High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Identifieur interne : 001188 ( Ncbi/Curation ); précédent : 001187; suivant : 001189High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Auteurs : Elmoubasher A. B. A. Farag [Qatar] ; Chantal B. E. M. Reusken [Pays-Bas] ; Bart L. Haagmans [Qatar] ; Khaled A. Mohran [Qatar] ; V. Stalin Raj [Pays-Bas] ; Suzan D. Pas [Pays-Bas] ; Jolanda Voermans [Pays-Bas] ; Saskia L. Smits [Pays-Bas] ; Gert-Jan Godeke [Pays-Bas] ; Mohd. M. Al-Hajri [Qatar] ; Farhoud H. Alhajri [Qatar] ; Hamad E. Al-Romaihi [Qatar] ; Hazem Ghobashy [Qatar] ; Mamdouh M. El-Maghraby [Qatar] ; Ahmed M. El-Sayed [Qatar] ; Mohamed H. J. Al Thani [Qatar] ; Salih Al-Marri [Qatar] ; Marion P. G. Koopmans [Pays-Bas]Source :
- Infection Ecology & Epidemiology [ 2000-8686 ] ; 2015.
Abstract
Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.
Url:
DOI: 10.3402/iee.v5.28305
PubMed: 26183160
PubMed Central: 4505336
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PMC:4505336Le document en format XML
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<author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name>
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<author><name sortKey="Al Hajri, Mohd M" sort="Al Hajri, Mohd M" uniqKey="Al Hajri M" first="Mohd. M." last="Al-Hajri">Mohd. M. Al-Hajri</name>
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<author><name sortKey="Alhajri, Farhoud H" sort="Alhajri, Farhoud H" uniqKey="Alhajri F" first="Farhoud H." last="Alhajri">Farhoud H. Alhajri</name>
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<author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E." last="Al-Romaihi">Hamad E. Al-Romaihi</name>
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<author><name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name>
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<author><name sortKey="El Maghraby, Mamdouh M" sort="El Maghraby, Mamdouh M" uniqKey="El Maghraby M" first="Mamdouh M." last="El-Maghraby">Mamdouh M. El-Maghraby</name>
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<author><name sortKey="El Sayed, Ahmed M" sort="El Sayed, Ahmed M" uniqKey="El Sayed A" first="Ahmed M." last="El-Sayed">Ahmed M. El-Sayed</name>
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<author><name sortKey="Al Thani, Mohamed H J" sort="Al Thani, Mohamed H J" uniqKey="Al Thani M" first="Mohamed H. J." last="Al Thani">Mohamed H. J. Al Thani</name>
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<author><name sortKey="Al Marri, Salih" sort="Al Marri, Salih" uniqKey="Al Marri S" first="Salih" last="Al-Marri">Salih Al-Marri</name>
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<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name>
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<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="AF0004">Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea>
<wicri:noRegion>Bilthoven</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Infection Ecology & Epidemiology</title>
<idno type="eISSN">2000-8686</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
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<profileDesc><textClass></textClass>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct></biblStruct>
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</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
</record>
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