Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
Identifieur interne : 000836 ( Pmc/Checkpoint ); précédent : 000835; suivant : 000837Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus
Auteurs : Jie Zhou [République populaire de Chine] ; Cun Li [République populaire de Chine] ; Guangyu Zhao [République populaire de Chine] ; Hin Chu [République populaire de Chine] ; Dong Wang [République populaire de Chine] ; Helen Hoi-Ning Yan [République populaire de Chine] ; Vincent Kwok-Man Poon [République populaire de Chine] ; Lei Wen [République populaire de Chine] ; Bosco Ho-Yin Wong [République populaire de Chine] ; Xiaoyu Zhao [République populaire de Chine] ; Man Chun Chiu [République populaire de Chine] ; Dong Yang [République populaire de Chine] ; Yixin Wang [République populaire de Chine] ; Rex K. H. Au-Yeung [République populaire de Chine] ; Ivy Hau-Yee Chan [République populaire de Chine] ; Shihui Sun [République populaire de Chine] ; Jasper Fuk-Woo Chan [République populaire de Chine] ; Kelvin Kai-Wang To [République populaire de Chine] ; Ziad A. Memish [États-Unis] ; Victor M. Corman [Allemagne] ; Christian Drosten [Allemagne] ; Ivan Fan-Ngai Hung [République populaire de Chine] ; Yusen Zhou [République populaire de Chine] ; Suet Yi Leung [République populaire de Chine] ; Kwok-Yung Yuen [République populaire de Chine]Source :
- Science Advances [ 2375-2548 ] ; 2017.
Abstract
Human intestinal tract as an alternative route to acquire MERS-CoV infection.
Url:
DOI: 10.1126/sciadv.aao4966
PubMed: 29152574
PubMed Central: 5687858
Affiliations:
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Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Helen Hoi Ning" sort="Yan, Helen Hoi Ning" uniqKey="Yan H" first="Helen Hoi-Ning" last="Yan">Helen Hoi-Ning Yan</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Poon, Vincent Kwok Man" sort="Poon, Vincent Kwok Man" uniqKey="Poon V" first="Vincent Kwok-Man" last="Poon">Vincent Kwok-Man Poon</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Lei" sort="Wen, Lei" uniqKey="Wen L" first="Lei" last="Wen">Lei Wen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Xiaoyu" sort="Zhao, Xiaoyu" uniqKey="Zhao X" first="Xiaoyu" last="Zhao">Xiaoyu Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chiu, Man Chun" sort="Chiu, Man Chun" uniqKey="Chiu M" first="Man Chun" last="Chiu">Man Chun Chiu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yixin" sort="Wang, Yixin" uniqKey="Wang Y" first="Yixin" last="Wang">Yixin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Au Yeung, Rex K H" sort="Au Yeung, Rex K H" uniqKey="Au Yeung R" first="Rex K. H." last="Au-Yeung">Rex K. H. Au-Yeung</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Surgery, Queen Mary Hospital, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Surgery, Queen Mary Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><affiliation wicri:level="3"><nlm:aff id="aff4">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="aff9">Ministry of Health and College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia.</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10">Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M." last="Corman">Victor M. Corman</name><affiliation wicri:level="3"><nlm:aff id="aff11">Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff12">German Centre for Infection Research (DZIF), Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>German Centre for Infection Research (DZIF), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:aff id="aff11">Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff12">German Centre for Infection Research (DZIF), Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>German Centre for Infection Research (DZIF), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hung, Ivan Fan Ngai" sort="Hung, Ivan Fan Ngai" uniqKey="Hung I" first="Ivan Fan-Ngai" last="Hung">Ivan Fan-Ngai Hung</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="3"><nlm:aff id="aff4">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Leung, Suet Yi" sort="Leung, Suet Yi" uniqKey="Leung S" first="Suet Yi" last="Leung">Suet Yi Leung</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29152574</idno><idno type="pmc">5687858</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687858</idno><idno type="RBID">PMC:5687858</idno><idno type="doi">10.1126/sciadv.aao4966</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">001140</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001140</idno><idno type="wicri:Area/Pmc/Curation">001140</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001140</idno><idno