Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia
Identifieur interne : 001B15 ( Ncbi/Merge ); précédent : 001B14; suivant : 001B16Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia
Auteurs : Anwar E. AhmedSource :
- International Journal of Infectious Diseases [ 1201-9712 ] ; 2017.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Arabie saoudite, Chameaux (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Infections à coronavirus (diagnostic), Jeune adulte, Mâle, Nourrisson, Retard de diagnostic, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
- MESH :
- diagnostic : Infections à coronavirus.
- virologie : Chameaux.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Retard de diagnostic, Sujet âgé, Sujet âgé de 80 ans ou plus, Études rétrospectives.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Coronavirus Infections.
- virology : Camelus.
- Adolescent, Adult, Aged, Aged, 80 and over, Animals, Child, Child, Preschool, Delayed Diagnosis, Female, Humans, Infant, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus, Retrospective Studies, Saudi Arabia, Young Adult.
Abstract
Although the literature indicates that patient delays in seeking medical support for Middle East respiratory syndrome coronavirus (MERS-CoV) infections are associated with poor clinical outcomes, delays in the diagnosis itself remain poorly understood in these patients. This study aimed to determine the median time interval from symptom onset to a confirmed diagnosis and to identify the potential predictors of this interval in Saudi Arabian MERS patients.
This was a retrospective study of patients with confirmed MERS who were publicly reported by the World Health Organization (WHO).
Five hundred and thirty-seven symptomatic cases of MERS-CoV infection were included. The median time interval between symptom onset and confirmation of the MERS diagnosis was 4 days (interquartile range 2–7 days), ranging from 0 to 36 days. According to the negative binomial model, the unadjusted rate ratio (RR) of delays in the diagnosis was significantly higher in older patients (>65 years) (RR 1.42), non-healthcare workers (RR 1.74), patients with severe illness (RR 1.22), those with an unknown source of infection (RR 1.84), and those who had been in close contact with camels (RR 1.74). After accounting for confounders, the adjusted rate ratio (aRR) of delays in the diagnosis was independently associated with unknown source of infection (aRR 1.68) and close contact with camels (aRR 1.58).
The time interval from symptom onset to diagnosis was greater in older patients, non-healthcare workers, patients with severe illness, patients with an unknown source of infection, and patients who had been in close contact with camels. The findings warrant educational interventions to raise general public awareness of the importance of early symptom notification.
Url:
DOI: 10.1016/j.ijid.2017.07.008
PubMed: 28728926
PubMed Central: 7110630
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PMC:7110630Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28728926</idno><idno type="pmc">7110630</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110630</idno><idno type="RBID">PMC:7110630</idno><idno type="doi">10.1016/j.ijid.2017.07.008</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000D53</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D53</idno><idno type="wicri:Area/Pmc/Curation">000D53</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D53</idno><idno type="wicri:Area/Pmc/Checkpoint">000885</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000885</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:28728926</idno><idno type="wicri:Area/PubMed/Corpus">000C20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C20</idno><idno type="wicri:Area/PubMed/Curation">000C20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C20</idno><idno type="wicri:Area/PubMed/Checkpoint">000D41</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D41</idno><idno type="wicri:Area/Ncbi/Merge">001B15</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Camelus (virology)</term><term>Child</term><term>Child, Preschool</term><term>Coronavirus Infections (diagnosis)</term><term>Delayed Diagnosis</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Retrospective Studies</term><term>Saudi Arabia</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Arabie saoudite</term><term>Chameaux (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (diagnostic)</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Retard de diagnostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Delayed Diagnosis</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Retrospective Studies</term><term>Saudi Arabia</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Retard de diagnostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Although the literature indicates that patient delays in seeking medical support for Middle East respiratory syndrome coronavirus (MERS-CoV) infections are associated with poor clinical outcomes, delays in the diagnosis itself remain poorly understood in these patients. This study aimed to determine the median time interval from symptom onset to a confirmed diagnosis and to identify the potential predictors of this interval in Saudi Arabian MERS patients.