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Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.

Identifieur interne : 002595 ( Ncbi/Merge ); précédent : 002594; suivant : 002596

Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.

Auteurs : Nisreen M A. Okba ; Ivy Widjaja ; Wentao Li ; Corine H. Geurtsvankessel ; Elmoubasher A B A. Farag ; Mohammed Al-Hajri ; Wan Beom Park ; Myoung-Don Oh ; Chantal B E M. Reusken ; Marion P G. Koopmans ; Berend-Jan Bosch ; Bart L. Haagmans

Source :

RBID : pubmed:32150528

Abstract

We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.

DOI: 10.3201/eid2605.190921
PubMed: 32150528

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pubmed:32150528

Le document en format XML

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<name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B E M" last="Reusken">Chantal B E M. Reusken</name>
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<div type="abstract" xml:lang="en">We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.</div>
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