D</given-names></name><name><surname>Demmers</surname><given-names>JA</given-names></name><name><surname>Zaki</surname><given-names>A</given-names></name><name><surname>Fouchier</surname><given-names>RA</given-names></name><name><surname>Thiel</surname><given-names>V</given-names></name><name><surname>Drosten</surname><given-names>C</given-names></name><name><surname>Rottier</surname><given-names>PJ</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name><name><surname>Bosch</surname><given-names>BJ</given-names></name><name><surname>Haagmans</surname><given-names>BL</given-names></name></person-group><article-title>Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC</article-title><source>Nature</source><year>2013</year><volume>495</volume><issue>7440</issue><fpage>251</fpage><lpage>254</lpage><pub-id pub-id-type="doi">10.1038/nature12005</pub-id><pub-id pub-id-type="pmid">23486063</pub-id></element-citation></ref><ref id="CR20"><label>20.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Meyerholz</surname><given-names>DK</given-names></name><name><surname>Lambertz</surname><given-names>AM</given-names></name><name><surname>McCray</surname><given-names>PB</given-names></name></person-group><article-title>Dipeptidyl peptidase 4 distribution in the human respiratory tract: implications for the middle east respiratory syndrome</article-title><source>Am J Pathol</source><year>2015</year><volume>186</volume><issue>1</issue><fpage>78</fpage><lpage>86</lpage><pub-id pub-id-type="doi">10.1016/j.ajpath.2015.09.014</pub-id><pub-id pub-id-type="pmid">26597880</pub-id></element-citation></ref><ref id="CR21"><label>21.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Siu</surname><given-names>KL</given-names></name><name><surname>Yeung</surname><given-names>ML</given-names></name><name><surname>Kok</surname><given-names>KH</given-names></name><name><surname>Yuen</surname><given-names>KS</given-names></name><name><surname>Kew</surname><given-names>C</given-names></name><name><surname>Lui</surname><given-names>PY</given-names></name><name><surname>Chan</surname><given-names>CP</given-names></name><name><surname>Tse</surname><given-names>H</given-names></name><name><surname>Woo</surname><given-names>PC</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name><name><surname>Jin</surname><given-names>DY</given-names></name></person-group><article-title>Middle East respiratory syndrome coronavirus 4a protein is a double-stranded RNA-binding protein that suppresses PACT-induced activation of RIG-I and MDA5 in the innate antiviral response</article-title><source>J Virol</source><year>2014</year><volume>88</volume><issue>9</issue><fpage>4866</fpage><lpage>4876</lpage><pub-id pub-id-type="doi">10.1128/JVI.03649-13</pub-id><pub-id pub-id-type="pmid">24522921</pub-id></element-citation></ref><ref id="CR22"><label>22.</label><mixed-citation publication-type="other">Faure E, Poissy J, Goffard A, Fournier C, Kipnis E, Titecat M, Bortolotti P, Martinez L, Dubucquoi S, Dessein R, Gosset P, Mathieu D, Guery B. Distinct immune response in two MERS-CoVinfected patients: can we go from bench to bedside? PLoS ONE 2014; 9(2): e88716</mixed-citation></ref><ref id="CR23"><label>23.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Josset</surname><given-names>L</given-names></name><name><surname>Menachery</surname><given-names>VD</given-names></name><name><surname>Gralinski</surname><given-names>LE</given-names></name><name><surname>Agnihothram</surname><given-names>S</given-names></name><name><surname>Sova</surname><given-names>P</given-names></name><name><surname>Carter</surname><given-names>VS</given-names></name><name><surname>Yount</surname><given-names>BL</given-names></name><name><surname>Graham</surname><given-names>RL</given-names></name><name><surname>Baric</surname><given-names>RS</given-names></name><name><surname>Katze</surname><given-names>MG</given-names></name></person-group><article-title>Cell host response to infection with novel human coronavirus EMC predicts potential antivirals and important differences with SARS coronavirus</article-title><source>MBio</source><year>2013</year><volume>4</volume><issue>3</issue><fpage>e00165</fpage><lpage>e13</lpage><pub-id pub-id-type="doi">10.1128/mBio.00165-13</pub-id><pub-id pub-id-type="pmid">23631916</pub-id></element-citation></ref><ref id="CR24"><label>24.