</p></sec><sec><title>Methods</title><p>This was a retrospective study of patients with confirmed MERS who were publicly reported by the World Health Organization (WHO).</p></sec><sec><title>Results</title><p>Five hundred and thirty-seven symptomatic cases of MERS-CoV infection were included. The median time interval between symptom onset and confirmation of the MERS diagnosis was 4 days (interquartile range 2–7 days), ranging from 0 to 36 days. According to the negative binomial model, the unadjusted rate ratio (RR) of delays in the diagnosis was significantly higher in older patients (>65 years) (RR 1.42), non-healthcare workers (RR 1.74), patients with severe illness (RR 1.22), those with an unknown source of infection (RR 1.84), and those who had been in close contact with camels (RR 1.74). After accounting for confounders, the adjusted rate ratio (aRR) of delays in the diagnosis was independently associated with unknown source of infection (aRR 1.68) and close contact with camels (aRR 1.58).</p></sec><sec><title>Conclusions</title><p>The time interval from symptom onset to diagnosis was greater in older patients, non-healthcare workers, patients with severe illness, patients with an unknown source of infection, and patients who had been in close contact with camels. The findings warrant educational interventions to raise general public awareness of the importance of early symptom notification.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Dorzi, H M" uniqKey="Al Dorzi H">H.M. Al-Dorzi</name></author><author><name sortKey="Aldawood, A S" uniqKey="Aldawood A">A.S. Aldawood</name></author><author><name sortKey="Khan, R" uniqKey="Khan R">R. 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Al-Abdely</name></author><author><name sortKey="Alzahrani, A" uniqKey="Alzahrani A">A. Alzahrani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alqahtani, A S" uniqKey="Alqahtani A">A.S. Alqahtani</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H. Rashid</name></author><author><name sortKey="Basyouni, M H" uniqKey="Basyouni M">M.H. Basyouni</name></author><author><name sortKey="Alhawassi, T M" uniqKey="Alhawassi T">T.M. Alhawassi</name></author><author><name sortKey="Bindhim, N F" uniqKey="Bindhim N">N.F. BinDhim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alsahafi, A J" uniqKey="Alsahafi A">A.J. Alsahafi</name></author><author><name sortKey="Cheng, A C" uniqKey="Cheng A">A.C. Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name></author><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. 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Al-Barrak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banik, G R" uniqKey="Banik G">G.R. Banik</name></author><author><name sortKey="Khandaker, G" uniqKey="Khandaker G">G. Khandaker</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H. Rashid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Banik, G R" uniqKey="Banik G">G.R. Banik</name></author><author><name sortKey="Alqahtani, A S" uniqKey="Alqahtani A">A.S. Alqahtani</name></author><author><name sortKey="Booy, R" uniqKey="Booy R">R. Booy</name></author><author><name sortKey="Rashid, H" uniqKey="Rashid H">H. Rashid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Das, K M" uniqKey="Das K">K.M. Das</name></author><author><name sortKey="Lee, E Y" uniqKey="Lee E">E.Y. Lee</name></author><author><name sortKey="Jawder, S E" uniqKey="Jawder S">S.E. 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Hamdan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. Van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A. Zumla</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="28728926"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28728926</idno><idno type="pmc">7110630</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110630</idno><idno type="RBID">PMC:7110630</idno><idno type="doi">10.1016/j.ijid.2017.07.008</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000D53</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000D53</idno><idno type="wicri:Area/Pmc/Curation">000D53</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000D53</idno><idno type="wicri:Area/Pmc/Checkpoint">000885</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000885</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E." last="Ahmed">Anwar E. Ahmed</name></author></analytic><series><title level="j">International Journal of Infectious Diseases</title><idno type="ISSN">1201-9712</idno><idno type="eISSN">1878-3511</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Although the literature indicates that patient delays in seeking medical support for Middle East respiratory syndrome coronavirus (MERS-CoV) infections are associated with poor clinical outcomes, delays in the diagnosis itself remain poorly understood in these patients. This study aimed to determine the median time interval from symptom onset to a confirmed diagnosis and to identify the potential predictors of this interval in Saudi Arabian MERS patients.