Le « syndrome respiratoire du Moyen-Orient » (MERS) : qui est responsable, les chauves-souris ou le dromadaire ?
Identifieur interne : 000C90 ( Ncbi/Merge ); précédent : 000C89; suivant : 000C91Le « syndrome respiratoire du Moyen-Orient » (MERS) : qui est responsable, les chauves-souris ou le dromadaire ?
Auteurs : C. Chastel [France]Source :
- Bulletin De La Societe De Pathologie Exotique (1990) [ 0037-9085 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Anticorps antiviraux (sang), Chameaux (immunologie), Chameaux (parasitologie), Chameaux (physiologie), Chameaux (virologie), Chiroptera (immunologie), Chiroptera (virologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Coronavirus humain OC43 (immunologie), Espagne (épidémiologie), Glycoprotéine de spicule des coronavirus (immunologie), Gènes viraux, Humains, Infections à coronavirus (transmission), Infections à coronavirus (épidémiologie), Infestations par les tiques (médecine vétérinaire), Infestations par les tiques (épidémiologie), Maladies transmises par les tiques (transmission), Maladies transmises par les tiques (épidémiologie), Modèles biologiques, Moyen Orient (épidémiologie), Réservoirs d'agents pathogènes (virologie), Similitude de séquences d'acides nucléiques, Tiques (virologie), Vecteurs arachnides (virologie), Zoonoses, Études séroépidémiologiques.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Chameaux, Chiroptera, Coronavirus humain OC43, Glycoprotéine de spicule des coronavirus.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- médecine vétérinaire : Infestations par les tiques.
- parasitologie : Chameaux.
- physiologie : Chameaux, Coronavirus du syndrome respiratoire du Moyen-Orient.
- sang : Anticorps antiviraux.
- virologie : Chameaux, Chiroptera, Réservoirs d'agents pathogènes, Tiques, Vecteurs arachnides.
- épidémiologie : Espagne, Infections à coronavirus, Infestations par les tiques, Maladies transmises par les tiques, Moyen Orient.
- Animaux, Gènes viraux, Humains, Modèles biologiques, Similitude de séquences d'acides nucléiques, Zoonoses, Études séroépidémiologiques.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Arachnid Vectors (virology), Camelus (immunology), Camelus (parasitology), Camelus (physiology), Camelus (virology), Chiroptera (immunology), Chiroptera (virology), Coronavirus Infections (epidemiology), Coronavirus Infections (transmission), Coronavirus OC43, Human (immunology), Disease Reservoirs (virology), Genes, Viral, Humans, Middle East (epidemiology), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Middle East Respiratory Syndrome Coronavirus (physiology), Models, Biological, Sequence Homology, Nucleic Acid, Seroepidemiologic Studies, Spain (epidemiology), Spike Glycoprotein, Coronavirus (immunology), Tick Infestations (epidemiology), Tick Infestations (veterinary), Tick-Borne Diseases (epidemiology), Tick-Borne Diseases (transmission), Ticks (virology), Zoonoses.
- MESH :
- chemical , blood : Antibodies, Viral.
- epidemiology : Coronavirus Infections, Middle East, Spain, Tick Infestations, Tick-Borne Diseases.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Camelus, Chiroptera, Coronavirus OC43, Human, Spike Glycoprotein, Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- parasitology : Camelus.
- physiology : Camelus, Middle East Respiratory Syndrome Coronavirus.
- transmission : Coronavirus Infections, Tick-Borne Diseases.
- veterinary : Tick Infestations.
- virology : Arachnid Vectors, Camelus, Chiroptera, Disease Reservoirs, Ticks.
- Animals, Genes, Viral, Humans, Models, Biological, Sequence Homology, Nucleic Acid, Seroepidemiologic Studies, Zoonoses.