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Assiri</surname><given-names>A</given-names></name><name><surname>Al-Tawfiq</surname><given-names>JA</given-names></name><name><surname>Al-Rabeeah</surname><given-names>AA</given-names></name><name><surname>Al-Rabiah</surname><given-names>FA</given-names></name><name><surname>Al-Hajjar</surname><given-names>S</given-names></name><name><surname>Al-Barrak</surname><given-names>A</given-names></name><name><surname>Flemban</surname><given-names>H</given-names></name><name><surname>Al-Nassir</surname><given-names>WN</given-names></name><name><surname>Balkhy</surname><given-names>H A-</given-names></name><name><surname>Hakeem</surname><given-names>RF</given-names></name><name><surname>Makhdoom</surname><given-names>HQ</given-names></name><name><surname>Zumla</surname><given-names>AI</given-names></name><name><surname>Memish</surname><given-names>ZA</given-names></name></person-group><article-title>Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study</article-title><source>Lancet Infect Dis</source><year>2013</year><volume>13</volume><issue>9</issue><fpage>752</fpage><lpage>761</lpage><pub-id pub-id-type="doi">10.1016/S1473-3099(13)70204-4</pub-id><pub-id pub-id-type="pmid">23891402</pub-id></element-citation></ref><ref id="CR25"><label>25.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Eckerle</surname><given-names>I M M</given-names></name><name><surname>Kallies</surname><given-names>S</given-names></name><name><surname>Gotthardt</surname><given-names>DN</given-names></name><name><surname>Drosten</surname><given-names>C</given-names></name></person-group><article-title>In-vitro renal epithelial cell infection reveals a viral kidney tropism as a potential mechanism for acute renal failure during Middle East respiratory syndrome (MERS) coronavirus infection</article-title><source>Virol J</source><year>2013</year><volume>23</volume><issue>10</issue><fpage>359</fpage><pub-id pub-id-type="doi">10.1186/1743-422X-10-359</pub-id></element-citation></ref><ref id="CR26"><label>26.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Saad</surname><given-names>M</given-names></name><name><surname>Omrani</surname><given-names>AS</given-names></name><name><surname>Baig</surname><given-names>K</given-names></name><name><surname>Bahloul</surname><given-names>A</given-names></name><name><surname>Elzein</surname><given-names>F</given-names></name><name><surname>Matin</surname><given-names>MA</given-names></name><name><surname>Selim</surname><given-names>MA</given-names></name><name><surname>Al Mutairi</surname><given-names>M</given-names></name><name><surname>Al Nakhli</surname><given-names>D</given-names></name><name><surname>Al Aidaroos</surname><given-names>AY</given-names></name><name><surname>Al Sherbeeni</surname><given-names>N</given-names></name><name><surname>Al-Khashan</surname><given-names>HI</given-names></name><name><surname>Memish</surname><given-names>ZA</given-names></name><name><surname>Albarrak</surname><given-names>AM</given-names></name></person-group><article-title>Clinical aspects and outcomes of 70 patients with Middle East respiratory syndrome coronavirus infection: a single-center experience in Saudi Arabia</article-title><source>Int J Infect Dis</source><year>2014</year><volume>29</volume><fpage>301</fpage><lpage>306</lpage><pub-id pub-id-type="doi">10.1016/j.ijid.2014.09.003</pub-id><pub-id pub-id-type="pmid">25303830</pub-id></element-citation></ref><ref id="CR27"><label>27.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Memish</surname><given-names>ZA</given-names></name><name><surname>Al-Tawfiq</surname><given-names>JA</given-names></name><name><surname>Makhdoom</surname><given-names>HQ</given-names></name><name><surname>Al-Rabeeah</surname><given-names>AA</given-names></name><name><surname>Assiri</surname><given-names>A</given-names></name><name><surname>Alhakeem</surname><given-names>RF</given-names></name><name><surname>AlRabiah</surname><given-names>FA</given-names></name><name><surname>Al Hajjar</surname><given-names>S</given-names></name><name><surname>Albarrak</surname><given-names>A</given-names></name><name><surname>Flemban</surname><given-names>H</given-names></name><name><surname>Balkhy</surname><given-names>H</given-names></name><name><surname>Barry</surname><given-names>M</given-names></name><name><surname>Alhassan</surname><given-names>S</given-names></name><name><surname>Alsubaie</surname><given-names>S</given-names></name><name><surname>Zumla</surname><given-names>A</given-names></name></person-group><article-title>Screening for Middle East respiratory syndrome coronavirus infection in hospital patients and their healthcare worker and family contacts: a prospective descriptive study</article-title><source>Clin Microbiol Infect</source><year>2014</year><volume>20</volume><issue>5</issue><fpage>469</fpage><lpage>474</lpage><pub-id pub-id-type="doi">10.1111/1469-0691.12562</pub-id><pub-id pub-id-type="pmid">24460984</pub-id></element-citation></ref><ref id="CR28"><label>28.