Vaccine Development Against Middle East Respiratory Syndrome
Identifieur interne : 000961 ( Pmc/Checkpoint ); précédent : 000960; suivant : 000962Vaccine Development Against Middle East Respiratory Syndrome
Auteurs : Hai Yen Lee [Malaisie, États-Unis] ; Mun Peak Nyon [Malaisie, États-Unis] ; Ulrich Strych [États-Unis]Source :
- Current Tropical Medicine Reports [ 2196-3045 ] ; 2016.
Abstract
Various types of vaccines are under pre-clinical and clinical development to address the recent appearance of Middle East respiratory syndrome or MERS, an emerging infectious disease that has already caused over 600 deaths and remains a threat to world health. The causative agent for this respiratory disease is a member of the betacoronavirus genus, phylogenetically closely related to the SARS coronavirus that caused an international health emergency in 2002. With lessons learned from the outbreak of severe acute respiratory syndrome, and with undeniable technological advances, vaccine development against MERS was initially fast-paced and has produced several DNA and protein vaccine candidates with promising results during early pre-clinical testing. At least one vaccine candidate has even entered
Url:
DOI: 10.1007/s40475-016-0084-0
PubMed: 32226714
PubMed Central: 7099997
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="Par1">Various types of vaccines are under pre-clinical and clinical development to address the recent appearance of Middle East respiratory syndrome or MERS, an emerging infectious disease that has already caused over 600 deaths and remains a threat to world health. The causative agent for this respiratory disease is a member of the betacoronavirus genus, phylogenetically closely related to the SARS coronavirus that caused an international health emergency in 2002. With lessons learned from the outbreak of severe acute respiratory syndrome, and with undeniable technological advances, vaccine development against MERS was initially fast-paced and has produced several DNA and protein vaccine candidates with promising results during early pre-clinical testing. At least one vaccine candidate has even entered <italic>first-in-humans</italic>
clinical trials now. With the number of MERS cases declining though and other infectious diseases attracting increased attention, the question remains, whether, similar to the situation after the SARS pandemic, vaccine development is halted or remains the priority it rightfully should.</p>
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</front>
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<issn pub-type="epub">2196-3045</issn>
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<article-categories><subj-group subj-group-type="heading"><subject>Viral Tropical Medicine (CM Beaumier, Section Editor)</subject>
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<title-group><article-title>Vaccine Development Against Middle East Respiratory Syndrome</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Lee</surname>
<given-names>Hai Yen</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
<xref ref-type="aff" rid="Aff3">3</xref>
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<contrib contrib-type="author"><name><surname>Nyon</surname>
<given-names>Mun Peak</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
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<contrib contrib-type="author" corresp="yes"><name><surname>Strych</surname>
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<pub-date pub-type="epub"><day>11</day>
<month>7</month>
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<pub-date pub-type="ppub"><year>2016</year>
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<volume>3</volume>
<issue>3</issue>
<fpage>80</fpage>
<lpage>86</lpage>
<permissions><copyright-statement>© Springer International Publishing AG 2016</copyright-statement>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.</license-p>
</license>
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<abstract id="Abs1"><p id="Par1">Various types of vaccines are under pre-clinical and clinical development to address the recent appearance of Middle East respiratory syndrome or MERS, an emerging infectious disease that has already caused over 600 deaths and remains a threat to world health. The causative agent for this respiratory disease is a member of the betacoronavirus genus, phylogenetically closely related to the SARS coronavirus that caused an international health emergency in 2002. With lessons learned from the outbreak of severe acute respiratory syndrome, and with undeniable technological advances, vaccine development against MERS was initially fast-paced and has produced several DNA and protein vaccine candidates with promising results during early pre-clinical testing. At least one vaccine candidate has even entered <italic>first-in-humans</italic>
clinical trials now. With the number of MERS cases declining though and other infectious diseases attracting increased attention, the question remains, whether, similar to the situation after the SARS pandemic, vaccine development is halted or remains the priority it rightfully should.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>MERS</kwd>
<kwd>SARS</kwd>
<kwd>RBD</kwd>
<kwd>Vaccines</kwd>
<kwd>Coronavirus</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Springer International Publishing AG 2016</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
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