Abstract
En 2012, une nouvelle maladie virale émergente est apparue au Moyen-Orient, le MERS, abréviation en anglais pour « Syndrome respiratoire du Moyen-Orient ». Au 9 janvier 2014, elle avait déjà touché 178 personnes dans le monde, dont 75 étaient décédées dans un tableau d’insuffisance respiratoire et de diarrhée. La nouvelle maladie ressemblait cliniquement au SRAS (2002–2003), de sinistre mémoire, et comme le SRAS, était provoquée par un
Url:
DOI: 10.1007/s13149-014-0333-1
PubMed: 24532303
PubMed Central: 7097389
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PMC:7097389Le document en format XML
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maladie virale émergente est apparue au Moyen-Orient, le MERS, abréviation en anglais pour « Syndrome respiratoire du Moyen-Orient ». Au 9 janvier 2014, elle avait déjà touché 178 personnes dans le monde, dont 75 étaient décédées dans un tableau d’insuffisance respiratoire et de diarrhée. La nouvelle maladie ressemblait cliniquement au SRAS (2002–2003), de sinistre mémoire, et comme le SRAS, était provoquée par un <italic>Betacoronavirus</italic> nouveau. On a donc pensé que des chiroptères pouvaient être à l’origine du MERS. D’ailleurs, de nouvelles études ont montré qu’en Arabie Saoudite un exemplaire de la chauve-souris <italic>Taphozous perforatus</italic> hébergeait un segment de quelques nucléotides identique au segment homologue de la souche isolée du cas-index de l’épidémie. De plus, de nombreuses souches de <italic>Betacoronavirus</italic>, plus ou moins proches génétiquement de celles responsables du MERS chez l’Homme, ont été isolées de chauves-souris en Afrique, en Asie et en Europe. Mais, une autre hypothèse a été proposée simultanément incriminant le dromadaire (<italic>Camelus dromedarius</italic> L) comme acteur très vraisemblable dans la transmission de la maladie. Elle est basée sur des observations épidémiologiques et les résultats de plusieurs enquêtes sérologiques. Un bilan des autres zoonoses virales dans lesquelles le dromadaire est plus ou moins impliqué renforce cette hypothèse: le MERS-CoV, l’agent étiologique du nouveau syndrome, pourrait bien être véhiculé par cet animal.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name></author><author><name sortKey="Baldwin, Hj" uniqKey="Baldwin H">HJ Baldwin</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouhous, A" uniqKey="Bouhous A">A Bouhous</name></author><author><name sortKey="Aissi, M" uniqKey="Aissi M">M Aissi</name></author><author><name sortKey="Harhour, Kh" uniqKey="Harhour K">KH Harhour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Breban, R" uniqKey="Breban R">R Breban</name></author><author><name sortKey="Riou, J" uniqKey="Riou J">J Riou</name></author><author><name sortKey="Fontanet, A" uniqKey="Fontanet A">A Fontanet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carletti, F" uniqKey="Carletti F">F Carletti</name></author><author><name sortKey="Castilletti, C" uniqKey="Castilletti C">C Castilletti</name></author><author><name sortKey="Di Caro, A" uniqKey="Di Caro A">A Di Caro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charrel, Rn" uniqKey="Charrel R">RN Charrel</name></author><author><name sortKey="De Lamballerie, X" uniqKey="De Lamballerie X">X de Lamballerie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Charrel, Rn" uniqKey="Charrel R">RN Charrel</name></author><author><name sortKey="Fagbo, S" uniqKey="Fagbo S">S Fagbo</name></author><author><name sortKey="Moureau, G" uniqKey="Moureau G">G Moureau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cotten, M" uniqKey="Cotten M">M Cotten</name></author><author><name sortKey="Watson, Sj" uniqKey="Watson S">SJ Watson</name></author><author><name sortKey="Kellam, P" uniqKey="Kellam P">P Kellam</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Fassi Fehri, Mm" uniqKey="Fassi Fehri M">MM Fassi-Fehri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guan, Y" uniqKey="Guan Y">Y Guan</name></author><author><name sortKey="Zheng, Bj" uniqKey="Zheng B">BJ Zheng</name></author><author><name sortKey="He, Yq" uniqKey="He Y">YQ He</name></author></analytic></biblStruct><biblStruct><analytic><author><name 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pmid="24532303"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Le « syndrome respiratoire du Moyen-Orient » (MERS) : qui est responsable, les chauves-souris ou le dromadaire ?