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Al-Abdallat</surname><given-names>MM</given-names></name><name><surname>Payne</surname><given-names>DC</given-names></name><name><surname>Alqasrawi</surname><given-names>S</given-names></name><name><surname>Rha</surname><given-names>B</given-names></name><name><surname>Tohme</surname><given-names>RA</given-names></name><name><surname>Abedi</surname><given-names>G A</given-names></name><name><surname>Nsour</surname><given-names>M</given-names></name><name><surname>Iblan</surname><given-names>I</given-names></name><name><surname>Jarour</surname><given-names>N</given-names></name><name><surname>Farag</surname><given-names>NH</given-names></name><name><surname>Haddadin</surname><given-names>A</given-names></name><name><surname>Al-Sanouri</surname><given-names>T</given-names></name><name><surname>Tamin</surname><given-names>A</given-names></name><name><surname>Harcourt</surname><given-names>JL</given-names></name><name><surname>Kuhar</surname><given-names>DT</given-names></name><name><surname>Swerdlow</surname><given-names>DL</given-names></name><name><surname>Erdman</surname><given-names>DD</given-names></name><name><surname>Pallansch</surname><given-names>MA</given-names></name><name><surname>Haynes</surname><given-names>LM</given-names></name><name><surname>Gerber</surname><given-names>SI</given-names></name><name><surname>Sabri</surname><given-names>N</given-names></name><name><surname>Al Azhari</surname><given-names>M</given-names></name><name><surname>Khazali</surname><given-names>H</given-names></name><name><surname>Al Maayah</surname><given-names>M</given-names></name><name><surname>Bilbeisi</surname><given-names>A</given-names></name><name><surname>Dawood</surname><given-names>N</given-names></name><name><surname>Al Zubi</surname><given-names>B</given-names></name><name><surname>Meflih</surname><given-names>J</given-names></name><name><surname>Mounds</surname><given-names>T</given-names></name><name><surname>Fitzner</surname><given-names>J</given-names></name><name><surname>Eltom</surname><given-names>A</given-names></name><name><surname>Mafi</surname><given-names>A</given-names></name><name><surname>Miao</surname><given-names>C</given-names></name><name><surname>Caidi</surname><given-names>H</given-names></name><name><surname>Trivedi</surname><given-names>S</given-names></name><name><surname>Kamili</surname><given-names>S</given-names></name><name><surname>Hall</surname><given-names>AJ</given-names></name><name><surname>Curns</surname><given-names>A</given-names></name><name><surname>Moore</surname><given-names>J</given-names></name><name><surname>Pham</surname><given-names>H</given-names></name><name><surname>Zimmerman</surname><given-names>C</given-names></name><name><surname>Farnon</surname><given-names>E</given-names></name><name><surname>Giorgi</surname><given-names>G</given-names></name><name><surname>Gerber</surname><given-names>R</given-names></name></person-group><article-title>Hospital-associated outbreak of Middle East respiratory syndrome coronavirus: a serologic, epidemiologic, and clinical description</article-title><source>Clin Infect Dis</source><year>2014</year><volume>59</volume><issue>9</issue><fpage>1225</fpage><lpage>1233</lpage><pub-id pub-id-type="doi">10.1093/cid/ciu359</pub-id><pub-id pub-id-type="pmid">24829216</pub-id></element-citation></ref><ref id="CR29"><label>29.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Assiri</surname><given-names>A</given-names></name><name><surname>McGeer</surname><given-names>A</given-names></name><name><surname>Perl</surname><given-names>TM</given-names></name><name><surname>Price</surname><given-names>C A</given-names></name><name><surname>Rabeeah</surname><given-names>AA</given-names></name><name><surname>Cummings</surname><given-names>DA</given-names></name><name><surname>Alabdullatif</surname><given-names>ZN</given-names></name><name><surname>Assad</surname><given-names>M</given-names></name><name><surname>Almulhim</surname><given-names>A</given-names></name><name><surname>Makhdoom</surname><given-names>H</given-names></name><name><surname>Madani</surname><given-names>H</given-names></name><name><surname>Alhakeem</surname><given-names>R</given-names></name><name><surname>Al-Tawfiq</surname><given-names>JA</given-names></name><name><surname>Cotten</surname><given-names>M</given-names></name><name><surname>Watson</surname><given-names>SJ</given-names></name><name><surname>Kellam</surname><given-names>P</given-names></name><name><surname>Zumla</surname><given-names>A M Z K M-C I Team</given-names></name></person-group><article-title>Hospital outbreak of Middle East respiratory syndrome coronavirus</article-title><source>N Engl J Med</source><year>2013</year><volume>369</volume><issue>5</issue><fpage>407</fpage><lpage>416</lpage><pub-id pub-id-type="doi">10.1056/NEJMoa1306742</pub-id><pub-id pub-id-type="pmid">23782161</pub-id></element-citation></ref><ref id="CR30"><label>30.