Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection
Identifieur interne : 002527 ( Ncbi/Merge ); précédent : 002526; suivant : 002528Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection
Auteurs : Enya Qing [États-Unis] ; Michael Hantak [États-Unis] ; Stanley Perlman [États-Unis] ; Tom Gallagher [États-Unis]Source :
- mBio [ 2150-7511 ] ; 2020.
Abstract
CoVs can transmit from animals to humans to cause serious disease. This zoonotic transmission uses spike proteins, which bind CoVs to cells with two receptor-binding domains. Here, we identified the roles for the two binding processes in the CoV infection process. Binding to sialic acids promoted infection and also supported the intercellular expansion of CoV infections through syncytial development. Adaptive mutations in the sialic acid-binding spike domains increased the intercellular expansion process. These findings raise the possibility that the lectin-like properties of many CoVs contribute to facile zoonotic transmission and intercellular spread within infected organisms.
Url:
DOI: 10.1128/mBio.02764-19
PubMed: 32047128
PubMed Central: 7018658
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last="Qing">Enya Qing</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hantak, Michael" sort="Hantak, Michael" uniqKey="Hantak M" first="Michael" last="Hantak">Michael Hantak</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Gallagher, Tom" sort="Gallagher, Tom" uniqKey="Gallagher T" first="Tom" last="Gallagher">Tom Gallagher</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>CoVs can transmit from animals to humans to cause serious disease. This zoonotic transmission uses spike proteins, which bind CoVs to cells with two receptor-binding domains. Here, we identified the roles for the two binding processes in the CoV infection process. Binding to sialic acids promoted infection and also supported the intercellular expansion of CoV infections through syncytial development. Adaptive mutations in the sialic acid-binding spike domains increased the intercellular expansion process. These findings raise the possibility that the lectin-like properties of many CoVs contribute to facile zoonotic transmission and intercellular spread within infected organisms.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Isaacs, D" uniqKey="Isaacs D">D Isaacs</name></author><author><name sortKey="Flowers, D" uniqKey="Flowers D">D Flowers</name></author><author><name sortKey="Clarke, Jr" uniqKey="Clarke J">JR Clarke</name></author><author><name sortKey="Valman, Hb" uniqKey="Valman H">HB Valman</name></author><author><name sortKey="Macnaughton, Mr" uniqKey="Macnaughton M">MR MacNaughton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S Su</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Lai, Ack" uniqKey="Lai A">ACK Lai</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Bi, Y" uniqKey="Bi Y">Y Bi</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author><author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name></author><author><name sortKey="Comer, Ja" uniqKey="Comer J">JA Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name></author><author><name sortKey="Dowell, Sf" uniqKey="Dowell S">SF Dowell</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A-E Ling</name></author><author><name sortKey="Humphrey, Cd" uniqKey="Humphrey C">CD Humphrey</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W-J Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name></author><author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B Fields</name></author><author><name sortKey="Derisi, J" uniqKey="Derisi J">J DeRisi</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J-Y Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name></author><author><name sortKey="Hughes, Jm" uniqKey="Hughes J">JM Hughes</name></author><author><name sortKey="Leduc, Jw" uniqKey="Leduc J">JW LeDuc</name></author><author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yam, Lyc" uniqKey="Yam L">LYC Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J Nicholls</name></author><author><name sortKey="Yee, Wks" uniqKey="Yee W">WKS Yee</name></author><author><name sortKey="Yan, Ww" uniqKey="Yan W">WW Yan</name></author><author><name sortKey="Cheung, Mt" uniqKey="Cheung M">MT Cheung</name></author><author><name sortKey="Cheng, Vcc" uniqKey="Cheng V">VCC Cheng</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Tsang, Dnc" uniqKey="Tsang D">DNC Tsang</name></author><author><name sortKey="Yung, Rwh" uniqKey="Yung R">RWH Yung</name></author><author><name sortKey="Ng, Tk" uniqKey="Ng T">TK Ng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author><author><name sortKey="Oberste, Ms" uniqKey="Oberste M">MS Oberste</name></author><author><name sortKey="Monroe, Ss" uniqKey="Monroe S">SS Monroe</name></author><author><name sortKey="Nix, Wa" uniqKey="Nix W">WA Nix</name></author><author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R Campagnoli</name></author><author><name sortKey="Icenogle, Jp" uniqKey="Icenogle J">JP Icenogle</name></author><author><name sortKey="Pe Aranda, S" uniqKey="Pe Aranda S">S Peñaranda</name></author><author><name sortKey="Bankamp, B" uniqKey="Bankamp B">B Bankamp</name></author><author><name sortKey="Maher, K" uniqKey="Maher K">K Maher</name></author><author><name sortKey="Chen, M H" uniqKey="Chen M">M-H Chen</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A Tamin</name></author><author><name sortKey="Lowe, L" uniqKey="Lowe L">L Lowe</name></author><author><name sortKey="Frace, M" uniqKey="Frace M">M Frace</name></author><author><name sortKey="Derisi, Jl" uniqKey="Derisi J">JL DeRisi</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Erdman, Dd" uniqKey="Erdman D">DD Erdman</name></author><author><name sortKey="Peret, Tct" uniqKey="Peret T">TCT Peret</name></author><author><name sortKey="Burns, C" uniqKey="Burns C">C Burns</name></author><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name></author><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A Sanchez</name></author><author><name sortKey="Liffick, S" uniqKey="Liffick S">S Liffick</name></author><author><name sortKey="Holloway, B" uniqKey="Holloway B">B Holloway</name></author><author><name sortKey="Limor, J" uniqKey="Limor J">J Limor</name></author><author><name sortKey="Mccaustland, K" uniqKey="Mccaustland K">K McCaustland</name></author><author><name sortKey="Olsen Rasmussen, M" uniqKey="Olsen Rasmussen M">M Olsen-Rasmussen</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R Fouchier</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Günther</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Pallansch, Ma" uniqKey="Pallansch M">MA Pallansch</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author><author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name></author><author><name sortKey="Jones, S" uniqKey="Jones S">S Jones</name></author><author><name sortKey="Astell, Cr" uniqKey="Astell C">CR Astell</name></author><author><name sortKey="Holt, Ra" uniqKey="Holt R">RA Holt</name></author><author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A Brooks-Wilson</name></author><author><name sortKey="Butterfield, Ysn" uniqKey="Butterfield Y">YSN Butterfield</name></author><author><name sortKey="Khattra, J" uniqKey="Khattra J">J Khattra</name></author><author><name sortKey="Asano, Jk" uniqKey="Asano J">JK Asano</name></author><author><name sortKey="Barber, Sa" uniqKey="Barber S">SA Barber</name></author><author><name sortKey="Chan, Sy" uniqKey="Chan S">SY Chan</name></author><author><name sortKey="Cloutier, A" uniqKey="Cloutier A">A Cloutier</name></author><author><name sortKey="Coughlin, Sm" uniqKey="Coughlin S">SM Coughlin</name></author><author><name sortKey="Freeman, D" uniqKey="Freeman D">D Freeman</name></author><author><name sortKey="Girn, N" uniqKey="Girn N">N Girn</name></author><author><name sortKey="Griffith, Ol" uniqKey="Griffith O">OL Griffith</name></author><author><name sortKey="Leach, Sr" uniqKey="Leach S">SR Leach</name></author><author><name sortKey="Mayo, M" uniqKey="Mayo M">M Mayo</name></author><author><name sortKey="Mcdonald, H" uniqKey="Mcdonald H">H McDonald</name></author><author><name sortKey="Montgomery, Sb" uniqKey="Montgomery S">SB Montgomery</name></author><author><name sortKey="Pandoh, Pk" uniqKey="Pandoh P">PK Pandoh</name></author><author><name sortKey="Petrescu, As" uniqKey="Petrescu A">AS Petrescu</name></author><author><name sortKey="Robertson, Ag" uniqKey="Robertson A">AG Robertson</name></author><author><name sortKey="Schein, Je" uniqKey="Schein J">JE Schein</name></author><author><name sortKey="Siddiqui, A" uniqKey="Siddiqui A">A Siddiqui</name></author><author><name sortKey="Smailus, De" uniqKey="Smailus D">DE Smailus</name></author><author><name sortKey="Stott, Jm" uniqKey="Stott J">JM Stott</name></author><author><name sortKey="Yang, Gs" uniqKey="Yang G">GS Yang</name></author><author><name sortKey="Plummer, F" uniqKey="Plummer F">F Plummer</name></author><author><name sortKey="Andonov, A" uniqKey="Andonov A">A Andonov</name></author><author><name sortKey="Artsob, H" uniqKey="Artsob H">H Artsob</name></author><author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name></author><author><name sortKey="Bernard, K" uniqKey="Bernard K">K Bernard</name></author><author><name sortKey="Booth, Tf" uniqKey="Booth T">TF Booth</name></author><author><name sortKey="Bowness, D" uniqKey="Bowness D">D Bowness</name></author><author><name sortKey="Czub, M" uniqKey="Czub M">M Czub</name></author><author><name sortKey="Drebot, M" uniqKey="Drebot M">M Drebot</name></author><author><name sortKey="Fernando, L" uniqKey="Fernando L">L Fernando</name></author><author><name sortKey="Flick, R" uniqKey="Flick R">R Flick</name></author><author><name sortKey="Garbutt, M" uniqKey="Garbutt M">M Garbutt</name></author><author><name sortKey="Gray, M" uniqKey="Gray M">M Gray</name></author><author><name sortKey="Grolla, A" uniqKey="Grolla A">A Grolla</name></author><author><name sortKey="Jones, S" uniqKey="Jones S">S Jones</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Meyers, A" uniqKey="Meyers A">A Meyers</name></author><author><name sortKey="Kabani, A" uniqKey="Kabani