Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset
Identifieur interne : 000837 ( Pmc/Checkpoint ); précédent : 000836; suivant : 000838Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset
Auteurs : Zhe Chen ; Linlin Bao ; Cong Chen ; Tingting Zou ; Ying Xue ; Fengdi Li ; Qi Lv ; Songzhi Gu ; Xiaopan Gao ; Sheng Cui ; Jianmin Wang ; Chuan Qin ; Qi Jin [République populaire de Chine]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2017.
Abstract
A human monoclonal antibody, MCA1, directly targeting the receptor-binding domain of Middle East respiratory syndrome coronavirus (MERS-CoV) S glycoprotein, was isolated from a human survivor. MCA1 highly neutralized MERS-CoV in vitro and completely inhibited viral replication in common marmosets.
Url:
DOI: 10.1093/infdis/jix209
PubMed: 28472421
PubMed Central: 7107363
Affiliations:
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<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p>A human monoclonal antibody, MCA1, directly targeting the receptor-binding domain of Middle East respiratory syndrome coronavirus (MERS-CoV) S glycoprotein, was isolated from a human survivor. MCA1 highly neutralized MERS-CoV in vitro and completely inhibited viral replication in common marmosets. </p>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Infect. Dis</journal-id>
<journal-id journal-id-type="publisher-id">jid</journal-id>
<journal-title-group><journal-title>The Journal of Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">0022-1899</issn>
<issn pub-type="epub">1537-6613</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
<publisher-loc>US</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28472421</article-id>
<article-id pub-id-type="pmc">7107363</article-id>
<article-id pub-id-type="doi">10.1093/infdis/jix209</article-id>
<article-id pub-id-type="publisher-id">jix209</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Major Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Zhe</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn-0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bao</surname>
<given-names>Linlin</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn-0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Cong</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn-0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zou</surname>
<given-names>Tingting</given-names>
</name>
<xref ref-type="aff" rid="AF0003"><sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn-0001"><sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Xue</surname>
<given-names>Ying</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Fengdi</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lv</surname>
<given-names>Qi</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gu</surname>
<given-names>Songzhi</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gao</surname>
<given-names>Xiaopan</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cui</surname>
<given-names>Sheng</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Jianmin</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn-0002"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Qin</surname>
<given-names>Chuan</given-names>
</name>
<xref ref-type="aff" rid="AF0002"><sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn-0002"><sup>b</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Jin</surname>
<given-names>Qi</given-names>
</name>
<xref ref-type="aff" rid="AF0001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="AF0004"><sup>4</sup>
</xref>
<xref ref-type="author-notes" rid="fn-0002"><sup>b</sup>
</xref>
<pmc-comment>zdsys@vip.sina.com </pmc-comment>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
<institution>MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College</institution>
,</aff>
<aff id="AF0002"><label>2</label>
<institution>Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Key Laboratory of Human Disease Comparative Medicine, Ministry of Health, Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases</institution>
</aff>
<aff id="AF0003"><label>3</label>
<institution>College of Life Sciences and Technology, Huazhong Agricultural University</institution>
,<addr-line>Wuhan</addr-line>
, and</aff>
<aff id="AF0004"><label>4</label>
<institution>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases</institution>
,<addr-line>Hangzhou</addr-line>
,<country>China</country>
</aff>
<author-notes><fn id="fn-0001"><p><sup>a</sup>
Z. C., L. B., C. C., and T. Z. contributed equally to this work.</p>
</fn>
<fn id="fn-0002"><p><sup>b</sup>
J. W., C. Q., and Q. J. contributed equally to this work.</p>
</fn>
<fn id="fn-0003"><p>Correspondence: Q. Jin, MD, MOH Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese of Medical Sciences and Peking Union Medical College, 6 Rongjing East Str, BDA, Beijing 100176, P. R. China (<email>zdsys@vip.sina.com</email>
).</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>6</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub" iso-8601-date="2017-05-02"><day>02</day>
<month>5</month>
<year>2017</year>
</pub-date>
<volume>215</volume>
<issue>12</issue>
<fpage>1807</fpage>
<lpage>1815</lpage>
<history><date date-type="received"><day>01</day>
<month>2</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>28</day>
<month>4</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© Crown copyright 2017.</copyright-statement>
<copyright-year>2017</copyright-year>
<license><license-p>This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.</license-p>
</license>
</permissions>
<self-uri xlink:href="jix209.pdf"></self-uri>
<abstract abstract-type="teaser"><title>Summary</title>
<p>A human monoclonal antibody, MCA1, directly targeting the receptor-binding domain of Middle East respiratory syndrome coronavirus (MERS-CoV) S glycoprotein, was isolated from a human survivor. MCA1 highly neutralized MERS-CoV in vitro and completely inhibited viral replication in common marmosets. </p>
</abstract>
<abstract><title>Abstract</title>
<p>Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.</p>
</abstract>
<kwd-group><kwd>human monoclonal antibody</kwd>
<kwd>MERS-CoV</kwd>
<kwd>common marmoset.</kwd>
</kwd-group>
<counts><page-count count="9"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><noCountry><name sortKey="Bao, Linlin" sort="Bao, Linlin" uniqKey="Bao L" first="Linlin" last="Bao">Linlin Bao</name>
<name sortKey="Chen, Cong" sort="Chen, Cong" uniqKey="Chen C" first="Cong" last="Chen">Cong Chen</name>
<name sortKey="Chen, Zhe" sort="Chen, Zhe" uniqKey="Chen Z" first="Zhe" last="Chen">Zhe Chen</name>
<name sortKey="Cui, Sheng" sort="Cui, Sheng" uniqKey="Cui S" first="Sheng" last="Cui">Sheng Cui</name>
<name sortKey="Gao, Xiaopan" sort="Gao, Xiaopan" uniqKey="Gao X" first="Xiaopan" last="Gao">Xiaopan Gao</name>
<name sortKey="Gu, Songzhi" sort="Gu, Songzhi" uniqKey="Gu S" first="Songzhi" last="Gu">Songzhi Gu</name>
<name sortKey="Li, Fengdi" sort="Li, Fengdi" uniqKey="Li F" first="Fengdi" last="Li">Fengdi Li</name>
<name sortKey="Lv, Qi" sort="Lv, Qi" uniqKey="Lv Q" first="Qi" last="Lv">Qi Lv</name>
<name sortKey="Qin, Chuan" sort="Qin, Chuan" uniqKey="Qin C" first="Chuan" last="Qin">Chuan Qin</name>
<name sortKey="Wang, Jianmin" sort="Wang, Jianmin" uniqKey="Wang J" first="Jianmin" last="Wang">Jianmin Wang</name>
<name sortKey="Xue, Ying" sort="Xue, Ying" uniqKey="Xue Y" first="Ying" last="Xue">Ying Xue</name>
<name sortKey="Zou, Tingting" sort="Zou, Tingting" uniqKey="Zou T" first="Tingting" last="Zou">Tingting Zou</name>
</noCountry>
<country name="République populaire de Chine"><noRegion><name sortKey="Jin, Qi" sort="Jin, Qi" uniqKey="Jin Q" first="Qi" last="Jin">Qi Jin</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>
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