Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances
Identifieur interne : 001C12 ( Ncbi/Merge ); précédent : 001C11; suivant : 001C13Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances
Auteurs : Stephen A. Goldstein [États-Unis] ; Susan R. Weiss [États-Unis]Source :
- F1000Research [ 2046-1402 ] ; 2017.
Abstract
Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery.
Url:
DOI: 10.12688/f1000research.11827.1
PubMed: 29026532
PubMed Central: 5583735
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name>
</author>
<author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name>
</author>
<author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cho, Sy" uniqKey="Cho S">SY Cho</name>
</author>
<author><name sortKey="Kang, Jm" uniqKey="Kang J">JM Kang</name>
</author>
<author><name sortKey="Ha, Ye" uniqKey="Ha Y">YE Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name>
</author>
<author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liljander, A" uniqKey="Liljander A">A Liljander</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name>
</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Benedictis, P" uniqKey="De Benedictis P">P De Benedictis</name>
</author>
<author><name sortKey="Marciano, S" uniqKey="Marciano S">S Marciano</name>
</author>
<author><name sortKey="Scaravelli, D" uniqKey="Scaravelli D">D Scaravelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lelli, D" uniqKey="Lelli D">D Lelli</name>
</author>
<author><name sortKey="Papetti, A" uniqKey="Papetti A">A Papetti</name>
</author>
<author><name sortKey="Sabelli, C" uniqKey="Sabelli C">C Sabelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Ojeda Flores, R" uniqKey="Ojeda Flores R">R Ojeda-Flores</name>
</author>
<author><name sortKey="Rico Chavez, O" uniqKey="Rico Chavez O">O Rico-Chávez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="G Es, Lg" uniqKey="G Es L">LG Góes</name>
</author>
<author><name sortKey="Ruvalcaba, Sg" uniqKey="Ruvalcaba S">SG Ruvalcaba</name>
</author>
<author><name sortKey="Campos, Aa" uniqKey="Campos A">AA Campos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wacharapluesadee, S" uniqKey="Wacharapluesadee S">S Wacharapluesadee</name>
</author>
<author><name sortKey="Sintunawa, C" uniqKey="Sintunawa C">C Sintunawa</name>
</author>
<author><name sortKey="Kaewpom, T" uniqKey="Kaewpom T">T Kaewpom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Johnson, Ck" uniqKey="Johnson C">CK Johnson</name>
</author>
<author><name sortKey="Greig, Dj" uniqKey="Greig D">DJ Greig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name>
</author>
<author><name sortKey="Olival, Kj" uniqKey="Olival K">KJ Olival</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ithete, Nl" uniqKey="Ithete N">NL Ithete</name>
</author>
<author><name sortKey="Stoffberg, S" uniqKey="Stoffberg S">S Stoffberg</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name>
</author>
<author><name sortKey="Baldwin, Hj" uniqKey="Baldwin H">HJ Baldwin</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Ithete, Nl" uniqKey="Ithete N">NL Ithete</name>
</author>
<author><name sortKey="Richards, Lr" uniqKey="Richards L">LR Richards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Gilardi, K" uniqKey="Gilardi K">K Gilardi</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name>
</author>
<author><name sortKey="Kayali, G" uniqKey="Kayali G">G Kayali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saeed, Aa" uniqKey="Saeed A">AA Saeed</name>
</author>
<author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name>
</author>
<author><name sortKey="Alzahrani, Ag" uniqKey="Alzahrani A">AG Alzahrani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Messadi, L" uniqKey="Messadi L">L Messadi</name>
</author>
<author><name sortKey="Feyisa, A" uniqKey="Feyisa A">A Feyisa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miguel, E" uniqKey="Miguel E">E Miguel</name>
</author>
<author><name sortKey="Chevalier, V" uniqKey="Chevalier V">V Chevalier</name>
</author>
<author><name sortKey="Ayelet, G" uniqKey="Ayelet G">G Ayelet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sabir, Js" uniqKey="Sabir J">JS Sabir</name>
</author>
<author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name>
</author>
<author><name sortKey="Ahmed, Mm" uniqKey="Ahmed M">MM Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Dl" uniqKey="Ng D">DL Ng</name>
</author>
<author><name sortKey="Al Hosani, F" uniqKey="Al Hosani F">F Al Hosani</name>
</author>
<author><name sortKey="Keating, Mk" uniqKey="Keating M">MK Keating</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y Yao</name>
</author>
<author><name sortKey="Bao, L" uniqKey="Bao L">L Bao</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baseler, Lj" uniqKey="Baseler L">LJ Baseler</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, P" uniqKey="Yu P">P Yu</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Rf" uniqKey="Johnson R">RF Johnson</name>
</author>
<author><name sortKey="Via, Le" uniqKey="Via L">LE Via</name>
</author>
<author><name sortKey="Kumar, Mr" uniqKey="Kumar M">MR Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Peck, Km" uniqKey="Peck K">KM Peck</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peck, Km" uniqKey="Peck K">KM Peck</name>