</title><author><name sortKey="Chastel, C" sort="Chastel, C" uniqKey="Chastel C" first="C." last="Chastel">C. Chastel</name><affiliation wicri:level="3"><nlm:aff id="Aff1">3, rue Rouget de l’Isle, 29200 Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>3, rue Rouget de l’Isle, 29200 Brest</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24532303</idno><idno type="pmc">7097389</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097389</idno><idno type="RBID">PMC:7097389</idno><idno type="doi">10.1007/s13149-014-0333-1</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000225</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000225</idno><idno type="wicri:Area/Pmc/Curation">000225</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000225</idno><idno type="wicri:Area/Pmc/Checkpoint">001046</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001046</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Le « syndrome respiratoire du Moyen-Orient » (MERS) : qui est responsable, les chauves-souris ou le dromadaire ?</title><author><name sortKey="Chastel, C" sort="Chastel, C" uniqKey="Chastel C" first="C." last="Chastel">C. Chastel</name><affiliation wicri:level="3"><nlm:aff id="Aff1">3, rue Rouget de l’Isle, 29200 Brest, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>3, rue Rouget de l’Isle, 29200 Brest</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Brest</settlement></placeName></affiliation></author></analytic><series><title level="j">Bulletin De La Societe De Pathologie Exotique (1990)</title><idno type="ISSN">0037-9085</idno><idno type="eISSN">1961-9049</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Résumé</title><p>En 2012, une nouvelle maladie virale émergente est apparue au Moyen-Orient, le MERS, abréviation en anglais pour « Syndrome respiratoire du Moyen-Orient ». Au 9 janvier 2014, elle avait déjà touché 178 personnes dans le monde, dont 75 étaient décédées dans un tableau d’insuffisance respiratoire et de diarrhée. La nouvelle maladie ressemblait cliniquement au SRAS (2002–2003), de sinistre mémoire, et comme le SRAS, était provoquée par un <italic>Betacoronavirus</italic> nouveau. On a donc pensé que des chiroptères pouvaient être à l’origine du MERS. D’ailleurs, de nouvelles études ont montré qu’en Arabie Saoudite un exemplaire de la chauve-souris <italic>Taphozous perforatus</italic> hébergeait un segment de quelques nucléotides identique au segment homologue de la souche isolée du cas-index de l’épidémie. De plus, de nombreuses souches de <italic>Betacoronavirus</italic>, plus ou moins proches génétiquement de celles responsables du MERS chez l’Homme, ont été isolées de chauves-souris en Afrique, en Asie et en Europe. Mais, une autre hypothèse a été proposée simultanément incriminant le dromadaire (<italic>Camelus dromedarius</italic> L) comme acteur très vraisemblable dans la transmission de la maladie. Elle est basée sur des observations épidémiologiques et les résultats de plusieurs enquêtes sérologiques. Un bilan des autres zoonoses virales dans lesquelles le dromadaire est plus ou moins impliqué renforce cette hypothèse: le MERS-CoV, l’agent étiologique du nouveau syndrome, pourrait bien être véhiculé par cet animal.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Annan, A" uniqKey="Annan A">A Annan</name></author><author><name sortKey="Baldwin, Hj" uniqKey="Baldwin H">HJ Baldwin</name></author><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A Assiri</name></author><author><name sortKey="Al Tawfiq, Ja" uniqKey="Al Tawfiq J">JA Al-Tawfiq</name></author><author><name sortKey="Al Rabeeah, Aa" uniqKey="Al Rabeeah A">AA Al-Rabeeah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouhous, A" uniqKey="Bouhous A">A Bouhous</name></author><author><name sortKey="Aissi, M" 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Aubert</name></author><author><name sortKey="Digoutte, Jp" uniqKey="Digoutte J">JP Digoutte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shommein, Am" uniqKey="Shommein A">AM Shommein</name></author><author><name sortKey="Osman, Am" uniqKey="Osman A">AM Osman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, I" uniqKey="Smith