type="wicri:Area/Pmc/Checkpoint">000836</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000836</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus</title><author><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><affiliation wicri:level="3"><nlm:aff id="aff4">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yan, Helen Hoi Ning" sort="Yan, Helen Hoi Ning" uniqKey="Yan H" first="Helen Hoi-Ning" last="Yan">Helen Hoi-Ning Yan</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Poon, Vincent Kwok Man" sort="Poon, Vincent Kwok Man" uniqKey="Poon V" first="Vincent Kwok-Man" last="Poon">Vincent Kwok-Man Poon</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wen, Lei" sort="Wen, Lei" uniqKey="Wen L" first="Lei" last="Wen">Lei Wen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zhao, Xiaoyu" sort="Zhao, Xiaoyu" uniqKey="Zhao X" first="Xiaoyu" last="Zhao">Xiaoyu Zhao</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chiu, Man Chun" sort="Chiu, Man Chun" uniqKey="Chiu M" first="Man Chun" last="Chiu">Man Chun Chiu</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Yixin" sort="Wang, Yixin" uniqKey="Wang Y" first="Yixin" last="Wang">Yixin Wang</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Au Yeung, Rex K H" sort="Au Yeung, Rex K H" uniqKey="Au Yeung R" first="Rex K. H." last="Au-Yeung">Rex K. H. Au-Yeung</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><affiliation wicri:level="1"><nlm:aff id="aff6">Department of Surgery, Queen Mary Hospital, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Surgery, Queen Mary Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><affiliation wicri:level="3"><nlm:aff id="aff4">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><affiliation><nlm:aff id="aff9">Ministry of Health and College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.</nlm:aff><wicri:noCountry code="subfield">Kingdom of Saudi Arabia.</wicri:noCountry></affiliation><affiliation wicri:level="2"><nlm:aff id="aff10">Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.</nlm:aff><country xml:lang="fr" wicri:curation="lc">États-Unis</country><wicri:regionArea>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M." last="Corman">Victor M. Corman</name><affiliation wicri:level="3"><nlm:aff id="aff11">Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff12">German Centre for Infection Research (DZIF), Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>German Centre for Infection Research (DZIF), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><affiliation wicri:level="3"><nlm:aff id="aff11">Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="aff12">German Centre for Infection Research (DZIF), Berlin, Germany.</nlm:aff><country xml:lang="fr" wicri:curation="lc">Allemagne</country><wicri:regionArea>German Centre for Infection Research (DZIF), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Hung, Ivan Fan Ngai" sort="Hung, Ivan Fan Ngai" uniqKey="Hung I" first="Ivan Fan-Ngai" last="Hung">Ivan Fan-Ngai Hung</name><affiliation wicri:level="1"><nlm:aff id="aff13">Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name><affiliation wicri:level="3"><nlm:aff id="aff4">State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Leung, Suet Yi" sort="Leung, Suet Yi" uniqKey="Leung S" first="Suet Yi" last="Leung">Suet Yi Leung</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><affiliation wicri:level="1"><nlm:aff id="aff1">State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3">Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7">Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Carol Yu Centre for Infection, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8">Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong</wicri:regionArea><wicri:noRegion>Hong Kong</wicri:noRegion></affiliation></author></analytic><series><title level="j">Science Advances</title><idno type="eISSN">2375-2548</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Human intestinal tract as an alternative route to acquire MERS-CoV infection.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Adv</journal-id><journal-id journal-id-type="iso-abbrev">Sci Adv</journal-id><journal-id journal-id-type="publisher-id">SciAdv</journal-id><journal-id journal-id-type="hwp">advances</journal-id><journal-title-group><journal-title>Science Advances</journal-title></journal-title-group><issn pub-type="epub">2375-2548</issn><publisher><publisher-name>American Association for the Advancement of Science</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">29152574</article-id><article-id pub-id-type="pmc">5687858</article-id><article-id pub-id-type="publisher-id">aao4966</article-id><article-id pub-id-type="doi">10.1126/sciadv.aao4966</article-id><article-categories><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group><subj-group