PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.
Identifieur interne : 002B17 ( PubMed/Curation ); précédent : 002B16; suivant : 002B18PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.
Auteurs : A. Delbarre ; B P Roques ; J B Le Pecq ; J Y Lallemand ; Nguyen-Dat-XuongSource :
- Biophysical chemistry [ 0301-4622 ] ; 1976.
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Abstract
In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.
DOI: 10.1016/0301-4622(76)80075-0
PubMed: 949529
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<author><name sortKey="Le Pecq, J B" sort="Le Pecq, J B" uniqKey="Le Pecq J" first="J B" last="Le Pecq">J B Le Pecq</name>
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<author><name sortKey="Lallemand, J Y" sort="Lallemand, J Y" uniqKey="Lallemand J" first="J Y" last="Lallemand">J Y Lallemand</name>
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<term>DNA</term>
<term>Ellipticines</term>
<term>Kinetics</term>
<term>Magnetic Resonance Spectroscopy</term>
<term>Mathematics</term>
<term>Molecular Conformation</term>
<term>Nucleic Acid Conformation</term>
<term>Structure-Activity Relationship</term>
<term>Thermodynamics</term>
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<term>Alcaloïdes</term>
<term>Calorimétrie</term>
<term>Cinétique</term>
<term>Conformation d'acide nucléique</term>
<term>Conformation moléculaire</term>
<term>Ellipticines</term>
<term>Mathématiques</term>
<term>Relation structure-activité</term>
<term>Sites de fixation</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Thermodynamique</term>
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<term>Conformation d'acide nucléique</term>
<term>Conformation moléculaire</term>
<term>Ellipticines</term>
<term>Mathématiques</term>
<term>Relation structure-activité</term>
<term>Sites de fixation</term>
<term>Spectroscopie par résonance magnétique</term>
<term>Thermodynamique</term>
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<front><div type="abstract" xml:lang="en">In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.</div>
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<Title>Biophysical chemistry</Title>
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<ArticleTitle>PMR studies of the self-association of DNA intercalating ellipticine derivatives in aqueous solution.</ArticleTitle>
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<Abstract><AbstractText>In aqueous solution DNA intercalating ellipticine derivatives aggregate in n-mers. The self-association constants K are higher than those of 2-methoxy-6-chloro-9-[3-dimethylaminopropyl-amino]-acridine and ethidium bromide. They are of the same order as that of actinomycin D but inferior to that of acridine orange. The increase of the 9-hydroxy-ellipticine constant by addition of sodium chloride shows the importance of anion participation in the mechanism of stacking in accordance with the high energy of self-association. In the stacked n-mers the ellipticine rings are inverted. The geometry shows the importance of the orientation of the quadrupole axis in the intermolecular association of the intercalating drugs.</AbstractText>
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