Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.
Identifieur interne : 000176 ( PubMed/Corpus ); précédent : 000175; suivant : 000177Serologic Detection of Middle East Respiratory Syndrome Coronavirus Functional Antibodies.
Auteurs : Nisreen M A. Okba ; Ivy Widjaja ; Wentao Li ; Corine H. Geurtsvankessel ; Elmoubasher A B A. Farag ; Mohammed Al-Hajri ; Wan Beom Park ; Myoung-Don Oh ; Chantal B E M. Reusken ; Marion P G. Koopmans ; Berend-Jan Bosch ; Bart L. HaagmansSource :
- Emerging infectious diseases [ 1080-6059 ] ; 2020.
Abstract
We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.
DOI: 10.3201/eid2605.190921
PubMed: 32150528
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pubmed:32150528Le document en format XML
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<author><name sortKey="Geurtsvankessel, Corine H" sort="Geurtsvankessel, Corine H" uniqKey="Geurtsvankessel C" first="Corine H" last="Geurtsvankessel">Corine H. Geurtsvankessel</name>
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<author><name sortKey="Al Hajri, Mohammed" sort="Al Hajri, Mohammed" uniqKey="Al Hajri M" first="Mohammed" last="Al-Hajri">Mohammed Al-Hajri</name>
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<series><title level="j">Emerging infectious diseases</title>
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<front><div type="abstract" xml:lang="en">We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.</div>
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<Abstract><AbstractText>We developed and validated 2 species-independent protein-based assays to detect Middle East respiratory syndrome coronavirus functional antibodies that can block virus receptor-binding or sialic acid-attachment. Antibody levels measured in both assays correlated strongly with virus-neutralizing antibody titers, proving their use for serologic confirmatory diagnosis of Middle East respiratory syndrome.</AbstractText>
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<Keyword MajorTopicYN="N">lumazine synthase</Keyword>
<Keyword MajorTopicYN="N">nanoparticle</Keyword>
<Keyword MajorTopicYN="N">neutralization</Keyword>
<Keyword MajorTopicYN="N">respiratory infections</Keyword>
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