</author>
<author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name>
</author>
<author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name>
</author>
<author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
<author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name>
</author>
<author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name>
</author>
<author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Sisk, Jm" uniqKey="Sisk J">JM Sisk</name>
</author>
<author><name sortKey="Halasz, G" uniqKey="Halasz G">G Halasz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamers, Mm" uniqKey="Lamers M">MM Lamers</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Shafei, M" uniqKey="Shafei M">M Shafei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, Cl" uniqKey="Wohlford Lenane C">CL Wohlford-Lenane</name>
</author>
<author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name>
</author>
<author><name sortKey="J Nsd Ttir, Hr" uniqKey="J Nsd Ttir H">HR Jónsdóttir</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zielecki, F" uniqKey="Zielecki F">F Zielecki</name>
</author>
<author><name sortKey="Weber, M" uniqKey="Weber M">M Weber</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rabouw, Hh" uniqKey="Rabouw H">HH Rabouw</name>
</author>
<author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name>
</author>
<author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Eisfeld, Aj" uniqKey="Eisfeld A">AJ Eisfeld</name>
</author>
<author><name sortKey="Sch Fer, A" uniqKey="Sch Fer A">A Schäfer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name>
</author>
<author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name>
</author>
<author><name sortKey="Nakagawa, K" uniqKey="Nakagawa K">K Nakagawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bailey Elkin, Ba" uniqKey="Bailey Elkin B">BA Bailey-Elkin</name>
</author>
<author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name>
</author>
<author><name sortKey="Johnson, Gg" uniqKey="Johnson G">GG Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mielech, Am" uniqKey="Mielech A">AM Mielech</name>
</author>
<author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A Kilianski</name>
</author>
<author><name sortKey="Baez Santos, Ym" uniqKey="Baez Santos Y">YM Baez-Santos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Geng, H" uniqKey="Geng H">H Geng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lui, Py" uniqKey="Lui P">PY Lui</name>
</author>
<author><name sortKey="Wong, Ly" uniqKey="Wong L">LY Wong</name>
</author>
<author><name sortKey="Fung, Cl" uniqKey="Fung C">CL Fung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siu, Kl" uniqKey="Siu K">KL Siu</name>
</author>
<author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name>
</author>
<author><name sortKey="Kok, Kh" uniqKey="Kok K">KH Kok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D Niemeyer</name>
</author>
<author><name sortKey="Zillinger, T" uniqKey="Zillinger T">T Zillinger</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthews, Kl" uniqKey="Matthews K">KL Matthews</name>
</author>
<author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Ye, F" uniqKey="Ye F">F Ye</name>
</author>
<author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thornbrough, Jm" uniqKey="Thornbrough J">JM Thornbrough</name>
</author>
<author><name sortKey="Jha, Bk" uniqKey="Jha B">BK Jha</name>
</author>
<author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
</author>
<author><name sortKey="Jha, Bk" uniqKey="Jha B">BK Jha</name>
</author>
<author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name>
</author>
<author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="Adney, Dr" uniqKey="Adney D">DR Adney</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adney, Dr" uniqKey="Adney D">DR Adney</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
<author><name sortKey="Brown, Vr" uniqKey="Brown V">VR Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khalafalla, Ai" uniqKey="Khalafalla A">AI Khalafalla</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Al Mubarak, Ai" uniqKey="Al Mubarak A">AI Al-Mubarak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<double pmid="29026532"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances</title>
<author><name sortKey="Goldstein, Stephen A" sort="Goldstein, Stephen A" uniqKey="Goldstein S" first="Stephen A." last="Goldstein">Stephen A. Goldstein</name>
<affiliation wicri:level="2"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="2"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
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<idno type="pmid">29026532</idno>
<idno type="pmc">5583735</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583735</idno>
<idno type="RBID">PMC:5583735</idno>
<idno type="doi">10.12688/f1000research.11827.1</idno>
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<idno type="wicri:Area/Pmc/Checkpoint">000759</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000759</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances</title>
<author><name sortKey="Goldstein, Stephen A" sort="Goldstein, Stephen A" uniqKey="Goldstein S" first="Stephen A." last="Goldstein">Stephen A. Goldstein</name>