A">A Kabani</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Normand, S" uniqKey="Normand S">S Normand</name></author><author><name sortKey="Stroher, U" uniqKey="Stroher U">U Stroher</name></author><author><name sortKey="Tipples, Ga" uniqKey="Tipples G">GA Tipples</name></author><author><name sortKey="Tyler, S" uniqKey="Tyler S">S Tyler</name></author><author><name sortKey="Vogrig, R" uniqKey="Vogrig R">R Vogrig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="De Haan, Cam" uniqKey="De Haan C">CAM de Haan</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Bosch, B" uniqKey="Bosch B">B Bosch</name></author><author><name sortKey="Frenz, B" uniqKey="Frenz B">B Frenz</name></author><author><name sortKey="Rottier, Pjm" uniqKey="Rottier P">PJM Rottier</name></author><author><name sortKey="Dimaio, F" uniqKey="Dimaio F">F DiMaio</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Frenz, B" uniqKey="Frenz B">B Frenz</name></author><author><name sortKey="Snijder, J" uniqKey="Snijder J">J Snijder</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Dimaio, F" uniqKey="Dimaio F">F DiMaio</name></author><author><name sortKey="Bosch, B" uniqKey="Bosch B">B Bosch</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirchdoerfer, Rn" uniqKey="Kirchdoerfer R">RN Kirchdoerfer</name></author><author><name sortKey="Cottrell, Ca" uniqKey="Cottrell C">CA Cottrell</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Pallesen, J" uniqKey="Pallesen J">J Pallesen</name></author><author><name sortKey="Yassine, Hm" uniqKey="Yassine H">HM Yassine</name></author><author><name sortKey="Turner, Hl" uniqKey="Turner H">HL Turner</name></author><author><name sortKey="Corbett, Ks" uniqKey="Corbett K">KS Corbett</name></author><author><name sortKey="Graham, Bs" uniqKey="Graham B">BS Graham</name></author><author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name></author><author><name sortKey="Ward, Ab" uniqKey="Ward A">AB Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gui, M" uniqKey="Gui M">M Gui</name></author><author><name sortKey="Song, W" uniqKey="Song W">W Song</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y Xiang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Cao, D" uniqKey="Cao D">D Cao</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Koerhuis, D" uniqKey="Koerhuis D">D Koerhuis</name></author><author><name sortKey="Boons, G J" uniqKey="Boons G">G-J Boons</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Lin, Y" uniqKey="Lin Y">Y Lin</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Pasquarella, Jr" uniqKey="Pasquarella J">JR Pasquarella</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seetharaman, J" uniqKey="Seetharaman J">J Seetharaman</name></author><author><name sortKey="Kanigsberg, A" uniqKey="Kanigsberg A">A Kanigsberg</name></author><author><name sortKey="Slaaby, R" uniqKey="Slaaby R">R Slaaby</name></author><author><name sortKey="Leffler, H" uniqKey="Leffler H">H Leffler</name></author><author><name sortKey="Barondes, Sh" uniqKey="Barondes S">SH Barondes</name></author><author><name sortKey="Rini, Jm" uniqKey="Rini J">JM Rini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="Widjaja, I" uniqKey="Widjaja I">I Widjaja</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name></author><author><name sortKey="Peng, W" uniqKey="Peng W">W Peng</name></author><author><name sortKey="Widagdo, W" uniqKey="Widagdo W">W Widagdo</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Van Dieren, B" uniqKey="Van Dieren B">B van Dieren</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Van Lent, Jwm" uniqKey="Van Lent J">JWM van Lent</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="De Haan, Cam" uniqKey="De Haan C">CAM de Haan</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Arledge, Kc" uniqKey="Arledge K">KC Arledge</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dhw" uniqKey="Dekkers D">DHW Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, Jaa" uniqKey="Demmers J">JAA Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Rottier, Pjm" uniqKey="Rottier P">PJM Rottier</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barlan, A" uniqKey="Barlan A">A Barlan</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Sarkar, Mk" uniqKey="Sarkar M">MK Sarkar</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Sun, D" uniqKey="Sun D">D Sun</name></author><author><name sortKey="Rajashankar, Kr" uniqKey="Rajashankar K">KR Rajashankar</name></author><author><name sortKey="Qian, Z" uniqKey="Qian Z">Z Qian</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krueger, Dk" uniqKey="Krueger D">DK Krueger</name></author><author><name sortKey="Kelly, Sm" uniqKey="Kelly S">SM Kelly</name></author><author><name sortKey="Lewicki, Dn" uniqKey="Lewicki D">DN Lewicki</name></author><author><name sortKey="Ruffolo, R" uniqKey="Ruffolo R">R Ruffolo</name></author><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, Cw" uniqKey="Tsai C">CW Tsai</name></author><author><name sortKey="Chang, Sc" uniqKey="Chang S">SC Chang</name></author><author><name sortKey="Chang, Mf" uniqKey="Chang M">MF Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parker, Se" uniqKey="Parker S">SE Parker</name></author><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miura, Ta" uniqKey="Miura T">TA Miura</name></author><author><name sortKey="Travanty, Ea" uniqKey="Travanty E">EA Travanty</name></author><author><name sortKey="Oko, L" uniqKey="Oko L">L Oko</name></author><author><name sortKey="Bielefeldt Ohmann, H" uniqKey="Bielefeldt Ohmann H">H Bielefeldt-Ohmann</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Beauchemin, N" uniqKey="Beauchemin N">N Beauchemin</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author><author><name sortKey="Saeki, K" uniqKey="Saeki K">K Saeki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, R" uniqKey="Watanabe R">R Watanabe</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokomori, K" uniqKey="Yokomori K">K Yokomori</name></author><author><name sortKey="Banner, Lr" uniqKey="Banner L">LR Banner</name></author><author><name sortKey="Lai, Mm" uniqKey="Lai M">MM Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokomori, K" uniqKey="Yokomori K">K Yokomori</name></author><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author><author><name sortKey="Lai, M" uniqKey="Lai M">M Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Godeke, Gj" uniqKey="Godeke G">GJ Godeke</name></author><author><name sortKey="Rossen, Jw" uniqKey="Rossen J">JW Rossen</name></author><author><name sortKey="Voorhout, Wf" uniqKey="Voorhout W">WF Voorhout</name></author><author><name sortKey="Horzinek, Mc" uniqKey="Horzinek M">MC Horzinek</name></author><author><name sortKey="Opstelten, Dj" uniqKey="Opstelten D">DJ Opstelten</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Kuo, L" uniqKey="Kuo L">L Kuo</name></author><author><name sortKey="Masters, Ps" uniqKey="Masters P">PS Masters</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Maeda, A" uniqKey="Maeda A">A Maeda</name></author><author><name sortKey="Maeda, J" uniqKey="Maeda J">J Maeda</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Bakkers, Mjg" uniqKey="Bakkers M">MJG Bakkers</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Schouten, A" uniqKey="Schouten A">A Schouten</name></author><author><name sortKey="Ophorst, B" uniqKey="Ophorst B">B Ophorst</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Boons, G J" uniqKey="Boons G">G-J Boons</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author><author><name sortKey="Huizinga, Eg" uniqKey="Huizinga E">EG Huizinga</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godeke, Gj" uniqKey="Godeke G">GJ Godeke</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Rossen, Jw" uniqKey="Rossen J">JW Rossen</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shirato, K" uniqKey="Shirato K">K Shirato</name></author><author><name sortKey="Kanou, K" uniqKey="Kanou K">K Kanou</name></author><author><name sortKey="Kawase, M" uniqKey="Kawase M">M Kawase</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulla, A" uniqKey="Shulla A">A Shulla</name></author><author><name sortKey="Heald Sargent, T" uniqKey="Heald Sargent T">T Heald-Sargent</name></author><author><name sortKey="Subramanya, G" uniqKey="Subramanya G">G Subramanya</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J" uniqKey="Park J">J Park</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Barlan, A" uniqKey="Barlan A">A Barlan</name></author><author><name sortKey="Fehr, Ar" uniqKey="Fehr A">AR Fehr</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phillips, Jm" uniqKey="Phillips J">JM Phillips</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S Belouzard</name></author><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Licitra, Bn" uniqKey="Licitra B">BN Licitra</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gamblin, Sj" uniqKey="Gamblin S">SJ Gamblin</name></author><author><name sortKey="Haire, Lf" uniqKey="Haire L">LF Haire</name></author><author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ Russell</name></author><author><name sortKey="Stevens, Dj" uniqKey="Stevens D">DJ Stevens</name></author><author><name sortKey="Xiao, B" uniqKey="Xiao B">B Xiao</name></author><author><name sortKey="Ha, Y" uniqKey="Ha Y">Y Ha</name></author><author><name sortKey="Vasisht, N" uniqKey="Vasisht N">N Vasisht</name></author><author><name sortKey="Steinhauer, Da" uniqKey="Steinhauer D">DA Steinhauer</name></author><author><name sortKey="Daniels, Rs" uniqKey="Daniels R">RS Daniels</name></author><author><name sortKey="Elliot, A" uniqKey="Elliot A">A Elliot</name></author><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stevens, J" uniqKey="Stevens J">J Stevens</name></author><author><name sortKey="Blixt, O" uniqKey="Blixt O">O Blixt</name></author><author><name sortKey="Glaser, L" uniqKey="Glaser L">L Glaser</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weis, W" uniqKey="Weis W">W Weis</name></author><author><name sortKey="Brown, Jh" uniqKey="Brown J">JH Brown</name></author><author><name sortKey="Cusack, S" uniqKey="Cusack S">S Cusack</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K