Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study
Identifieur interne : 001D89 ( Ncbi/Merge ); précédent : 001D88; suivant : 001D90Factors associated with recovery delay in a sample of patients diagnosed by MERS‐CoV rRT‐PCR: A Saudi Arabian multicenter retrospective study
Auteurs : Anwar E. Ahmed ; Hamdan Al-Jahdali ; Mody Alaqeel ; Salma S. Siddiq ; Hanan A. Alsaab ; Ezzeldin A. Sakr ; Hamed A. Alyahya ; Munzir M. Alandonisi ; Alaa T. Subedar ; Yosra Z. Ali ; Hazza Al Otaibi ; Nouf M. Aloudah ; Salim Baharoon ; Sameera Al Johani ; Mohammed G. AlghamdiSource :
- Influenza and Other Respiratory Viruses [ 1750-2640 ] ; 2018.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Arabie saoudite (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Enfant, Enfant d'âge préscolaire, Facteurs temps, Femelle, Humains, Infections à coronavirus (anatomopathologie), Infections à coronavirus (épidémiologie), Jeune adulte, Mâle, Nourrisson, RT-PCR, Réaction de polymérisation en chaine en temps réel, Rémission spontanée, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
- MESH :
- anatomopathologie : Infections à coronavirus.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- épidémiologie : Arabie saoudite, Infections à coronavirus.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Facteurs temps, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, RT-PCR, Réaction de polymérisation en chaine en temps réel, Rémission spontanée, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
- Wicri :
- geographic : Arabie saoudite.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Coronavirus Infections (epidemiology), Coronavirus Infections (pathology), Female, Humans, Infant, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Real-Time Polymerase Chain Reaction, Remission, Spontaneous, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Saudi Arabia (epidemiology), Time Factors, Young Adult.
- MESH :
- geographic , epidemiology : Saudi Arabia.
- epidemiology : Coronavirus Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- pathology : Coronavirus Infections.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Real-Time Polymerase Chain Reaction, Remission, Spontaneous, Retrospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Time Factors, Young Adult.
Abstract
Research evidence exists that poor prognosis is common in Middle East respiratory syndrome coronavirus (
This study estimates recovery delay intervals and identifies associated factors in a sample of Saudi Arabian patients admitted for suspected
A multicenter retrospective study was conducted on 829 patients admitted between September 2012 and June 2016 and diagnosed by
The median recovery delay in our sample was 5 days. According to the multivariate negative binomial model, elderly (age ≥ 65),
The study evidence supports that longer recovery delay was seen in patients of older age,
Url:
DOI: 10.1111/irv.12560
PubMed: 29624866
PubMed Central: 6086845
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PMC:6086845Le document en format XML
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Ahmed</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Ahdali, Hamdan" sort="Al Ahdali, Hamdan" uniqKey="Al Ahdali H" first="Hamdan" last="Al-Jahdali">Hamdan Al-Jahdali</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Alaqeel, Mody" sort="Alaqeel, Mody" uniqKey="Alaqeel M" first="Mody" last="Alaqeel">Mody Alaqeel</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Siddiq, Salma S" sort="Siddiq, Salma S" uniqKey="Siddiq S" first="Salma S." last="Siddiq">Salma S. Siddiq</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alsaab, Hanan A" sort="Alsaab, Hanan A" uniqKey="Alsaab H" first="Hanan A." last="Alsaab">Hanan A. Alsaab</name><affiliation><nlm:aff id="irv12560-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Sakr, Ezzeldin A" sort="Sakr, Ezzeldin A" uniqKey="Sakr E" first="Ezzeldin A." last="Sakr">Ezzeldin A. Sakr</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alyahya, Hamed A" sort="Alyahya, Hamed A" uniqKey="Alyahya H" first="Hamed A." last="Alyahya">Hamed A. Alyahya</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alandonisi, Munzir M" sort="Alandonisi, Munzir M" uniqKey="Alandonisi M" first="Munzir M." last="Alandonisi">Munzir M. Alandonisi</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Subedar, Alaa T" sort="Subedar, Alaa T" uniqKey="Subedar