subj-group-type="heading"><subject>Research Articles</subject></subj-group><subj-group subj-group-type="legacy-article-type"><subject>SciAdv r-articles</subject></subj-group><subj-group subj-group-type="field"><subject>Health and Medicine</subject><subject>Virology</subject></subj-group><subj-group subj-group-type="overline"><subject>Virology</subject></subj-group></article-categories><title-group><article-title>Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Jie</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2948-3873</contrib-id><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="author-notes" rid="afn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Cun</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-3003-0000</contrib-id><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="author-notes" rid="afn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Guangyu</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="author-notes" rid="afn1">*</xref></contrib><contrib contrib-type="author"><name><surname>Chu</surname><given-names>Hin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Dong</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yan</surname><given-names>Helen Hoi-Ning</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Poon</surname><given-names>Vincent Kwok-Man</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wen</surname><given-names>Lei</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wong</surname><given-names>Bosco Ho-Yin</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Xiaoyu</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-0347-9104</contrib-id><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chiu</surname><given-names>Man Chun</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-9503-6396</contrib-id><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yang</surname><given-names>Dong</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Wang</surname><given-names>Yixin</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Au-Yeung</surname><given-names>Rex K. H.</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-3137-0886</contrib-id><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Ivy Hau-Yee</given-names></name><xref ref-type="aff" rid="aff6"><sup>6</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Shihui</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Jasper Fuk-Woo</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>To</surname><given-names>Kelvin Kai-Wang</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-1921-5824</contrib-id><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref></contrib><contrib contrib-type="author"><name><surname>Memish</surname><given-names>Ziad A.</given-names></name><xref ref-type="aff" rid="aff9"><sup>9</sup></xref><xref ref-type="aff" rid="aff10"><sup>10</sup></xref></contrib><contrib contrib-type="author"><name><surname>Corman</surname><given-names>Victor M.</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-3605-0136</contrib-id><xref ref-type="aff" rid="aff11"><sup>11</sup></xref><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Drosten</surname><given-names>Christian</given-names></name><xref ref-type="aff" rid="aff11"><sup>11</sup></xref><xref ref-type="aff" rid="aff12"><sup>12</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hung</surname><given-names>Ivan Fan-Ngai</given-names></name><xref ref-type="aff" rid="aff13"><sup>13</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Yusen</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="author-notes" rid="afn2">†</xref></contrib><contrib contrib-type="author"><name><surname>Leung</surname><given-names>Suet Yi</given-names></name><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yuen</surname><given-names>Kwok-Yung</given-names></name><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2948-3873</contrib-id><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><xref ref-type="aff" rid="aff7"><sup>7</sup></xref><xref ref-type="aff" rid="aff8"><sup>8</sup></xref><xref ref-type="author-notes" rid="afn2">†</xref><xref ref-type="corresp" rid="cor1">‡</xref></contrib><aff id="aff1"><label>1</label>State Key Laboratory of Emerging Infectious Diseases, University of Hong Kong, Hong Kong, China.</aff><aff id="aff2"><label>2</label>Department of Microbiology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</aff><aff id="aff3"><label>3</label>Research Centre of Infection and Immunology, University of Hong Kong, Hong Kong, China.</aff><aff id="aff4"><label>4</label>State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.</aff><aff id="aff5"><label>5</label>Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam, Hong Kong, China.