Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances
Identifieur interne : 001327 ( Pmc/Curation ); précédent : 001326; suivant : 001328Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances
Auteurs : Stephen A. Goldstein [États-Unis] ; Susan R. Weiss [États-Unis]Source :
- F1000Research [ 2046-1402 ] ; 2017.
Abstract
Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery.
Url:
DOI: 10.12688/f1000research.11827.1
PubMed: 29026532
PubMed Central: 5583735
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001327
Links to Exploration step
PMC:5583735Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances</title>
<author><name sortKey="Goldstein, Stephen A" sort="Goldstein, Stephen A" uniqKey="Goldstein S" first="Stephen A." last="Goldstein">Stephen A. Goldstein</name>
<affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">29026532</idno>
<idno type="pmc">5583735</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583735</idno>
<idno type="RBID">PMC:5583735</idno>
<idno type="doi">10.12688/f1000research.11827.1</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">001327</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001327</idno>
<idno type="wicri:Area/Pmc/Curation">001327</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">001327</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances</title>
<author><name sortKey="Goldstein, Stephen A" sort="Goldstein, Stephen A" uniqKey="Goldstein S" first="Stephen A." last="Goldstein">Stephen A. Goldstein</name>
<affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Weiss, Susan R" sort="Weiss, Susan R" uniqKey="Weiss S" first="Susan R." last="Weiss">Susan R. Weiss</name>
<affiliation wicri:level="1"><nlm:aff id="a1">Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">F1000Research</title>
<idno type="eISSN">2046-1402</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name>
</author>
<author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Abdallat, Mm" uniqKey="Al Abdallat M">MM Al-Abdallat</name>
</author>
<author><name sortKey="Payne, Dc" uniqKey="Payne D">DC Payne</name>
</author>
<author><name sortKey="Alqasrawi, S" uniqKey="Alqasrawi S">S Alqasrawi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cho, Sy" uniqKey="Cho S">SY Cho</name>
</author>
<author><name sortKey="Kang, Jm" uniqKey="Kang J">JM Kang</name>
</author>
<author><name sortKey="Ha, Ye" uniqKey="Ha Y">YE Ha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name>
</author>
<author><name sortKey="De Graaf, M" uniqKey="De Graaf M">M de Graaf</name>
</author>
<author><name sortKey="Lauber, C" uniqKey="Lauber C">C Lauber</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liljander, A" uniqKey="Liljander A">A Liljander</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name>
</author>
<author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name>
</author>
<author><name sortKey="Lau, Sk" uniqKey="Lau S">SK Lau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Benedictis, P" uniqKey="De Benedictis P">P De Benedictis</name>
</author>
<author><name sortKey="Marciano, S" uniqKey="Marciano S">S Marciano</name>
</author>
<author><name sortKey="Scaravelli, D" uniqKey="Scaravelli D">D Scaravelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lelli, D" uniqKey="Lelli D">D Lelli</name>
</author>
<author><name sortKey="Papetti, A" uniqKey="Papetti A">A Papetti</name>
</author>
<author><name sortKey="Sabelli, C" uniqKey="Sabelli C">C Sabelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Ojeda Flores, R" uniqKey="Ojeda Flores R">R Ojeda-Flores</name>
</author>
<author><name sortKey="Rico Chavez, O" uniqKey="Rico Chavez O">O Rico-Chávez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="G Es, Lg" uniqKey="G Es L">LG Góes</name>
</author>
<author><name sortKey="Ruvalcaba, Sg" uniqKey="Ruvalcaba S">SG Ruvalcaba</name>
</author>
<author><name sortKey="Campos, Aa" uniqKey="Campos A">AA Campos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wacharapluesadee, S" uniqKey="Wacharapluesadee S">S Wacharapluesadee</name>
</author>
<author><name sortKey="Sintunawa, C" uniqKey="Sintunawa C">C Sintunawa</name>
</author>
<author><name sortKey="Kaewpom, T" uniqKey="Kaewpom T">T Kaewpom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Johnson, Ck" uniqKey="Johnson C">CK Johnson</name>
</author>
<author><name sortKey="Greig, Dj" uniqKey="Greig D">DJ Greig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name>
</author>
<author><name sortKey="Olival, Kj" uniqKey="Olival K">KJ Olival</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ithete, Nl" uniqKey="Ithete N">NL Ithete</name>
</author>
