Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients
Identifieur interne : 001616 ( Ncbi/Merge ); précédent : 001615; suivant : 001617Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients
Auteurs : Ghaleb A. Almekhlafi [Arabie saoudite] ; Mohammed M. Albarrak [Arabie saoudite] ; Yasser Mandourah [Arabie saoudite] ; Sahar Hassan [Arabie saoudite] ; Abid Alwan [Arabie saoudite] ; Abdullah Abudayah [Arabie saoudite] ; Sultan Altayyar [Arabie saoudite] ; Mohamed Mustafa [Arabie saoudite] ; Tareef Aldaghestani [Arabie saoudite] ; Adnan Alghamedi [Arabie saoudite] ; Ali Talag [Arabie saoudite] ; Muhammad K. Malik [Arabie saoudite] ; Ali S. Omrani [Arabie saoudite] ; Yasser Sakr [Allemagne]Source :
- Critical Care [ 1364-8535 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Arabie saoudite, Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité), Femelle, Humains, Infections à coronavirus (), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Mâle, Sujet âgé, Unités de soins intensifs, Ventilation artificielle (mortalité), Études de cohortes, Études rétrospectives.
- MESH :
- diagnostic : Infections à coronavirus.
- mortalité : Infections à coronavirus, Ventilation artificielle.
- pathogénicité : Coronavirus du syndrome respiratoire du Moyen-Orient.
- Adulte, Adulte d'âge moyen, Arabie saoudite, Femelle, Humains, Infections à coronavirus, Mâle, Sujet âgé, Unités de soins intensifs, Études de cohortes, Études rétrospectives.
English descriptors
- KwdEn :
- Adult, Aged, Cohort Studies, Coronavirus Infections (diagnosis), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Female, Humans, Intensive Care Units, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Respiration, Artificial (mortality), Retrospective Studies, Saudi Arabia.
- MESH :
- diagnosis : Coronavirus Infections.
- mortality : Coronavirus Infections, Respiration, Artificial.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- therapy : Coronavirus Infections.
- Adult, Aged, Cohort Studies, Female, Humans, Intensive Care Units, Male, Middle Aged, Retrospective Studies, Saudi Arabia.
Abstract
Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.
Retrospective analysis of data from all adult (>18 years old) patients admitted to our 20-bed mixed ICU with Middle East respiratory syndrome coronavirus infection between October 1, 2012 and May 31, 2014. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples.
During the observation period, 31 patients were admitted with MERS-CoV infection (mean age 59 ± 20 years, 22 [71 %] males). Cough and tachypnea were reported in all patients; 22 (77.4 %) patients had bilateral pulmonary infiltrates. Invasive mechanical ventilation was applied in 27 (87.1 %) and vasopressor therapy in 25 (80.6 %) patients during the intensive care unit stay. Twenty-three (74.2 %) patients died in the ICU. Nonsurvivors were older, had greater APACHE II and SOFA scores on admission, and were more likely to have received invasive mechanical ventilation and vasopressor therapy. After adjustment for the severity of illness and the degree of organ dysfunction, the need for vasopressors was an independent risk factor for death in the ICU (odds ratio = 18.33, 95 % confidence interval: 1.11–302.1,
MERS-CoV infection requiring admission to the ICU is associated with high morbidity and mortality. The need for vasopressor therapy is the main risk factor for death in these patients.
The online version of this article (doi:10.1186/s13054-016-1303-8) contains supplementary material, which is available to authorized users.
