Antibodies and vaccines against Middle East respiratory syndrome coronavirus
Identifieur interne : 000398 ( Pmc/Checkpoint ); précédent : 000397; suivant : 000399Antibodies and vaccines against Middle East respiratory syndrome coronavirus
Auteurs : Jiuyang Xu [République populaire de Chine] ; Wenxu Jia [République populaire de Chine] ; Pengfei Wang [République populaire de Chine] ; Senyan Zhang [République populaire de Chine] ; Xuanling Shi [République populaire de Chine] ; Xinquan Wang [République populaire de Chine] ; Linqi Zhang [République populaire de Chine]Source :
- Emerging Microbes & Infections [ 2222-1751 ] ; 2019.
Abstract
The Middle East respiratory syndrome coronavirus (MERS-CoV) has spread through 27 countries and infected more than 2,200 people since its first outbreak in Saudi Arabia in 2012. The high fatality rate (35.4%) of this novel coronavirus and its persistent wide spread infectiousness in animal reservoirs have generated tremendous global public health concern. However, no licensed therapeutic agents or vaccines against MERS-CoV are currently available and only a limited few have entered clinical trials. Among all the potential targets of MERS-CoV, the spike glycoprotein (S) has been the most well-studied due to its critical role in mediating viral entry and in inducing a protective antibody response in infected individuals. The most notable studies include the recent discoveries of monoclonal antibodies and development of candidate vaccines against the S glycoprotein. Structural characterization of MERS-CoV S protein bound with these monoclonal antibodies has provided insights into the mechanisms of humoral immune responses against MERS-CoV infection. The current review aims to highlight these developments and discuss possible hurdles and strategies to translate these discoveries into ultimate medical interventions against MERS-CoV infection.
Url:
DOI: 10.1080/22221751.2019.1624482
PubMed: 31169078
PubMed Central: 6567157
Affiliations:
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>The Middle East respiratory syndrome coronavirus (MERS-CoV) has spread through 27 countries and infected more than 2,200 people since its first outbreak in Saudi Arabia in 2012. The high fatality rate (35.4%) of this novel coronavirus and its persistent wide spread infectiousness in animal reservoirs have generated tremendous global public health concern. However, no licensed therapeutic agents or vaccines against MERS-CoV are currently available and only a limited few have entered clinical trials. Among all the potential targets of MERS-CoV, the spike glycoprotein (S) has been the most well-studied due to its critical role in mediating viral entry and in inducing a protective antibody response in infected individuals. The most notable studies include the recent discoveries of monoclonal antibodies and development of candidate vaccines against the S glycoprotein. Structural characterization of MERS-CoV S protein bound with these monoclonal antibodies has provided insights into the mechanisms of humoral immune responses against MERS-CoV infection. The current review aims to highlight these developments and discuss possible hurdles and strategies to translate these discoveries into ultimate medical interventions against MERS-CoV infection.</p>
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<journal-id journal-id-type="iso-abbrev">Emerg Microbes Infect</journal-id>
<journal-id journal-id-type="publisher-id">TEMI</journal-id>
<journal-id journal-id-type="publisher-id">temi20</journal-id>
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<publisher><publisher-name>Taylor & Francis</publisher-name>
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<article-id pub-id-type="pmc">6567157</article-id>
<article-id pub-id-type="publisher-id">1624482</article-id>
<article-id pub-id-type="doi">10.1080/22221751.2019.1624482</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
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<title-group><article-title>Antibodies and vaccines against Middle East respiratory syndrome coronavirus</article-title>
<alt-title alt-title-type="running-title">Emerging Microbes & Infections</alt-title>
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</contrib>
<aff id="AF1"><label>a</label>
<institution>Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, Tsinghua University School of Medicine</institution>
, Beijing,<country>People’s Republic of China</country>
</aff>
<aff id="AF2"><label>b</label>
<institution>Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, Tsinghua University School of Life Sciences</institution>
