MersV1, PascalFrancis, Corpus, bibRecord, 000117

Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie α

Identifieur interne : 000117 ( PascalFrancis/Corpus ); précédent : 000116; suivant : 000118

Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie α

Auteurs : B. Rayner ; M. Matsukura ; F. Morvan ; J. S. Cohen ; J.-L. Imbach

Source :

Comptes rendus de l'Académie des sciences. Série 3, Sciences de la vie [ 0764-4469 ] ; 1990.

RBID : Pascal:90-0282557

Descripteurs français

Pascal (Inist)
- Oligodésoxyribonucléotide, Analyse, Anomère alpha, Produit synthétique, Activité biologique, Antiviral, In vitro, Inhibition, Cytopathologie, Relation dose réponse, Cytotoxicité, Virus immunodéficience humaine.

English descriptors

KwdEn :
- Alpha anomer, Analysis, Antiviral, Biological activity, Cytopathology, Cytotoxicity, Dose activity relation, Human immunodeficiency virus, In vitro, Inhibition, Oligodeoxyribonucleotide, Synthetic product.

Abstract

Oligonucleotide analogs consisting exclusively of α-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents agains human immunodeficiency virus in human T cells. Two 28-mers, an homopolymer α-S-Cd₂₈ and an oligomer α-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding β-anomeric phosphorothioate analogs

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A05				`@2 310`
A06				`@2 3`
A08	`01`	`1`	`FRE`	`@1 Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie α`
A11	`01`	`1`		`@1 RAYNER (B.)`
A11	`02`	`1`		`@1 MATSUKURA (M.)`
A11	`03`	`1`		`@1 MORVAN (F.)`
A11	`04`	`1`		`@1 COHEN (J. S.)`
A11	`05`	`1`		`@1 IMBACH (J.-L.)`
A14	`01`			`@1 Univ. Montpellier-II, lab. chimie bio-organique @2 Montpellier 34060 @3 FRA @Z A11011000`
A20				`@1 61-64`
A21				`@1 1990`
A23	`01`			`@0 FRE`
A24	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 116D @3 354000007602400040/NUM`
A44				`@0 0000`
A45				`@0 11 ref.`
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A60				`@1 P`
A61				`@0 A`
A64		`1`		`@0 Comptes rendus de l'Académie des sciences. Série 3, Sciences de la vie`
A66	`01`			`@0 FRA`
A68	`01`	`1`	`ENG`	`@1 In vitro anti-HIV activity of phosphorothioate α-anomeric oligodeoxynucleotides`
C01	`01`		`ENG`	@0 Oligonucleotide analogs consisting exclusively of α-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents agains human immunodeficiency virus in human T cells. Two 28-mers, an homopolymer α-S-Cd₂₈ and an oligomer α-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding β-anomeric phosphorothioate analogs
C02	`01`	`X`		`@0 002B02S05`
C03	`02`	`X`	`FRE`	`@0 Oligodésoxyribonucléotide`
C03	`04`	`X`	`FRE`	`@0 Analyse`
C03	`05`	`X`	`FRE`	`@0 Anomère alpha`
C03	`06`	`X`	`FRE`	`@0 Produit synthétique`
C03	`07`	`X`	`FRE`	`@0 Activité biologique`
C03	`08`	`X`	`FRE`	`@0 Antiviral`
C03	`10`	`X`	`FRE`	`@0 In vitro`
C03	`12`	`X`	`FRE`	`@0 Inhibition`
C03	`13`	`X`	`FRE`	`@0 Cytopathologie`
C03	`15`	`X`	`FRE`	`@0 Relation dose réponse`
C03	`19`	`X`	`FRE`	`@0 Cytotoxicité`
C03	`21`	`X`	`FRE`	`@0 Virus immunodéficience humaine`
C03	`02`	`X`	`ENG`	`@0 Oligodeoxyribonucleotide`
C03	`04`	`X`	`ENG`	`@0 Analysis`
C03	`05`	`X`	`ENG`	`@0 Alpha anomer`
C03	`06`	`X`	`ENG`	`@0 Synthetic product`
C03	`07`	`X`	`ENG`	`@0 Biological activity`
C03	`08`	`X`	`ENG`	`@0 Antiviral`
C03	`10`	`X`	`ENG`	`@0 In vitro`
C03	`12`	`X`	`ENG`	`@0 Inhibition`
C03	`13`	`X`	`ENG`	`@0 Cytopathology`
C03	`15`	`X`	`ENG`	`@0 Dose activity relation`
C03	`19`	`X`	`ENG`	`@0 Cytotoxicity`
C03	`21`	`X`	`ENG`	`@0 Human immunodeficiency virus`
C03	`02`	`X`	`SPA`	`@0 Oligodesoxirribonucleótido`
C03	`04`	`X`	`SPA`	`@0 Análisis`
C03	`05`	`X`	`SPA`	`@0 Anómero alfa`
C03	`06`	`X`	`SPA`	`@0 Producto sintético`
C03	`07`	`X`	`SPA`	`@0 Actividad biológica`
C03	`08`	`X`	`SPA`	`@0 Antiviral`
C03	`10`	`X`	`SPA`	`@0 In vitro`
C03	`12`	`X`	`SPA`	`@0 Inhibición`
C03	`13`	`X`	`SPA`	`@0 Citopatología`
C03	`15`	`X`	`SPA`	`@0 Relación dosis respuesta`
C03	`19`	`X`	`SPA`	`@0 Citotoxicidad`
C03	`21`	`X`	`SPA`	`@0 Human immunodeficiency virus`
C04	`01`	`X`		`@0 PU21!02,07,10`
C04	`02`	`X`		`@0 PU02!21,07,10`
C07	`01`	`X`	`FRE`	`@0 Retroviridae`
C07	`02`	`X`	`FRE`	`@0 Virus`
C07	`03`	`X`	`ENG`	`@0 Retroviridae`
C07	`04`	`X`	`ENG`	`@0 Virus`
C07	`05`	`X`	`SPA`	`@0 Retroviridae`
C07	`06`	`X`	`SPA`	`@0 Virus`
N21				`@1 015`