<author><name sortKey="Stoffberg, S" uniqKey="Stoffberg S">S Stoffberg</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name>
</author>
<author><name sortKey="Baldwin, Hj" uniqKey="Baldwin H">HJ Baldwin</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Ithete, Nl" uniqKey="Ithete N">NL Ithete</name>
</author>
<author><name sortKey="Richards, Lr" uniqKey="Richards L">LR Richards</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anthony, Sj" uniqKey="Anthony S">SJ Anthony</name>
</author>
<author><name sortKey="Gilardi, K" uniqKey="Gilardi K">K Gilardi</name>
</author>
<author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Memish, Za" uniqKey="Memish Z">ZA Memish</name>
</author>
<author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name>
</author>
<author><name sortKey="Kayali, G" uniqKey="Kayali G">G Kayali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farag, Ea" uniqKey="Farag E">EA Farag</name>
</author>
<author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saeed, Aa" uniqKey="Saeed A">AA Saeed</name>
</author>
<author><name sortKey="Abedi, Gr" uniqKey="Abedi G">GR Abedi</name>
</author>
<author><name sortKey="Alzahrani, Ag" uniqKey="Alzahrani A">AG Alzahrani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Müller</name>
</author>
<author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name>
</author>
<author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name>
</author>
<author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name>
</author>
<author><name sortKey="Messadi, L" uniqKey="Messadi L">L Messadi</name>
</author>
<author><name sortKey="Feyisa, A" uniqKey="Feyisa A">A Feyisa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miguel, E" uniqKey="Miguel E">E Miguel</name>
</author>
<author><name sortKey="Chevalier, V" uniqKey="Chevalier V">V Chevalier</name>
</author>
<author><name sortKey="Ayelet, G" uniqKey="Ayelet G">G Ayelet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sabir, Js" uniqKey="Sabir J">JS Sabir</name>
</author>
<author><name sortKey="Lam, Tt" uniqKey="Lam T">TT Lam</name>
</author>
<author><name sortKey="Ahmed, Mm" uniqKey="Ahmed M">MM Ahmed</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ng, Dl" uniqKey="Ng D">DL Ng</name>
</author>
<author><name sortKey="Al Hosani, F" uniqKey="Al Hosani F">F Al Hosani</name>
</author>
<author><name sortKey="Keating, Mk" uniqKey="Keating M">MK Keating</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Rasmussen, Al" uniqKey="Rasmussen A">AL Rasmussen</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yao, Y" uniqKey="Yao Y">Y Yao</name>
</author>
<author><name sortKey="Bao, L" uniqKey="Bao L">L Bao</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Sims, Ac" uniqKey="Sims A">AC Sims</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name>
</author>
<author><name sortKey="Feldmann, F" uniqKey="Feldmann F">F Feldmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baseler, Lj" uniqKey="Baseler L">LJ Baseler</name>
</author>
<author><name sortKey="Falzarano, D" uniqKey="Falzarano D">D Falzarano</name>
</author>
<author><name sortKey="Scott, Dp" uniqKey="Scott D">DP Scott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, P" uniqKey="Yu P">P Yu</name>
</author>
<author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johnson, Rf" uniqKey="Johnson R">RF Johnson</name>
</author>
<author><name sortKey="Via, Le" uniqKey="Via L">LE Via</name>
</author>
<author><name sortKey="Kumar, Mr" uniqKey="Kumar M">MR Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Peck, Km" uniqKey="Peck K">KM Peck</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peck, Km" uniqKey="Peck K">KM Peck</name>
</author>
<author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cockrell, As" uniqKey="Cockrell A">AS Cockrell</name>
</author>
<author><name sortKey="Yount, Bl" uniqKey="Yount B">BL Yount</name>
</author>
<author><name sortKey="Scobey, T" uniqKey="Scobey T">T Scobey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name>
</author>
<author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name>
</author>
<author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tao, X" uniqKey="Tao X">X Tao</name>
</author>
<author><name sortKey="Garron, T" uniqKey="Garron T">T Garron</name>
</author>
<author><name sortKey="Agrawal, As" uniqKey="Agrawal A">AS Agrawal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Jiang, Y" uniqKey="Jiang Y">Y Jiang</name>
</author>
<author><name sortKey="Qiu, H" uniqKey="Qiu H">H Qiu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, C" uniqKey="Wohlford Lenane C">C Wohlford-Lenane</name>
</author>
