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PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.

Identifieur interne : 002B03 ( Ncbi/Curation ); précédent : 002B02; suivant : 002B04

PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.

Auteurs : A. Delbarre ; B P Roques ; J B Le Pecq ; J Y Lallemand ; Nguyen-Dat-Xuong

Source :

Biophysical chemistry [ 0301-4622 ] ; 1976.

RBID : pubmed:949529

Descripteurs français

KwdFr :
- ADN, Alcaloïdes, Calorimétrie, Cinétique, Conformation d'acide nucléique, Conformation moléculaire, Ellipticines, Mathématiques, Relation structure-activité, Sites de fixation, Spectroscopie par résonance magnétique, Thermodynamique.
MESH :
- ADN, Alcaloïdes, Calorimétrie, Cinétique, Conformation d'acide nucléique, Conformation moléculaire, Ellipticines, Mathématiques, Relation structure-activité, Sites de fixation, Spectroscopie par résonance magnétique, Thermodynamique.

English descriptors

KwdEn :
- Alkaloids, Binding Sites, Calorimetry, DNA, Ellipticines, Kinetics, Magnetic Resonance Spectroscopy, Mathematics, Molecular Conformation, Nucleic Acid Conformation, Structure-Activity Relationship, Thermodynamics.
MESH :
- chemical : Alkaloids, DNA, Ellipticines.
- Binding Sites, Calorimetry, Kinetics, Magnetic Resonance Spectroscopy, Mathematics, Molecular Conformation, Nucleic Acid Conformation, Structure-Activity Relationship, Thermodynamics.

Abstract

In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.

DOI: 10.1016/0301-4622(76)80075-0
PubMed: 949529

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Le document en format XML

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<author><name sortKey="Delbarre, A" sort="Delbarre, A" uniqKey="Delbarre A" first="A" last="Delbarre">A. Delbarre</name>
</author>
<author><name sortKey="Roques, B P" sort="Roques, B P" uniqKey="Roques B" first="B P" last="Roques">B P Roques</name>
</author>
<author><name sortKey="Le Pecq, J B" sort="Le Pecq, J B" uniqKey="Le Pecq J" first="J B" last="Le Pecq">J B Le Pecq</name>
</author>
<author><name sortKey="Lallemand, J Y" sort="Lallemand, J Y" uniqKey="Lallemand J" first="J Y" last="Lallemand">J Y Lallemand</name>
</author>
<author><name sortKey="Nguyen Dat Xuong" sort="Nguyen Dat Xuong" uniqKey="Nguyen Dat Xuong" last="Nguyen-Dat-Xuong">Nguyen-Dat-Xuong</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.</title>
<author><name sortKey="Delbarre, A" sort="Delbarre, A" uniqKey="Delbarre A" first="A" last="Delbarre">A. Delbarre</name>
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<author><name sortKey="Roques, B P" sort="Roques, B P" uniqKey="Roques B" first="B P" last="Roques">B P Roques</name>
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<author><name sortKey="Le Pecq, J B" sort="Le Pecq, J B" uniqKey="Le Pecq J" first="J B" last="Le Pecq">J B Le Pecq</name>
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<author><name sortKey="Lallemand, J Y" sort="Lallemand, J Y" uniqKey="Lallemand J" first="J Y" last="Lallemand">J Y Lallemand</name>
</author>
<author><name sortKey="Nguyen Dat Xuong" sort="Nguyen Dat Xuong" uniqKey="Nguyen Dat Xuong" last="Nguyen-Dat-Xuong">Nguyen-Dat-Xuong</name>
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<series><title level="j">Biophysical chemistry</title>
<idno type="ISSN">0301-4622</idno>
<imprint><date when="1976" type="published">1976</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alkaloids</term>
<term>Binding Sites</term>
<term>Calorimetry</term>
<term>DNA</term>
<term>Ellipticines</term>
<term>Kinetics</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Mathematics</term>
<term>Molecular Conformation</term>
<term>Nucleic Acid Conformation</term>
<term>Structure-Activity Relationship</term>
<term>Thermodynamics</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>ADN</term>
<term>Alcaloïdes</term>
<term>Calorimétrie</term>
<term>Cinétique</term>
<term>Conformation d'acide nucléique</term>
<term>Conformation moléculaire</term>
<term>Ellipticines</term>
<term>Mathématiques</term>
<term>Relation structure-activité</term>
<term>Sites de fixation</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Thermodynamique</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Alkaloids</term>
<term>DNA</term>
<term>Ellipticines</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Binding Sites</term>
<term>Calorimetry</term>
<term>Kinetics</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Mathematics</term>
<term>Molecular Conformation</term>
<term>Nucleic Acid Conformation</term>
<term>Structure-Activity Relationship</term>
<term>Thermodynamics</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>ADN</term>
<term>Alcaloïdes</term>
<term>Calorimétrie</term>
<term>Cinétique</term>
<term>Conformation d'acide nucléique</term>
<term>Conformation moléculaire</term>
<term>Ellipticines</term>
<term>Mathématiques</term>
<term>Relation structure-activité</term>
<term>Sites de fixation</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Thermodynamique</term>
</keywords>
</textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en">In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.</div>
</front>
</TEI>
</record>

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PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.

PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki