Evaluating the potential impact of targeted vaccination strategies against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks in the healthcare setting
Identifieur interne : 000315 ( Pmc/Checkpoint ); précédent : 000314; suivant : 000316Evaluating the potential impact of targeted vaccination strategies against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks in the healthcare setting
Auteurs : Fatima Abdirizak ; Rayleen Lewis ; Gerardo ChowellSource :
- Theoretical Biology & Medical Modelling [ 1742-4682 ] ; 2019.
Abstract
Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are two coronaviruses with demonstrated potential to generate significant nosocomial outbreaks. In particular, MERS continues to pose a significant threat in the Middle East since 2012. Currently, no licensed vaccine or drug treatment is available to treat patients infected with either coronavirus. However, there are some MERS vaccines in the preclinical stage of development. We sought to evaluate the potential impact of targeted vaccination strategies for mitigating SARS and MERS outbreaks in healthcare settings using simple mathematical models and detailed historic transmission trees describing the progression of past nosocomial outbreaks of SARS and MERS.
Our findings suggest that vaccination strategies targeting patients and healthcare workers, which have been disproportionately affected during past outbreaks, and assuming two vaccination coverage levels at 50 and 75% have the potential to avert nearly 50% or more of MERS or SARS cases.
Our modeling results informed by historic outbreak data for SARS and MERS suggest that vaccination strategies targeting patients could be an effective measure to mitigate and prevent outbreaks in the healthcare setting.
The online version of this article (10.1186/s12976-019-0112-6) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s12976-019-0112-6
PubMed: 31587665
PubMed Central: 6778978
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Evaluating the potential impact of targeted vaccination strategies against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks in the healthcare setting</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are two coronaviruses with demonstrated potential to generate significant nosocomial outbreaks. In particular, MERS continues to pose a significant threat in the Middle East since 2012. Currently, no licensed vaccine or drug treatment is available to treat patients infected with either coronavirus. However, there are some MERS vaccines in the preclinical stage of development. We sought to evaluate the potential impact of targeted vaccination strategies for mitigating SARS and MERS outbreaks in healthcare settings using simple mathematical models and detailed historic transmission trees describing the progression of past nosocomial outbreaks of SARS and MERS.</p>
</sec>
<sec><title>Results</title>
<p id="Par2">Our findings suggest that vaccination strategies targeting patients and healthcare workers, which have been disproportionately affected during past outbreaks, and assuming two vaccination coverage levels at 50 and 75% have the potential to avert nearly 50% or more of MERS or SARS cases.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par3">Our modeling results informed by historic outbreak data for SARS and MERS suggest that vaccination strategies targeting patients could be an effective measure to mitigate and prevent outbreaks in the healthcare setting.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (10.1186/s12976-019-0112-6) contains supplementary material, which is available to authorized users.</p>
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<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name>
</author>
<author><name sortKey="Auwaerter, Pg" uniqKey="Auwaerter P">PG Auwaerter</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Cowling, Bj" uniqKey="Cowling B">BJ Cowling</name>
</author>
<author><name sortKey="Park, M" uniqKey="Park M">M Park</name>
</author>
<author><name sortKey="Fang, Vj" uniqKey="Fang V">VJ Fang</name>
</author>
<author><name sortKey="Wu, P" uniqKey="Wu P">P Wu</name>
</author>
<author><name sortKey="Leung, Gm" uniqKey="Leung G">GM Leung</name>
</author>