Wu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Y" uniqKey="Park Y">Y Park</name></author><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Sauer, Mm" uniqKey="Sauer M">MM Sauer</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Bosch, B" uniqKey="Bosch B">B Bosch</name></author><author><name sortKey="Dimaio, F" uniqKey="Dimaio F">F DiMaio</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Widjaja, I" uniqKey="Widjaja I">I Widjaja</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Van Haperen, R" uniqKey="Van Haperen R">R van Haperen</name></author><author><name sortKey="Gutierrez Lvarez, J" uniqKey="Gutierrez Lvarez J">J Gutiérrez-Álvarez</name></author><author><name sortKey="Van Dieren, B" uniqKey="Van Dieren B">B van Dieren</name></author><author><name sortKey="Okba, Nma" uniqKey="Okba N">NMA Okba</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Fernandez Delgado, R" uniqKey="Fernandez Delgado R">R Fernandez-Delgado</name></author><author><name sortKey="Grosveld, F" uniqKey="Grosveld F">F Grosveld</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author><author><name sortKey="Drabek, D" uniqKey="Drabek D">D Drabek</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sohrab, Ss" uniqKey="Sohrab S">SS Sohrab</name></author><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Douglas, Mg" uniqKey="Douglas M">MG Douglas</name></author><author><name sortKey="Kocher, Jf" uniqKey="Kocher J">JF Kocher</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Wohlford Lenane, Cl" uniqKey="Wohlford Lenane C">CL Wohlford-Lenane</name></author><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Park, J" uniqKey="Park J">J Park</name></author><author><name sortKey="Earnest, Jt" uniqKey="Earnest J">JT Earnest</name></author><author><name sortKey="Bair, Tb" uniqKey="Bair T">TB Bair</name></author><author><name sortKey="Bates, Am" uniqKey="Bates A">AM Bates</name></author><author><name sortKey="Brogden, Ka" uniqKey="Brogden K">KA Brogden</name></author><author><name sortKey="Flaherty, Ha" uniqKey="Flaherty H">HA Flaherty</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Niu, P" uniqKey="Niu P">P Niu</name></author><author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name></author><author><name sortKey="Jia, W" uniqKey="Jia W">W Jia</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Xiong, X" uniqKey="Xiong X">X Xiong</name></author><author><name sortKey="Park, Y J" uniqKey="Park Y">Y-J Park</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Snijder, J" uniqKey="Snijder J">J Snijder</name></author><author><name sortKey="Quispe, J" uniqKey="Quispe J">J Quispe</name></author><author><name sortKey="Cameroni, E" uniqKey="Cameroni E">E Cameroni</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name></author><author><name sortKey="Dai, M" uniqKey="Dai M">M Dai</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stencel Baerenwald, Je" uniqKey="Stencel Baerenwald J">JE Stencel-Baerenwald</name></author><author><name sortKey="Reiss, K" uniqKey="Reiss K">K Reiss</name></author><author><name sortKey="Reiter, Dm" uniqKey="Reiter D">DM Reiter</name></author><author><name sortKey="Stehle, T" uniqKey="Stehle T">T Stehle</name></author><author><name sortKey="Dermody, Ts" uniqKey="Dermody T">TS Dermody</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nash, Tc" uniqKey="Nash T">TC Nash</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakagaki, K" uniqKey="Nakagaki K">K Nakagaki</name></author><author><name sortKey="Nakagaki, K" uniqKey="Nakagaki K">K Nakagaki</name></author><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiong, X" uniqKey="Xiong X">X Xiong</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Snijder, J" uniqKey="Snijder J">J Snijder</name></author><author><name sortKey="Yoshioka, C" uniqKey="Yoshioka C">C Yoshioka</name></author><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Mcguire, At" uniqKey="Mcguire A">AT McGuire</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bakkers, Mjg" uniqKey="Bakkers M">MJG Bakkers</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Feitsma, Lj" uniqKey="Feitsma L">LJ Feitsma</name></author><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="De Poot, Sah" uniqKey="De Poot S">SAH de Poot</name></author><author><name sortKey="Van Vliet, Alw" uniqKey="Van Vliet A">ALW van Vliet</name></author><author><name sortKey="Margine, I" uniqKey="Margine I">I Margine</name></author><author><name sortKey="De Groot Mijnes, Jdf" uniqKey="De Groot Mijnes J">JDF de Groot-Mijnes</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name></author><author><name sortKey="Huizinga, Eg" uniqKey="Huizinga E">EG Huizinga</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wasik, Br" uniqKey="Wasik B">BR Wasik</name></author><author><name sortKey="Barnard, Kn" uniqKey="Barnard K">KN Barnard</name></author><author><name sortKey="Ossiboff, Rj" uniqKey="Ossiboff R">RJ Ossiboff</name></author><author><name sortKey="Khedri, Z" uniqKey="Khedri Z">Z Khedri</name></author><author><name sortKey="Feng, Kh" uniqKey="Feng K">KH Feng</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name></author><author><name sortKey="Varki, A" uniqKey="Varki A">A Varki</name></author><author><name sortKey="Parrish, Cr" uniqKey="Parrish C">CR Parrish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name></author><author><name sortKey="Dong, W" uniqKey="Dong W">W Dong</name></author><author><name sortKey="Milewska, A" uniqKey="Milewska A">A Milewska</name></author><author><name sortKey="Golda, A" uniqKey="Golda A">A Golda</name></author><author><name sortKey="Qi, Y" uniqKey="Qi Y">Y Qi</name></author><author><name sortKey="Zhu, Qk" uniqKey="Zhu Q">QK Zhu</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name></author><author><name sortKey="Zeng, Q" uniqKey="Zeng Q">Q Zeng</name></author><author><name sortKey="Heesters, B" uniqKey="Heesters B">B Heesters</name></author><author><name sortKey="Huizinga, Eg" uniqKey="Huizinga E">EG Huizinga</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hensley, Le" uniqKey="Hensley L">LE Hensley</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Beauchemin, N" uniqKey="Beauchemin N">N Beauchemin</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, C M" uniqKey="Chan C">C-M Chan</name></author><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wong, B Y" uniqKey="Wong B">B-Y Wong</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name></author><author><name sortKey="Leung, Sp" uniqKey="Leung S">SP Leung</name></author><author><name sortKey="Chan, J W" uniqKey="Chan J">J-W Chan</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M-L Yeung</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K-Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Chan, C M" uniqKey="Chan C">C-M Chan</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Yuan, S" uniqKey="Yuan S">S Yuan</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Au Yeung, R H" uniqKey="Au Yeung R">R-H Au-Yeung</name></author><author><name sortKey="Sze, K H" uniqKey="Sze K">K-H Sze</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name></author><author><name sortKey="Shuai, H" uniqKey="Shuai H">H Shuai</name></author><author><name sortKey="Hou, Y" uniqKey="Hou Y">Y Hou</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Poon, V M" uniqKey="Poon V">V-M Poon</name></author><author><name sortKey="Leung, Sp" uniqKey="Leung S">SP Leung</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M-L Yeung</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Jin, D Y" uniqKey="Jin D">D-Y Jin</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Chan, J W" uniqKey="Chan J">J-W Chan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K-Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schnaar, Rl" uniqKey="Schnaar R">RL Schnaar</name></author><author><name sortKey="Gerardy Schahn, R" uniqKey="Gerardy Schahn R">R Gerardy-Schahn</name></author><author><name sortKey="Hildebrandt, H" uniqKey="Hildebrandt H">H Hildebrandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massa, Pt" uniqKey="Massa P">PT Massa</name></author><author><name sortKey="Wege, H" uniqKey="Wege H">H Wege</name></author><author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V ter Meulen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massa, Pt" uniqKey="Massa P">PT Massa</name></author><author><name sortKey="Wege, H" uniqKey="Wege H">H Wege</name></author><author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V ter Meulen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Berlo, Mf" uniqKey="Van Berlo M">MF van Berlo</name></author><author><name sortKey="Warringa, R" uniqKey="Warringa R">R Warringa</name></author><author><name sortKey="Wolswijk, G" uniqKey="Wolswijk G">G Wolswijk</name></author><author><name sortKey="Lopes Cardozo, M" uniqKey="Lopes Cardozo M">M Lopes-Cardozo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Lu, S" uniqKey="Lu S">S Lu</name></author><author><name sortKey="Jia, H" uniqKey="Jia H">H Jia</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Lou, Y" uniqKey="Lou Y">Y Lou</name></author><author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Pv" uniqKey="Rao P">PV Rao</name></author><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberger, Cm" uniqKey="Rosenberger C">CM Rosenberger</name></author><author><name sortKey="Podyminogin, Rl" uniqKey="Podyminogin R">RL Podyminogin</name></author><author><name sortKey="Askovich, Ps" uniqKey="Askovich P">PS Askovich</name></author><author><name sortKey="Navarro, G" uniqKey="Navarro G">G Navarro</name></author><author><name sortKey="Kaiser, Sm" uniqKey="Kaiser S">SM Kaiser</name></author><author><name sortKey="Sanders, Cj" uniqKey="Sanders C">CJ Sanders</name></author><author><name sortKey="Mcclaren, Jl" uniqKey="Mcclaren J">JL McClaren</name></author><author><name sortKey="Tam, Vc" uniqKey="Tam V">VC Tam</name></author><author><name sortKey="Dash, P" uniqKey="Dash P">P Dash</name></author><author><name sortKey="Noonan, Jg" uniqKey="Noonan J">JG Noonan</name></author><author><name sortKey="Jones, Bg" uniqKey="Jones B">BG Jones</name></author><author><name sortKey="Surman, Sl" uniqKey="Surman S">SL Surman</name></author><author><name sortKey="Peschon, Jj" uniqKey="Peschon