<affiliation wicri:level="2"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="2"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">F1000Research</title>
<idno type="eISSN">2046-1402</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
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</profileDesc>
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name>
</author>
<author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name>
</author>
<author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cho, Sy" uniqKey="Cho S">SY Cho</name>
</author>
<author><name sortKey="Kang, Jm" uniqKey="Kang J">JM Kang</name>
</author>
<author><name sortKey="Ha, Ye" uniqKey="Ha Y">YE Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name>
</author>
<author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liljander, A" uniqKey="Liljander A">A Liljander</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name>
</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Benedictis, P" uniqKey="De Benedictis P">P De Benedictis</name>
</author>
<author><name sortKey="Marciano, S" uniqKey="Marciano S">S Marciano</name>
</author>
<author><name sortKey="Scaravelli, D" uniqKey="Scaravelli D">D Scaravelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lelli, D" uniqKey="Lelli D">D Lelli</name>
</author>
<author><name sortKey="Papetti, A" uniqKey="Papetti A">A Papetti</name>
</author>
<author><name sortKey="Sabelli, C" uniqKey="Sabelli C">C Sabelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Ojeda Flores, R" uniqKey="Ojeda Flores R">R Ojeda-Flores</name>
</author>
<author><name sortKey="Rico Chavez, O" uniqKey="Rico Chavez O">O Rico-Chávez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="G Es, Lg" uniqKey="G Es L">LG Góes</name>
</author>
<author><name sortKey="Ruvalcaba, Sg" uniqKey="Ruvalcaba S">SG Ruvalcaba</name>
</author>
<author><name sortKey="Campos, Aa" uniqKey="Campos A">AA Campos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wacharapluesadee, S" uniqKey="Wacharapluesadee S">S Wacharapluesadee</name>
</author>
<author><name sortKey="Sintunawa, C" uniqKey="Sintunawa C">C Sintunawa</name>
</author>
<author><name sortKey="Kaewpom, T" uniqKey="Kaewpom T">T Kaewpom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Johnson, Ck" uniqKey="Johnson C">CK Johnson</name>
</author>
<author><name sortKey="Greig, Dj" uniqKey="Greig D">DJ Greig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name>
</author>
<author><name sortKey="Olival, Kj" uniqKey="Olival K">KJ Olival</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ithete, Nl" uniqKey="Ithete N">NL Ithete</name>
</author>
<author><name sortKey="Stoffberg, S" uniqKey="Stoffberg S">S Stoffberg</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name>
</author>
<author><name sortKey="Baldwin, Hj" uniqKey="Baldwin H">HJ Baldwin</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Ithete, Nl" uniqKey="Ithete N">NL Ithete</name>
</author>
<author><name sortKey="Richards, Lr" uniqKey="Richards L">LR Richards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Gilardi, K" uniqKey="Gilardi K">K Gilardi</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name>
</author>
<author><name sortKey="Kayali, G" uniqKey="Kayali G">G Kayali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saeed, Aa" uniqKey="Saeed A">AA Saeed</name>
</author>
<author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name>
</author>
<author><name sortKey="Alzahrani, Ag" uniqKey="Alzahrani A">AG Alzahrani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Messadi, L" uniqKey="Messadi L">L Messadi</name>
</author>
<author><name sortKey="Feyisa, A" uniqKey="Feyisa A">A Feyisa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miguel, E" uniqKey="Miguel E">E Miguel</name>
</author>
<author><name sortKey="Chevalier, V" uniqKey="Chevalier V">V Chevalier</name>
</author>
<author><name sortKey="Ayelet, G" uniqKey="Ayelet G">G Ayelet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sabir, Js" uniqKey="Sabir J">JS Sabir</name>
</author>
<author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name>
</author>
<author><name sortKey="Ahmed, Mm" uniqKey="Ahmed M">MM Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Dl" uniqKey="Ng D">DL Ng</name>
</author>
<author><name sortKey="Al Hosani, F" uniqKey="Al Hosani F">F Al Hosani</name>
</author>
<author><name sortKey="Keating, Mk" uniqKey="Keating M">MK Keating</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y Yao</name>
</author>
<author><name sortKey="Bao, L" uniqKey="Bao L">L Bao</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baseler, Lj" uniqKey="Baseler L">LJ Baseler</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, P" uniqKey="Yu P">P Yu</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Rf" uniqKey="Johnson R">RF Johnson</name>
</author>
<author><name sortKey="Via, Le" uniqKey="Via L">LE Via</name>
</author>
<author><name sortKey="Kumar, Mr" uniqKey="Kumar M">MR Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Peck, Km" uniqKey="Peck K">KM Peck</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peck, Km" uniqKey="Peck K">KM Peck</name>
</author>
<author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name>
</author>
<author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name>
</author>