<author><name sortKey="Wu, Jt" uniqKey="Wu J">JT Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Choi, Jy" uniqKey="Choi J">JY Choi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mackay, Im" uniqKey="Mackay I">IM Mackay</name>
</author>
<author><name sortKey="Arden, Ke" uniqKey="Arden K">KE Arden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Park, Jw" uniqKey="Park J">JW Park</name>
</author>
<author><name sortKey="Lee, Kj" uniqKey="Lee K">KJ Lee</name>
</author>
<author><name sortKey="Lee, Kh" uniqKey="Lee K">KH Lee</name>
</author>
<author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name>
</author>
<author><name sortKey="Cho, Jr" uniqKey="Cho J">JR Cho</name>
</author>
<author><name sortKey="Mo, Jw" uniqKey="Mo J">JW Mo</name>
</author>
<author><name sortKey="Choi, Sy" uniqKey="Choi S">SY Choi</name>
</author>
<author><name sortKey="Kwon, Gy" uniqKey="Kwon G">GY Kwon</name>
</author>
<author><name sortKey="Shin, Jy" uniqKey="Shin J">JY Shin</name>
</author>
<author><name sortKey="Hong, Jy" uniqKey="Hong J">JY Hong</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chowell, G" uniqKey="Chowell G">G Chowell</name>
</author>
<author><name sortKey="Abdirizak, F" uniqKey="Abdirizak F">F Abdirizak</name>
</author>
<author><name sortKey="Lee, S" uniqKey="Lee S">S Lee</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name>
</author>
<author><name sortKey="Jung, E" uniqKey="Jung E">E Jung</name>
</author>
<author><name sortKey="Nishiura, H" uniqKey="Nishiura H">H Nishiura</name>
</author>
<author><name sortKey="Viboud, C" uniqKey="Viboud C">C Viboud</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name>
</author>
<author><name sortKey="Watson, Jt" uniqKey="Watson J">JT Watson</name>
</author>
<author><name sortKey="Almarashi, A" uniqKey="Almarashi A">A Almarashi</name>
</author>
<author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name>
</author>
<author><name sortKey="Turkistani, A" uniqKey="Turkistani A">A Turkistani</name>
</author>
<author><name sortKey="Sadran, M" uniqKey="Sadran M">M Sadran</name>
</author>
<author><name sortKey="Housa, A" uniqKey="Housa A">A Housa</name>
</author>
<author><name sortKey="Almazroa, Ma" uniqKey="Almazroa M">MA Almazroa</name>
</author>
<author><name sortKey="Alraihan, N" uniqKey="Alraihan N">N Alraihan</name>
</author>
<author><name sortKey="Banjar, A" uniqKey="Banjar A">A Banjar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name>
</author>
<author><name sortKey="Saeed, Aa" uniqKey="Saeed A">AA Saeed</name>
</author>
<author><name sortKey="Abdalla, Ma" uniqKey="Abdalla M">MA Abdalla</name>
</author>
<author><name sortKey="Al Masry, M" uniqKey="Al Masry M">M Al-Masry</name>
</author>
<author><name sortKey="Choudhry, Aj" uniqKey="Choudhry A">AJ Choudhry</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Erdman, Dd" uniqKey="Erdman D">DD Erdman</name>
</author>
<author><name sortKey="Tatti, K" uniqKey="Tatti K">K Tatti</name>
</author>
<author><name sortKey="Binder, Am" uniqKey="Binder A">AM Binder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Oboho, Ik" uniqKey="Oboho I">IK Oboho</name>
</author>
<author><name sortKey="Tomczyk, Sm" uniqKey="Tomczyk S">SM Tomczyk</name>
</author>
<author><name sortKey="Al Asmari, Am" uniqKey="Al Asmari A">AM Al-Asmari</name>
</author>
<author><name sortKey="Banjar, Aa" uniqKey="Banjar A">AA Banjar</name>
</author>
<author><name sortKey="Al Mugti, H" uniqKey="Al Mugti H">H Al-Mugti</name>
</author>
<author><name sortKey="Aloraini, Ms" uniqKey="Aloraini M">MS Aloraini</name>
</author>
<author><name sortKey="Alkhaldi, Kz" uniqKey="Alkhaldi K">KZ Alkhaldi</name>
</author>
<author><name sortKey="Almohammadi, El" uniqKey="Almohammadi E">EL Almohammadi</name>
</author>
<author><name sortKey="Alraddadi, Bm" uniqKey="Alraddadi B">BM Alraddadi</name>
</author>
<author><name sortKey="Gerber, Si" uniqKey="Gerber S">SI Gerber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name>
</author>
<author><name sortKey="Alenazi, Th" uniqKey="Alenazi T">TH Alenazi</name>
</author>
<author><name sortKey="Alshamrani, Mm" uniqKey="Alshamrani M">MM Alshamrani</name>
</author>
<author><name sortKey="Baffoe Bonnie, H" uniqKey="Baffoe Bonnie H">H Baffoe-Bonnie</name>
</author>
<author><name sortKey="Al Abdely, Hm" uniqKey="Al Abdely H">HM Al-Abdely</name>
</author>
<author><name sortKey="El Saed, A" uniqKey="El Saed A">A El-Saed</name>