Url:
DOI: 10.1186/s13054-016-1303-8
PubMed: 27153800
PubMed Central: 4859954
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<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id>
<institution-id institution-id-type="ISNI">0000000121914301</institution-id>
<institution>Department of Medicine, King Faisal Specialist Hospital and Research Centre,</institution>
</institution-wrap>
Riyadh, 11211 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.275559.9</institution-id>
<institution-id institution-id-type="ISNI">0000 0000 8517 6224</institution-id>
<institution>Department of Anesthesiology and Intensive Care,</institution>
<institution>Uniklinikum Jena,</institution>
</institution-wrap>
07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>07743 Jena</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Critical Care</title>
<idno type="ISSN">1364-8535</idno>
<idno type="eISSN">1466-609X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Respiration, Artificial (mortality)</term>
<term>Retrospective Studies</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Arabie saoudite</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Ventilation artificielle (mortalité)</term>
<term>Études de cohortes</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Respiration, Artificial</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Ventilation artificielle</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Arabie saoudite</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Études de cohortes</term>
<term>Études rétrospectives</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">Retrospective analysis of data from all adult (>18 years old) patients admitted to our 20-bed mixed ICU with Middle East respiratory syndrome coronavirus infection between October 1, 2012 and May 31, 2014. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">During the observation period, 31 patients were admitted with MERS-CoV infection (mean age 59 ± 20 years, 22 [71 %] males). Cough and tachypnea were reported in all patients; 22 (77.4 %) patients had bilateral pulmonary infiltrates. Invasive mechanical ventilation was applied in 27 (87.1 %) and vasopressor therapy in 25 (80.6 %) patients during the intensive care unit stay. Twenty-three (74.2 %) patients died in the ICU. Nonsurvivors were older, had greater APACHE II and SOFA scores on admission, and were more likely to have received invasive mechanical ventilation and vasopressor therapy. After adjustment for the severity of illness and the degree of organ dysfunction, the need for vasopressors was an independent risk factor for death in the ICU (odds ratio = 18.33, 95 % confidence interval: 1.11–302.1, <italic>P</italic>
= 0.04).</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par4">MERS-CoV infection requiring admission to the ICU is associated with high morbidity and mortality. The need for vasopressor therapy is the main risk factor for death in these patients.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s13054-016-1303-8) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
</front>
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<double pmid="27153800"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients</title>
<author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
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</author>
<author><name sortKey="Albarrak, Mohammed M" sort="Albarrak, Mohammed M" uniqKey="Albarrak M" first="Mohammed M." last="Albarrak">Mohammed M. Albarrak</name>
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<institution>Intensive Care Unit,</institution>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
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</author>
<author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hassan, Sahar" sort="Hassan, Sahar" uniqKey="Hassan S" first="Sahar" last="Hassan">Sahar Hassan</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alwan, Abid" sort="Alwan, Abid" uniqKey="Alwan A" first="Abid" last="Alwan">Abid Alwan</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Abudayah, Abdullah" sort="Abudayah, Abdullah" uniqKey="Abudayah A" first="Abdullah" last="Abudayah">Abdullah Abudayah</name>
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<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Altayyar, Sultan" sort="Altayyar, Sultan" uniqKey="Altayyar S" first="Sultan" last="Altayyar">Sultan Altayyar</name>
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<wicri:regionArea>Riyadh</wicri:regionArea>
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</author>
<author><name sortKey="Mustafa, Mohamed" sort="Mustafa, Mohamed" uniqKey="Mustafa M" first="Mohamed" last="Mustafa">Mohamed Mustafa</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aldaghestani, Tareef" sort="Aldaghestani, Tareef" uniqKey="Aldaghestani T" first="Tareef" last="Aldaghestani">Tareef Aldaghestani</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alghamedi, Adnan" sort="Alghamedi, Adnan" uniqKey="Alghamedi A" first="Adnan" last="Alghamedi">Adnan Alghamedi</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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</author>