, Beijing,<country>People’s Republic of China</country>
</aff>
</contrib-group>
<author-notes><corresp id="cor1"><label>CONTACT</label>
Xinquan Wang <email xlink:href="zhanglinqi@mail.tsinghua.edu.cn">xinquanwang@tsinghua.edu.cn</email>
<institution>Ministry of Education Key Laboratory of Protein Science, Beijing Advanced Innovation Center for Structural Biology, Collaborative Innovation Center for Biotherapy, Tsinghua University School of Life Sciences</institution>
, <addr-line>Medical Building C226, 1 Tsinghua Yuan</addr-line>
, Beijing100084, <country>People’s Republic of China</country>
</corresp>
<corresp id="cor2">Linqi Zhang <email xlink:href="zhanglinqi@mail.tsinghua.edu.cn">zhanglinqi@mail.tsinghua.edu.cn</email>
<institution>Comprehensive AIDS Research Center, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing Advanced Innovation Center for Structural Biology, Department of Basic Medical Sciences, Tsinghua University School of Medicine</institution>
, <addr-line>Medical Building A208, 1 Tsinghua Yuan</addr-line>
, Beijing100084, <country>People’s Republic of China</country>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>06</day>
<month>6</month>
<year>2019</year>
</pub-date>
<volume>8</volume>
<issue>1</issue>
<fpage seq="83">841</fpage>
<lpage>856</lpage>
<history><date date-type="received"><day>26</day>
<month>3</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>10</day>
<month>5</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>13</day>
<month>5</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>The Author(s)</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="temi-8-1624482.pdf"></self-uri>
<abstract><title>ABSTRACT</title>
<p>The Middle East respiratory syndrome coronavirus (MERS-CoV) has spread through 27 countries and infected more than 2,200 people since its first outbreak in Saudi Arabia in 2012. The high fatality rate (35.4%) of this novel coronavirus and its persistent wide spread infectiousness in animal reservoirs have generated tremendous global public health concern. However, no licensed therapeutic agents or vaccines against MERS-CoV are currently available and only a limited few have entered clinical trials. Among all the potential targets of MERS-CoV, the spike glycoprotein (S) has been the most well-studied due to its critical role in mediating viral entry and in inducing a protective antibody response in infected individuals. The most notable studies include the recent discoveries of monoclonal antibodies and development of candidate vaccines against the S glycoprotein. Structural characterization of MERS-CoV S protein bound with these monoclonal antibodies has provided insights into the mechanisms of humoral immune responses against MERS-CoV infection. The current review aims to highlight these developments and discuss possible hurdles and strategies to translate these discoveries into ultimate medical interventions against MERS-CoV infection.</p>
</abstract>
<abstract abstract-type="graphical"><title>GRAPHICAL ABSTRACT</title>
<p><fig id="UF0001" orientation="portrait" position="anchor"><alternatives><graphic specific-use="web-only" content-type="color" xlink:href="TEMI_A_1624482_UF0001_OC"></graphic>
<graphic specific-use="print-only" content-type="black-white" xlink:href="TEMI_A_1624482_UF0001_PB"></graphic>
</alternatives>
</fig>
</p>
</abstract>
<kwd-group kwd-group-type="author"><title>KEYWORDS</title>
<kwd>Coronavirus</kwd>
<kwd>MERS-CoV</kwd>
<kwd>spike glycoprotein</kwd>
<kwd>monoclonal antibody</kwd>
<kwd>vaccine</kwd>
</kwd-group>
<counts><fig-count count="5"></fig-count>
<table-count count="2"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="97"></ref-count>
<page-count count="16"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Xu, Jiuyang" sort="Xu, Jiuyang" uniqKey="Xu J" first="Jiuyang" last="Xu">Jiuyang Xu</name>
</noRegion>
<name sortKey="Jia, Wenxu" sort="Jia, Wenxu" uniqKey="Jia W" first="Wenxu" last="Jia">Wenxu Jia</name>
<name sortKey="Shi, Xuanling" sort="Shi, Xuanling" uniqKey="Shi X" first="Xuanling" last="Shi">Xuanling Shi</name>
<name sortKey="Wang, Pengfei" sort="Wang, Pengfei" uniqKey="Wang P" first="Pengfei" last="Wang">Pengfei Wang</name>
<name sortKey="Wang, Xinquan" sort="Wang, Xinquan" uniqKey="Wang X" first="Xinquan" last="Wang">Xinquan Wang</name>
<name sortKey="Zhang, Linqi" sort="Zhang, Linqi" uniqKey="Zhang L" first="Linqi" last="Zhang">Linqi Zhang</name>
<name sortKey="Zhang, Senyan" sort="Zhang, Senyan" uniqKey="Zhang S" first="Senyan" last="Zhang">Senyan Zhang</name>
</country>
</tree>
</affiliations>
</record>
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