Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice
Identifieur interne : 002439 ( Ncbi/Curation ); précédent : 002438; suivant : 002440Recombinant adenoviral vaccine encoding the spike 1 subunit of the Middle East Respiratory Syndrome Coronavirus elicits strong humoral and cellular immune responses in mice
Auteurs : Mustafa Ababneh [Jordanie] ; Mu En Alrwashdeh [Jordanie] ; Mohammad Khalifeh [Jordanie]Source :
- Veterinary World [ 0972-8988 ] ; 2019.
Abstract
Mice were immunized initially by intramuscular injection and boosted 3 weeks later by intranasal application. Expression of the S1 protein in the lungs and kidneys was detected using conventional polymerase chain reaction (PCR) and immunohistochemistry (IHC) targeting specific regions within the S1 subunit at weeks 3, 4, 5, and 6 after the first vaccination. Antigen-specific humoral and cellular immune responses were evaluated in serum and in cell culture following
S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime. The vaccine elicited a specific S1-immunoglobulin G antibody response, which was detected in the sera of the vaccinated mice at weeks 4 and 6 from the onset of the first immunization. There was a significant increase in the amount of Th1-related cytokines (interferon-γ and interleukin [IL] 12), and a significant decrease in the Th2-related cytokine IL-4 in splenocyte cell culture of the vaccinated group compared with the control groups.
The results of this study suggest that this recombinant adenovirus vaccine encoding the S1 subunit of MERS-CoV elicits potentially protective antigen-specific humoral and cellular immune responses in mice. This study demonstrates a promising vaccine for the control and/or prevention of MERS-CoV infection in humans.
Url:
DOI: 10.14202/vetworld.2019.1554-1562
PubMed: 31849416
PubMed Central: 6868266
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PMC:6868266Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Recombinant adenoviral vaccine encoding the spike 1 subunit of the <italic>Middle East Respiratory Syndrome Coronavirus</italic>
elicits strong humoral and cellular immune responses in mice</title>
<author><name sortKey="Ababneh, Mustafa" sort="Ababneh, Mustafa" uniqKey="Ababneh M" first="Mustafa" last="Ababneh">Mustafa Ababneh</name>
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<country xml:lang="fr">Jordanie</country>
<wicri:regionArea>Department of Basic Medical Veterinary Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110</wicri:regionArea>
<wicri:noRegion>Irbid 22110</wicri:noRegion>
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<author><name sortKey="Alrwashdeh, Mu En" sort="Alrwashdeh, Mu En" uniqKey="Alrwashdeh M" first="Mu En" last="Alrwashdeh">Mu En Alrwashdeh</name>
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<country xml:lang="fr">Jordanie</country>
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<author><name sortKey="Khalifeh, Mohammad" sort="Khalifeh, Mohammad" uniqKey="Khalifeh M" first="Mohammad" last="Khalifeh">Mohammad Khalifeh</name>
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<series><title level="j">Veterinary World</title>
<idno type="ISSN">0972-8988</idno>
<idno type="eISSN">2231-0916</idno>
<imprint><date when="2019">2019</date>
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<front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background and Aim:</title>
<p><italic>Middle East respiratory syndrome coronavirus</italic>
(MERS-CoV) has rapidly spread throughout the Middle East since its discovery in 2012. The virus poses a significant global public health threat with potentially devastating effects. In this study, a recombinant adenoviral-based vaccine encoding the spike 1 (S1) subunit of the MERS-CoV genome was constructed, and its humoral, and cellular immune responses were evaluated in mice.</p>
</sec>
<sec id="st2"><title>Materials and Methods:</title>
<p>Mice were immunized initially by intramuscular injection and boosted 3 weeks later by intranasal application. Expression of the S1 protein in the lungs and kidneys was detected using conventional polymerase chain reaction (PCR) and immunohistochemistry (IHC) targeting specific regions within the S1 subunit at weeks 3, 4, 5, and 6 after the first vaccination. Antigen-specific humoral and cellular immune responses were evaluated in serum and in cell culture following <italic>in vitro</italic>
stimulation with a specific 9-mer epitope within the S1 protein (CYSSLILDY).</p>
</sec>
<sec id="st3"><title>Results:</title>
<p>S1 protein expression was only detected by IHC in the kidneys of the Ad-MERS-S1 group at week 6 from first immunization, and in both lungs and kidneys of Ad-MERS-S1 group by conventional PCR at weeks 3 and 5 post-prime. The vaccine elicited a specific S1-immunoglobulin G antibody response, which was detected in the sera of the vaccinated mice at weeks 4 and 6 from the onset of the first immunization. There was a significant increase in the amount of Th1-related cytokines (interferon-γ and interleukin [IL] 12), and a significant decrease in the Th2-related cytokine IL-4 in splenocyte cell culture of the vaccinated group compared with the control groups.</p>
</sec>
<sec id="st4"><title>Conclusion:</title>
<p>The results of this study suggest that this recombinant adenovirus vaccine encoding the S1 subunit of MERS-CoV elicits potentially protective antigen-specific humoral and cellular immune responses in mice. This study demonstrates a promising vaccine for the control and/or prevention of MERS-CoV infection in humans.</p>
</sec>
</div>
</front>
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</TEI>
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