Web-based design and evaluation of T-cell vaccine candidates.
Identifieur interne : 000602 ( Ncbi/Merge ); précédent : 000601; suivant : 000603Web-based design and evaluation of T-cell vaccine candidates.
Auteurs : James Thurmond [États-Unis] ; Hyejin Yoon ; Carla Kuiken ; Karina Yusim ; Simon Perkins ; James Theiler ; Tanmoy Bhattacharya ; Bette Korber ; Will FischerSource :
- Bioinformatics (Oxford, England) [ 1367-4811 ] ; 2008.
Descripteurs français
- KwdFr :
- Algorithmes, Antigènes (), Conception de médicament, Déterminants antigéniques des lymphocytes T (), Humains, Infections à VIH (), Infections à VIH (virologie), Internet, Logiciel, Lymphocytes T (métabolisme), Ordinateurs, Technologie pharmaceutique (instrumentation), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Vaccins (), Vaccins contre le SIDA (), Épitopes ().
- MESH :
- génétique : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- immunologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- métabolisme : Lymphocytes T.
- virologie : Infections à VIH.
- Algorithmes, Antigènes, Conception de médicament, Déterminants antigéniques des lymphocytes T, Humains, Infections à VIH, Internet, Logiciel, Ordinateurs, Technologie pharmaceutique, Vaccins, Vaccins contre le SIDA, Épitopes.
English descriptors
- KwdEn :
- AIDS Vaccines (chemistry), Algorithms, Antigens (chemistry), Computers, Drug Design, Epitopes (chemistry), Epitopes, T-Lymphocyte (chemistry), HIV Infections (prevention & control), HIV Infections (virology), HIV-1 (genetics), HIV-1 (immunology), Humans, Internet, Software, T-Lymphocytes (metabolism), Technology, Pharmaceutical (instrumentation), Vaccines (chemistry).
- MESH :
- chemical , chemistry : AIDS Vaccines, Antigens, Epitopes, Epitopes, T-Lymphocyte, Vaccines.
- genetics : HIV-1.
- immunology : HIV-1.
- instrumentation : Technology, Pharmaceutical.
- metabolism : T-Lymphocytes.
- prevention & control : HIV Infections.
- virology : HIV Infections.
- Algorithms, Computers, Drug Design, Humans, Internet, Software.
Abstract
We present a suite of on-line tools to design candidate vaccine proteins, and to assess antigen potential, using coverage of k-mers (as proxies for potential T-cell epitopes) as a metric. The vaccine design tool uses the recently published 'mosaic' method to generate protein sequences optimized for coverage of high-frequency k-mers; the coverage-assessment tools facilitate coverage comparisons for any potential antigens. To demonstrate these tools, we designed mosaic protein sets for B-clade HIV-1 Gag, Pol and Nef, and compared them to antigens used in a recent human vaccine trial.
DOI: 10.1093/bioinformatics/btn251
PubMed: 18515277
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The vaccine design tool uses the recently published 'mosaic' method to generate protein sequences optimized for coverage of high-frequency k-mers; the coverage-assessment tools facilitate coverage comparisons for any potential antigens. To demonstrate these tools, we designed mosaic protein sets for B-clade HIV-1 Gag, Pol and Nef, and compared them to antigens used in a recent human vaccine trial.</AbstractText><AbstractText Label="AVAILABILITY" NlmCategory="BACKGROUND">http://hiv.lanl.gov/content/sequence/MOSAIC/.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Thurmond</LastName><ForeName>James</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Los Alamos National Laboratory, Los Alamos, NM 87545, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yoon</LastName><ForeName>Hyejin</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Kuiken</LastName><ForeName>Carla</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Yusim</LastName><ForeName>Karina</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Perkins</LastName><ForeName>Simon</ForeName><Initials>S</Initials></Author><Author 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IdType="doi">10.1093/bioinformatics/btn251</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Nouveau-Mexique</li></region></list><tree><noCountry><name sortKey="Bhattacharya, Tanmoy" sort="Bhattacharya, Tanmoy" uniqKey="Bhattacharya T" first="Tanmoy" last="Bhattacharya">Tanmoy Bhattacharya</name><name sortKey="Fischer, Will" sort="Fischer, Will" uniqKey="Fischer W" first="Will" last="Fischer">Will Fischer</name><name sortKey="Korber, Bette" sort="Korber, Bette" uniqKey="Korber B" first="Bette" last="Korber">Bette Korber</name><name sortKey="Kuiken, Carla" sort="Kuiken, Carla" uniqKey="Kuiken C" first="Carla" last="Kuiken">Carla Kuiken</name><name sortKey="Perkins, Simon" sort="Perkins, Simon" uniqKey="Perkins S" first="Simon" last="Perkins">Simon Perkins</name><name sortKey="Theiler, James" sort="Theiler, James" uniqKey="Theiler J" first="James" last="Theiler">James Theiler</name><name sortKey="Yoon, Hyejin" sort="Yoon, Hyejin" uniqKey="Yoon H" first="Hyejin" last="Yoon">Hyejin Yoon</name><name sortKey="Yusim, Karina" sort="Yusim, Karina" uniqKey="Yusim K" first="Karina" last="Yusim">Karina Yusim</name></noCountry><country name="États-Unis"><region name="Nouveau-Mexique"><name sortKey="Thurmond, James" sort="Thurmond, James" uniqKey="Thurmond J" first="James" last="Thurmond">James Thurmond</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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