J">JJ Peschon</name></author><author><name sortKey="Diercks, Ah" uniqKey="Diercks A">AH Diercks</name></author><author><name sortKey="Hurwitz, Jl" uniqKey="Hurwitz J">JL Hurwitz</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author><author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name></author><author><name sortKey="Aderem, A" uniqKey="Aderem A">A Aderem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirano, N" uniqKey="Hirano N">N Hirano</name></author><author><name sortKey="Fujiwara, K" uniqKey="Fujiwara K">K Fujiwara</name></author><author><name sortKey="Hino, S" uniqKey="Hino S">S Hino</name></author><author><name sortKey="Matumoto, M" uniqKey="Matumoto M">M Matumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirano, N" uniqKey="Hirano N">N Hirano</name></author><author><name sortKey="Fujiwara, K" uniqKey="Fujiwara K">K Fujiwara</name></author><author><name sortKey="Matumoto, M" uniqKey="Matumoto M">M Matumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Cowley, Tj" uniqKey="Cowley T">TJ Cowley</name></author><author><name sortKey="Steinbrenner, Ad" uniqKey="Steinbrenner A">AD Steinbrenner</name></author><author><name sortKey="Phillips, Jm" uniqKey="Phillips J">JM Phillips</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulla, A" uniqKey="Shulla A">A Shulla</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakane, S" uniqKey="Nakane S">S Nakane</name></author><author><name sortKey="Matsuda, Z" uniqKey="Matsuda Z">Z Matsuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teeranaipong, P" uniqKey="Teeranaipong P">P Teeranaipong</name></author><author><name sortKey="Hosoya, N" uniqKey="Hosoya N">N Hosoya</name></author><author><name sortKey="Kawana Tachikawa, A" uniqKey="Kawana Tachikawa A">A Kawana-Tachikawa</name></author><author><name sortKey="Fujii, T" uniqKey="Fujii T">T Fujii</name></author><author><name sortKey="Koibuchi, T" uniqKey="Koibuchi T">T Koibuchi</name></author><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H Nakamura</name></author><author><name sortKey="Koga, M" uniqKey="Koga M">M Koga</name></author><author><name sortKey="Kondo, N" uniqKey="Kondo N">N Kondo</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Hoshino, H" uniqKey="Hoshino H">H Hoshino</name></author><author><name sortKey="Matsuda, Z" uniqKey="Matsuda Z">Z Matsuda</name></author><author><name sortKey="Iwamoto, A" uniqKey="Iwamoto A">A Iwamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitt, Ma" uniqKey="Whitt M">MA Whitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brouillette, Rb" uniqKey="Brouillette R">RB Brouillette</name></author><author><name sortKey="Phillips, Ek" uniqKey="Phillips E">EK Phillips</name></author><author><name sortKey="Ayithan, N" uniqKey="Ayithan N">N Ayithan</name></author><author><name sortKey="Maury, W" uniqKey="Maury W">W Maury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bender, Sj" uniqKey="Bender S">SJ Bender</name></author><author><name sortKey="Phillips, Jm" uniqKey="Phillips J">JM Phillips</name></author><author><name sortKey="Scott, Ep" uniqKey="Scott E">EP Scott</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phillips, Jj" uniqKey="Phillips J">JJ Phillips</name></author><author><name sortKey="Chua, Mm" uniqKey="Chua M">MM Chua</name></author><author><name sortKey="Rall, Gf" uniqKey="Rall G">GF Rall</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="32047128"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection</title><author><name sortKey="Qing, Enya" sort="Qing, Enya" uniqKey="Qing E" first="Enya" last="Qing">Enya Qing</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hantak, Michael" sort="Hantak, Michael" uniqKey="Hantak M" first="Michael" last="Hantak">Michael Hantak</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Gallagher, Tom" sort="Gallagher, Tom" uniqKey="Gallagher T" first="Tom" last="Gallagher">Tom Gallagher</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32047128</idno><idno type="pmc">7018658</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018658</idno><idno type="RBID">PMC:7018658</idno><idno type="doi">10.1128/mBio.02764-19</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">001249</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001249</idno><idno type="wicri:Area/Pmc/Curation">001249</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001249</idno><idno type="wicri:Area/Pmc/Checkpoint">000091</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000091</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection</title><author><name sortKey="Qing, Enya" sort="Qing, Enya" uniqKey="Qing E" first="Enya" last="Qing">Enya Qing</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hantak, Michael" sort="Hantak, Michael" uniqKey="Hantak M" first="Michael" last="Hantak">Michael Hantak</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Gallagher, Tom" sort="Gallagher, Tom" uniqKey="Gallagher T" first="Tom" last="Gallagher">Tom Gallagher</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>CoVs can transmit from animals to humans to cause serious disease. This zoonotic transmission uses spike proteins, which bind CoVs to cells with two receptor-binding domains. Here, we identified the roles for the two binding processes in the CoV infection process. Binding to sialic acids promoted infection and also supported the intercellular expansion of CoV infections through syncytial development. Adaptive mutations in the sialic acid-binding spike domains increased the intercellular expansion process. These findings raise the possibility that the lectin-like properties of many CoVs contribute to facile zoonotic transmission and intercellular spread within infected organisms.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Isaacs, D" uniqKey="Isaacs D">D Isaacs</name></author><author><name sortKey="Flowers, D" uniqKey="Flowers D">D Flowers</name></author><author><name sortKey="Clarke, Jr" uniqKey="Clarke J">JR Clarke</name></author><author><name sortKey="Valman, Hb" uniqKey="Valman H">HB Valman</name></author><author><name sortKey="Macnaughton, Mr" uniqKey="Macnaughton M">MR MacNaughton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Su, S" uniqKey="Su S">S Su</name></author><author><name sortKey="Wong, G" uniqKey="Wong G">G Wong</name></author><author><name sortKey="Shi, W" uniqKey="Shi W">W Shi</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Lai, Ack" uniqKey="Lai A">ACK Lai</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name></author><author><name sortKey="Bi, Y" uniqKey="Bi Y">Y Bi</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Erdman, D" uniqKey="Erdman D">D Erdman</name></author><author><name sortKey="Goldsmith, Cs" uniqKey="Goldsmith C">CS Goldsmith</name></author><author><name sortKey="Zaki, Sr" uniqKey="Zaki S">SR Zaki</name></author><author><name sortKey="Peret, T" uniqKey="Peret T">T Peret</name></author><author><name sortKey="Emery, S" uniqKey="Emery S">S Emery</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Urbani, C" uniqKey="Urbani C">C Urbani</name></author><author><name sortKey="Comer, Ja" uniqKey="Comer J">JA Comer</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name></author><author><name sortKey="Dowell, Sf" uniqKey="Dowell S">SF Dowell</name></author><author><name sortKey="Ling, A E" uniqKey="Ling A">A-E Ling</name></author><author><name sortKey="Humphrey, Cd" uniqKey="Humphrey C">CD Humphrey</name></author><author><name sortKey="Shieh, W J" uniqKey="Shieh W">W-J Shieh</name></author><author><name sortKey="Guarner, J" uniqKey="Guarner J">J Guarner</name></author><author><name sortKey="Paddock, Cd" uniqKey="Paddock C">CD Paddock</name></author><author><name sortKey="Rota, P" uniqKey="Rota P">P Rota</name></author><author><name sortKey="Fields, B" uniqKey="Fields B">B Fields</name></author><author><name sortKey="Derisi, J" uniqKey="Derisi J">J DeRisi</name></author><author><name sortKey="Yang, J Y" uniqKey="Yang J">J-Y Yang</name></author><author><name sortKey="Cox, N" uniqKey="Cox N">N Cox</name></author><author><name sortKey="Hughes, Jm" uniqKey="Hughes J">JM Hughes</name></author><author><name sortKey="Leduc, Jw" uniqKey="Leduc J">JW LeDuc</name></author><author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peiris, Jsm" uniqKey="Peiris J">JSM Peiris</name></author><author><name sortKey="Lai, St" uniqKey="Lai S">ST Lai</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Yam, Lyc" uniqKey="Yam L">LYC Yam</name></author><author><name sortKey="Lim, W" uniqKey="Lim W">W Lim</name></author><author><name sortKey="Nicholls, J" uniqKey="Nicholls J">J Nicholls</name></author><author><name sortKey="Yee, Wks" uniqKey="Yee W">WKS Yee</name></author><author><name sortKey="Yan, Ww" uniqKey="Yan W">WW Yan</name></author><author><name sortKey="Cheung, Mt" uniqKey="Cheung M">MT Cheung</name></author><author><name sortKey="Cheng, Vcc" uniqKey="Cheng V">VCC Cheng</name></author><author><name sortKey="Chan, Kh" uniqKey="Chan K">KH Chan</name></author><author><name sortKey="Tsang, Dnc" uniqKey="Tsang D">DNC Tsang</name></author><author><name sortKey="Yung, Rwh" uniqKey="Yung R">RWH Yung</name></author><author><name sortKey="Ng, Tk" uniqKey="Ng T">TK Ng</name></author><author><name sortKey="Yuen, Ky" uniqKey="Yuen K">KY Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rota, Pa" uniqKey="Rota P">PA Rota</name></author><author><name sortKey="Oberste, Ms" uniqKey="Oberste M">MS Oberste</name></author><author><name sortKey="Monroe, Ss" uniqKey="Monroe S">SS Monroe</name></author><author><name sortKey="Nix, Wa" uniqKey="Nix W">WA Nix</name></author><author><name sortKey="Campagnoli, R" uniqKey="Campagnoli R">R Campagnoli</name></author><author><name sortKey="Icenogle, Jp" uniqKey="Icenogle J">JP Icenogle</name></author><author><name sortKey="Pe Aranda, S" uniqKey="Pe Aranda S">S Peñaranda</name></author><author><name sortKey="Bankamp, B" uniqKey="Bankamp B">B Bankamp</name></author><author><name sortKey="Maher, K" uniqKey="Maher K">K Maher</name></author><author><name sortKey="Chen, M H" uniqKey="Chen M">M-H Chen</name></author><author><name sortKey="Tong, S" uniqKey="Tong S">S Tong</name></author><author><name sortKey="Tamin, A" uniqKey="Tamin A">A