The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates
Identifieur interne : 000388 ( Ncbi/Merge ); précédent : 000387; suivant : 000389The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates
Auteurs : Laurence Ettwiller [Royaume-Uni] ; Benedict Paten [Royaume-Uni] ; Marcel Souren [Allemagne] ; Felix Loosli [Allemagne] ; Jochen Wittbrodt [Allemagne] ; Ewan Birney [Royaume-Uni]Source :
- Genome Biology [ 1465-6906 ] ; 2005.
Descripteurs français
- KwdFr :
- Animaux, Délétion de séquence (génétique), Embryon non mammalien (cytologie), Humains, Reproductibilité des résultats, Régions promotrices (génétique) (génétique), Séquence conservée, Séquences d'acides nucléiques régulatrices (génétique), Takifugu (génétique), Technique SELEX, Transcription génétique (génétique), Transgènes, Vertébrés (génétique), Évolution moléculaire.
- MESH :
- cytologie : Embryon non mammalien.
- génétique : Délétion de séquence, Régions promotrices (génétique), Séquences d'acides nucléiques régulatrices, Takifugu, Transcription génétique, Vertébrés.
- Animaux, Humains, Reproductibilité des résultats, Séquence conservée, Technique SELEX, Transgènes, Évolution moléculaire.
English descriptors
- KwdEn :
- Animals, Conserved Sequence, Embryo, Nonmammalian (cytology), Evolution, Molecular, Humans, Promoter Regions, Genetic (genetics), Regulatory Sequences, Nucleic Acid (genetics), Reproducibility of Results, SELEX Aptamer Technique, Sequence Deletion (genetics), Takifugu (genetics), Transcription, Genetic (genetics), Transgenes, Vertebrates (genetics).
- MESH :
Abstract
Several new methods and a specific alignment tool for investigating transcriptional motifs in vertebrates were used to identify all possible 12mers involved in transcription. Active instances of these motifs were identified using comparative analysis across vertebrates.
Url:
DOI: 10.1186/gb-2005-6-12-r104
PubMed: 16356267
PubMed Central: 1414082
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PMC:1414082Le document en format XML
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Active instances of these motifs were identified using comparative analysis across vertebrates.</p></div></front><back><div1 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Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD</wicri:regionArea><wicri:noRegion>CB10 1SD</wicri:noRegion></affiliation></author></analytic><series><title level="j">Genome Biology</title><idno type="ISSN">1465-6906</idno><idno type="eISSN">1465-6914</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Several new methods and a specific alignment tool for investigating transcriptional motifs in vertebrates were used to identify all possible 12mers involved in transcription. Active instances of these motifs were identified using comparative analysis across vertebrates.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates.</title><author><name sortKey="Ettwiller, Laurence" sort="Ettwiller, Laurence" uniqKey="Ettwiller L" first="Laurence" last="Ettwiller">Laurence Ettwiller</name><affiliation wicri:level="1"><nlm:affiliation>EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. Laurence.Ettwiller@espci.fr</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD</wicri:regionArea><wicri:noRegion>CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Paten, Benedict" sort="Paten, Benedict" uniqKey="Paten B" first="Benedict" last="Paten">Benedict Paten</name></author><author><name sortKey="Souren, Marcel" sort="Souren, Marcel" uniqKey="Souren M" first="Marcel" last="Souren">Marcel Souren</name></author><author><name sortKey="Loosli, Felix" sort="Loosli, Felix" uniqKey="Loosli F" first="Felix" last="Loosli">Felix Loosli</name></author><author><name sortKey="Wittbrodt, Jochen" sort="Wittbrodt, Jochen" uniqKey="Wittbrodt J" first="Jochen" last="Wittbrodt">Jochen Wittbrodt</name></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16356267</idno><idno type="pmid">16356267</idno><idno type="doi">10.1186/gb-2005-6-12-r104</idno><idno type="wicri:Area/PubMed/Corpus">002293</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002293</idno><idno type="wicri:Area/PubMed/Curation">002293</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002293</idno><idno type="wicri:Area/PubMed/Checkpoint">002171</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002171</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The discovery, positioning and verification of a set of transcription-associated motifs in vertebrates.