A" first="Alaa T." last="Subedar">Alaa T. Subedar</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ali, Yosra Z" sort="Ali, Yosra Z" uniqKey="Ali Y" first="Yosra Z." last="Ali">Yosra Z. Ali</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Otaibi, Hazza" sort="Al Otaibi, Hazza" uniqKey="Al Otaibi H" first="Hazza" last="Al Otaibi">Hazza Al Otaibi</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Aloudah, Nouf M" sort="Aloudah, Nouf M" uniqKey="Aloudah N" first="Nouf M." last="Aloudah">Nouf M. Aloudah</name><affiliation><nlm:aff id="irv12560-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Baharoon, Salim" sort="Baharoon, Salim" uniqKey="Baharoon S" first="Salim" last="Baharoon">Salim Baharoon</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Johani, Sameera" sort="Al Johani, Sameera" uniqKey="Al Johani S" first="Sameera" last="Al Johani">Sameera Al Johani</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Alghamdi, Mohammed G" sort="Alghamdi, Mohammed G" uniqKey="Alghamdi M" first="Mohammed G." last="Alghamdi">Mohammed G. Alghamdi</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (pathology)</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Real-Time Polymerase Chain Reaction</term><term>Remission, Spontaneous</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Saudi Arabia (epidemiology)</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Arabie saoudite (épidémiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>RT-PCR</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Rémission spontanée</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Remission, Spontaneous</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>RT-PCR</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Rémission spontanée</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="irv12560-sec-0001"><title>Background</title><p>Research evidence exists that poor prognosis is common in Middle East respiratory syndrome coronavirus (<styled-content style="fixed-case">MERS</styled-content>‐CoV) patients.</p></sec><sec id="irv12560-sec-0002"><title>Objectives</title><p>This study estimates recovery delay intervals and identifies associated factors in a sample of Saudi Arabian patients admitted for suspected <styled-content style="fixed-case">MERS</styled-content>‐CoV and diagnosed by <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> assay.</p></sec><sec id="irv12560-sec-0003"><title>Methods</title><p>A multicenter retrospective study was conducted on 829 patients admitted between September 2012 and June 2016 and diagnosed by <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> procedures to have <styled-content style="fixed-case">MERS</styled-content>‐CoV and non‐<styled-content style="fixed-case">MERS</styled-content>‐CoV infection in which 396 achieved recovery. Detailed medical charts were reviewed for each patient who achieved recovery. Time intervals in days were calculated from presentation to the initial <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> diagnosis (diagnosis delay) and from the initial <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> diagnosis to recovery (recovery delay).</p></sec><sec id="irv12560-sec-0004"><title>Results</title><p>The median recovery delay in our sample was 5 days. According to the multivariate negative binomial model, elderly (age ≥ 65), <styled-content style="fixed-case">MERS</styled-content>‐CoV infection, <styled-content style="fixed-case">ICU</styled-content> admission, and abnormal radiology findings were associated with longer recovery delay (adjusted relative risk (<styled-content style="fixed-case">aRR</styled-content>): 1.741, 2.138, 2.048, and 1.473, respectively). Camel contact and the presence of respiratory symptoms at presentation were associated with a shorter recovery delay (expedited recovery) (<styled-content style="fixed-case">aRR</styled-content>: 0.267 and 0.537, respectively). Diagnosis delay is a positive predictor for recovery delay (<italic>r</italic> = .421; <italic>P</italic> = .001).