Tamin</name></author><author><name sortKey="Lowe, L" uniqKey="Lowe L">L Lowe</name></author><author><name sortKey="Frace, M" uniqKey="Frace M">M Frace</name></author><author><name sortKey="Derisi, Jl" uniqKey="Derisi J">JL DeRisi</name></author><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Erdman, Dd" uniqKey="Erdman D">DD Erdman</name></author><author><name sortKey="Peret, Tct" uniqKey="Peret T">TCT Peret</name></author><author><name sortKey="Burns, C" uniqKey="Burns C">C Burns</name></author><author><name sortKey="Ksiazek, Tg" uniqKey="Ksiazek T">TG Ksiazek</name></author><author><name sortKey="Rollin, Pe" uniqKey="Rollin P">PE Rollin</name></author><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A Sanchez</name></author><author><name sortKey="Liffick, S" uniqKey="Liffick S">S Liffick</name></author><author><name sortKey="Holloway, B" uniqKey="Holloway B">B Holloway</name></author><author><name sortKey="Limor, J" uniqKey="Limor J">J Limor</name></author><author><name sortKey="Mccaustland, K" uniqKey="Mccaustland K">K McCaustland</name></author><author><name sortKey="Olsen Rasmussen, M" uniqKey="Olsen Rasmussen M">M Olsen-Rasmussen</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R Fouchier</name></author><author><name sortKey="Gunther, S" uniqKey="Gunther S">S Günther</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Pallansch, Ma" uniqKey="Pallansch M">MA Pallansch</name></author><author><name sortKey="Anderson, Lj" uniqKey="Anderson L">LJ Anderson</name></author><author><name sortKey="Bellini, Wj" uniqKey="Bellini W">WJ Bellini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marra, Ma" uniqKey="Marra M">MA Marra</name></author><author><name sortKey="Jones, S" uniqKey="Jones S">S Jones</name></author><author><name sortKey="Astell, Cr" uniqKey="Astell C">CR Astell</name></author><author><name sortKey="Holt, Ra" uniqKey="Holt R">RA Holt</name></author><author><name sortKey="Brooks Wilson, A" uniqKey="Brooks Wilson A">A Brooks-Wilson</name></author><author><name sortKey="Butterfield, Ysn" uniqKey="Butterfield Y">YSN Butterfield</name></author><author><name sortKey="Khattra, J" uniqKey="Khattra J">J Khattra</name></author><author><name sortKey="Asano, Jk" uniqKey="Asano J">JK Asano</name></author><author><name sortKey="Barber, Sa" uniqKey="Barber S">SA Barber</name></author><author><name sortKey="Chan, Sy" uniqKey="Chan S">SY Chan</name></author><author><name sortKey="Cloutier, A" uniqKey="Cloutier A">A Cloutier</name></author><author><name sortKey="Coughlin, Sm" uniqKey="Coughlin S">SM Coughlin</name></author><author><name sortKey="Freeman, D" uniqKey="Freeman D">D Freeman</name></author><author><name sortKey="Girn, N" uniqKey="Girn N">N Girn</name></author><author><name sortKey="Griffith, Ol" uniqKey="Griffith O">OL Griffith</name></author><author><name sortKey="Leach, Sr" uniqKey="Leach S">SR Leach</name></author><author><name sortKey="Mayo, M" uniqKey="Mayo M">M Mayo</name></author><author><name sortKey="Mcdonald, H" uniqKey="Mcdonald H">H McDonald</name></author><author><name sortKey="Montgomery, Sb" uniqKey="Montgomery S">SB Montgomery</name></author><author><name sortKey="Pandoh, Pk" uniqKey="Pandoh P">PK Pandoh</name></author><author><name sortKey="Petrescu, As" uniqKey="Petrescu A">AS Petrescu</name></author><author><name sortKey="Robertson, Ag" uniqKey="Robertson A">AG Robertson</name></author><author><name sortKey="Schein, Je" uniqKey="Schein J">JE Schein</name></author><author><name sortKey="Siddiqui, A" uniqKey="Siddiqui A">A Siddiqui</name></author><author><name sortKey="Smailus, De" uniqKey="Smailus D">DE Smailus</name></author><author><name sortKey="Stott, Jm" uniqKey="Stott J">JM Stott</name></author><author><name sortKey="Yang, Gs" uniqKey="Yang G">GS Yang</name></author><author><name sortKey="Plummer, F" uniqKey="Plummer F">F Plummer</name></author><author><name sortKey="Andonov, A" uniqKey="Andonov A">A Andonov</name></author><author><name sortKey="Artsob, H" uniqKey="Artsob H">H Artsob</name></author><author><name sortKey="Bastien, N" uniqKey="Bastien N">N Bastien</name></author><author><name sortKey="Bernard, K" uniqKey="Bernard K">K Bernard</name></author><author><name sortKey="Booth, Tf" uniqKey="Booth T">TF Booth</name></author><author><name sortKey="Bowness, D" uniqKey="Bowness D">D Bowness</name></author><author><name sortKey="Czub, M" uniqKey="Czub M">M Czub</name></author><author><name sortKey="Drebot, M" uniqKey="Drebot M">M Drebot</name></author><author><name sortKey="Fernando, L" uniqKey="Fernando L">L Fernando</name></author><author><name sortKey="Flick, R" uniqKey="Flick R">R Flick</name></author><author><name sortKey="Garbutt, M" uniqKey="Garbutt M">M Garbutt</name></author><author><name sortKey="Gray, M" uniqKey="Gray M">M Gray</name></author><author><name sortKey="Grolla, A" uniqKey="Grolla A">A Grolla</name></author><author><name sortKey="Jones, S" uniqKey="Jones S">S Jones</name></author><author><name sortKey="Feldmann, H" uniqKey="Feldmann H">H Feldmann</name></author><author><name sortKey="Meyers, A" uniqKey="Meyers A">A Meyers</name></author><author><name sortKey="Kabani, A" uniqKey="Kabani A">A Kabani</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Normand, S" uniqKey="Normand S">S Normand</name></author><author><name sortKey="Stroher, U" uniqKey="Stroher U">U Stroher</name></author><author><name sortKey="Tipples, Ga" uniqKey="Tipples G">GA Tipples</name></author><author><name sortKey="Tyler, S" uniqKey="Tyler S">S Tyler</name></author><author><name sortKey="Vogrig, R" uniqKey="Vogrig R">R Vogrig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name></author><author><name sortKey="Frieman, Mb" uniqKey="Frieman M">MB Frieman</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="De Haan, Cam" uniqKey="De Haan C">CAM de Haan</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Bosch, B" uniqKey="Bosch B">B Bosch</name></author><author><name sortKey="Frenz, B" uniqKey="Frenz B">B Frenz</name></author><author><name sortKey="Rottier, Pjm" uniqKey="Rottier P">PJM Rottier</name></author><author><name sortKey="Dimaio, F" uniqKey="Dimaio F">F DiMaio</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Frenz, B" uniqKey="Frenz B">B Frenz</name></author><author><name sortKey="Snijder, J" uniqKey="Snijder J">J Snijder</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Dimaio, F" uniqKey="Dimaio F">F DiMaio</name></author><author><name sortKey="Bosch, B" uniqKey="Bosch B">B Bosch</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kirchdoerfer, Rn" uniqKey="Kirchdoerfer R">RN Kirchdoerfer</name></author><author><name sortKey="Cottrell, Ca" uniqKey="Cottrell C">CA Cottrell</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Pallesen, J" uniqKey="Pallesen J">J Pallesen</name></author><author><name sortKey="Yassine, Hm" uniqKey="Yassine H">HM Yassine</name></author><author><name sortKey="Turner, Hl" uniqKey="Turner H">HL Turner</name></author><author><name sortKey="Corbett, Ks" uniqKey="Corbett K">KS Corbett</name></author><author><name sortKey="Graham, Bs" uniqKey="Graham B">BS Graham</name></author><author><name sortKey="Mclellan, Js" uniqKey="Mclellan J">JS McLellan</name></author><author><name sortKey="Ward, Ab" uniqKey="Ward A">AB Ward</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gui, M" uniqKey="Gui M">M Gui</name></author><author><name sortKey="Song, W" uniqKey="Song W">W Song</name></author><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name></author><author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y Xiang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yuan, Y" uniqKey="Yuan Y">Y Yuan</name></author><author><name sortKey="Cao, D" uniqKey="Cao D">D Cao</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Ma, J" uniqKey="Ma J">J Ma</name></author><author><name sortKey="Qi, J" uniqKey="Qi J">J Qi</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q Wang</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Shi, Y" uniqKey="Shi Y">Y Shi</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Koerhuis, D" uniqKey="Koerhuis D">D Koerhuis</name></author><author><name sortKey="Boons, G J" uniqKey="Boons G">G-J Boons</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Xu, L" uniqKey="Xu L">L Xu</name></author><author><name sortKey="Lin, Y" uniqKey="Lin Y">Y Lin</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Pasquarella, Jr" uniqKey="Pasquarella J">JR Pasquarella</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seetharaman, J" uniqKey="Seetharaman J">J Seetharaman</name></author><author><name sortKey="Kanigsberg, A" uniqKey="Kanigsberg A">A Kanigsberg</name></author><author><name sortKey="Slaaby, R" uniqKey="Slaaby R">R Slaaby</name></author><author><name sortKey="Leffler, H" uniqKey="Leffler H">H Leffler</name></author><author><name sortKey="Barondes, Sh" uniqKey="Barondes S">SH Barondes</name></author><author><name sortKey="Rini, Jm" uniqKey="Rini J">JM Rini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="Widjaja, I" uniqKey="Widjaja I">I Widjaja</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mcbride, R" uniqKey="Mcbride R">R McBride</name></author><author><name sortKey="Peng, W" uniqKey="Peng W">W Peng</name></author><author><name sortKey="Widagdo, W" uniqKey="Widagdo W">W Widagdo</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Van Dieren, B" uniqKey="Van Dieren B">B van Dieren</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Van Lent, Jwm" uniqKey="Van Lent J">JWM van Lent</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="De Haan, Cam" uniqKey="De Haan C">CAM de Haan</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, N" uniqKey="Wang N">N Wang</name></author><author><name sortKey="Shi, X" uniqKey="Shi X">X Shi</name></author><author><name sortKey="Jiang, L" uniqKey="Jiang L">L Jiang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Wang, D" uniqKey="Wang D">D Wang</name></author><author><name sortKey="Tong, P" uniqKey="Tong P">P Tong</name></author><author><name sortKey="Guo, D" uniqKey="Guo D">D Guo</name></author><author><name sortKey="Fu, L" uniqKey="Fu L">L Fu</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Liu, X" uniqKey="Liu X">X Liu</name></author><author><name sortKey="Arledge, Kc" uniqKey="Arledge