Development of immunoglobulin variable heavy chain gene consensus probes with conjugated 3' minor groove binder groups for monitoring minimal residual disease in childhood acute lymphoblastic leukaemia.
Identifieur interne : 000244 ( Ncbi/Merge ); précédent : 000243; suivant : 000245Development of immunoglobulin variable heavy chain gene consensus probes with conjugated 3' minor groove binder groups for monitoring minimal residual disease in childhood acute lymphoblastic leukaemia.
Auteurs : M. Uchiyama [Japon] ; C. Maesawa ; A. Yashima ; T. Itabashi ; T. Satoh ; M. Tarusawa ; M. Endo ; Y. Takahashi ; S. Sasaki ; S. Tsuchiya ; Y. Ishida ; T. MasudaSource :
- Journal of clinical pathology [ 0021-9746 ] ; 2003.
Descripteurs français
- KwdFr :
- Alignement de séquences, Chaines lourdes des immunoglobulines (génétique), Enfant, Humains, Leucémie-lymphome lymphoblastique à précurseurs B et T (diagnostic), Maladie résiduelle, Réaction de polymérisation en chaîne (), Réarrangement des gènes des chaines lourdes des lymphocytes B, Région variable d'immunoglobuline (génétique), Sondes oligonucléotidiques, Séquence consensus (génétique).
- MESH :
- diagnostic : Leucémie-lymphome lymphoblastique à précurseurs B et T.
- génétique : Chaines lourdes des immunoglobulines, Région variable d'immunoglobuline, Séquence consensus.
- Alignement de séquences, Enfant, Humains, Maladie résiduelle, Réaction de polymérisation en chaîne, Réarrangement des gènes des chaines lourdes des lymphocytes B, Sondes oligonucléotidiques.
English descriptors
- KwdEn :
- Child, Consensus Sequence (genetics), Gene Rearrangement, B-Lymphocyte, Heavy Chain, Humans, Immunoglobulin Heavy Chains (genetics), Immunoglobulin Variable Region (genetics), Neoplasm, Residual, Oligonucleotide Probes, Polymerase Chain Reaction (methods), Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis), Sequence Alignment.
- MESH :
- chemical , genetics : Immunoglobulin Heavy Chains, Immunoglobulin Variable Region.
- diagnosis : Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- genetics : Consensus Sequence.
- methods : Polymerase Chain Reaction.
- Child, Gene Rearrangement, B-Lymphocyte, Heavy Chain, Humans, Neoplasm, Residual, Oligonucleotide Probes, Sequence Alignment.
Abstract
To develop immunoglobulin heavy chain variable (VH) gene probes that are shorter and more flexible in position for monitoring minimal residual disease (MRD) in childhood leukaemia (ALL), using minor groove binder (MGB) technology.
DOI: 10.1136/jcp.56.12.952
PubMed: 14645357
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 002425
- to stream PubMed, to step Curation: 002425
- to stream PubMed, to step Checkpoint: 002328
Links to Exploration step
pubmed:14645357Le document en format XML
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<term>Humans</term>
<term>Immunoglobulin Heavy Chains (genetics)</term>
<term>Immunoglobulin Variable Region (genetics)</term>
<term>Neoplasm, Residual</term>
<term>Oligonucleotide Probes</term>
<term>Polymerase Chain Reaction (methods)</term>
<term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis)</term>
<term>Sequence Alignment</term>
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<term>Chaines lourdes des immunoglobulines (génétique)</term>
<term>Enfant</term>
<term>Humains</term>
<term>Leucémie-lymphome lymphoblastique à précurseurs B et T (diagnostic)</term>
<term>Maladie résiduelle</term>
<term>Réaction de polymérisation en chaîne ()</term>
<term>Réarrangement des gènes des chaines lourdes des lymphocytes B</term>
<term>Région variable d'immunoglobuline (génétique)</term>
<term>Sondes oligonucléotidiques</term>
<term>Séquence consensus (génétique)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Immunoglobulin Heavy Chains</term>
<term>Immunoglobulin Variable Region</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term>
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<term>Séquence consensus</term>
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<term>Réaction de polymérisation en chaîne</term>
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<front><div type="abstract" xml:lang="en">To develop immunoglobulin heavy chain variable (VH) gene probes that are shorter and more flexible in position for monitoring minimal residual disease (MRD) in childhood leukaemia (ALL), using minor groove binder (MGB) technology.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14645357</PMID>
<DateCompleted><Year>2004</Year>
<Month>01</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2019</Year>
<Month>05</Month>
<Day>01</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0021-9746</ISSN>
<JournalIssue CitedMedium="Print"><Volume>56</Volume>
<Issue>12</Issue>
<PubDate><Year>2003</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Journal of clinical pathology</Title>
<ISOAbbreviation>J. Clin. Pathol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Development of immunoglobulin variable heavy chain gene consensus probes with conjugated 3' minor groove binder groups for monitoring minimal residual disease in childhood acute lymphoblastic leukaemia.</ArticleTitle>
<Pagination><MedlinePgn>952-5</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="AIMS" NlmCategory="OBJECTIVE">To develop immunoglobulin heavy chain variable (VH) gene probes that are shorter and more flexible in position for monitoring minimal residual disease (MRD) in childhood leukaemia (ALL), using minor groove binder (MGB) technology.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">All VH germline sequences registered in the database were aligned and the consensus regions were determined. The reliability of the MGB probes was compared with non-MGB probes in all 24 cases of ALL.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Ten MGB probes (16 to 18 mers) were designed that enabled all the germline sequences on the database to be analysed, whereas the conventional non-MGB probes (21 to 27 mers) did not allow the analysis of four of the VH1 and five of the VH3 germline sequences. The sequencing results in five of the 24 cases of ALL were not matched to the non-MGB probes.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">MGB technology allows shorter probes to be designed, enabling MRD to be detected in childhood ALL. This would provide a considerable reduction in cost for a large MRD study.</AbstractText>
</Abstract>
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<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Department of Pathology, Iwate Medical University School of Medicine, Uchimaru 19-1, Morioka 020-8505, Japan.</Affiliation>
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<Author ValidYN="Y"><LastName>Yashima</LastName>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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