<author><name sortKey="Perlman, S" uniqKey="Perlman S">S Perlman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pascal, Ke" uniqKey="Pascal K">KE Pascal</name>
</author>
<author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Mujica, Ao" uniqKey="Mujica A">AO Mujica</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Sisk, Jm" uniqKey="Sisk J">JM Sisk</name>
</author>
<author><name sortKey="Halasz, G" uniqKey="Halasz G">G Halasz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lamers, Mm" uniqKey="Lamers M">MM Lamers</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
<author><name sortKey="Shafei, M" uniqKey="Shafei M">M Shafei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wohlford Lenane, Cl" uniqKey="Wohlford Lenane C">CL Wohlford-Lenane</name>
</author>
<author><name sortKey="Channappanavar, R" uniqKey="Channappanavar R">R Channappanavar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kindler, E" uniqKey="Kindler E">E Kindler</name>
</author>
<author><name sortKey="J Nsd Ttir, Hr" uniqKey="J Nsd Ttir H">HR Jónsdóttir</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chan, Rw" uniqKey="Chan R">RW Chan</name>
</author>
<author><name sortKey="Chan, Mc" uniqKey="Chan M">MC Chan</name>
</author>
<author><name sortKey="Agnihothram, S" uniqKey="Agnihothram S">S Agnihothram</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zielecki, F" uniqKey="Zielecki F">F Zielecki</name>
</author>
<author><name sortKey="Weber, M" uniqKey="Weber M">M Weber</name>
</author>
<author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M Eickmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rabouw, Hh" uniqKey="Rabouw H">HH Rabouw</name>
</author>
<author><name sortKey="Langereis, Ma" uniqKey="Langereis M">MA Langereis</name>
</author>
<author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name>
</author>
<author><name sortKey="Eisfeld, Aj" uniqKey="Eisfeld A">AJ Eisfeld</name>
</author>
<author><name sortKey="Sch Fer, A" uniqKey="Sch Fer A">A Schäfer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lokugamage, Kg" uniqKey="Lokugamage K">KG Lokugamage</name>
</author>
<author><name sortKey="Narayanan, K" uniqKey="Narayanan K">K Narayanan</name>
</author>
<author><name sortKey="Nakagawa, K" uniqKey="Nakagawa K">K Nakagawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bailey Elkin, Ba" uniqKey="Bailey Elkin B">BA Bailey-Elkin</name>
</author>
<author><name sortKey="Knaap, Rc" uniqKey="Knaap R">RC Knaap</name>
</author>
<author><name sortKey="Johnson, Gg" uniqKey="Johnson G">GG Johnson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mielech, Am" uniqKey="Mielech A">AM Mielech</name>
</author>
<author><name sortKey="Kilianski, A" uniqKey="Kilianski A">A Kilianski</name>
</author>
<author><name sortKey="Baez Santos, Ym" uniqKey="Baez Santos Y">YM Baez-Santos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Zhang, L" uniqKey="Zhang L">L Zhang</name>
</author>
<author><name sortKey="Geng, H" uniqKey="Geng H">H Geng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lui, Py" uniqKey="Lui P">PY Lui</name>
</author>
<author><name sortKey="Wong, Ly" uniqKey="Wong L">LY Wong</name>
</author>
<author><name sortKey="Fung, Cl" uniqKey="Fung C">CL Fung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siu, Kl" uniqKey="Siu K">KL Siu</name>
</author>
<author><name sortKey="Yeung, Ml" uniqKey="Yeung M">ML Yeung</name>
</author>
<author><name sortKey="Kok, Kh" uniqKey="Kok K">KH Kok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Niemeyer, D" uniqKey="Niemeyer D">D Niemeyer</name>
</author>
<author><name sortKey="Zillinger, T" uniqKey="Zillinger T">T Zillinger</name>
</author>
<author><name sortKey="Muth, D" uniqKey="Muth D">D Muth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matthews, Kl" uniqKey="Matthews K">KL Matthews</name>
</author>
<author><name sortKey="Coleman, Cm" uniqKey="Coleman C">CM Coleman</name>
</author>
<author><name sortKey="Van Der Meer, Y" uniqKey="Van Der Meer Y">Y van der Meer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name>
</author>
<author><name sortKey="Ye, F" uniqKey="Ye F">F Ye</name>
</author>
<author><name sortKey="Zhu, N" uniqKey="Zhu N">N Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thornbrough, Jm" uniqKey="Thornbrough J">JM Thornbrough</name>
</author>
<author><name sortKey="Jha, Bk" uniqKey="Jha B">BK Jha</name>
</author>
<author><name sortKey="Yount, B" uniqKey="Yount B">B Yount</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L Zhao</name>
</author>
<author><name sortKey="Jha, Bk" uniqKey="Jha B">BK Jha</name>
</author>