K">KC Arledge</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Mou, H" uniqKey="Mou H">H Mou</name></author><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Dekkers, Dhw" uniqKey="Dekkers D">DHW Dekkers</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name></author><author><name sortKey="Dijkman, R" uniqKey="Dijkman R">R Dijkman</name></author><author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name></author><author><name sortKey="Demmers, Jaa" uniqKey="Demmers J">JAA Demmers</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Fouchier, Ram" uniqKey="Fouchier R">RAM Fouchier</name></author><author><name sortKey="Thiel, V" uniqKey="Thiel V">V Thiel</name></author><author><name sortKey="Drosten, C" uniqKey="Drosten C">C Drosten</name></author><author><name sortKey="Rottier, Pjm" uniqKey="Rottier P">PJM Rottier</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Bosch, Bj" uniqKey="Bosch B">BJ Bosch</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barlan, A" uniqKey="Barlan A">A Barlan</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Sarkar, Mk" uniqKey="Sarkar M">MK Sarkar</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Sun, D" uniqKey="Sun D">D Sun</name></author><author><name sortKey="Rajashankar, Kr" uniqKey="Rajashankar K">KR Rajashankar</name></author><author><name sortKey="Qian, Z" uniqKey="Qian Z">Z Qian</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Krueger, Dk" uniqKey="Krueger D">DK Krueger</name></author><author><name sortKey="Kelly, Sm" uniqKey="Kelly S">SM Kelly</name></author><author><name sortKey="Lewicki, Dn" uniqKey="Lewicki D">DN Lewicki</name></author><author><name sortKey="Ruffolo, R" uniqKey="Ruffolo R">R Ruffolo</name></author><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsai, Cw" uniqKey="Tsai C">CW Tsai</name></author><author><name sortKey="Chang, Sc" uniqKey="Chang S">SC Chang</name></author><author><name sortKey="Chang, Mf" uniqKey="Chang M">MF Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parker, Se" uniqKey="Parker S">SE Parker</name></author><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miura, Ta" uniqKey="Miura T">TA Miura</name></author><author><name sortKey="Travanty, Ea" uniqKey="Travanty E">EA Travanty</name></author><author><name sortKey="Oko, L" uniqKey="Oko L">L Oko</name></author><author><name sortKey="Bielefeldt Ohmann, H" uniqKey="Bielefeldt Ohmann H">H Bielefeldt-Ohmann</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author><author><name sortKey="Beauchemin, N" uniqKey="Beauchemin N">N Beauchemin</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author><author><name sortKey="Saeki, K" uniqKey="Saeki K">K Saeki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Watanabe, R" uniqKey="Watanabe R">R Watanabe</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokomori, K" uniqKey="Yokomori K">K Yokomori</name></author><author><name sortKey="Banner, Lr" uniqKey="Banner L">LR Banner</name></author><author><name sortKey="Lai, Mm" uniqKey="Lai M">MM Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yokomori, K" uniqKey="Yokomori K">K Yokomori</name></author><author><name sortKey="Stohlman, Sa" uniqKey="Stohlman S">SA Stohlman</name></author><author><name sortKey="Lai, M" uniqKey="Lai M">M Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Godeke, Gj" uniqKey="Godeke G">GJ Godeke</name></author><author><name sortKey="Rossen, Jw" uniqKey="Rossen J">JW Rossen</name></author><author><name sortKey="Voorhout, Wf" uniqKey="Voorhout W">WF Voorhout</name></author><author><name sortKey="Horzinek, Mc" uniqKey="Horzinek M">MC Horzinek</name></author><author><name sortKey="Opstelten, Dj" uniqKey="Opstelten D">DJ Opstelten</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Kuo, L" uniqKey="Kuo L">L Kuo</name></author><author><name sortKey="Masters, Ps" uniqKey="Masters P">PS Masters</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name></author><author><name sortKey="Maeda, A" uniqKey="Maeda A">A Maeda</name></author><author><name sortKey="Maeda, J" uniqKey="Maeda J">J Maeda</name></author><author><name sortKey="Makino, S" uniqKey="Makino S">S Makino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Bakkers, Mjg" uniqKey="Bakkers M">MJG Bakkers</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name></author><author><name sortKey="Schouten, A" uniqKey="Schouten A">A Schouten</name></author><author><name sortKey="Ophorst, B" uniqKey="Ophorst B">B Ophorst</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Boons, G J" uniqKey="Boons G">G-J Boons</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author><author><name sortKey="Huizinga, Eg" uniqKey="Huizinga E">EG Huizinga</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godeke, Gj" uniqKey="Godeke G">GJ Godeke</name></author><author><name sortKey="De Haan, Ca" uniqKey="De Haan C">CA de Haan</name></author><author><name sortKey="Rossen, Jw" uniqKey="Rossen J">JW Rossen</name></author><author><name sortKey="Vennema, H" uniqKey="Vennema H">H Vennema</name></author><author><name sortKey="Rottier, Pj" uniqKey="Rottier P">PJ Rottier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shirato, K" uniqKey="Shirato K">K Shirato</name></author><author><name sortKey="Kanou, K" uniqKey="Kanou K">K Kanou</name></author><author><name sortKey="Kawase, M" uniqKey="Kawase M">M Kawase</name></author><author><name sortKey="Matsuyama, S" uniqKey="Matsuyama S">S Matsuyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulla, A" uniqKey="Shulla A">A Shulla</name></author><author><name sortKey="Heald Sargent, T" uniqKey="Heald Sargent T">T Heald-Sargent</name></author><author><name sortKey="Subramanya, G" uniqKey="Subramanya G">G Subramanya</name></author><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, J" uniqKey="Park J">J Park</name></author><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Barlan, A" uniqKey="Barlan A">A Barlan</name></author><author><name sortKey="Fehr, Ar" uniqKey="Fehr A">AR Fehr</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phillips, Jm" uniqKey="Phillips J">JM Phillips</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Belouzard, S" uniqKey="Belouzard S">S Belouzard</name></author><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Licitra, Bn" uniqKey="Licitra B">BN Licitra</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Millet, Jk" uniqKey="Millet J">JK Millet</name></author><author><name sortKey="Whittaker, Gr" uniqKey="Whittaker G">GR Whittaker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gamblin, Sj" uniqKey="Gamblin S">SJ Gamblin</name></author><author><name sortKey="Haire, Lf" uniqKey="Haire L">LF Haire</name></author><author><name sortKey="Russell, Rj" uniqKey="Russell R">RJ Russell</name></author><author><name sortKey="Stevens, Dj" uniqKey="Stevens D">DJ Stevens</name></author><author><name sortKey="Xiao, B" uniqKey="Xiao B">B Xiao</name></author><author><name sortKey="Ha, Y" uniqKey="Ha Y">Y Ha</name></author><author><name sortKey="Vasisht, N" uniqKey="Vasisht N">N Vasisht</name></author><author><name sortKey="Steinhauer, Da" uniqKey="Steinhauer D">DA Steinhauer</name></author><author><name sortKey="Daniels, Rs" uniqKey="Daniels R">RS Daniels</name></author><author><name sortKey="Elliot, A" uniqKey="Elliot A">A Elliot</name></author><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stevens, J" uniqKey="Stevens J">J Stevens</name></author><author><name sortKey="Blixt, O" uniqKey="Blixt O">O Blixt</name></author><author><name sortKey="Glaser, L" uniqKey="Glaser L">L Glaser</name></author><author><name sortKey="Taubenberger, Jk" uniqKey="Taubenberger J">JK Taubenberger</name></author><author><name sortKey="Palese, P" uniqKey="Palese P">P Palese</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Wilson, Ia" uniqKey="Wilson I">IA Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weis, W" uniqKey="Weis W">W Weis</name></author><author><name sortKey="Brown, Jh" uniqKey="Brown J">JH Brown</name></author><author><name sortKey="Cusack, S" uniqKey="Cusack S">S Cusack</name></author><author><name sortKey="Paulson, Jc" uniqKey="Paulson J">JC Paulson</name></author><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, K" uniqKey="Wu K">K Wu</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Peng, G" uniqKey="Peng G">G Peng</name></author><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, F" uniqKey="Li F">F Li</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Farzan, M" uniqKey="Farzan M">M Farzan</name></author><author><name sortKey="Harrison, Sc" uniqKey="Harrison S">SC Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Y" uniqKey="Park Y">Y Park</name></author><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name></author><author><name sortKey="Sauer, Mm" uniqKey="Sauer M">MM Sauer</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Bosch, B" uniqKey="Bosch B">B Bosch</name></author><author><name sortKey="Dimaio, F" uniqKey="Dimaio F">F DiMaio</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Widjaja, I" uniqKey="Widjaja I">I Widjaja</name></author><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Van Haperen, R" uniqKey="Van Haperen R">R van Haperen</name></author><author><name sortKey="Gutierrez Lvarez, J" uniqKey="Gutierrez Lvarez J">J Gutiérrez-Álvarez</name></author><author><name sortKey="Van Dieren, B" uniqKey="Van Dieren B">B van Dieren</name></author><author><name sortKey="Okba, Nma" uniqKey="Okba N">NMA Okba</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Fernandez Delgado, R" uniqKey="Fernandez Delgado R">R Fernandez-Delgado</name></author><author><name sortKey="Grosveld, F" uniqKey="Grosveld F">F Grosveld</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Enjuanes, L" uniqKey="Enjuanes L">L Enjuanes</name></author><author><name sortKey="Drabek, D" uniqKey="Drabek D">D Drabek</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sohrab, Ss" uniqKey="Sohrab S">SS Sohrab</name></author><author><name sortKey="Azhar, Ei" uniqKey="Azhar E">EI Azhar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Douglas, Mg" uniqKey="Douglas M">MG Douglas</name></author><author><name sortKey="Kocher, Jf" uniqKey="Kocher J">JF Kocher</name></author><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name></author><author><name