</p></sec><sec><title>Methods</title><p>This was a retrospective study of patients with confirmed MERS who were publicly reported by the World Health Organization (WHO).</p></sec><sec><title>Results</title><p>Five hundred and thirty-seven symptomatic cases of MERS-CoV infection were included. The median time interval between symptom onset and confirmation of the MERS diagnosis was 4 days (interquartile range 2–7 days), ranging from 0 to 36 days. According to the negative binomial model, the unadjusted rate ratio (RR) of delays in the diagnosis was significantly higher in older patients (>65 years) (RR 1.42), non-healthcare workers (RR 1.74), patients with severe illness (RR 1.22), those with an unknown source of infection (RR 1.84), and those who had been in close contact with camels (RR 1.74). After accounting for confounders, the adjusted rate ratio (aRR) of delays in the diagnosis was independently associated with unknown source of infection (aRR 1.68) and close contact with camels (aRR 1.58).</p></sec><sec><title>Conclusions</title><p>The time interval from symptom onset to diagnosis was greater in older patients, non-healthcare workers, patients with severe illness, patients with an unknown source of infection, and patients who had been in close contact with camels. The findings warrant educational interventions to raise general public awareness of the importance of early symptom notification.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Al Dorzi, H M" uniqKey="Al Dorzi H">H.M. Al-Dorzi</name></author><author><name sortKey="Aldawood, A S" uniqKey="Aldawood A">A.S. Aldawood</name></author><author><name sortKey="Khan, R" uniqKey="Khan R">R. 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Hamdan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. Van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zumla, A" uniqKey="Zumla A">A. Zumla</name></author><author><name sortKey="Hui, D S" uniqKey="Hui D">D.S. Hui</name></author><author><name sortKey="Perlman, S" uniqKey="Perlman S">S. Perlman</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia.</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E" last="Ahmed">Anwar E. Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. Electronic address: ahmeda5@vcu.edu.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28728926</idno><idno type="pmid">28728926</idno><idno type="doi">10.1016/j.ijid.2017.07.008</idno><idno type="wicri:Area/PubMed/Corpus">000C20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C20</idno><idno type="wicri:Area/PubMed/Curation">000C20</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C20</idno><idno type="wicri:Area/PubMed/Checkpoint">000D41</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Diagnostic delays in 537 symptomatic cases of Middle East respiratory syndrome coronavirus infection in Saudi Arabia.</title><author><name sortKey="Ahmed, Anwar E" sort="Ahmed, Anwar E" uniqKey="Ahmed A" first="Anwar E" last="Ahmed">Anwar E. Ahmed</name><affiliation wicri:level="1"><nlm:affiliation>College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. Electronic address: ahmeda5@vcu.edu.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Public Health and Health Informatics, King Saud bin Abdulaziz University for Health Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases</title><idno type="eISSN">1878-3511</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Camelus (virology)</term><term>Child</term><term>Child, Preschool</term><term>Coronavirus Infections (diagnosis)</term><term>Delayed Diagnosis</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Retrospective Studies</term><term>Saudi Arabia</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Arabie saoudite</term><term>Chameaux (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Infections à coronavirus (diagnostic)</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Retard de diagnostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Camelus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Delayed Diagnosis</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus</term><term>Retrospective Studies</term><term>Saudi Arabia</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Arabie saoudite</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Nourrisson</term><term>Retard de diagnostic</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although the literature indicates that patient delays in seeking medical support for Middle East respiratory syndrome coronavirus (MERS-CoV) infections are associated with poor clinical outcomes, delays in the diagnosis itself remain poorly understood in these patients. This study aimed to determine the median time interval from symptom onset to a confirmed diagnosis and to identify the potential predictors of this interval in Saudi Arabian MERS patients.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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