Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.
Identifieur interne : 002637 ( Ncbi/Merge ); précédent : 002636; suivant : 002638Tilorone: A Broad-Spectrum Antiviral For Emerging Viruses.
Auteurs : Sean Ekins [Oman] ; Peter B. Madrid [États-Unis]Source :
- Antimicrobial agents and chemotherapy [ 1098-6596 ] ; 2020.
Abstract
Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity in vitro and in vivo against the Ebola Virus. After a broad screening of additional viruses, we now describe in vitro activity against Chikungunya virus (CHIK) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).
DOI: 10.1128/AAC.00440-20
PubMed: 32205350
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pubmed:32205350Le document en format XML
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<front><div type="abstract" xml:lang="en">Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity <i>in vitro</i>
and <i>in vivo</i>
against the Ebola Virus. After a broad screening of additional viruses, we now describe <i>in vitro</i>
activity against Chikungunya virus (CHIK) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).</div>
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<Abstract><AbstractText>Tilorone is a 50-year-old synthetic small-molecule compound with antiviral activity that is proposed to induce interferon after oral administration. This drug is used as a broad-spectrum antiviral in several countries of the Russian Federation. We have recently described activity <i>in vitro</i>
and <i>in vivo</i>
against the Ebola Virus. After a broad screening of additional viruses, we now describe <i>in vitro</i>
activity against Chikungunya virus (CHIK) and Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV).</AbstractText>
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