</p></sec><sec id="irv12560-sec-0005"><title>Conclusions</title><p>The study evidence supports that longer recovery delay was seen in patients of older age, <styled-content style="fixed-case">MERS</styled-content>‐CoV infection, <styled-content style="fixed-case">ICU</styled-content> admission, and abnormal radiology findings. Shorter recovery delay was found in patients who had camel contact and respiratory symptoms at presentation. These findings may help us understand clinical decision making on directing hospital resources toward prompt screening, monitoring, and implementing clinical recovery and treatment strategies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><double pmid="29624866"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors associated with recovery delay in a sample of patients diagnosed by <styled-content style="fixed-case">MERS</styled-content>‐CoV <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content>: A Saudi Arabian multicenter retrospective study</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Ahdali, Hamdan" sort="Al Ahdali, Hamdan" uniqKey="Al Ahdali H" first="Hamdan" last="Al-Jahdali">Hamdan Al-Jahdali</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Alaqeel, Mody" sort="Alaqeel, Mody" uniqKey="Alaqeel M" first="Mody" last="Alaqeel">Mody Alaqeel</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Siddiq, Salma S" sort="Siddiq, Salma S" uniqKey="Siddiq S" first="Salma S." last="Siddiq">Salma S. Siddiq</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alsaab, Hanan A" sort="Alsaab, Hanan A" uniqKey="Alsaab H" first="Hanan A." last="Alsaab">Hanan A. Alsaab</name><affiliation><nlm:aff id="irv12560-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Sakr, Ezzeldin A" sort="Sakr, Ezzeldin A" uniqKey="Sakr E" first="Ezzeldin A." last="Sakr">Ezzeldin A. Sakr</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alyahya, Hamed A" sort="Alyahya, Hamed A" uniqKey="Alyahya H" first="Hamed A." last="Alyahya">Hamed A. Alyahya</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alandonisi, Munzir M" sort="Alandonisi, Munzir M" uniqKey="Alandonisi M" first="Munzir M." last="Alandonisi">Munzir M. Alandonisi</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Subedar, Alaa T" sort="Subedar, Alaa T" uniqKey="Subedar A" first="Alaa T." last="Subedar">Alaa T. Subedar</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ali, Yosra Z" sort="Ali, Yosra Z" uniqKey="Ali Y" first="Yosra Z." last="Ali">Yosra Z. Ali</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Otaibi, Hazza" sort="Al Otaibi, Hazza" uniqKey="Al Otaibi H" first="Hazza" last="Al Otaibi">Hazza Al Otaibi</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Aloudah, Nouf M" sort="Aloudah, Nouf M" uniqKey="Aloudah N" first="Nouf M." last="Aloudah">Nouf M. Aloudah</name><affiliation><nlm:aff id="irv12560-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Baharoon, Salim" sort="Baharoon, Salim" uniqKey="Baharoon S" first="Salim" last="Baharoon">Salim Baharoon</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Johani, Sameera" sort="Al Johani, Sameera" uniqKey="Al Johani S" first="Sameera" last="Al Johani">Sameera Al Johani</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Alghamdi, Mohammed G" sort="Alghamdi, Mohammed G" uniqKey="Alghamdi M" first="Mohammed G." last="Alghamdi">Mohammed G. Alghamdi</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29624866</idno><idno type="pmc">6086845</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086845</idno><idno type="RBID">PMC:6086845</idno><idno type="doi">10.1111/irv.12560</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000D28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D28</idno><idno type="wicri:Area/Pmc/Curation">000D28</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D28</idno><idno type="wicri:Area/Pmc/Checkpoint">000578</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000578</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Factors associated with recovery delay in a sample of patients diagnosed by <styled-content style="fixed-case">MERS</styled-content>‐CoV <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content>: A Saudi Arabian multicenter retrospective study</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Ahdali, Hamdan" sort="Al Ahdali, Hamdan" uniqKey="Al Ahdali H" first="Hamdan" last="Al-Jahdali">Hamdan Al-Jahdali</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Alaqeel, Mody" sort="Alaqeel, Mody" uniqKey="Alaqeel M" first="Mody" last="Alaqeel">Mody Alaqeel</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Siddiq, Salma S" sort="Siddiq, Salma S" uniqKey="Siddiq S" first="Salma S." last="Siddiq">Salma