<author><name sortKey="Wu, A" uniqKey="Wu A">A Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name>
</author>
<author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name>
</author>
<author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Munster, Vj" uniqKey="Munster V">VJ Munster</name>
</author>
<author><name sortKey="Adney, Dr" uniqKey="Adney D">DR Adney</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Adney, Dr" uniqKey="Adney D">DR Adney</name>
</author>
<author><name sortKey="Van Doremalen, N" uniqKey="Van Doremalen N">N van Doremalen</name>
</author>
<author><name sortKey="Brown, Vr" uniqKey="Brown V">VR Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khalafalla, Ai" uniqKey="Khalafalla A">AI Khalafalla</name>
</author>
<author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name>
</author>
<author><name sortKey="Al Mubarak, Ai" uniqKey="Al Mubarak A">AI Al-Mubarak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name>
</author>
<author><name sortKey="Van Den Brand, Jm" uniqKey="Van Den Brand J">JM van den Brand</name>
</author>
<author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">F1000Res</journal-id>
<journal-id journal-id-type="iso-abbrev">F1000Res</journal-id>
<journal-id journal-id-type="pmc">F1000Research</journal-id>
<journal-title-group><journal-title>F1000Research</journal-title>
</journal-title-group>
<issn pub-type="epub">2046-1402</issn>
<publisher><publisher-name>F1000Research</publisher-name>
<publisher-loc>London, UK</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">29026532</article-id>
<article-id pub-id-type="pmc">5583735</article-id>
<article-id pub-id-type="doi">10.12688/f1000research.11827.1</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
<subj-group><subject>Articles</subject>
<subj-group><subject>Animal Genetics</subject>
</subj-group>
<subj-group><subject>Cellular Microbiology & Pathogenesis</subject>
</subj-group>
<subj-group><subject>Epidemiology</subject>
</subj-group>
<subj-group><subject>Genetics of the Immune System</subject>
</subj-group>
<subj-group><subject>Immune Response</subject>
</subj-group>
<subj-group><subject>Immunity to Infections</subject>
</subj-group>
<subj-group><subject>Leukocyte Signaling & Gene Expression</subject>
</subj-group>
<subj-group><subject>Medical Microbiology</subject>
</subj-group>
<subj-group><subject>Microbial Evolution & Genomics</subject>
</subj-group>
<subj-group><subject>Nosocomial & Healthcare-Associated Infections</subject>
</subj-group>
<subj-group><subject>Tropical & Travel-Associated Diseases</subject>
</subj-group>
<subj-group><subject>Viral Infections (without HIV)</subject>
</subj-group>
<subj-group><subject>Virology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances</article-title>
<fn-group content-type="pub-status"><fn><p>[version 1; referees: 3 approved]</p>
</fn>
</fn-group>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Goldstein</surname>
<given-names>Stephen A.</given-names>
</name>
<role content-type="http://credit.casrai.org/">Conceptualization</role>
<role content-type="http://credit.casrai.org/">Writing – Original Draft Preparation</role>
<role content-type="http://credit.casrai.org/">Writing – Review & Editing</role>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Weiss</surname>
<given-names>Susan R.</given-names>
</name>
<role content-type="http://credit.casrai.org/">Conceptualization</role>
<role content-type="http://credit.casrai.org/">Funding Acquisition</role>
<role content-type="http://credit.casrai.org/">Writing – Review & Editing</role>
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8155-4528</contrib-id>
<xref ref-type="corresp" rid="c1">a</xref>
<xref ref-type="aff" rid="a1">1</xref>
</contrib>
<aff id="a1"><label>1</label>
Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA</aff>
</contrib-group>
<author-notes><corresp id="c1"><label>a</label>
<email xlink:href="mailto:weisssr@mail.med.upenn.edu">weisssr@mail.med.upenn.edu</email>
</corresp>
<fn fn-type="COI-statement"><p><bold>Competing interests: </bold>
The authors declare that they have no competing interests.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>1</day>
<month>9</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<volume>6</volume>
<elocation-id>1628</elocation-id>
<history><date date-type="accepted"><day>22</day>
<month>8</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © 2017 Goldstein SA and Weiss SR</copyright-statement>
<copyright-year>2017</copyright-year>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="f1000research-6-12781.pdf"></self-uri>