<author><name sortKey="Talag, Ali" sort="Talag, Ali" uniqKey="Talag A" first="Ali" last="Talag">Ali Talag</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malik, Muhammad K" sort="Malik, Muhammad K" uniqKey="Malik M" first="Muhammad K." last="Malik">Muhammad K. Malik</name>
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<institution>Department of Intensive Care Services,</institution>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name>
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<institution-id institution-id-type="ISNI">0000000121914301</institution-id>
<institution>Department of Medicine, King Faisal Specialist Hospital and Research Centre,</institution>
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Riyadh, 11211 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name>
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<institution>Department of Anesthesiology and Intensive Care,</institution>
<institution>Uniklinikum Jena,</institution>
</institution-wrap>
07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>07743 Jena</wicri:regionArea>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients</title>
<author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A." last="Almekhlafi">Ghaleb A. Almekhlafi</name>
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<institution>Department of Intensive Care Services,</institution>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Albarrak, Mohammed M" sort="Albarrak, Mohammed M" uniqKey="Albarrak M" first="Mohammed M." last="Albarrak">Mohammed M. Albarrak</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<wicri:regionArea>Riyadh</wicri:regionArea>
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</author>
<author><name sortKey="Hassan, Sahar" sort="Hassan, Sahar" uniqKey="Hassan S" first="Sahar" last="Hassan">Sahar Hassan</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<author><name sortKey="Alwan, Abid" sort="Alwan, Abid" uniqKey="Alwan A" first="Abid" last="Alwan">Abid Alwan</name>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<wicri:regionArea>Riyadh</wicri:regionArea>
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</author>
<author><name sortKey="Abudayah, Abdullah" sort="Abudayah, Abdullah" uniqKey="Abudayah A" first="Abdullah" last="Abudayah">Abdullah Abudayah</name>
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<institution-id institution-id-type="ISNI">0000000097598141</institution-id>
<institution>Department of Intensive Care Services,</institution>
<institution>Prince Sultan Military Medical City,</institution>
</institution-wrap>
Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Altayyar, Sultan" sort="Altayyar, Sultan" uniqKey="Altayyar S" first="Sultan" last="Altayyar">Sultan Altayyar</name>
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<institution-id institution-id-type="ISNI">0000000097598141</institution-id>
<institution>Department of Intensive Care Services,</institution>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
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<wicri:regionArea>Riyadh</wicri:regionArea>
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</author>
<author><name sortKey="Mustafa, Mohamed" sort="Mustafa, Mohamed" uniqKey="Mustafa M" first="Mohamed" last="Mustafa">Mohamed Mustafa</name>
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<institution-id institution-id-type="ISNI">0000000097598141</institution-id>
<institution>Department of Intensive Care Services,</institution>
<institution>Prince Sultan Military Medical City,</institution>
</institution-wrap>
Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Aldaghestani, Tareef" sort="Aldaghestani, Tareef" uniqKey="Aldaghestani T" first="Tareef" last="Aldaghestani">Tareef Aldaghestani</name>
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<institution-id institution-id-type="ISNI">0000000097598141</institution-id>
<institution>Department of Intensive Care Services,</institution>
<institution>Prince Sultan Military Medical City,</institution>
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Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Alghamedi, Adnan" sort="Alghamedi, Adnan" uniqKey="Alghamedi A" first="Adnan" last="Alghamedi">Adnan Alghamedi</name>
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<institution-id institution-id-type="ISNI">0000000097598141</institution-id>
<institution>Department of Intensive Care Services,</institution>
<institution>Prince Sultan Military Medical City,</institution>
</institution-wrap>
Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Talag, Ali" sort="Talag, Ali" uniqKey="Talag A" first="Ali" last="Talag">Ali Talag</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.415989.8</institution-id>
<institution-id institution-id-type="ISNI">0000000097598141</institution-id>
