Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients.
Identifieur interne : 001129 ( PubMed/Corpus ); précédent : 001128; suivant : 001130Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients.
Auteurs : Ghaleb A. Almekhlafi ; Mohammed M. Albarrak ; Yasser Mandourah ; Sahar Hassan ; Abid Alwan ; Abdullah Abudayah ; Sultan Altayyar ; Mohamed Mustafa ; Tareef Aldaghestani ; Adnan Alghamedi ; Ali Talag ; Muhammad K. Malik ; Ali S. Omrani ; Yasser SakrSource :
- Critical care (London, England) [ 1466-609X ] ; 2016.
English descriptors
- KwdEn :
- Adult, Aged, Cohort Studies, Coronavirus Infections (diagnosis), Coronavirus Infections (mortality), Coronavirus Infections (therapy), Female, Humans, Intensive Care Units, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (pathogenicity), Respiration, Artificial (mortality), Retrospective Studies, Saudi Arabia.
- MESH :
- diagnosis : Coronavirus Infections.
- mortality : Coronavirus Infections, Respiration, Artificial.
- pathogenicity : Middle East Respiratory Syndrome Coronavirus.
- therapy : Coronavirus Infections.
- Adult, Aged, Cohort Studies, Female, Humans, Intensive Care Units, Male, Middle Aged, Retrospective Studies, Saudi Arabia.
Abstract
Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.
DOI: 10.1186/s13054-016-1303-8
PubMed: 27153800
Links to Exploration step
pubmed:27153800Le document en format XML
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<author><name sortKey="Alghamedi, Adnan" sort="Alghamedi, Adnan" uniqKey="Alghamedi A" first="Adnan" last="Alghamedi">Adnan Alghamedi</name>
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<author><name sortKey="Omrani, Ali S" sort="Omrani, Ali S" uniqKey="Omrani A" first="Ali S" last="Omrani">Ali S. Omrani</name>
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<author><name sortKey="Sakr, Yasser" sort="Sakr, Yasser" uniqKey="Sakr Y" first="Yasser" last="Sakr">Yasser Sakr</name>
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<front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.</div>
</front>
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<DateCompleted><Year>2017</Year>
<Month>01</Month>
<Day>17</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
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<PubDate><Year>2016</Year>
<Month>May</Month>
<Day>07</Day>
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<Title>Critical care (London, England)</Title>
<ISOAbbreviation>Crit Care</ISOAbbreviation>
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<ArticleTitle>Presentation and outcome of Middle East respiratory syndrome in Saudi intensive care unit patients.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Middle East respiratory syndrome coronavirus infection is associated with high mortality rates but limited clinical data have been reported. We describe the clinical features and outcomes of patients admitted to an intensive care unit (ICU) with Middle East respiratory syndrome coronavirus (MERS-CoV) infection.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Retrospective analysis of data from all adult (>18 years old) patients admitted to our 20-bed mixed ICU with Middle East respiratory syndrome coronavirus infection between October 1, 2012 and May 31, 2014. Diagnosis was confirmed in all patients using real-time reverse transcription polymerase chain reaction on respiratory samples.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">During the observation period, 31 patients were admitted with MERS-CoV infection (mean age 59 ± 20 years, 22 [71 %] males). Cough and tachypnea were reported in all patients; 22 (77.4 %) patients had bilateral pulmonary infiltrates. Invasive mechanical ventilation was applied in 27 (87.1 %) and vasopressor therapy in 25 (80.6 %) patients during the intensive care unit stay. Twenty-three (74.2 %) patients died in the ICU. Nonsurvivors were older, had greater APACHE II and SOFA scores on admission, and were more likely to have received invasive mechanical ventilation and vasopressor therapy. After adjustment for the severity of illness and the degree of organ dysfunction, the need for vasopressors was an independent risk factor for death in the ICU (odds ratio = 18.33, 95 % confidence interval: 1.11-302.1, P = 0.04).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">MERS-CoV infection requiring admission to the ICU is associated with high morbidity and mortality. The need for vasopressor therapy is the main risk factor for death in these patients.</AbstractText>
</Abstract>
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<ForeName>Ghaleb A</ForeName>
<Initials>GA</Initials>
<AffiliationInfo><Affiliation>Department of Intensive Care Services, Prince Sultan Military Medical City, Riyadh, 11159, Saudi Arabia. gmekhlafi@yahoo.com.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Albarrak</LastName>
<ForeName>Mohammed M</ForeName>
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<AffiliationInfo><Affiliation>Intensive Care Unit, Prince Sultan Cardiac Center, Riyadh, 11159, Saudi Arabia.</Affiliation>
</AffiliationInfo>
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