Nucleotide excision repair in the third kingdom.
Identifieur interne : 002B41 ( Ncbi/Curation ); précédent : 002B40; suivant : 002B42Nucleotide excision repair in the third kingdom.
Auteurs : M. Ogrünç [États-Unis] ; D F Becker ; S W Ragsdale ; A. SancarSource :
- Journal of bacteriology [ 0021-9193 ] ; 1998.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : DNA, Archaeal, Nucleotides.
- genetics : Escherichia coli, Methanobacterium.
- Animals, CHO Cells, Cricetinae, DNA Damage, DNA Repair.
Abstract
Nucleotide excision repair, a general repair mechanism for removing DNA damage, is initiated by dual incisions bracketing the lesion. In procaryotes, the dual incisions result in excision of the damage in 12- to 13-nucleotide-long oligomers, and in eucaryotes they result in excision of the damage in the form of 24- to 32-nucleotide-long oligomers. We wished to find out if Archaea perform excision repair. Using cell extracts from Methanobacterium thermoautotrophicum, we found that this organism removes UV-induced (6-4) photoproducts in the form of 10- to 11-mers by incising the sixth to seventh phosphodiester bond 5' to the damage and the fourth phosphodiester bond 3' to the damage.
PubMed: 9791138
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<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599</wicri:regionArea>
<wicri:noRegion>North Carolina 27599</wicri:noRegion>
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<author><name sortKey="Becker, D F" sort="Becker, D F" uniqKey="Becker D" first="D F" last="Becker">D F Becker</name>
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<author><name sortKey="Ragsdale, S W" sort="Ragsdale, S W" uniqKey="Ragsdale S" first="S W" last="Ragsdale">S W Ragsdale</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Nucleotide excision repair in the third kingdom.</title>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Becker, D F" sort="Becker, D F" uniqKey="Becker D" first="D F" last="Becker">D F Becker</name>
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<author><name sortKey="Ragsdale, S W" sort="Ragsdale, S W" uniqKey="Ragsdale S" first="S W" last="Ragsdale">S W Ragsdale</name>
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<series><title level="j">Journal of bacteriology</title>
<idno type="ISSN">0021-9193</idno>
<imprint><date when="1998" type="published">1998</date>
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<term>CHO Cells</term>
<term>Cricetinae</term>
<term>DNA Damage</term>
<term>DNA Repair</term>
<term>DNA, Archaeal</term>
<term>Escherichia coli (genetics)</term>
<term>Methanobacterium (genetics)</term>
<term>Nucleotides</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>ADN des archées</term>
<term>Altération de l'ADN</term>
<term>Animaux</term>
<term>Cellules CHO</term>
<term>Cricetinae</term>
<term>Escherichia coli (génétique)</term>
<term>Methanobacterium (génétique)</term>
<term>Nucléotides</term>
<term>Réparation de l'ADN</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>DNA, Archaeal</term>
<term>Nucleotides</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Escherichia coli</term>
<term>Methanobacterium</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Escherichia coli</term>
<term>Methanobacterium</term>
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<term>CHO Cells</term>
<term>Cricetinae</term>
<term>DNA Damage</term>
<term>DNA Repair</term>
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<term>Altération de l'ADN</term>
<term>Animaux</term>
<term>Cellules CHO</term>
<term>Cricetinae</term>
<term>Nucléotides</term>
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<front><div type="abstract" xml:lang="en">Nucleotide excision repair, a general repair mechanism for removing DNA damage, is initiated by dual incisions bracketing the lesion. In procaryotes, the dual incisions result in excision of the damage in 12- to 13-nucleotide-long oligomers, and in eucaryotes they result in excision of the damage in the form of 24- to 32-nucleotide-long oligomers. We wished to find out if Archaea perform excision repair. Using cell extracts from Methanobacterium thermoautotrophicum, we found that this organism removes UV-induced (6-4) photoproducts in the form of 10- to 11-mers by incising the sixth to seventh phosphodiester bond 5' to the damage and the fourth phosphodiester bond 3' to the damage.</div>
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