</title><author><name sortKey="Ettwiller, Laurence" sort="Ettwiller, Laurence" uniqKey="Ettwiller L" first="Laurence" last="Ettwiller">Laurence Ettwiller</name><affiliation wicri:level="1"><nlm:affiliation>EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD, UK. Laurence.Ettwiller@espci.fr</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>EBI, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire, CB10 1SD</wicri:regionArea><wicri:noRegion>CB10 1SD</wicri:noRegion></affiliation></author><author><name sortKey="Paten, Benedict" sort="Paten, Benedict" uniqKey="Paten B" first="Benedict" last="Paten">Benedict Paten</name></author><author><name sortKey="Souren, Marcel" sort="Souren, Marcel" uniqKey="Souren M" first="Marcel" last="Souren">Marcel Souren</name></author><author><name sortKey="Loosli, Felix" sort="Loosli, Felix" uniqKey="Loosli F" first="Felix" last="Loosli">Felix Loosli</name></author><author><name sortKey="Wittbrodt, Jochen" sort="Wittbrodt, Jochen" uniqKey="Wittbrodt J" first="Jochen" last="Wittbrodt">Jochen Wittbrodt</name></author><author><name sortKey="Birney, Ewan" sort="Birney, Ewan" uniqKey="Birney E" first="Ewan" last="Birney">Ewan Birney</name></author></analytic><series><title level="j">Genome biology</title><idno type="eISSN">1474-760X</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Conserved Sequence</term><term>Embryo, Nonmammalian (cytology)</term><term>Evolution, Molecular</term><term>Humans</term><term>Promoter Regions, Genetic (genetics)</term><term>Regulatory Sequences, Nucleic Acid (genetics)</term><term>Reproducibility of Results</term><term>SELEX Aptamer Technique</term><term>Sequence Deletion (genetics)</term><term>Takifugu (genetics)</term><term>Transcription, Genetic (genetics)</term><term>Transgenes</term><term>Vertebrates (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Délétion de séquence (génétique)</term><term>Embryon non mammalien (cytologie)</term><term>Humains</term><term>Reproductibilité des résultats</term><term>Régions promotrices (génétique) (génétique)</term><term>Séquence conservée</term><term>Séquences d'acides nucléiques régulatrices (génétique)</term><term>Takifugu (génétique)</term><term>Technique SELEX</term><term>Transcription génétique (génétique)</term><term>Transgènes</term><term>Vertébrés (génétique)</term><term>Évolution moléculaire</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Embryon non mammalien</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Embryo, Nonmammalian</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Promoter Regions, Genetic</term><term>Regulatory Sequences, Nucleic Acid</term><term>Sequence Deletion</term><term>Takifugu</term><term>Transcription, Genetic</term><term>Vertebrates</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Délétion de séquence</term><term>Régions promotrices (génétique)</term><term>Séquences d'acides nucléiques régulatrices</term><term>Takifugu</term><term>Transcription génétique</term><term>Vertébrés</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Conserved Sequence</term><term>Evolution, Molecular</term><term>Humans</term><term>Reproducibility of Results</term><term>SELEX Aptamer Technique</term><term>Transgenes</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Reproductibilité des résultats</term><term>Séquence conservée</term><term>Technique SELEX</term><term>Transgènes</term><term>Évolution moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have developed several new methods to investigate transcriptional motifs in vertebrates. We developed a specific alignment tool appropriate for regions involved in transcription control, and exhaustively enumerated all possible 12-mers for involvement in transcription by virtue of their mammalian conservation. We then used deeper comparative analysis across vertebrates to identify the active instances of these motifs. We have shown experimentally in Medaka fish that a subset of these predictions is involved in transcription.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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