Format Inist (serveur)

NO :	PASCAL 90-0282557 INIST
FT :	Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie α
ET :	(In vitro anti-HIV activity of phosphorothioate α-anomeric oligodeoxynucleotides)
AU :	RAYNER (B.); MATSUKURA (M.); MORVAN (F.); COHEN (J. S.); IMBACH (J.-L.)
AF :	Univ. Montpellier-II, lab. chimie bio-organique/Montpellier 34060/France (A11011000)
DT :	Publication en série; Niveau analytique
SO :	Comptes rendus de l'Académie des sciences. Série 3, Sciences de la vie; ISSN 0764-4469; France; Da. 1990; Vol. 310; No. 3; Pp. 61-64; Abs. ENG; Bibl. 11 ref.
LA :	Français
EA :	Oligonucleotide analogs consisting exclusively of α-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents agains human immunodeficiency virus in human T cells. Two 28-mers, an homopolymer α-S-Cd₂₈ and an oligomer α-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding β-anomeric phosphorothioate analogs
CC :	002B02S05
FD :	Oligodésoxyribonucléotide; Analyse; Anomère alpha; Produit synthétique; Activité biologique; Antiviral; In vitro; Inhibition; Cytopathologie; Relation dose réponse; Cytotoxicité; Virus immunodéficience humaine
FG :	Retroviridae; Virus
ED :	Oligodeoxyribonucleotide; Analysis; Alpha anomer; Synthetic product; Biological activity; Antiviral; In vitro; Inhibition; Cytopathology; Dose activity relation; Cytotoxicity; Human immunodeficiency virus
EG :	Retroviridae; Virus
SD :	Oligodesoxirribonucleótido; Análisis; Anómero alfa; Producto sintético; Actividad biológica; Antiviral; In vitro; Inhibición; Citopatología; Relación dosis respuesta; Citotoxicidad; Human immunodeficiency virus
LO :	INIST-116D
ID :	90-0282557

Links to Exploration step

Pascal:90-0282557

Le document en format XML

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   |texte=   Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie α
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Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie α

Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie α

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