<author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
<author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name>
</author>
<author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name>
</author>
<author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Sisk, Jm" uniqKey="Sisk J">JM Sisk</name>
</author>
<author><name sortKey="Halasz, G" uniqKey="Halasz G">G Halasz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamers, Mm" uniqKey="Lamers M">MM Lamers</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Shafei, M" uniqKey="Shafei M">M Shafei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, Cl" uniqKey="Wohlford Lenane C">CL Wohlford-Lenane</name>
</author>
<author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name>
</author>
<author><name sortKey="J Nsd Ttir, Hr" uniqKey="J Nsd Ttir H">HR Jónsdóttir</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zielecki, F" uniqKey="Zielecki F">F Zielecki</name>
</author>
<author><name sortKey="Weber, M" uniqKey="Weber M">M Weber</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rabouw, Hh" uniqKey="Rabouw H">HH Rabouw</name>
</author>
<author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name>
</author>
<author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Eisfeld, Aj" uniqKey="Eisfeld A">AJ Eisfeld</name>
</author>
<author><name sortKey="Sch Fer, A" uniqKey="Sch Fer A">A Schäfer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name>
</author>
<author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name>
</author>
<author><name sortKey="Nakagawa, K" uniqKey="Nakagawa K">K Nakagawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bailey Elkin, Ba" uniqKey="Bailey Elkin B">BA Bailey-Elkin</name>
</author>
<author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name>
</author>
<author><name sortKey="Johnson, Gg" uniqKey="Johnson G">GG Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mielech, Am" uniqKey="Mielech A">AM Mielech</name>
</author>
<author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A Kilianski</name>
</author>
<author><name sortKey="Baez Santos, Ym" uniqKey="Baez Santos Y">YM Baez-Santos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Geng, H" uniqKey="Geng H">H Geng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lui, Py" uniqKey="Lui P">PY Lui</name>
</author>
<author><name sortKey="Wong, Ly" uniqKey="Wong L">LY Wong</name>
</author>
<author><name sortKey="Fung, Cl" uniqKey="Fung C">CL Fung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siu, Kl" uniqKey="Siu K">KL Siu</name>
</author>
<author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name>
</author>
<author><name sortKey="Kok, Kh" uniqKey="Kok K">KH Kok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D Niemeyer</name>
</author>
<author><name sortKey="Zillinger, T" uniqKey="Zillinger T">T Zillinger</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthews, Kl" uniqKey="Matthews K">KL Matthews</name>
</author>
<author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Ye, F" uniqKey="Ye F">F Ye</name>
</author>
<author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thornbrough, Jm" uniqKey="Thornbrough J">JM Thornbrough</name>
</author>
<author><name sortKey="Jha, Bk" uniqKey="Jha B">BK Jha</name>
</author>
<author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
</author>
<author><name sortKey="Jha, Bk" uniqKey="Jha B">BK Jha</name>
</author>
<author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name>
</author>
<author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="Adney, Dr" uniqKey="Adney D">DR Adney</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adney, Dr" uniqKey="Adney D">DR Adney</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
<author><name sortKey="Brown, Vr" uniqKey="Brown V">VR Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khalafalla, Ai" uniqKey="Khalafalla A">AI Khalafalla</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Al Mubarak, Ai" uniqKey="Al Mubarak A">AI Al-Mubarak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances.</title>
<author><name sortKey="Goldstein, Stephen A" sort="Goldstein, Stephen A" uniqKey="Goldstein S" first="Stephen A" last="Goldstein">Stephen A. Goldstein</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R" last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
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<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2017">2017</date>
<idno type="RBID">pubmed:29026532</idno>
<idno type="pmid">29026532</idno>
<idno type="doi">10.12688/f1000research.11827.1</idno>
<idno type="wicri:Area/PubMed/Corpus">000B21</idno>
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<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B84</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances.</title>
<author><name sortKey="Goldstein, Stephen A" sort="Goldstein, Stephen A" uniqKey="Goldstein S" first="Stephen A" last="Goldstein">Stephen A. Goldstein</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R" last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">F1000Research</title>
<idno type="ISSN">2046-1402</idno>
<imprint><date when="2017" type="published">2017</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery.</div>
</front>
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