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Al-Tawfiq</surname><given-names>JA</given-names></name><name><surname>Hinedi</surname><given-names>K</given-names></name><name><surname>Ghandour</surname><given-names>J</given-names></name><name><surname>Khairalla</surname><given-names>H</given-names></name><name><surname>Musleh</surname><given-names>S</given-names></name><name><surname>Ujayli</surname><given-names>A</given-names></name><name><surname>Memish</surname><given-names>ZA</given-names></name></person-group><article-title>Middle East respiratory syndrome coronavirus: a case-control study of hospitalized patients</article-title><source>Clin Infect Dis</source><year>2014</year><volume>59</volume><issue>2</issue><fpage>160</fpage><lpage>165</lpage><pub-id pub-id-type="doi">10.1093/cid/ciu226</pub-id><pub-id pub-id-type="pmid">24723278</pub-id></element-citation></ref><ref id="CR31"><label>31.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Arabi</surname><given-names>YM</given-names></name><name><surname>Arifi</surname><given-names>AA</given-names></name><name><surname>Balkhy</surname><given-names>HH</given-names></name><name><surname>Najm</surname><given-names>H</given-names></name><name><surname>Aldawood</surname><given-names>AS</given-names></name><name><surname>Ghabashi</surname><given-names>A</given-names></name><name><surname>Hawa</surname><given-names>H</given-names></name><name><surname>Alothman</surname><given-names>A</given-names></name><name><surname>Khaldi</surname><given-names>A</given-names></name><name><surname>Al Raiy</surname><given-names>B</given-names></name></person-group><article-title>Clinical course and outcomes of critically ill patients with Middle East respiratory syndrome coronavirus infection</article-title><source>Ann Intern Med</source><year>2014</year><volume>160</volume><issue>6</issue><fpage>389</fpage><lpage>397</lpage><pub-id pub-id-type="doi">10.7326/M13-2486</pub-id><pub-id pub-id-type="pmid">24474051</pub-id></element-citation></ref><ref id="CR32"><label>32.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thabet</surname><given-names>F</given-names></name><name><surname>Chehab</surname><given-names>M</given-names></name><name><surname>Bafaqih</surname><given-names>H</given-names></name><name><surname>Al Mohaimeed</surname><given-names>S</given-names></name></person-group><article-title>Middle East respiratory syndrome coronavirus in children</article-title><source>Saudi Med J</source><year>2015</year><volume>36</volume><issue>4</issue><fpage>484</fpage><lpage>486</lpage><pub-id pub-id-type="doi">10.15537/smj.2015.4.10243</pub-id><pub-id pub-id-type="pmid">25828287</pub-id></element-citation></ref><ref id="CR33"><label>33.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Denison</surname><given-names>MR</given-names></name></person-group><article-title>Severe acute respiratory syndrome coronavirus pathogenesis, disease and vaccines: an update</article-title><source>Pediatr Infect Dis J</source><year>2004</year><volume>23</volume><fpage>S207</fpage><lpage>S214</lpage><pub-id pub-id-type="doi">10.1097/01.inf.0000144666.95284.05</pub-id><pub-id pub-id-type="pmid">15577575</pub-id></element-citation></ref><ref id="CR34"><label>34.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bin Seo</surname><given-names>Y</given-names></name><name><surname>Heo</surname><given-names>JY</given-names></name><name><surname>Song</surname><given-names>MS</given-names></name><name><surname>Lee</surname><given-names>J</given-names></name><name><surname>Kim</surname><given-names>EH</given-names></name><name><surname>Park</surname><given-names>SJ</given-names></name><name><surname>Kwon</surname><given-names>HI</given-names></name><name><surname>Kim</surname><given-names>SM</given-names></name><name><surname>Kim</surname><given-names>YI</given-names></name><name><surname>Si</surname><given-names>YJ</given-names></name><name><surname>Lee</surname><given-names>IW</given-names></name><name><surname>Baek</surname><given-names>YH</given-names></name><name><surname>Choi</surname><given-names>WS</given-names></name><name><surname>Min</surname><given-names>J</given-names></name><name><surname>Jeong</surname><given-names>HW</given-names></name><name><surname>Choi</surname><given-names>YK</given-names></name></person-group><article-title>Environmental contamination and viral shedding in MERS patients during MERS-CoV Outbreak in South Korea</article-title><source>Clin Infect Dis</source><year>2016</year><volume>62</volume><issue>6</issue><fpage>755</fpage><lpage>760</lpage><pub-id pub-id-type="doi">10.1093/cid/civ1020</pub-id><pub-id pub-id-type="pmid">26679623</pub-id></element-citation></ref><ref id="CR35"><label>35.