SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets
Identifieur interne : 001181 ( Pmc/Checkpoint ); précédent : 001180; suivant : 001182SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets
Auteurs : Lorenzo Subissi ; Isabelle Imbert ; François Ferron ; Axelle Collet ; Bruno Coutard ; Etienne Decroly ; Bruno CanardSource :
- Antiviral Research [ 0166-3542 ] ; 2013.
Abstract
This paper presents an in-depth review of coronavirus Orf1b enzymes. It is organized in sections on RNA synthesis, RNA degradation, and RNA capping. It discusses integration of these functions into the coronavirus replication/transcription complex. It reviews published inhibitors of any of these functions.
Url:
DOI: 10.1016/j.antiviral.2013.11.006
PubMed: 24269475
PubMed Central: 7113864
Affiliations:
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PMC:7113864Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets</title>
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<author><name sortKey="Collet, Axelle" sort="Collet, Axelle" uniqKey="Collet A" first="Axelle" last="Collet">Axelle Collet</name>
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<author><name sortKey="Coutard, Bruno" sort="Coutard, Bruno" uniqKey="Coutard B" first="Bruno" last="Coutard">Bruno Coutard</name>
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<author><name sortKey="Decroly, Etienne" sort="Decroly, Etienne" uniqKey="Decroly E" first="Etienne" last="Decroly">Etienne Decroly</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets</title>
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<author><name sortKey="Ferron, Francois" sort="Ferron, Francois" uniqKey="Ferron F" first="François" last="Ferron">François Ferron</name>
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<author><name sortKey="Collet, Axelle" sort="Collet, Axelle" uniqKey="Collet A" first="Axelle" last="Collet">Axelle Collet</name>
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<series><title level="j">Antiviral Research</title>
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label>
<p id="p0170">This paper presents an in-depth review of coronavirus Orf1b enzymes.</p>
</list-item>
<list-item id="o0010"><label>•</label>
<p id="p0175">It is organized in sections on RNA synthesis, RNA degradation, and RNA capping.</p>
</list-item>
<list-item id="o0015"><label>•</label>
<p id="p0180">It discusses integration of these functions into the coronavirus replication/transcription complex.</p>
</list-item>
<list-item id="o0020"><label>•</label>
<p id="p0185">It reviews published inhibitors of any of these functions.</p>
</list-item>
</list>
</p>
</div>
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<author><name sortKey="Szretter, K J" uniqKey="Szretter K">K.J. Szretter</name>
</author>
<author><name sortKey="Baker, S C" uniqKey="Baker S">S.C. Baker</name>
</author>
<author><name sortKey="Barchet, W" uniqKey="Barchet W">W. Barchet</name>
</author>
<author><name sortKey="Diamond, M S" uniqKey="Diamond M">M.S. Diamond</name>
</author>
<author><name sortKey="Siddell, S G" uniqKey="Siddell S">S.G. Siddell</name>
</author>
<author><name sortKey="Ludewig, B" uniqKey="Ludewig B">B. Ludewig</name>
</author>
<author><name sortKey="Thiel, V" uniqKey="Thiel V">V. Thiel</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antiviral Res</journal-id>
<journal-id journal-id-type="iso-abbrev">Antiviral Res</journal-id>
<journal-title-group><journal-title>Antiviral Research</journal-title>
</journal-title-group>
<issn pub-type="ppub">0166-3542</issn>
<issn pub-type="epub">1872-9096</issn>
<publisher><publisher-name>Elsevier B.V.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24269475</article-id>
<article-id pub-id-type="pmc">7113864</article-id>
<article-id pub-id-type="publisher-id">S0166-3542(13)00337-9</article-id>
<article-id pub-id-type="doi">10.1016/j.antiviral.2013.11.006</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>SARS-CoV ORF1b-encoded nonstructural proteins 12–16: Replicative enzymes as antiviral targets</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="au005"><name><surname>Subissi</surname>
<given-names>Lorenzo</given-names>
</name>
<xref rid="fn1" ref-type="fn">1</xref>
</contrib>
<contrib contrib-type="author" id="au010"><name><surname>Imbert</surname>
<given-names>Isabelle</given-names>
</name>
<xref rid="fn1" ref-type="fn">1</xref>
</contrib>
<contrib contrib-type="author" id="au015"><name><surname>Ferron</surname>
<given-names>François</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="au020"><name><surname>Collet</surname>