sortKey="Wohlford Lenane, Cl" uniqKey="Wohlford Lenane C">CL Wohlford-Lenane</name></author><author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name></author><author><name sortKey="Park, J" uniqKey="Park J">J Park</name></author><author><name sortKey="Earnest, Jt" uniqKey="Earnest J">JT Earnest</name></author><author><name sortKey="Bair, Tb" uniqKey="Bair T">TB Bair</name></author><author><name sortKey="Bates, Am" uniqKey="Bates A">AM Bates</name></author><author><name sortKey="Brogden, Ka" uniqKey="Brogden K">KA Brogden</name></author><author><name sortKey="Flaherty, Ha" uniqKey="Flaherty H">HA Flaherty</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author><author><name sortKey="Meyerholz, Dk" uniqKey="Meyerholz D">DK Meyerholz</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name></author><author><name sortKey="Mccray, Pb" uniqKey="Mccray P">PB McCray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name></author><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Niu, P" uniqKey="Niu P">P Niu</name></author><author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name></author><author><name sortKey="Jia, W" uniqKey="Jia W">W Jia</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name></author><author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Xiong, X" uniqKey="Xiong X">X Xiong</name></author><author><name sortKey="Park, Y J" uniqKey="Park Y">Y-J Park</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Snijder, J" uniqKey="Snijder J">J Snijder</name></author><author><name sortKey="Quispe, J" uniqKey="Quispe J">J Quispe</name></author><author><name sortKey="Cameroni, E" uniqKey="Cameroni E">E Cameroni</name></author><author><name sortKey="Gopal, R" uniqKey="Gopal R">R Gopal</name></author><author><name sortKey="Dai, M" uniqKey="Dai M">M Dai</name></author><author><name sortKey="Lanzavecchia, A" uniqKey="Lanzavecchia A">A Lanzavecchia</name></author><author><name sortKey="Zambon, M" uniqKey="Zambon M">M Zambon</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Corti, D" uniqKey="Corti D">D Corti</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stencel Baerenwald, Je" uniqKey="Stencel Baerenwald J">JE Stencel-Baerenwald</name></author><author><name sortKey="Reiss, K" uniqKey="Reiss K">K Reiss</name></author><author><name sortKey="Reiter, Dm" uniqKey="Reiter D">DM Reiter</name></author><author><name sortKey="Stehle, T" uniqKey="Stehle T">T Stehle</name></author><author><name sortKey="Dermody, Ts" uniqKey="Dermody T">TS Dermody</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nash, Tc" uniqKey="Nash T">TC Nash</name></author><author><name sortKey="Buchmeier, Mj" uniqKey="Buchmeier M">MJ Buchmeier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakagaki, K" uniqKey="Nakagaki K">K Nakagaki</name></author><author><name sortKey="Nakagaki, K" uniqKey="Nakagaki K">K Nakagaki</name></author><author><name sortKey="Taguchi, F" uniqKey="Taguchi F">F Taguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiong, X" uniqKey="Xiong X">X Xiong</name></author><author><name sortKey="Tortorici, Ma" uniqKey="Tortorici M">MA Tortorici</name></author><author><name sortKey="Snijder, J" uniqKey="Snijder J">J Snijder</name></author><author><name sortKey="Yoshioka, C" uniqKey="Yoshioka C">C Yoshioka</name></author><author><name sortKey="Walls, Ac" uniqKey="Walls A">AC Walls</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Mcguire, At" uniqKey="Mcguire A">AT McGuire</name></author><author><name sortKey="Rey, Fa" uniqKey="Rey F">FA Rey</name></author><author><name sortKey="Bosch, B J" uniqKey="Bosch B">B-J Bosch</name></author><author><name sortKey="Veesler, D" uniqKey="Veesler D">D Veesler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bakkers, Mjg" uniqKey="Bakkers M">MJG Bakkers</name></author><author><name sortKey="Lang, Y" uniqKey="Lang Y">Y Lang</name></author><author><name sortKey="Feitsma, Lj" uniqKey="Feitsma L">LJ Feitsma</name></author><author><name sortKey="Hulswit, Rjg" uniqKey="Hulswit R">RJG Hulswit</name></author><author><name sortKey="De Poot, Sah" uniqKey="De Poot S">SAH de Poot</name></author><author><name sortKey="Van Vliet, Alw" uniqKey="Van Vliet A">ALW van Vliet</name></author><author><name sortKey="Margine, I" uniqKey="Margine I">I Margine</name></author><author><name sortKey="De Groot Mijnes, Jdf" uniqKey="De Groot Mijnes J">JDF de Groot-Mijnes</name></author><author><name sortKey="Van Kuppeveld, Fjm" uniqKey="Van Kuppeveld F">FJM van Kuppeveld</name></author><author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name></author><author><name sortKey="Huizinga, Eg" uniqKey="Huizinga E">EG Huizinga</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wasik, Br" uniqKey="Wasik B">BR Wasik</name></author><author><name sortKey="Barnard, Kn" uniqKey="Barnard K">KN Barnard</name></author><author><name sortKey="Ossiboff, Rj" uniqKey="Ossiboff R">RJ Ossiboff</name></author><author><name sortKey="Khedri, Z" uniqKey="Khedri Z">Z Khedri</name></author><author><name sortKey="Feng, Kh" uniqKey="Feng K">KH Feng</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name></author><author><name sortKey="Perez, Dr" uniqKey="Perez D">DR Perez</name></author><author><name sortKey="Varki, A" uniqKey="Varki A">A Varki</name></author><author><name sortKey="Parrish, Cr" uniqKey="Parrish C">CR Parrish</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name></author><author><name sortKey="Dong, W" uniqKey="Dong W">W Dong</name></author><author><name sortKey="Milewska, A" uniqKey="Milewska A">A Milewska</name></author><author><name sortKey="Golda, A" uniqKey="Golda A">A Golda</name></author><author><name sortKey="Qi, Y" uniqKey="Qi Y">Y Qi</name></author><author><name sortKey="Zhu, Qk" uniqKey="Zhu Q">QK Zhu</name></author><author><name sortKey="Marasco, Wa" uniqKey="Marasco W">WA Marasco</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name></author><author><name sortKey="Pyrc, K" uniqKey="Pyrc K">K Pyrc</name></author><author><name sortKey="Li, W" uniqKey="Li W">W Li</name></author><author><name sortKey="Sui, J" uniqKey="Sui J">J Sui</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name></author><author><name sortKey="Zeng, Q" uniqKey="Zeng Q">Q Zeng</name></author><author><name sortKey="Heesters, B" uniqKey="Heesters B">B Heesters</name></author><author><name sortKey="Huizinga, Eg" uniqKey="Huizinga E">EG Huizinga</name></author><author><name sortKey="De Groot, Rj" uniqKey="De Groot R">RJ de Groot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hensley, Le" uniqKey="Hensley L">LE Hensley</name></author><author><name sortKey="Holmes, Kv" uniqKey="Holmes K">KV Holmes</name></author><author><name sortKey="Beauchemin, N" uniqKey="Beauchemin N">N Beauchemin</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, C M" uniqKey="Chan C">C-M Chan</name></author><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Wong, B Y" uniqKey="Wong B">B-Y Wong</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name></author><author><name sortKey="Leung, Sp" uniqKey="Leung S">SP Leung</name></author><author><name sortKey="Chan, J W" uniqKey="Chan J">J-W Chan</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M-L Yeung</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K-Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, H" uniqKey="Chu H">H Chu</name></author><author><name sortKey="Chan, C M" uniqKey="Chan C">C-M Chan</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name></author><author><name sortKey="Yuan, S" uniqKey="Yuan S">S Yuan</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Au Yeung, R H" uniqKey="Au Yeung R">R-H Au-Yeung</name></author><author><name sortKey="Sze, K H" uniqKey="Sze K">K-H Sze</name></author><author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name></author><author><name sortKey="Shuai, H" uniqKey="Shuai H">H Shuai</name></author><author><name sortKey="Hou, Y" uniqKey="Hou Y">Y Hou</name></author><author><name sortKey="Li, C" uniqKey="Li C">C Li</name></author><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name></author><author><name sortKey="Poon, V M" uniqKey="Poon V">V-M Poon</name></author><author><name sortKey="Leung, Sp" uniqKey="Leung S">SP Leung</name></author><author><name sortKey="Yeung, M L" uniqKey="Yeung M">M-L Yeung</name></author><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name></author><author><name sortKey="Lu, G" uniqKey="Lu G">G Lu</name></author><author><name sortKey="Jin, D Y" uniqKey="Jin D">D-Y Jin</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Chan, J W" uniqKey="Chan J">J-W Chan</name></author><author><name sortKey="Yuen, K Y" uniqKey="Yuen K">K-Y Yuen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schnaar, Rl" uniqKey="Schnaar R">RL Schnaar</name></author><author><name sortKey="Gerardy Schahn, R" uniqKey="Gerardy Schahn R">R Gerardy-Schahn</name></author><author><name sortKey="Hildebrandt, H" uniqKey="Hildebrandt H">H Hildebrandt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massa, Pt" uniqKey="Massa P">PT Massa</name></author><author><name sortKey="Wege, H" uniqKey="Wege H">H Wege</name></author><author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V ter Meulen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Massa, Pt" uniqKey="Massa P">PT Massa</name></author><author><name sortKey="Wege, H" uniqKey="Wege H">H Wege</name></author><author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V ter Meulen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Berlo, Mf" uniqKey="Van Berlo M">MF van Berlo</name></author><author><name sortKey="Warringa, R" uniqKey="Warringa R">R Warringa</name></author><author><name sortKey="Wolswijk, G" uniqKey="Wolswijk G">G Wolswijk</name></author><author><name sortKey="Lopes Cardozo, M" uniqKey="Lopes Cardozo M">M Lopes-Cardozo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name></author><author><name sortKey="Lu, S" uniqKey="Lu S">S Lu</name></author><author><name sortKey="Jia, H" uniqKey="Jia H">H Jia</name></author><author><name sortKey="Deng, Y" uniqKey="Deng Y">Y Deng</name></author><author><name sortKey="Zhou, J" uniqKey="Zhou J">J Zhou</name></author><author><name sortKey="Huang, B" uniqKey="Huang B">B