</author>
<author><name sortKey="Al Arbash, Ha" uniqKey="Al Arbash H">HA Al Arbash</name>
</author>
<author><name sortKey="Al Mayahi, Zk" uniqKey="Al Mayahi Z">ZK Al Mayahi</name>
</author>
<author><name sortKey="Assiri, Am" uniqKey="Assiri A">AM Assiri</name>
</author>
<author><name sortKey="Bin Saeed, A" uniqKey="Bin Saeed A">A Bin Saeed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alenazi, Th" uniqKey="Alenazi T">TH Alenazi</name>
</author>
<author><name sortKey="Al Arbash, H" uniqKey="Al Arbash H">H Al Arbash</name>
</author>
<author><name sortKey="El Saed, A" uniqKey="El Saed A">A El-Saed</name>
</author>
<author><name sortKey="Alshamrani, Mm" uniqKey="Alshamrani M">MM Alshamrani</name>
</author>
<author><name sortKey="Baffoe Bonnie, H" uniqKey="Baffoe Bonnie H">H Baffoe-Bonnie</name>
</author>
<author><name sortKey="Arabi, Ym" uniqKey="Arabi Y">YM Arabi</name>
</author>
<author><name sortKey="Al Johani, Sm" uniqKey="Al Johani S">SM Al Johani</name>
</author>
<author><name sortKey="Hijazi, R" uniqKey="Hijazi R">R Hijazi</name>
</author>
<author><name sortKey="Alothman, A" uniqKey="Alothman A">A Alothman</name>
</author>
<author><name sortKey="Balkhy, Hh" uniqKey="Balkhy H">HH Balkhy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name>
</author>
<author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Chafekar, A" uniqKey="Chafekar A">A Chafekar</name>
</author>
<author><name sortKey="Fielding, Bc" uniqKey="Fielding B">BC Fielding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Modjarrad, K" uniqKey="Modjarrad K">K Modjarrad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coltart, Ce" uniqKey="Coltart C">CE Coltart</name>
</author>
<author><name sortKey="Johnson, Am" uniqKey="Johnson A">AM Johnson</name>
</author>
<author><name sortKey="Whitty, Cj" uniqKey="Whitty C">CJ Whitty</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Goh, Kt" uniqKey="Goh K">KT Goh</name>
</author>
<author><name sortKey="Cutter, J" uniqKey="Cutter J">J Cutter</name>
</author>
<author><name sortKey="Heng, Bh" uniqKey="Heng B">BH Heng</name>
</author>
<author><name sortKey="Ma, S" uniqKey="Ma S">S Ma</name>
</author>
<author><name sortKey="Koh, Bk" uniqKey="Koh B">BK Koh</name>
</author>
<author><name sortKey="Kwok, C" uniqKey="Kwok C">C Kwok</name>
</author>
<author><name sortKey="Toh, Cm" uniqKey="Toh C">CM Toh</name>
</author>
<author><name sortKey="Chew, Sk" uniqKey="Chew S">SK Chew</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Varia, M" uniqKey="Varia M">M Varia</name>
</author>
<author><name sortKey="Wilson, S" uniqKey="Wilson S">S Wilson</name>
</author>
<author><name sortKey="Sarwal, S" uniqKey="Sarwal S">S Sarwal</name>
</author>
<author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name>
</author>
<author><name sortKey="Gournis, E" uniqKey="Gournis E">E Gournis</name>
</author>
<author><name sortKey="Galanis, E" uniqKey="Galanis E">E Galanis</name>
</author>
<author><name sortKey="Henry, B" uniqKey="Henry B">B Henry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name>
</author>
<author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A McGeer</name>
</author>
<author><name sortKey="Perl, Tm" uniqKey="Perl T">TM Perl</name>
</author>
<author><name sortKey="Price, Cs" uniqKey="Price C">CS Price</name>
</author>
<author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al Rabeeah</name>
</author>
<author><name sortKey="Cummings, Da" uniqKey="Cummings D">DA Cummings</name>
</author>
<author><name sortKey="Alabdullatif, Zn" uniqKey="Alabdullatif Z">ZN Alabdullatif</name>
</author>
<author><name sortKey="Assad, M" uniqKey="Assad M">M Assad</name>
</author>
<author><name sortKey="Almulhim, A" uniqKey="Almulhim A">A Almulhim</name>
</author>
<author><name sortKey="Makhdoom, H" uniqKey="Makhdoom H">H Makhdoom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Zhou, B" uniqKey="Zhou B">B Zhou</name>
</author>
<author><name sortKey="Bi, Y" uniqKey="Bi Y">Y Bi</name>
</author>
<author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
<biblStruct></biblStruct>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Theor Biol Med Model</journal-id>
<journal-id journal-id-type="iso-abbrev">Theor Biol Med Model</journal-id>
<journal-title-group><journal-title>Theoretical Biology & Medical Modelling</journal-title>
