Web-based design and evaluation of T-cell vaccine candidates.
Identifieur interne : 002107 ( PubMed/Curation ); précédent : 002106; suivant : 002108Web-based design and evaluation of T-cell vaccine candidates.
Auteurs : James Thurmond [États-Unis] ; Hyejin Yoon ; Carla Kuiken ; Karina Yusim ; Simon Perkins ; James Theiler ; Tanmoy Bhattacharya ; Bette Korber ; Will FischerSource :
- Bioinformatics (Oxford, England) [ 1367-4811 ] ; 2008.
Descripteurs français
- KwdFr :
- Algorithmes, Antigènes (), Conception de médicament, Déterminants antigéniques des lymphocytes T (), Humains, Infections à VIH (), Infections à VIH (virologie), Internet, Logiciel, Lymphocytes T (métabolisme), Ordinateurs, Technologie pharmaceutique (instrumentation), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (génétique), VIH-1 (Virus de l'Immunodéficience Humaine de type 1) (immunologie), Vaccins (), Vaccins contre le SIDA (), Épitopes ().
- MESH :
- génétique : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- immunologie : VIH-1 (Virus de l'Immunodéficience Humaine de type 1).
- métabolisme : Lymphocytes T.
- virologie : Infections à VIH.
- Algorithmes, Antigènes, Conception de médicament, Déterminants antigéniques des lymphocytes T, Humains, Infections à VIH, Internet, Logiciel, Ordinateurs, Technologie pharmaceutique, Vaccins, Vaccins contre le SIDA, Épitopes.
English descriptors
- KwdEn :
- AIDS Vaccines (chemistry), Algorithms, Antigens (chemistry), Computers, Drug Design, Epitopes (chemistry), Epitopes, T-Lymphocyte (chemistry), HIV Infections (prevention & control), HIV Infections (virology), HIV-1 (genetics), HIV-1 (immunology), Humans, Internet, Software, T-Lymphocytes (metabolism), Technology, Pharmaceutical (instrumentation), Vaccines (chemistry).
- MESH :
- chemical , chemistry : AIDS Vaccines, Antigens, Epitopes, Epitopes, T-Lymphocyte, Vaccines.
- genetics : HIV-1.
- immunology : HIV-1.
- instrumentation : Technology, Pharmaceutical.
- metabolism : T-Lymphocytes.
- prevention & control : HIV Infections.
- virology : HIV Infections.
- Algorithms, Computers, Drug Design, Humans, Internet, Software.
Abstract
We present a suite of on-line tools to design candidate vaccine proteins, and to assess antigen potential, using coverage of k-mers (as proxies for potential T-cell epitopes) as a metric. The vaccine design tool uses the recently published 'mosaic' method to generate protein sequences optimized for coverage of high-frequency k-mers; the coverage-assessment tools facilitate coverage comparisons for any potential antigens. To demonstrate these tools, we designed mosaic protein sets for B-clade HIV-1 Gag, Pol and Nef, and compared them to antigens used in a recent human vaccine trial.
DOI: 10.1093/bioinformatics/btn251
PubMed: 18515277
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pubmed:18515277Le document en format XML
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<term>Déterminants antigéniques des lymphocytes T</term>
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<front><div type="abstract" xml:lang="en">We present a suite of on-line tools to design candidate vaccine proteins, and to assess antigen potential, using coverage of k-mers (as proxies for potential T-cell epitopes) as a metric. The vaccine design tool uses the recently published 'mosaic' method to generate protein sequences optimized for coverage of high-frequency k-mers; the coverage-assessment tools facilitate coverage comparisons for any potential antigens. To demonstrate these tools, we designed mosaic protein sets for B-clade HIV-1 Gag, Pol and Nef, and compared them to antigens used in a recent human vaccine trial.</div>
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