S. Siddiq</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alsaab, Hanan A" sort="Alsaab, Hanan A" uniqKey="Alsaab H" first="Hanan A." last="Alsaab">Hanan A. Alsaab</name><affiliation><nlm:aff id="irv12560-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Sakr, Ezzeldin A" sort="Sakr, Ezzeldin A" uniqKey="Sakr E" first="Ezzeldin A." last="Sakr">Ezzeldin A. Sakr</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alyahya, Hamed A" sort="Alyahya, Hamed A" uniqKey="Alyahya H" first="Hamed A." last="Alyahya">Hamed A. Alyahya</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Alandonisi, Munzir M" sort="Alandonisi, Munzir M" uniqKey="Alandonisi M" first="Munzir M." last="Alandonisi">Munzir M. Alandonisi</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Subedar, Alaa T" sort="Subedar, Alaa T" uniqKey="Subedar A" first="Alaa T." last="Subedar">Alaa T. Subedar</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Ali, Yosra Z" sort="Ali, Yosra Z" uniqKey="Ali Y" first="Yosra Z." last="Ali">Yosra Z. Ali</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Otaibi, Hazza" sort="Al Otaibi, Hazza" uniqKey="Al Otaibi H" first="Hazza" last="Al Otaibi">Hazza Al Otaibi</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Aloudah, Nouf M" sort="Aloudah, Nouf M" uniqKey="Aloudah N" first="Nouf M." last="Aloudah">Nouf M. Aloudah</name><affiliation><nlm:aff id="irv12560-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Baharoon, Salim" sort="Baharoon, Salim" uniqKey="Baharoon S" first="Salim" last="Baharoon">Salim Baharoon</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Al Johani, Sameera" sort="Al Johani, Sameera" uniqKey="Al Johani S" first="Sameera" last="Al Johani">Sameera Al Johani</name><affiliation><nlm:aff id="irv12560-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Alghamdi, Mohammed G" sort="Alghamdi, Mohammed G" uniqKey="Alghamdi M" first="Mohammed G." last="Alghamdi">Mohammed G. Alghamdi</name><affiliation><nlm:aff id="irv12560-aff-0002"></nlm:aff></affiliation></author></analytic><series><title level="j">Influenza and Other Respiratory Viruses</title><idno type="ISSN">1750-2640</idno><idno type="eISSN">1750-2659</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="irv12560-sec-0001"><title>Background</title><p>Research evidence exists that poor prognosis is common in Middle East respiratory syndrome coronavirus (<styled-content style="fixed-case">MERS</styled-content>‐CoV) patients.</p></sec><sec id="irv12560-sec-0002"><title>Objectives</title><p>This study estimates recovery delay intervals and identifies associated factors in a sample of Saudi Arabian patients admitted for suspected <styled-content style="fixed-case">MERS</styled-content>‐CoV and diagnosed by <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> assay.</p></sec><sec id="irv12560-sec-0003"><title>Methods</title><p>A multicenter retrospective study was conducted on 829 patients admitted between September 2012 and June 2016 and diagnosed by <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> procedures to have <styled-content style="fixed-case">MERS</styled-content>‐CoV and non‐<styled-content style="fixed-case">MERS</styled-content>‐CoV infection in which 396 achieved recovery. Detailed medical charts were reviewed for each patient who achieved recovery. Time intervals in days were calculated from presentation to the initial <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> diagnosis (diagnosis delay) and from the initial <styled-content style="fixed-case">rRT</styled-content>‐<styled-content style="fixed-case">PCR</styled-content> diagnosis to recovery (recovery delay).</p></sec><sec id="irv12560-sec-0004"><title>Results</title><p>The median recovery delay in our sample was 5 days. According to the multivariate negative binomial model, elderly (age ≥ 65), <styled-content style="fixed-case">MERS</styled-content>‐CoV infection, <styled-content style="fixed-case">ICU</styled-content> admission, and abnormal radiology findings were associated with longer recovery delay (adjusted relative risk (<styled-content style="fixed-case">aRR</styled-content>): 1.741, 2.138, 2.048, and 1.473, respectively). Camel contact and the presence of respiratory symptoms at presentation were associated with a shorter recovery delay (expedited recovery) (<styled-content style="fixed-case">aRR</styled-content>: 0.267 and 0.537, respectively). Diagnosis delay is a positive predictor for recovery delay (<italic>r</italic> = .421; <italic>P</italic> = .001).