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Hui</surname><given-names>DS</given-names></name><name><surname>Memish</surname><given-names>ZA</given-names></name><name><surname>Zumla</surname><given-names>A</given-names></name></person-group><article-title>Severe acute respiratory syndrome vs</article-title><source>the Middle East respiratory syndrome. Curr Opin Pulm Med</source><year>2014</year><volume>20</volume><issue>3</issue><fpage>233</fpage><lpage>241</lpage><pub-id pub-id-type="pmid">24626235</pub-id></element-citation></ref><ref id="CR36"><label>36.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>de Wilde</surname><given-names>AH</given-names></name><name><surname>Raj</surname><given-names>VS</given-names></name><name><surname>Oudshoorn</surname><given-names>D</given-names></name><name><surname>Bestebroer</surname><given-names>TM</given-names></name><name><surname>van Nieuwkoop</surname><given-names>S</given-names></name><name><surname>Limpens</surname><given-names>RW</given-names></name><name><surname>Posthuma</surname><given-names>CC</given-names></name><name><surname>van der Meer</surname><given-names>Y</given-names></name><name><surname>Bárcena</surname><given-names>M</given-names></name><name><surname>Haagmans</surname><given-names>BL</given-names></name><name><surname>Snijder</surname><given-names>EJ</given-names></name><name><surname>van den Hoogen</surname><given-names>BG</given-names></name></person-group><article-title>MERS-coronavirus replication induces severe <italic>in vitro</italic> cytopathology and is strongly inhibited by cyclosporin A or interferon-a treatment</article-title><source>J Gen Virol</source><year>2013</year><volume>94</volume><fpage>1749</fpage><lpage>1760</lpage><pub-id pub-id-type="doi">10.1099/vir.0.052910-0</pub-id><pub-id pub-id-type="pmid">23620378</pub-id></element-citation></ref><ref id="CR37"><label>37.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Falzarano</surname><given-names>D</given-names></name><name><surname>de Wit</surname><given-names>E</given-names></name><name><surname>Martellaro</surname><given-names>C</given-names></name><name><surname>Callison</surname><given-names>J</given-names></name><name><surname>Munster</surname><given-names>VJ</given-names></name><name><surname>Feldmann</surname><given-names>H</given-names></name></person-group><article-title>Inhibition of novel β coronavirus replication by a combination of interferon-α2b and ribavirin</article-title><source>Sci Rep</source><year>2013</year><volume>3</volume><fpage>1686</fpage><pub-id pub-id-type="doi">10.1038/srep01686</pub-id><pub-id pub-id-type="pmid">23594967</pub-id></element-citation></ref><ref id="CR38"><label>38.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Omrani</surname><given-names>AS</given-names></name><name><surname>Saad</surname><given-names>MM</given-names></name><name><surname>Baig</surname><given-names>K</given-names></name><name><surname>Bahloul</surname><given-names>A</given-names></name><name><surname>Abdul-Matin</surname><given-names>M</given-names></name><name><surname>Alaidaroos</surname><given-names>AY</given-names></name><name><surname>Almakhlafi</surname><given-names>GA</given-names></name><name><surname>Albarrak</surname><given-names>MM</given-names></name><name><surname>Memish</surname><given-names>ZA</given-names></name><name><surname>Albarrak</surname><given-names>AM</given-names></name></person-group><article-title>Ribavirin and interferon α-2a for severe Middle East respiratory syndrome coronavirus infection: a retrospective cohort study</article-title><source>Lancet Infect Dis</source><year>2014</year><volume>14</volume><issue>11</issue><fpage>1090</fpage><lpage>1095</lpage><pub-id pub-id-type="doi">10.1016/S1473-3099(14)70920-X</pub-id><pub-id pub-id-type="pmid">25278221</pub-id></element-citation></ref><ref id="CR39"><label>39.