<abstract><p>Middle East respiratory syndrome-associated coronavirus (MERS-CoV) has been a significant research focus since its discovery in 2012. Since 2012, 2,040 cases and 712 deaths have been recorded (as of August 11, 2017), representing a strikingly high case fatality rate of 36%. Over the last several years, MERS-CoV research has progressed in several parallel and complementary directions. This review will focus on three particular areas: the origins and evolution of MERS-CoV, the challenges and achievements in the development of MERS-CoV animal models, and our understanding of how novel proteins unique to MERS-CoV counter the host immune response. The origins of MERS-CoV, likely in African bats, are increasingly clear, although important questions remain about the establishment of dromedary camels as a reservoir seeding human outbreaks. Likewise, there have been important advances in the development of animal models, and both non-human primate and mouse models that seem to recapitulate human disease are now available. How MERS-CoV evades and inhibits the host innate immune response remains less clear. Although several studies have identified MERS-CoV proteins as innate immune antagonists, little of this work has been conducted using live virus under conditions of actual infection, but rather with ectopically expressed proteins. Accordingly, considerable space remains for major contributions to understanding unique ways in which MERS-CoV interacts with and modulates the host response. Collectively, these areas have seen significant advances over the last several years but continue to offer exciting opportunities for discovery.</p>
</abstract>
<kwd-group kwd-group-type="author"><kwd>MERS</kwd>
<kwd>CoV</kwd>
<kwd>origin</kwd>
<kwd>pathogenesis</kwd>
</kwd-group>
<funding-group><award-group id="fund-1"><funding-source>National Institute of Allergy and Infectious Diseases, National Institutes of Health</funding-source>
<award-id>R01AI104887</award-id>
</award-group>
<award-group id="fund-2" xlink:href="http://dx.doi.org/10.13039/100000060"><funding-source>National Institute of Allergy and Infectious Diseases, National Institutes of Health</funding-source>
<award-id>R21AI114920</award-id>
</award-group>
<funding-statement>SRW received funding from the National Institute of Allergy and Infectious Disease of the National Institutes of Health under award numbers R21AI114920 and R01AI104887.</funding-statement>
<funding-statement><italic>The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</italic>
</funding-statement>
</funding-group>
</article-meta>
<notes><sec sec-type="editor-note"><title>Editorial Note on the Review Process</title>
<p><ext-link ext-link-type="uri" xlink:href="http://f1000research.com/browse/f1000-faculty-reviews">F1000 Faculty Reviews</ext-link>
are commissioned from members of the prestigious
<ext-link ext-link-type="uri" xlink:href="http://f1000.com/prime/thefaculty">F1000 Faculty</ext-link>
and are edited as a service to readers. In order to make these reviews as comprehensive and accessible as possible, the referees provide input before publication and only the final, revised version is published. The referees who approved the final version are listed with their names and affiliations but without their reports on earlier versions (any comments will already have been addressed in the published version).</p>
<p>The referees who approved this article are: </p>
<list list-type="simple" list-content="reviewer-list"><list-item><p><named-content content-type="reviewer-name">Vincent Munster</named-content>
, Rocky Mountain Laboratories, National Institutes of Health, Hamilton, MO, USA
<fn fn-type="COI-statement"><p>No competing interests were disclosed.</p>
</fn>
</p>
</list-item>
<list-item><p><named-content content-type="reviewer-name">Stanley Perlman</named-content>
, University of Iowa, Iowa City, USA
<fn fn-type="COI-statement"><p>No competing interests were disclosed.</p>
</fn>
</p>
</list-item>
<list-item><p><named-content content-type="reviewer-name">Shibo Jiang</named-content>
, New York Blood Center, New York, USA
<fn fn-type="COI-statement"><p>No competing interests were disclosed.</p>
</fn>
</p>
</list-item>
</list>
</sec>
</notes>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001327 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 001327 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:5583735 |texte= Origins and pathogenesis of Middle East respiratory syndrome-associated coronavirus: recent advances }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:29026532" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
This area was generated with Dilib version V0.6.33. |