</aff><aff id="aff6"><label>6</label>Department of Surgery, Queen Mary Hospital, Hong Kong, China.</aff><aff id="aff7"><label>7</label>Carol Yu Centre for Infection, University of Hong Kong, Hong Kong, China.</aff><aff id="aff8"><label>8</label>Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, University of Hong Kong, Hong Kong, China.</aff><aff id="aff9"><label>9</label>Ministry of Health and College of Medicine, Alfaisal University, Riyadh, Kingdom of Saudi Arabia.</aff><aff id="aff10"><label>10</label>Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.</aff><aff id="aff11"><label>11</label>Institute of Virology, Charité–Universitätsmedizin Berlin, Berlin, Germany.</aff><aff id="aff12"><label>12</label>German Centre for Infection Research (DZIF), Berlin, Germany.</aff><aff id="aff13"><label>13</label>Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China.</aff></contrib-group><author-notes><fn id="afn1" fn-type="equal"><label>*</label><p>These authors contributed equally to this work.</p></fn><fn id="afn2" fn-type="equal"><label>†</label><p>These authors contributed equally to this work.</p></fn><corresp id="cor1"><label>‡</label>Corresponding author. Email: <email xlink:href="kyyuen@hku.hk">kyyuen@hku.hk</email></corresp></author-notes><pub-date pub-type="collection"><month>11</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>15</day><month>11</month><year>2017</year></pub-date><volume>3</volume><issue>11</issue><elocation-id>eaao4966</elocation-id><history><date date-type="received"><day>27</day><month>7</month><year>2017</year></date><date date-type="accepted"><day>20</day><month>10</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>The Authors</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/" id="p-2"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">Creative Commons Attribution-NonCommercial license</ext-link>, which permits use, distribution, and reproduction in any medium, so long as the resultant use is <bold>not</bold> for commercial advantage and provided the original work is properly cited.</license-p></license></permissions><abstract abstract-type="teaser"><p>Human intestinal tract as an alternative route to acquire MERS-CoV infection.</p></abstract><abstract><p>Middle East respiratory syndrome coronavirus (MERS-CoV) has caused human respiratory infections with a high case fatality rate since 2012. However, the mode of virus transmission is not well understood. The findings of epidemiological and virological studies prompted us to hypothesize that the human gastrointestinal tract could serve as an alternative route to acquire MERS-CoV infection. We demonstrated that human primary intestinal epithelial cells, small intestine explants, and intestinal organoids were highly susceptible to MERS-CoV and can sustain robust viral replication. We also identified the evidence of enteric MERS-CoV infection in the stool specimen of a clinical patient. MERS-CoV was considerably resistant to fed-state gastrointestinal fluids but less tolerant to highly acidic fasted-state gastric fluid. In polarized Caco-2 cells cultured in Transwell inserts, apical MERS-CoV inoculation was more effective in establishing infection than basolateral inoculation. Notably, direct intragastric inoculation of MERS-CoV caused a lethal infection in human DPP4 transgenic mice. Histological examination revealed MERS-CoV enteric infection in all inoculated mice, as shown by the presence of virus-positive cells, progressive inflammation, and epithelial degeneration in small intestines, which were exaggerated in the mice pretreated with the proton pump inhibitor pantoprazole. With the progression of the enteric infection, inflammation, virus-positive cells, and live viruses emerged in the lung tissues, indicating the development of sequential respiratory infection. Taken together, these data suggest that the human intestinal tract may serve as an alternative infection route for MERS-CoV.</p></abstract><funding-group><award-group><funding-source><institution-wrap><institution>Ministry of Science and Technology of China</institution></institution-wrap></funding-source><award-id>award353208</award-id><award-id>2014ZX10004001004</award-id></award-group><award-group><funding-source><institution-wrap><institution>NSFC/RGC Joint Research Scheme</institution></institution-wrap></funding-source><award-id>award341714</award-id><award-id>N_HKU728/14</award-id></award-group><award-group><funding-source><institution-wrap><institution>Food and Health Bureau, Hong Kong Special Administrative Region</institution></institution-wrap></funding-source><award-id>award341712</award-id><award-id>14131392, 15140762</award-id></award-group><award-group><funding-source><institution-wrap><institution>Theme-Based