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chan</surname><given-names>JF</given-names></name><name><surname>Chan</surname><given-names>KH</given-names></name><name><surname>Kao</surname><given-names>RY</given-names></name><name><surname>To</surname><given-names>KK</given-names></name><name><surname>Zheng</surname><given-names>BJ</given-names></name><name><surname>Li</surname><given-names>CP</given-names></name><name><surname>Li</surname><given-names>PT</given-names></name><name><surname>Dai</surname><given-names>J</given-names></name><name><surname>Mok</surname><given-names>FK</given-names></name><name><surname>Chen</surname><given-names>H</given-names></name><name><surname>Hayden</surname><given-names>FG</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name></person-group><article-title>Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus</article-title><source>J Infect</source><year>2013</year><volume>67</volume><issue>6</issue><fpage>606</fpage><lpage>616</lpage><pub-id pub-id-type="doi">10.1016/j.jinf.2013.09.029</pub-id><pub-id pub-id-type="pmid">24096239</pub-id></element-citation></ref><ref id="CR40"><label>40.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sui</surname><given-names>J</given-names></name><name><surname>Li</surname><given-names>W</given-names></name><name><surname>Murakami</surname><given-names>A</given-names></name><name><surname>Tamin</surname><given-names>A M L</given-names></name><name><surname>Wong</surname><given-names>SK</given-names></name><name><surname>Moore</surname><given-names>MJ</given-names></name><name><surname>Tallarico</surname><given-names>AS</given-names></name><name><surname>Olurinde</surname><given-names>M</given-names></name><name><surname>Choe</surname><given-names>H</given-names></name><name><surname>Anderson</surname><given-names>LJ</given-names></name><name><surname>Bellini</surname><given-names>WJ</given-names></name><name><surname>Farzan</surname><given-names>M</given-names></name><name><surname>Marasco</surname><given-names>WA</given-names></name></person-group><article-title>Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association</article-title><source>Proc Natl Acad Sci U S A</source><year>2004</year><volume>101</volume><issue>8</issue><fpage>2536</fpage><lpage>2541</lpage><pub-id pub-id-type="doi">10.1073/pnas.0307140101</pub-id><pub-id pub-id-type="pmid">14983044</pub-id></element-citation></ref><ref id="CR41"><label>41.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>ter Meulen</surname><given-names>J</given-names></name><name><surname>Bakker</surname><given-names>AB</given-names></name><name><surname>van den Brink</surname><given-names>EN</given-names></name><name><surname>Weverling</surname><given-names>GJ</given-names></name><name><surname>Martina</surname><given-names>BE</given-names></name><name><surname>Haagmans</surname><given-names>BL</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name><name><surname>de Kruif</surname><given-names>J</given-names></name><name><surname>Preiser</surname><given-names>W</given-names></name><name><surname>Spaan</surname><given-names>W</given-names></name><name><surname>Gelderblom</surname><given-names>HR</given-names></name><name><surname>Goudsmit</surname><given-names>J</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name></person-group><article-title>Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets</article-title><source>Lancet</source><year>2004</year><volume>363</volume><issue>9427</issue><fpage>2139</fpage><lpage>2141</lpage><pub-id pub-id-type="doi">10.1016/S0140-6736(04)16506-9</pub-id><pub-id pub-id-type="pmid">15220038</pub-id></element-citation></ref><ref id="CR42"><label>42.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Traggiai</surname><given-names>E</given-names></name><name><surname>Becker</surname><given-names>S</given-names></name><name><surname>Subbarao</surname><given-names>K</given-names></name><name><surname>Kolesnikova</surname><given-names>L</given-names></name><name><surname>Uematsu</surname><given-names>Y</given-names></name><name><surname>Gismondo</surname><given-names>MR</given-names></name><name><surname>Murphy</surname><given-names>BR</given-names></name><name><surname>Rappuoli</surname><given-names>R</given-names></name><name><surname>Lanzavecchia</surname><given-names>A</given-names></name></person-group><article-title>An efficient method to make human monoclonal antibodies from memory B cells: potent neutralization of SARS coronavirus</article-title><source>Nat Med</source><year>2004</year><volume>10</volume><issue>8</issue><fpage>871</fpage><lpage>875</lpage><pub-id pub-id-type="doi">10.1038/nm1080</pub-id><pub-id pub-id-type="pmid">15247913</pub-id></element-citation></ref><ref id="CR43"><label>43.