<institution>Department of Intensive Care Services,</institution>
<institution>Prince Sultan Military Medical City,</institution>
</institution-wrap>
Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Malik, Muhammad K" sort="Malik, Muhammad K" uniqKey="Malik M" first="Muhammad K." last="Malik">Muhammad K. Malik</name>
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<institution-id institution-id-type="ISNI">0000000097598141</institution-id>
<institution>Department of Intensive Care Services,</institution>
<institution>Prince Sultan Military Medical City,</institution>
</institution-wrap>
Riyadh, 11159 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S." last="Omrani">Ali S. Omrani</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.415310.2</institution-id>
<institution-id institution-id-type="ISNI">0000000121914301</institution-id>
<institution>Department of Medicine, King Faisal Specialist Hospital and Research Centre,</institution>
</institution-wrap>
Riyadh, 11211 Saudi Arabia</nlm:aff>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Riyadh</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name>
<affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.275559.9</institution-id>
<institution-id institution-id-type="ISNI">0000 0000 8517 6224</institution-id>
<institution>Department of Anesthesiology and Intensive Care,</institution>
<institution>Uniklinikum Jena,</institution>
</institution-wrap>
07743 Jena, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>07743 Jena</wicri:regionArea>
</affiliation>
</author>
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<series><title level="j">Critical Care</title>
<idno type="ISSN">1364-8535</idno>
<idno type="eISSN">1466-609X</idno>
<imprint><date when="2016">2016</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.</p>
</sec>
<sec><title>Methods</title>
<p id="Par2">Retrospective analysis of data from all adult (>18 years old) patients admitted to our 20-bed mixed ICU with Middle East respiratory syndrome coronavirus infection between October 1, 2012 and May 31, 2014. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">During the observation period, 31 patients were admitted with MERS-CoV infection (mean age 59 ± 20 years, 22 [71 %] males). Cough and tachypnea were reported in all patients; 22 (77.4 %) patients had bilateral pulmonary infiltrates. Invasive mechanical ventilation was applied in 27 (87.1 %) and vasopressor therapy in 25 (80.6 %) patients during the intensive care unit stay. Twenty-three (74.2 %) patients died in the ICU. Nonsurvivors were older, had greater APACHE II and SOFA scores on admission, and were more likely to have received invasive mechanical ventilation and vasopressor therapy. After adjustment for the severity of illness and the degree of organ dysfunction, the need for vasopressors was an independent risk factor for death in the ICU (odds ratio = 18.33, 95 % confidence interval: 1.11–302.1, <italic>P</italic>
= 0.04).</p>
</sec>
<sec><title>Conclusions</title>
<p id="Par4">MERS-CoV infection requiring admission to the ICU is associated with high morbidity and mortality. The need for vasopressor therapy is the main risk factor for death in these patients.</p>
</sec>
<sec><title>Electronic supplementary material</title>
<p>The online version of this article (doi:10.1186/s13054-016-1303-8) contains supplementary material, which is available to authorized users.</p>
</sec>
</div>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients.</title>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia. gmekhlafi@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Prince Sultan Cardiac Center, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
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<country xml:lang="fr">Arabie saoudite</country>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
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</author>
<author><name sortKey="Altayyar, Sultan" sort="Altayyar, Sultan" uniqKey="Altayyar S" first="Sultan" last="Altayyar">Sultan Altayyar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mustafa, Mohamed" sort="Mustafa, Mohamed" uniqKey="Mustafa M" first="Mohamed" last="Mustafa">Mohamed Mustafa</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aldaghestani, Tareef" sort="Aldaghestani, Tareef" uniqKey="Aldaghestani T" first="Tareef" last="Aldaghestani">Tareef Aldaghestani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alghamedi, Adnan" sort="Alghamedi, Adnan" uniqKey="Alghamedi A" first="Adnan" last="Alghamedi">Adnan Alghamedi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Talag, Ali" sort="Talag, Ali" uniqKey="Talag A" first="Ali" last="Talag">Ali Talag</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malik, Muhammad K" sort="Malik, Muhammad K" uniqKey="Malik M" first="Muhammad K" last="Malik">Muhammad K. Malik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211</wicri:regionArea>