I">I Smith</name></author><author><name sortKey="Wang, Lf" uniqKey="Wang L">LF Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Straten, M" uniqKey="Van Straten M">M Van Straten</name></author><author><name sortKey="Jongejan, F" uniqKey="Jongejan F">F Jongejan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name></author><author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Williams, Re" uniqKey="Williams R">RE Williams</name></author><author><name sortKey="Hoogstraal, H" uniqKey="Hoogstraal H">H Hoogstraal</name></author><author><name sortKey="Casals, J" uniqKey="Casals J">J Casals</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wunschmann, A" uniqKey="Wunschmann A">A Wünschmann</name></author><author><name sortKey="Frank, R" uniqKey="Frank R">R Frank</name></author><author><name sortKey="Pomeroy, K" uniqKey="Pomeroy K">K Pomeroy</name></author><author><name sortKey="Kapil, S" uniqKey="Kapil S">S Kapil</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, Am" uniqKey="Zaki A">AM Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S van Boheemen</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Middle East respiratory syndrome (MERS): bats or dromedary, which of them is responsible?].</title><author><name sortKey="Chastel, C" sort="Chastel, C" uniqKey="Chastel C" first="C" last="Chastel">C. Chastel</name><affiliation wicri:level="1"><nlm:affiliation>, 3, rue Rouget de l'Isle, 29200, Brest, France, chastelc@aol.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>, 3, rue Rouget de l'Isle, 29200, Brest, France</wicri:regionArea><wicri:noRegion>France</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24532303</idno><idno type="pmid">24532303</idno><idno type="doi">10.1007/s13149-014-0333-1</idno><idno type="wicri:Area/PubMed/Corpus">001A54</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001A54</idno><idno type="wicri:Area/PubMed/Curation">001A54</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001A54</idno><idno type="wicri:Area/PubMed/Checkpoint">001678</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001678</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Middle East respiratory syndrome (MERS): bats or dromedary, which of them is responsible?].</title><author><name sortKey="Chastel, C" sort="Chastel, C" uniqKey="Chastel C" first="C" last="Chastel">C. Chastel</name><affiliation wicri:level="1"><nlm:affiliation>, 3, rue Rouget de l'Isle, 29200, Brest, France, chastelc@aol.com.</nlm:affiliation><country wicri:rule="url">Oman</country><wicri:regionArea>, 3, rue Rouget de l'Isle, 29200, Brest, France</wicri:regionArea><wicri:noRegion>France</wicri:noRegion></affiliation></author></analytic><series><title level="j">Bulletin de la Societe de pathologie exotique (1990)</title><idno type="eISSN">1961-9049</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Arachnid Vectors (virology)</term><term>Camelus (immunology)</term><term>Camelus (parasitology)</term><term>Camelus (physiology)</term><term>Camelus (virology)</term><term>Chiroptera (immunology)</term><term>Chiroptera (virology)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (transmission)</term><term>Coronavirus OC43, Human (immunology)</term><term>Disease Reservoirs (virology)</term><term>Genes, Viral</term><term>Humans</term><term>Middle East (epidemiology)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Middle East Respiratory Syndrome Coronavirus (physiology)</term><term>Models, Biological</term><term>Sequence Homology, Nucleic Acid</term><term>Seroepidemiologic Studies</term><term>Spain (epidemiology)</term><term>Spike Glycoprotein, Coronavirus (immunology)</term><term>Tick Infestations (epidemiology)</term><term>Tick Infestations (veterinary)</term><term>Tick-Borne Diseases (epidemiology)</term><term>Tick-Borne Diseases (transmission)</term><term>Ticks (virology)</term><term>Zoonoses</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Chameaux (immunologie)</term><term>Chameaux (parasitologie)</term><term>Chameaux (physiologie)</term><term>Chameaux (virologie)</term><term>Chiroptera (immunologie)</term><term>Chiroptera (virologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie)</term><term>Coronavirus humain OC43 (immunologie)</term><term>Espagne (épidémiologie)</term><term>Glycoprotéine