</p></sec><sec id="irv12560-sec-0005"><title>Conclusions</title><p>The study evidence supports that longer recovery delay was seen in patients of older age, <styled-content style="fixed-case">MERS</styled-content>‐CoV infection, <styled-content style="fixed-case">ICU</styled-content> admission, and abnormal radiology findings. Shorter recovery delay was found in patients who had camel contact and respiratory symptoms at presentation. These findings may help us understand clinical decision making on directing hospital resources toward prompt screening, monitoring, and implementing clinical recovery and treatment strategies.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Factors associated with recovery delay in a sample of patients diagnosed by MERS-CoV rRT-PCR: A Saudi Arabian multicenter retrospective study.</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E" last="Ahmed">Anwar E. Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Jahdali, Hamdan" sort="Al Jahdali, Hamdan" uniqKey="Al Jahdali H" first="Hamdan" last="Al-Jahdali">Hamdan Al-Jahdali</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alaqeel, Mody" sort="Alaqeel, Mody" uniqKey="Alaqeel M" first="Mody" last="Alaqeel">Mody Alaqeel</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Siddiq, Salma S" sort="Siddiq, Salma S" uniqKey="Siddiq S" first="Salma S" last="Siddiq">Salma S. Siddiq</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Alsaab, Hanan A" sort="Alsaab, Hanan A" uniqKey="Alsaab H" first="Hanan A" last="Alsaab">Hanan A. Alsaab</name><affiliation wicri:level="1"><nlm:affiliation>Medical Records Department, Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Medical Records Department, Ministry of Health, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Sakr, Ezzeldin A" sort="Sakr, Ezzeldin A" uniqKey="Sakr E" first="Ezzeldin A" last="Sakr">Ezzeldin A. Sakr</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Alyahya, Hamed A" sort="Alyahya, Hamed A" uniqKey="Alyahya H" first="Hamed A" last="Alyahya">Hamed A. Alyahya</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Alandonisi, Munzir M" sort="Alandonisi, Munzir M" uniqKey="Alandonisi M" first="Munzir M" last="Alandonisi">Munzir M. Alandonisi</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Subedar, Alaa T" sort="Subedar, Alaa T" uniqKey="Subedar A" first="Alaa T" last="Subedar">Alaa T. Subedar</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Yosra Z" sort="Ali, Yosra Z" uniqKey="Ali Y" first="Yosra Z" last="Ali">Yosra Z. Ali</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Otaibi, Hazza" sort="Al Otaibi, Hazza" uniqKey="Al Otaibi H" first="Hazza" last="Al Otaibi">Hazza Al Otaibi</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aloudah, Nouf M" sort="Aloudah, Nouf M" uniqKey="Aloudah N" first="Nouf M" last="Aloudah">Nouf M. Aloudah</name><affiliation wicri:level="1"><nlm:affiliation>King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Baharoon, Salim" sort="Baharoon, Salim" uniqKey="Baharoon S" first="Salim" last="Baharoon">Salim Baharoon</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Johani, Sameera" sort="Al Johani, Sameera" uniqKey="Al Johani S" first="Sameera" last="Al Johani">Sameera Al Johani</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alghamdi, Mohammed G" sort="Alghamdi, Mohammed G" uniqKey="Alghamdi M" first="Mohammed G" last="Alghamdi">Mohammed G. Alghamdi</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29624866</idno><idno type="pmid">29624866</idno><idno type="doi">10.1111/irv.12560</idno><idno type="wicri:Area/PubMed/Corpus">000943</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000943</idno><idno type="wicri:Area/PubMed/Curation">000943</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000943</idno><idno type="wicri:Area/PubMed/Checkpoint">000916</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000916</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Factors associated with recovery delay in a sample of patients diagnosed by MERS-CoV rRT-PCR: A Saudi Arabian multicenter retrospective study.</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E" last="Ahmed">Anwar E. Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Jahdali, Hamdan" sort="Al Jahdali, Hamdan" uniqKey="Al Jahdali H" first="Hamdan" last="Al-Jahdali">Hamdan Al-Jahdali</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alaqeel, Mody" sort="Alaqeel, Mody" uniqKey="Alaqeel M" first="Mody" last="Alaqeel">Mody Alaqeel</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Siddiq, Salma S" sort="Siddiq, Salma S" uniqKey="Siddiq S" first="Salma S" last="Siddiq">Salma S. Siddiq</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Alsaab, Hanan A" sort="Alsaab, Hanan A" uniqKey="Alsaab H" first="Hanan A" last="Alsaab">Hanan A. Alsaab</name><affiliation wicri:level="1"><nlm:affiliation>Medical Records Department, Ministry of Health, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Medical Records Department, Ministry of Health, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Sakr, Ezzeldin A" sort="Sakr, Ezzeldin A" uniqKey="Sakr E" first="Ezzeldin A" last="Sakr">Ezzeldin A. Sakr</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Alyahya, Hamed A" sort="Alyahya, Hamed A" uniqKey="Alyahya H" first="Hamed A" last="Alyahya">Hamed A. Alyahya</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Alandonisi, Munzir M" sort="Alandonisi, Munzir M" uniqKey="Alandonisi M" first="Munzir M" last="Alandonisi">Munzir M. Alandonisi</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Subedar, Alaa T" sort="Subedar, Alaa T" uniqKey="Subedar A" first="Alaa T" last="Subedar">Alaa T. Subedar</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author><author><name sortKey="Ali, Yosra Z" sort="Ali, Yosra Z" uniqKey="Ali Y" first="Yosra Z" last="Ali">Yosra Z. Ali</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Otaibi, Hazza" sort="Al Otaibi, Hazza" uniqKey="Al Otaibi H" first="Hazza" last="Al Otaibi">Hazza Al Otaibi</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aloudah, Nouf M" sort="Aloudah, Nouf M" uniqKey="Aloudah N" first="Nouf M" last="Aloudah">Nouf M. Aloudah</name><affiliation wicri:level="1"><nlm:affiliation>King Saud University, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Baharoon, Salim" sort="Baharoon, Salim" uniqKey="Baharoon S" first="Salim" last="Baharoon">Salim Baharoon</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Al Johani, Sameera" sort="Al Johani, Sameera" uniqKey="Al Johani S" first="Sameera" last="Al Johani">Sameera Al Johani</name><affiliation wicri:level="1"><nlm:affiliation>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Abdullah International Medical Research Center (KAIMRC)/King Saud bin Abdulaziz University for Health Sciences (KSAU-HS)/King Abdulaziz Medical City (KAMC), Ministry of National Guard - Health Affairs, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alghamdi, Mohammed G" sort="Alghamdi, Mohammed G" uniqKey="Alghamdi M" first="Mohammed G" last="Alghamdi">Mohammed G. Alghamdi</name><affiliation wicri:level="1"><nlm:affiliation>King Fahad General Hospital - Jeddah, Jeddah, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>King Fahad General Hospital - Jeddah, Jeddah</wicri:regionArea><wicri:noRegion>Jeddah</wicri:noRegion></affiliation></author></analytic><series><title level="j">Influenza and other respiratory viruses</title><idno type="eISSN">1750-2659</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (pathology)</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Real-Time Polymerase Chain Reaction</term><term>Remission, Spontaneous</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Saudi Arabia (epidemiology)</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Arabie saoudite (épidémiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>RT-PCR</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Rémission spontanée</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Real-Time Polymerase Chain Reaction</term><term>Remission, Spontaneous</term><term>Retrospective Studies</term><term>Reverse Transcriptase Polymerase Chain Reaction</term><term>Time Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Facteurs temps</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>RT-PCR</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Rémission spontanée</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Arabie saoudite</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Research evidence exists that poor prognosis is common in Middle East respiratory syndrome coronavirus (MERS-CoV) patients.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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