<wicri:noRegion>11211</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care, Uniklinikum Jena, 07743, Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Anesthesiology and Intensive Care, Uniklinikum Jena, 07743, Jena</wicri:regionArea>
<wicri:noRegion>07743, Jena</wicri:noRegion>
<wicri:noRegion>07743, Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:27153800</idno>
<idno type="pmid">27153800</idno>
<idno type="doi">10.1186/s13054-016-1303-8</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients.</title>
<author><name sortKey="Almekhlafi, Ghaleb A" sort="Almekhlafi, Ghaleb A" uniqKey="Almekhlafi G" first="Ghaleb A" last="Almekhlafi">Ghaleb A. Almekhlafi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia. gmekhlafi@yahoo.com.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Albarrak, Mohammed M" sort="Albarrak, Mohammed M" uniqKey="Albarrak M" first="Mohammed M" last="Albarrak">Mohammed M. Albarrak</name>
<affiliation wicri:level="1"><nlm:affiliation>Intensive Care Unit, Prince Sultan Cardiac Center, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Intensive Care Unit, Prince Sultan Cardiac Center, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mandourah, Yasser" sort="Mandourah, Yasser" uniqKey="Mandourah Y" first="Yasser" last="Mandourah">Yasser Mandourah</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hassan, Sahar" sort="Hassan, Sahar" uniqKey="Hassan S" first="Sahar" last="Hassan">Sahar Hassan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alwan, Abid" sort="Alwan, Abid" uniqKey="Alwan A" first="Abid" last="Alwan">Abid Alwan</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Abudayah, Abdullah" sort="Abudayah, Abdullah" uniqKey="Abudayah A" first="Abdullah" last="Abudayah">Abdullah Abudayah</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Altayyar, Sultan" sort="Altayyar, Sultan" uniqKey="Altayyar S" first="Sultan" last="Altayyar">Sultan Altayyar</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mustafa, Mohamed" sort="Mustafa, Mohamed" uniqKey="Mustafa M" first="Mohamed" last="Mustafa">Mohamed Mustafa</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Aldaghestani, Tareef" sort="Aldaghestani, Tareef" uniqKey="Aldaghestani T" first="Tareef" last="Aldaghestani">Tareef Aldaghestani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Alghamedi, Adnan" sort="Alghamedi, Adnan" uniqKey="Alghamedi A" first="Adnan" last="Alghamedi">Adnan Alghamedi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Talag, Ali" sort="Talag, Ali" uniqKey="Talag A" first="Ali" last="Talag">Ali Talag</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Malik, Muhammad K" sort="Malik, Muhammad K" uniqKey="Malik M" first="Muhammad K" last="Malik">Muhammad K. Malik</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159</wicri:regionArea>
<wicri:noRegion>11159</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia.</nlm:affiliation>
<country xml:lang="fr">Arabie saoudite</country>
<wicri:regionArea>Department of Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211</wicri:regionArea>
<wicri:noRegion>11211</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Anesthesiology and Intensive Care, Uniklinikum Jena, 07743, Jena, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Anesthesiology and Intensive Care, Uniklinikum Jena, 07743, Jena</wicri:regionArea>
<wicri:noRegion>07743, Jena</wicri:noRegion>
<wicri:noRegion>07743, Jena</wicri:noRegion>
<wicri:noRegion>Jena</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Critical care (London, England)</title>
<idno type="eISSN">1466-609X</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Coronavirus Infections (diagnosis)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (therapy)</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Middle East Respiratory Syndrome Coronavirus (pathogenicity)</term>
<term>Respiration, Artificial (mortality)</term>
<term>Retrospective Studies</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Arabie saoudite</term>
<term>Coronavirus du syndrome respiratoire du Moyen-Orient (pathogénicité)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus ()</term>
<term>Infections à coronavirus (diagnostic)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Ventilation artificielle (mortalité)</term>
<term>Études de cohortes</term>
<term>Études rétrospectives</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Respiration, Artificial</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Ventilation artificielle</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Intensive Care Units</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Retrospective Studies</term>
<term>Saudi Arabia</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Arabie saoudite</term>
<term>Femelle</term>
<term>Humains</term>
<term>Infections à coronavirus</term>
<term>Mâle</term>
<term>Sujet âgé</term>
<term>Unités de soins intensifs</term>
<term>Études de cohortes</term>
<term>Études rétrospectives</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.</div>
</front>
</TEI>
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