Genotype and phenotype of COVID-19: Their roles in pathogenesis
Identifieur interne : 000076 ( Pmc/Checkpoint ); précédent : 000075; suivant : 000077Genotype and phenotype of COVID-19: Their roles in pathogenesis
Auteurs : Leila Mousavizadeh [Allemagne] ; Sorayya Ghasemi [Iran]Source :
- Journal of Microbiology, Immunology, and Infection [ 1684-1182 ] ; 2020.
Abstract
COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence their pathogenesis. COVID-19 is containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. A typical CoV contains at least six ORFs in its genome. All the structural and accessory proteins are translated from the sgRNAs of CoVs. Four main structural proteins are encoded by ORFs 10, 11 on the one-third of the genome near the 3′-terminus. The genetic and phenotypic structure of COVID-19 in pathogenesis is important. This article highlights the most important of these features compared to other Betacoronaviruses.
Url:
DOI: 10.1016/j.jmii.2020.03.022
PubMed: 32265180
PubMed Central: 7138183
Affiliations:
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Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence their pathogenesis. COVID-19 is containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. A typical CoV contains at least six ORFs in its genome. All the structural and accessory proteins are translated from the sgRNAs of CoVs. Four main structural proteins are encoded by ORFs 10, 11 on the one-third of the genome near the 3′-terminus. The genetic and phenotypic structure of COVID-19 in pathogenesis is important. This article highlights the most important of these features compared to other Betacoronaviruses.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Microbiol Immunol Infect</journal-id><journal-id journal-id-type="iso-abbrev">J Microbiol Immunol Infect</journal-id><journal-title-group><journal-title>Journal of Microbiology, Immunology, and Infection</journal-title></journal-title-group><issn pub-type="ppub">1684-1182</issn><issn pub-type="epub">1995-9133</issn><publisher><publisher-name>Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32265180</article-id><article-id pub-id-type="pmc">7138183</article-id><article-id pub-id-type="publisher-id">S1684-1182(20)30082-7</article-id><article-id pub-id-type="doi">10.1016/j.jmii.2020.03.022</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Genotype and phenotype of COVID-19: Their roles in pathogenesis</article-title></title-group><contrib-group><contrib contrib-type="author" id="au1"><name><surname>Mousavizadeh</surname><given-names>Leila</given-names></name><email>lmosavi2007@yahoo.com</email><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author" id="au2"><name><surname>Ghasemi</surname><given-names>Sorayya</given-names></name><email>sorayya.ghasemi@gmail.com</email><xref rid="aff2" ref-type="aff">b</xref><xref rid="aff3" ref-type="aff">c</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Virus-host Interaction, Heinrich-Pette-Institut (HPI), Martinistrasse 52, 20251 Hamburg, Germany</aff><aff id="aff2"><label>b</label>Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran</aff><aff id="aff3"><label>c</label>Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran</aff><author-notes><corresp id="cor1"><label>∗</label>Corresponding author. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Rahmatiyeh, Shahrekord, 8813833435, Iran. Fax: +98 3833330709. <email>sorayya.ghasemi@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>31</day><month>3</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="epub"><day>31</day><month>3</month><year>2020</year></pub-date><elocation-id></elocation-id><history><date date-type="received"><day>20</day><month>3</month><year>2020</year></date><date date-type="rev-recd"><day>22</day><month>3</month><year>2020</year></date><date date-type="accepted"><day>22</day><month>3</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder></copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract id="abs0010"><p>COVID-19 is a novel coronavirus with an outbreak of unusual viral pneumonia in Wuhan, China, and then pandemic. Based on its phylogenetic relationships and genomic structures the COVID-19 belongs to genera Betacoronavirus. Human Betacoronaviruses (SARS-CoV-2, SARS-CoV, and MERS-CoV) have many similarities, but also have differences in their genomic and phenotypic structure that can influence their pathogenesis. COVID-19 is containing single-stranded (positive-sense) RNA associated with a nucleoprotein within a capsid comprised of matrix protein. A typical CoV contains at least six ORFs in its genome. All the structural and accessory proteins are translated from the sgRNAs of CoVs. Four main structural proteins are encoded by ORFs 10, 11 on the one-third of the genome near the 3′-terminus. The genetic and phenotypic structure of COVID-19 in pathogenesis is important. This article highlights the most important of these features compared to other Betacoronaviruses.</p></abstract><kwd-group id="kwrds0010"><title>Keywords</title><kwd>COVID-19</kwd><kwd>Genotype</kwd><kwd>Phenotype</kwd><kwd>Pathogenesis</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Iran</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Mousavizadeh, Leila" sort="Mousavizadeh, Leila" uniqKey="Mousavizadeh L" first="Leila" last="Mousavizadeh">Leila Mousavizadeh</name></region></country><country name="Iran"><noRegion><name sortKey="Ghasemi, Sorayya" sort="Ghasemi, Sorayya" uniqKey="Ghasemi S" first="Sorayya" last="Ghasemi">Sorayya Ghasemi</name></noRegion><name sortKey="Ghasemi, Sorayya" sort="Ghasemi, Sorayya" uniqKey="Ghasemi S" first="Sorayya" last="Ghasemi">Sorayya Ghasemi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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