<given-names>Axelle</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="au025"><name><surname>Coutard</surname>
<given-names>Bruno</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="au030"><name><surname>Decroly</surname>
<given-names>Etienne</given-names>
</name>
</contrib>
<contrib contrib-type="author" id="au035"><name><surname>Canard</surname>
<given-names>Bruno</given-names>
</name>
<email>bruno.canard@afmb.univ-mrs.fr</email>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff id="af005">Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257 – CNRS et Aix-Marseille Université, ESIL Case 925, 13288 Marseille, France</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Corresponding author. <email>bruno.canard@afmb.univ-mrs.fr</email>
</corresp>
<fn id="fn1"><label>1</label>
<p id="np005">These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="pmc-release"><day>20</day>
<month>11</month>
<year>2013</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><month>1</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>20</day>
<month>11</month>
<year>2013</year>
</pub-date>
<volume>101</volume>
<fpage>122</fpage>
<lpage>130</lpage>
<history><date date-type="received"><day>26</day>
<month>9</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>22</day>
<month>10</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>11</day>
<month>11</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2013 Elsevier B.V. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
<copyright-holder>Elsevier B.V.</copyright-holder>
<license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p>
</license>
</permissions>
<abstract abstract-type="author-highlights" id="ab005"><title>Highlights</title>
<p><list list-type="simple" id="l0005"><list-item id="o0005"><label>•</label>
<p id="p0170">This paper presents an in-depth review of coronavirus Orf1b enzymes.</p>
</list-item>
<list-item id="o0010"><label>•</label>
<p id="p0175">It is organized in sections on RNA synthesis, RNA degradation, and RNA capping.</p>
</list-item>
<list-item id="o0015"><label>•</label>
<p id="p0180">It discusses integration of these functions into the coronavirus replication/transcription complex.</p>
</list-item>
<list-item id="o0020"><label>•</label>
<p id="p0185">It reviews published inhibitors of any of these functions.</p>
</list-item>
</list>
</p>
</abstract>
<abstract id="ab010"><p>The SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replication-transcription complex (RTC). The RTC directs and coordinates processes in order to replicate and transcribe the coronavirus genome, a single-stranded, positive-sense RNA of outstanding length (∼27–32 kilobases). Here, we review the up-to-date knowledge on SARS-CoV replicative enzymes encoded in the ORF1b, <italic>i</italic>
.<italic>e</italic>
., the main RNA-dependent RNA polymerase (nsp12), the helicase/triphosphatase (nsp13), two unusual ribonucleases (nsp14, nsp15) and RNA-cap methyltransferases (nsp14, nsp16). We also review how these enzymes co-operate with other viral co-factors (nsp7, nsp8, and nsp10) to regulate their activity. These last ten years of research on SARS-CoV have considerably contributed to unravel structural and functional details of one of the most fascinating replication/transcription machineries of the RNA virus world. This paper forms part of a series of invited articles in <italic>Antiviral Research</italic>
on “From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses”.</p>
</abstract>
<kwd-group id="kg005"><title>Keywords</title>
<kwd>Coronavirus</kwd>
<kwd>SARS-CoV</kwd>
<kwd>Replication</kwd>
<kwd>Transcription</kwd>
<kwd>Nonstructural proteins</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Canard, Bruno" sort="Canard, Bruno" uniqKey="Canard B" first="Bruno" last="Canard">Bruno Canard</name>
<name sortKey="Collet, Axelle" sort="Collet, Axelle" uniqKey="Collet A" first="Axelle" last="Collet">Axelle Collet</name>
<name sortKey="Coutard, Bruno" sort="Coutard, Bruno" uniqKey="Coutard B" first="Bruno" last="Coutard">Bruno Coutard</name>
<name sortKey="Decroly, Etienne" sort="Decroly, Etienne" uniqKey="Decroly E" first="Etienne" last="Decroly">Etienne Decroly</name>
<name sortKey="Ferron, Francois" sort="Ferron, Francois" uniqKey="Ferron F" first="François" last="Ferron">François Ferron</name>
<name sortKey="Imbert, Isabelle" sort="Imbert, Isabelle" uniqKey="Imbert I" first="Isabelle" last="Imbert">Isabelle Imbert</name>
<name sortKey="Subissi, Lorenzo" sort="Subissi, Lorenzo" uniqKey="Subissi L" first="Lorenzo" last="Subissi">Lorenzo Subissi</name>
</noCountry>
</tree>
</affiliations>
</record>
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