Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.
Identifieur interne : 002B50 ( Ncbi/Curation ); précédent : 002B49; suivant : 002B51Oligonucleotides bearing 5-formyl-2'-O-methyluridine: preference in binding affinity to the NF-kappa B (p50)2 homo- and p50/p65 heterodimers.
Auteurs : A. Kittaka [Japon] ; T. Kuze ; T. Asakura ; K. Ito ; T. Miyasaka ; J. InoueSource :
- Bioorganic & medicinal chemistry letters [ 0960-894X ] ; 1998.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Uridine.
- métabolisme : ADN, Facteur de transcription NF-kappa B, Oligonucléotides, Uridine.
- Dimérisation.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : Uridine.
- chemical , metabolism : DNA, NF-kappa B, Oligonucleotides, Uridine.
- Dimerization.
Abstract
5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.
DOI: 10.1016/s0960-894x(98)00584-8
PubMed: 9873704
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pubmed:9873704Le document en format XML
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<author><name sortKey="Kittaka, A" sort="Kittaka, A" uniqKey="Kittaka A" first="A" last="Kittaka">A. Kittaka</name>
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<placeName><settlement type="city">Tokyo</settlement>
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<author><name sortKey="Asakura, T" sort="Asakura, T" uniqKey="Asakura T" first="T" last="Asakura">T. Asakura</name>
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<author><name sortKey="Ito, K" sort="Ito, K" uniqKey="Ito K" first="K" last="Ito">K. Ito</name>
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<author><name sortKey="Miyasaka, T" sort="Miyasaka, T" uniqKey="Miyasaka T" first="T" last="Miyasaka">T. Miyasaka</name>
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<author><name sortKey="Inoue, J" sort="Inoue, J" uniqKey="Inoue J" first="J" last="Inoue">J. Inoue</name>
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<series><title level="j">Bioorganic & medicinal chemistry letters</title>
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<imprint><date when="1998" type="published">1998</date>
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<term>Dimerization</term>
<term>NF-kappa B (metabolism)</term>
<term>Oligonucleotides (metabolism)</term>
<term>Uridine (analogs & derivatives)</term>
<term>Uridine (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN (métabolisme)</term>
<term>Dimérisation</term>
<term>Facteur de transcription NF-kappa B (métabolisme)</term>
<term>Oligonucléotides (métabolisme)</term>
<term>Uridine (analogues et dérivés)</term>
<term>Uridine (métabolisme)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Uridine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA</term>
<term>NF-kappa B</term>
<term>Oligonucleotides</term>
<term>Uridine</term>
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<term>Facteur de transcription NF-kappa B</term>
<term>Oligonucléotides</term>
<term>Uridine</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Dimérisation</term>
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<front><div type="abstract" xml:lang="en">5-Formyl-2'-O-methyluridine was incorporated into the various positions of oligonucleotide 26-mers containing the NF-kappa B binding sequence. Some of them showed binding selectivity toward the homo- and heterodimers of subunits of NF-kappa B.</div>
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