Huang</name></author><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name></author><author><name sortKey="Lan, J" uniqKey="Lan J">J Lan</name></author><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name></author><author><name sortKey="Lou, Y" uniqKey="Lou Y">Y Lou</name></author><author><name sortKey="Qin, K" uniqKey="Qin K">K Qin</name></author><author><name sortKey="Tan, W" uniqKey="Tan W">W Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rao, Pv" uniqKey="Rao P">PV Rao</name></author><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallagher, Tm" uniqKey="Gallagher T">TM Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rosenberger, Cm" uniqKey="Rosenberger C">CM Rosenberger</name></author><author><name sortKey="Podyminogin, Rl" uniqKey="Podyminogin R">RL Podyminogin</name></author><author><name sortKey="Askovich, Ps" uniqKey="Askovich P">PS Askovich</name></author><author><name sortKey="Navarro, G" uniqKey="Navarro G">G Navarro</name></author><author><name sortKey="Kaiser, Sm" uniqKey="Kaiser S">SM Kaiser</name></author><author><name sortKey="Sanders, Cj" uniqKey="Sanders C">CJ Sanders</name></author><author><name sortKey="Mcclaren, Jl" uniqKey="Mcclaren J">JL McClaren</name></author><author><name sortKey="Tam, Vc" uniqKey="Tam V">VC Tam</name></author><author><name sortKey="Dash, P" uniqKey="Dash P">P Dash</name></author><author><name sortKey="Noonan, Jg" uniqKey="Noonan J">JG Noonan</name></author><author><name sortKey="Jones, Bg" uniqKey="Jones B">BG Jones</name></author><author><name sortKey="Surman, Sl" uniqKey="Surman S">SL Surman</name></author><author><name sortKey="Peschon, Jj" uniqKey="Peschon J">JJ Peschon</name></author><author><name sortKey="Diercks, Ah" uniqKey="Diercks A">AH Diercks</name></author><author><name sortKey="Hurwitz, Jl" uniqKey="Hurwitz J">JL Hurwitz</name></author><author><name sortKey="Doherty, Pc" uniqKey="Doherty P">PC Doherty</name></author><author><name sortKey="Thomas, Pg" uniqKey="Thomas P">PG Thomas</name></author><author><name sortKey="Aderem, A" uniqKey="Aderem A">A Aderem</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirano, N" uniqKey="Hirano N">N Hirano</name></author><author><name sortKey="Fujiwara, K" uniqKey="Fujiwara K">K Fujiwara</name></author><author><name sortKey="Hino, S" uniqKey="Hino S">S Hino</name></author><author><name sortKey="Matumoto, M" uniqKey="Matumoto M">M Matumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirano, N" uniqKey="Hirano N">N Hirano</name></author><author><name sortKey="Fujiwara, K" uniqKey="Fujiwara K">K Fujiwara</name></author><author><name sortKey="Matumoto, M" uniqKey="Matumoto M">M Matumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, R" uniqKey="Zhang R">R Zhang</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Cowley, Tj" uniqKey="Cowley T">TJ Cowley</name></author><author><name sortKey="Steinbrenner, Ad" uniqKey="Steinbrenner A">AD Steinbrenner</name></author><author><name sortKey="Phillips, Jm" uniqKey="Phillips J">JM Phillips</name></author><author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name></author><author><name sortKey="Baric, Rs" uniqKey="Baric R">RS Baric</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulla, A" uniqKey="Shulla A">A Shulla</name></author><author><name sortKey="Gallagher, T" uniqKey="Gallagher T">T Gallagher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name></author><author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Osterhaus, A" uniqKey="Osterhaus A">A Osterhaus</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Gorbalenya, Ae" uniqKey="Gorbalenya A">AE Gorbalenya</name></author><author><name sortKey="Snijder, Ej" uniqKey="Snijder E">EJ Snijder</name></author><author><name sortKey="Fouchier, R" uniqKey="Fouchier R">R Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nakane, S" uniqKey="Nakane S">S Nakane</name></author><author><name sortKey="Matsuda, Z" uniqKey="Matsuda Z">Z Matsuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Teeranaipong, P" uniqKey="Teeranaipong P">P Teeranaipong</name></author><author><name sortKey="Hosoya, N" uniqKey="Hosoya N">N Hosoya</name></author><author><name sortKey="Kawana Tachikawa, A" uniqKey="Kawana Tachikawa A">A Kawana-Tachikawa</name></author><author><name sortKey="Fujii, T" uniqKey="Fujii T">T Fujii</name></author><author><name sortKey="Koibuchi, T" uniqKey="Koibuchi T">T Koibuchi</name></author><author><name sortKey="Nakamura, H" uniqKey="Nakamura H">H Nakamura</name></author><author><name sortKey="Koga, M" uniqKey="Koga M">M Koga</name></author><author><name sortKey="Kondo, N" uniqKey="Kondo N">N Kondo</name></author><author><name sortKey="Gao, Gf" uniqKey="Gao G">GF Gao</name></author><author><name sortKey="Hoshino, H" uniqKey="Hoshino H">H Hoshino</name></author><author><name sortKey="Matsuda, Z" uniqKey="Matsuda Z">Z Matsuda</name></author><author><name sortKey="Iwamoto, A" uniqKey="Iwamoto A">A Iwamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitt, Ma" uniqKey="Whitt M">MA Whitt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brouillette, Rb" uniqKey="Brouillette R">RB Brouillette</name></author><author><name sortKey="Phillips, Ek" uniqKey="Phillips E">EK Phillips</name></author><author><name sortKey="Ayithan, N" uniqKey="Ayithan N">N Ayithan</name></author><author><name sortKey="Maury, W" uniqKey="Maury W">W Maury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bender, Sj" uniqKey="Bender S">SJ Bender</name></author><author><name sortKey="Phillips, Jm" uniqKey="Phillips J">JM Phillips</name></author><author><name sortKey="Scott, Ep" uniqKey="Scott E">EP Scott</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Phillips, Jj" uniqKey="Phillips J">JJ Phillips</name></author><author><name sortKey="Chua, Mm" uniqKey="Chua M">MM Chua</name></author><author><name sortKey="Rall, Gf" uniqKey="Rall G">GF Rall</name></author><author><name sortKey="Weiss, Sr" uniqKey="Weiss S">SR Weiss</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection.</title><author><name sortKey="Qing, Enya" sort="Qing, Enya" uniqKey="Qing E" first="Enya" last="Qing">Enya Qing</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hantak, Michael" sort="Hantak, Michael" uniqKey="Hantak M" first="Michael" last="Hantak">Michael Hantak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Gallagher, Tom" sort="Gallagher, Tom" uniqKey="Gallagher T" first="Tom" last="Gallagher">Tom Gallagher</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA tgallag@luc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32047128</idno><idno type="pmid">32047128</idno><idno type="doi">10.1128/mBio.02764-19</idno><idno type="wicri:Area/PubMed/Corpus">000242</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000242</idno><idno type="wicri:Area/PubMed/Curation">000242</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000242</idno><idno type="wicri:Area/PubMed/Checkpoint">000224</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000224</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Distinct Roles for Sialoside and Protein Receptors in Coronavirus Infection.</title><author><name sortKey="Qing, Enya" sort="Qing, Enya" uniqKey="Qing E" first="Enya" last="Qing">Enya Qing</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Hantak, Michael" sort="Hantak, Michael" uniqKey="Hantak M" first="Michael" last="Hantak">Michael Hantak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region><settlement type="city">Iowa City</settlement></placeName><orgName type="university">Université de l'Iowa</orgName></affiliation></author><author><name sortKey="Gallagher, Tom" sort="Gallagher, Tom" uniqKey="Gallagher T" first="Tom" last="Gallagher">Tom Gallagher</name><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois, USA tgallag@luc.edu.</nlm:affiliation><country wicri:rule="url">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">mBio</title><idno type="eISSN">2150-7511</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Coronaviruses (CoVs) are common human and animal pathogens that can transmit zoonotically and cause severe respiratory disease syndromes. CoV infection requires spike proteins, which bind viruses to host cell receptors and catalyze virus-cell membrane fusion. Several CoV strains have spike proteins with two receptor-binding domains, an S1A that engages host sialic acids and an S1B that recognizes host transmembrane proteins. As this bivalent binding may enable broad zoonotic CoV infection, we aimed to identify roles for each receptor in distinct infection stages. Focusing on two betacoronaviruses, murine JHM-CoV and human Middle East respiratory syndrome coronavirus (MERS-CoV), we found that virus particle binding to cells was mediated by sialic acids; however, the transmembrane protein receptors were required for a subsequent virus infection. These results favored a two-step process in which viruses first adhere to sialic acids and then require subsequent engagement with protein receptors during infectious cell entry. However, sialic acids sufficiently facilitated the later stages of virus spread through cell-cell membrane fusion, without requiring protein receptors. This virus spread in the absence of the prototype protein receptors was increased by adaptive S1A mutations. Overall, these findings reveal roles for sialic acids in virus-cell binding, viral spike protein-directed cell-cell fusion, and resultant spread of CoV infections.<b>IMPORTANCE</b> CoVs can transmit from animals to humans to cause serious disease. This zoonotic transmission uses spike proteins, which bind CoVs to cells with two receptor-binding domains. Here, we identified the roles for the two binding processes in the CoV infection process. Binding to sialic acids promoted infection and also supported the intercellular expansion of CoV infections through syncytial development. Adaptive mutations in the sialic acid-binding spike domains increased the intercellular expansion process. These findings raise the possibility that the lectin-like properties of many CoVs contribute to facile zoonotic transmission and intercellular spread within infected organisms.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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