Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
Identifieur interne : 000513 ( Pmc/Corpus ); précédent : 000512; suivant : 000514Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns
Auteurs : Jaffar A. Al-Tawfiq ; Ali S. Omrani ; Ziad A. MemishSource :
- Frontiers of Medicine [ 2095-0217 ] ; 2016.
Abstract
The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.
Url:
DOI: 10.1007/s11684-016-0446-y
PubMed: 27146399
PubMed Central: 7089395
Links to Exploration step
PMC:7089395Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415305.6</institution-id><institution-id institution-id-type="ISNI">000000009702165X</institution-id><institution>Johns Hopkins Aramco Healthcare,</institution></institution-wrap>Dhahran, 31311 Kingdom of Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.257413.6</institution-id><institution-id institution-id-type="ISNI">0000000122873919</institution-id><institution>Indiana University School of Medicine,</institution></institution-wrap>Indianapolis, IN 46202-3082 USA</nlm:aff></affiliation></author><author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, 11211 Kingdom of Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>Ministry of Health,</institution></institution-wrap>Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.411335.1</institution-id><institution-id institution-id-type="ISNI">0000000417587207</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University,</institution></institution-wrap>Riyadh, 11533 Kingdom of Saudi Arabia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27146399</idno><idno type="pmc">7089395</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7089395</idno><idno type="RBID">PMC:7089395</idno><idno type="doi">10.1007/s11684-016-0446-y</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000513</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000513</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns</title><author><name sortKey="Al Tawfiq, Jaffar A" sort="Al Tawfiq, Jaffar A" uniqKey="Al Tawfiq J" first="Jaffar A." last="Al-Tawfiq">Jaffar A. Al-Tawfiq</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415305.6</institution-id><institution-id institution-id-type="ISNI">000000009702165X</institution-id><institution>Johns Hopkins Aramco Healthcare,</institution></institution-wrap>Dhahran, 31311 Kingdom of Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.257413.6</institution-id><institution-id institution-id-type="ISNI">0000000122873919</institution-id><institution>Indiana University School of Medicine,</institution></institution-wrap>Indianapolis, IN 46202-3082 USA</nlm:aff></affiliation></author><author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, 11211 Kingdom of Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>Ministry of Health,</institution></institution-wrap>Riyadh, 11514 Kingdom of Saudi Arabia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.411335.1</institution-id><institution-id institution-id-type="ISNI">0000000417587207</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University,</institution></institution-wrap>Riyadh, 11533 Kingdom of Saudi Arabia</nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers of Medicine</title><idno type="ISSN">2095-0217</idno><idno type="eISSN">2095-0225</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. In this review, we summarize the current knowledge about MERS-CoV and highlight travel-related issues.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Zumla, A" uniqKey="Zumla A">A Zumla</name></author><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Med</journal-id><journal-id journal-id-type="iso-abbrev">Front Med</journal-id><journal-title-group><journal-title>Frontiers of Medicine</journal-title></journal-title-group><issn pub-type="ppub">2095-0217</issn><issn pub-type="epub">2095-0225</issn><publisher><publisher-name>Higher Education Press</publisher-name><publisher-loc>Beijing</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27146399</article-id><article-id pub-id-type="pmc">7089395</article-id><article-id pub-id-type="publisher-id">446</article-id><article-id pub-id-type="doi">10.1007/s11684-016-0446-y</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Middle East respiratory syndrome coronavirus: current situation and travel-associated concerns</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Al-Tawfiq</surname><given-names>Jaffar A.</given-names></name><xref ref-type="aff" rid="Aff1">1</xref><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Omrani</surname><given-names>Ali S.</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Memish</surname><given-names>Ziad A.</given-names></name><address><email>zmemish@yahoo.com</email></address><xref ref-type="aff" rid="Aff4">4</xref><xref ref-type="aff" rid="Aff5">5</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.415305.6</institution-id><institution-id institution-id-type="ISNI">000000009702165X</institution-id><institution>Johns Hopkins Aramco Healthcare,</institution></institution-wrap>Dhahran, 31311 Kingdom of Saudi Arabia</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.257413.6</institution-id><institution-id institution-id-type="ISNI">0000000122873919</institution-id><institution>Indiana University School of Medicine,</institution></institution-wrap>Indianapolis, IN 46202-3082 USA</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id><institution-id institution-id-type="ISNI">0000000121914301</institution-id><institution>Department of Medicine, Section of Infectious Diseases,</institution><institution>King Faisal Specialist Hospital and Research Centre,</institution></institution-wrap>Riyadh, 11211 Kingdom of Saudi Arabia</aff><aff id="Aff4"><label>4</label><institution-wrap><institution-id institution-id-type="GRID">grid.415696.9</institution-id><institution>Ministry of Health,</institution></institution-wrap>Riyadh, 11514 Kingdom of Saudi Arabia</aff><aff id="Aff5"><label>5</label><institution-wrap><institution-id institution-id-type="GRID">grid.411335.1</institution-id><institution-id institution-id-type="ISNI">0000000417587207</institution-id><institution>College of Medicine,</institution><institution>Alfaisal University,</institution></institution-wrap>Riyadh, 11533 Kingdom of Saudi Arabia</aff></contrib-group><pub-date pub-type="epub"><day>4</day><month>5</month><year>2016</year></pub-date><pub-date pub-type="ppub"><year>2016</year></pub-date><volume>10</volume><issue>2</issue><fpage>111</fpage><lpage>119</lpage><history><date date-type="received"><day>30</day><month>9</month><year>2015</year></date><date date-type="accepted"><day>21</day><month>3</month><year>2016</year></date></history><permissions><copyright-statement>© Higher Education Press and Springer-Verlag Berlin Heidelberg 2016</copyright-statement><license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p></license></permissions><abstract id="Abs1"><p>The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 brought back memories of the occurrence of severe acute respiratory syndrome coronavirus (SARS-CoV) in 2002. More than 1500 MERS-CoV cases were recorded in 42 months with a case fatality rate (CFR) of 40%. Meanwhile, 8000 cases of SARS-CoV were confirmed in six months with a CFR of 10%. The clinical presentation of MERS-CoV ranges from mild and non-specific presentation to progressive and severe pneumonia. No predictive signs or symptoms exist to differentiate MERS-CoV from community-acquired pneumonia in hospitalized patients. An apparent heterogeneity was observed in transmission. Most MERS-CoV cases were secondary to large outbreaks in healthcare settings. These cases were secondary to community-acquired cases, which may also cause family outbreaks. Travel-associated MERS infection remains low. However, the virus exhibited a clear tendency to cause large outbreaks outside the Arabian Peninsula as exemplified by the outbreak in the Republic of Korea. 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