Research Scheme,Research Grants Council</institution></institution-wrap></funding-source><award-id>award341716</award-id><award-id>T11/707/15</award-id></award-group><award-group><funding-source><institution-wrap><institution>Collaborative Research Fund, Research Grants Council</institution></institution-wrap></funding-source><award-id>award341715</award-id><award-id>C7011-15R</award-id></award-group><award-group><funding-source><institution-wrap><institution>The German Research Foundation</institution></institution-wrap></funding-source><award-id>award353209</award-id><award-id>Deutsche Forschungsgemeinschaft grant DR772/12-1 and DR772/7-2</award-id></award-group><award-group><funding-source><institution-wrap><institution>European Commission project PREPARE</institution></institution-wrap></funding-source><award-id>award353210</award-id><award-id>contract number 602525</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>Copyeditor</meta-name><meta-value>Justin Noriel</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Berlin</li><li>Géorgie (États-Unis)</li></region><settlement><li>Berlin</li><li>Pékin</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name></noRegion><name sortKey="Au Yeung, Rex K H" sort="Au Yeung, Rex K H" uniqKey="Au Yeung R" first="Rex K. H." last="Au-Yeung">Rex K. H. Au-Yeung</name><name sortKey="Chan, Ivy Hau Yee" sort="Chan, Ivy Hau Yee" uniqKey="Chan I" first="Ivy Hau-Yee" last="Chan">Ivy Hau-Yee Chan</name><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><name sortKey="Chan, Jasper Fuk Woo" sort="Chan, Jasper Fuk Woo" uniqKey="Chan J" first="Jasper Fuk-Woo" last="Chan">Jasper Fuk-Woo Chan</name><name sortKey="Chiu, Man Chun" sort="Chiu, Man Chun" uniqKey="Chiu M" first="Man Chun" last="Chiu">Man Chun Chiu</name><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><name sortKey="Chu, Hin" sort="Chu, Hin" uniqKey="Chu H" first="Hin" last="Chu">Hin Chu</name><name sortKey="Hung, Ivan Fan Ngai" sort="Hung, Ivan Fan Ngai" uniqKey="Hung I" first="Ivan Fan-Ngai" last="Hung">Ivan Fan-Ngai Hung</name><name sortKey="Leung, Suet Yi" sort="Leung, Suet Yi" uniqKey="Leung S" first="Suet Yi" last="Leung">Suet Yi Leung</name><name sortKey="Li, Cun" sort="Li, Cun" uniqKey="Li C" first="Cun" last="Li">Cun Li</name><name sortKey="Poon, Vincent Kwok Man" sort="Poon, Vincent Kwok Man" uniqKey="Poon V" first="Vincent Kwok-Man" last="Poon">Vincent Kwok-Man Poon</name><name sortKey="Sun, Shihui" sort="Sun, Shihui" uniqKey="Sun S" first="Shihui" last="Sun">Shihui Sun</name><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><name sortKey="To, Kelvin Kai Wang" sort="To, Kelvin Kai Wang" uniqKey="To K" first="Kelvin Kai-Wang" last="To">Kelvin Kai-Wang To</name><name sortKey="Wang, Dong" sort="Wang, Dong" uniqKey="Wang D" first="Dong" last="Wang">Dong Wang</name><name sortKey="Wang, Yixin" sort="Wang, Yixin" uniqKey="Wang Y" first="Yixin" last="Wang">Yixin Wang</name><name sortKey="Wen, Lei" sort="Wen, Lei" uniqKey="Wen L" first="Lei" last="Wen">Lei Wen</name><name sortKey="Wong, Bosco Ho Yin" sort="Wong, Bosco Ho Yin" uniqKey="Wong B" first="Bosco Ho-Yin" last="Wong">Bosco Ho-Yin Wong</name><name sortKey="Yan, Helen Hoi Ning" sort="Yan, Helen Hoi Ning" uniqKey="Yan H" first="Helen Hoi-Ning" last="Yan">Helen Hoi-Ning Yan</name><name sortKey="Yang, Dong" sort="Yang, Dong" uniqKey="Yang D" first="Dong" last="Yang">Dong Yang</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Yuen, Kwok Yung" sort="Yuen, Kwok Yung" uniqKey="Yuen K" first="Kwok-Yung" last="Yuen">Kwok-Yung Yuen</name><name sortKey="Zhao, Guangyu" sort="Zhao, Guangyu" uniqKey="Zhao G" first="Guangyu" last="Zhao">Guangyu Zhao</name><name sortKey="Zhao, Xiaoyu" sort="Zhao, Xiaoyu" uniqKey="Zhao X" first="Xiaoyu" last="Zhao">Xiaoyu Zhao</name><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><name sortKey="Zhou, Jie" sort="Zhou, Jie" uniqKey="Zhou J" first="Jie" last="Zhou">Jie Zhou</name><name sortKey="Zhou, Yusen" sort="Zhou, Yusen" uniqKey="Zhou Y" first="Yusen" last="Zhou">Yusen Zhou</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name></region></country><country name="Allemagne"><region name="Berlin"><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M." last="Corman">Victor M. Corman</name></region><name sortKey="Corman, Victor M" sort="Corman, Victor M" uniqKey="Corman V" first="Victor M." last="Corman">Victor M. Corman</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name><name sortKey="Drosten, Christian" sort="Drosten, Christian" uniqKey="Drosten C" first="Christian" last="Drosten">Christian Drosten</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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