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Du</surname><given-names>L</given-names></name><name><surname>Zhao</surname><given-names>G</given-names></name><name><surname>Yang</surname><given-names>Y</given-names></name><name><surname>Qiu</surname><given-names>H</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Kou</surname><given-names>Z</given-names></name><name><surname>Tao</surname><given-names>X</given-names></name><name><surname>Yu</surname><given-names>H</given-names></name><name><surname>Sun</surname><given-names>S</given-names></name><name><surname>Tseng</surname><given-names>CT</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Li</surname><given-names>F</given-names></name><name><surname>Zhou</surname><given-names>Y</given-names></name></person-group><article-title>A conformation-dependent neutralizing monoclonal antibody specifically targeting receptorbinding domain in Middle East respiratory syndrome coronavirus spike protein</article-title><source>J Virol</source><year>2014</year><volume>88</volume><issue>12</issue><fpage>7045</fpage><lpage>7053</lpage><pub-id pub-id-type="doi">10.1128/JVI.00433-14</pub-id><pub-id pub-id-type="pmid">24719424</pub-id></element-citation></ref><ref id="CR44"><label>44.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ying</surname><given-names>T</given-names></name><name><surname>Du</surname><given-names>L</given-names></name><name><surname>Ju</surname><given-names>TW</given-names></name><name><surname>Prabakaran</surname><given-names>P</given-names></name><name><surname>Lau</surname><given-names>CC</given-names></name><name><surname>Lu</surname><given-names>L</given-names></name><name><surname>Liu</surname><given-names>Q</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Feng</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Zheng</surname><given-names>BJ</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name><name><surname>Dimitrov</surname><given-names>DS</given-names></name></person-group><article-title>Exceptionally potent neutralization of Middle East respiratory syndrome coronavirus by human monoclonal antibodies</article-title><source>J Virol</source><year>2014</year><volume>88</volume><issue>14</issue><fpage>7796</fpage><lpage>7805</lpage><pub-id pub-id-type="doi">10.1128/JVI.00912-14</pub-id><pub-id pub-id-type="pmid">24789777</pub-id></element-citation></ref><ref id="CR45"><label>45.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jiang</surname><given-names>L</given-names></name><name><surname>Wang</surname><given-names>N</given-names></name><name><surname>Zuo</surname><given-names>T</given-names></name><name><surname>Shi</surname><given-names>X</given-names></name><name><surname>Poon</surname><given-names>KM</given-names></name><name><surname>Wu</surname><given-names>Y</given-names></name><name><surname>Gao</surname><given-names>F</given-names></name><name><surname>Li</surname><given-names>D</given-names></name><name><surname>Wang</surname><given-names>R</given-names></name><name><surname>Guo</surname><given-names>J</given-names></name><name><surname>Fu</surname><given-names>L</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name><name><surname>Zheng</surname><given-names>BJ</given-names></name><name><surname>Wang</surname><given-names>X</given-names></name><name><surname>Zhang</surname><given-names>L</given-names></name></person-group><article-title>Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein</article-title><source>Sci Transl Med</source><year>2014</year><volume>6</volume><issue>234</issue><fpage>234ra59</fpage><pub-id pub-id-type="doi">10.1126/scitranslmed.3008140</pub-id><pub-id pub-id-type="pmid">24778414</pub-id></element-citation></ref><ref id="CR46"><label>46.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tang</surname><given-names>XC</given-names></name><name><surname>Agnihothram</surname><given-names>SS</given-names></name><name><surname>Jiao</surname><given-names>Y</given-names></name><name><surname>Stanhope</surname><given-names>J</given-names></name><name><surname>Graham</surname><given-names>RL</given-names></name><name><surname>Peterson</surname><given-names>EC</given-names></name><name><surname>Avnir</surname><given-names>Y</given-names></name><name><surname>Tallarico</surname><given-names>AS</given-names></name><name><surname>Sheehan</surname><given-names>J</given-names></name><name><surname>Zhu</surname><given-names>Q</given-names></name><name><surname>Baric</surname><given-names>RS</given-names></name><name><surname>Marasco</surname><given-names>WA</given-names></name></person-group><article-title>Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution</article-title><source>Proc Natl Acad Sci USA</source><year>2014</year><volume>111</volume><issue>19</issue><fpage>E2018</fpage><lpage>E2026</lpage><pub-id pub-id-type="doi">10.1073/pnas.1402074111</pub-id><pub-id pub-id-type="pmid">24778221</pub-id></element-citation></ref><ref id="CR47"><label>47.