de spicule des coronavirus (immunologie)</term><term>Gènes viraux</term><term>Humains</term><term>Infections à coronavirus (transmission)</term><term>Infections à coronavirus (épidémiologie)</term><term>Infestations par les tiques (médecine vétérinaire)</term><term>Infestations par les tiques (épidémiologie)</term><term>Maladies transmises par les tiques (transmission)</term><term>Maladies transmises par les tiques (épidémiologie)</term><term>Modèles biologiques</term><term>Moyen Orient (épidémiologie)</term><term>Réservoirs d'agents pathogènes (virologie)</term><term>Similitude de séquences d'acides nucléiques</term><term>Tiques (virologie)</term><term>Vecteurs arachnides (virologie)</term><term>Zoonoses</term><term>Études séroépidémiologiques</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Middle East</term><term>Spain</term><term>Tick Infestations</term><term>Tick-Borne Diseases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Chameaux</term><term>Chiroptera</term><term>Coronavirus humain OC43</term><term>Glycoprotéine de spicule des coronavirus</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Camelus</term><term>Chiroptera</term><term>Coronavirus OC43, Human</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infestations par les tiques</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Chameaux</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Camelus</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Chameaux</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Camelus</term><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" qualifier="transmission" xml:lang="en"><term>Coronavirus Infections</term><term>Tick-Borne Diseases</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Tick Infestations</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Chameaux</term><term>Chiroptera</term><term>Réservoirs d'agents pathogènes</term><term>Tiques</term><term>Vecteurs arachnides</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Arachnid Vectors</term><term>Camelus</term><term>Chiroptera</term><term>Disease Reservoirs</term><term>Ticks</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term><term>Infections à coronavirus</term><term>Infestations par les tiques</term><term>Maladies transmises par les tiques</term><term>Moyen Orient</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genes, Viral</term><term>Humans</term><term>Models, Biological</term><term>Sequence Homology, Nucleic Acid</term><term>Seroepidemiologic Studies</term><term>Zoonoses</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Gènes viraux</term><term>Humains</term><term>Modèles biologiques</term><term>Similitude de séquences d'acides nucléiques</term><term>Zoonoses</term><term>Études séroépidémiologiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 2012 a new viral emergent human disease appeared in the Middle East. This entity was named MERS for' Middle East respiratory syndrome'. By January 9, 2014, the disease had already struck 178 persons of whom 75 died from respiratory failure and diarrhoea. As the new disease was very similar to the deadly SARS (2002-2003) and since it was provoked by a Betacoronavirus, chiroptera were first suspected to be at the origin of this infection. Morever, recent studies performed in Saudi Arabia showed that one individual of the bat Taphozous perforatus harbored a short nucleotide segment identical to the homologous segment present in the viral strain isolated from the index-case of the epidemic. In addition, many strains of Betacoronavirus more or less related to those responsible for the MERS disease in man have been isolated from bats in Africa, Asia and Europe. However, another hypothesis was simultaneously proposed incriminating dromedary (Camelus dromedarius L.) as a likely actor in the transmission to human beings of the disease.We then reviewed data relative to other viral zoonosis in which dromedary was possibly implicated. This led to the provisional conclusion that this large mammal might play a role in the dissemination of the MERS-COV, the etiologic agent of the disease. This is based on epidemiological data and results of several serological surveys in animals.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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