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<issn pub-type="epub">1742-4682</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
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<article-id pub-id-type="publisher-id">112</article-id>
<article-id pub-id-type="doi">10.1186/s12976-019-0112-6</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
</subj-group>
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<title-group><article-title>Evaluating the potential impact of targeted vaccination strategies against severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks in the healthcare setting</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Abdirizak</surname>
<given-names>Fatima</given-names>
</name>
<address><email>fabdirizak@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lewis</surname>
<given-names>Rayleen</given-names>
</name>
<address><email>rayleen.lewis@gmail.com</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chowell</surname>
<given-names>Gerardo</given-names>
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<address><email>gchowell@gsu.edu</email>
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<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7400</institution-id>
<institution-id institution-id-type="GRID">grid.256304.6</institution-id>
<institution>Department of Population Health Sciences, School of Public Health,</institution>
<institution>Georgia State University,</institution>
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P.O. Box 3984, Atlanta, GA 30302-3984 USA</aff>
</contrib-group>
<pub-date pub-type="epub"><day>7</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>7</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>16</volume>
<elocation-id>16</elocation-id>
<history><date date-type="received"><day>18</day>
<month>3</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>28</day>
<month>8</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p id="Par1">Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are two coronaviruses with demonstrated potential to generate significant nosocomial outbreaks. In particular, MERS continues to pose a significant threat in the Middle East since 2012. Currently, no licensed vaccine or drug treatment is available to treat patients infected with either coronavirus. However, there are some MERS vaccines in the preclinical stage of development. We sought to evaluate the potential impact of targeted vaccination strategies for mitigating SARS and MERS outbreaks in healthcare settings using simple mathematical models and detailed historic transmission trees describing the progression of past nosocomial outbreaks of SARS and MERS.</p>
</sec>
<sec><title>Results</title>
<p id="Par2">Our findings suggest that vaccination strategies targeting patients and healthcare workers, which have been disproportionately affected during past outbreaks, and assuming two vaccination coverage levels at 50 and 75% have the potential to avert nearly 50% or more of MERS or SARS cases.</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par3">Our modeling results informed by historic outbreak data for SARS and MERS suggest that vaccination strategies targeting patients could be an effective measure to mitigate and prevent outbreaks in the healthcare setting.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (10.1186/s12976-019-0112-6) contains supplementary material, which is available to authorized users.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>MERS</kwd>
<kwd>SARS</kwd>
<kwd>Coronavirus</kwd>
<kwd>Nosocomial</kwd>
<kwd>Hospital transmission</kwd>
<kwd>Vaccine</kwd>
<kwd>Vaccination strategy</kwd>
<kwd>South Korea</kwd>
<kwd>Middle East</kwd>
<kwd>Stochastic simulation</kwd>
<kwd>And infection control and prevention</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Abdirizak, Fatima" sort="Abdirizak, Fatima" uniqKey="Abdirizak F" first="Fatima" last="Abdirizak">Fatima Abdirizak</name>
<name sortKey="Chowell, Gerardo" sort="Chowell, Gerardo" uniqKey="Chowell G" first="Gerardo" last="Chowell">Gerardo Chowell</name>
<name sortKey="Lewis, Rayleen" sort="Lewis, Rayleen" uniqKey="Lewis R" first="Rayleen" last="Lewis">Rayleen Lewis</name>
</noCountry>
</tree>
</affiliations>
</record>
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