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ying</surname><given-names>T</given-names></name><name><surname>Li</surname><given-names>H</given-names></name><name><surname>Lu</surname><given-names>L</given-names></name><name><surname>Dimitrov</surname><given-names>DS</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name></person-group><article-title>Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections</article-title><source>Microbes Infect</source><year>2015</year><volume>17</volume><issue>2</issue><fpage>142</fpage><lpage>148</lpage><pub-id pub-id-type="doi">10.1016/j.micinf.2014.11.008</pub-id><pub-id pub-id-type="pmid">25456101</pub-id></element-citation></ref><ref id="CR48"><label>48.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lu</surname><given-names>L</given-names></name><name><surname>Liu</surname><given-names>Q</given-names></name><name><surname>Zhu</surname><given-names>Y</given-names></name><name><surname>Chan</surname><given-names>KH</given-names></name><name><surname>Qin</surname><given-names>L</given-names></name><name><surname>Li</surname><given-names>Y</given-names></name><name><surname>Wang</surname><given-names>Q</given-names></name><name><surname>Chan</surname><given-names>JF</given-names></name><name><surname>Du</surname><given-names>L</given-names></name><name><surname>Yu</surname><given-names>F</given-names></name><name><surname>Ma</surname><given-names>C</given-names></name><name><surname>Ye</surname><given-names>S</given-names></name><name><surname>Yuen</surname><given-names>KY</given-names></name><name><surname>Zhang</surname><given-names>R</given-names></name><name><surname>Jiang</surname><given-names>S</given-names></name></person-group><article-title>Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor</article-title><source>Nat Commun</source><year>2014</year><volume>5</volume><fpage>3067</fpage><pub-id pub-id-type="doi">10.1038/ncomms4067</pub-id><pub-id pub-id-type="pmid">24473083</pub-id></element-citation></ref><ref id="CR49"><label>49.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Borio</surname><given-names>L</given-names></name><name><surname>Cox</surname><given-names>E</given-names></name><name><surname>Lurie</surname><given-names>N</given-names></name></person-group><article-title>Combating emerging threats—accelerating the availability of medical therapies</article-title><source>N Engl J Med</source><year>2015</year><volume>373</volume><issue>11</issue><fpage>993</fpage><lpage>995</lpage><pub-id pub-id-type="doi">10.1056/NEJMp1508708</pub-id><pub-id pub-id-type="pmid">26244879</pub-id></element-citation></ref><ref id="CR50"><label>50.</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haagmans</surname><given-names>BL</given-names></name><name><surname>van den Brand</surname><given-names>JM</given-names></name><name><surname>Raj</surname><given-names>VS</given-names></name><name><surname>Volz</surname><given-names>A</given-names></name><name><surname>Wohlsein</surname><given-names>P</given-names></name><name><surname>Smits</surname><given-names>SL</given-names></name><name><surname>Schipper</surname><given-names>D</given-names></name><name><surname>Bestebroer</surname><given-names>TM</given-names></name><name><surname>Okba</surname><given-names>N</given-names></name><name><surname>Fux</surname><given-names>R</given-names></name><name><surname>Bensaid</surname><given-names>A</given-names></name><name><surname>Solanes Foz</surname><given-names>D</given-names></name><name><surname>Kuiken</surname><given-names>T</given-names></name><name><surname>Baumgärtner</surname><given-names>W</given-names></name><name><surname>Segalés</surname><given-names>J</given-names></name><name><surname>Sutter</surname><given-names>G</given-names></name><name><surname>Osterhaus</surname><given-names>AD</given-names></name></person-group><article-title>An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels</article-title><source>Science</source><year>2016</year><volume>351</volume><issue>6268</issue><fpage>77</fpage><lpage>81</lpage><pub-id pub-id-type="doi">10.1126/science.aad1283</pub-id><pub-id pub-id-type="pmid">26678878</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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