High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Identifieur interne : 001188 ( Ncbi/Curation ); précédent : 001187; suivant : 001189High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Auteurs : Elmoubasher A. B. A. Farag [Qatar] ; Chantal B. E. M. Reusken [Pays-Bas] ; Bart L. Haagmans [Qatar] ; Khaled A. Mohran [Qatar] ; V. Stalin Raj [Pays-Bas] ; Suzan D. Pas [Pays-Bas] ; Jolanda Voermans [Pays-Bas] ; Saskia L. Smits [Pays-Bas] ; Gert-Jan Godeke [Pays-Bas] ; Mohd. M. Al-Hajri [Qatar] ; Farhoud H. Alhajri [Qatar] ; Hamad E. Al-Romaihi [Qatar] ; Hazem Ghobashy [Qatar] ; Mamdouh M. El-Maghraby [Qatar] ; Ahmed M. El-Sayed [Qatar] ; Mohamed H. J. Al Thani [Qatar] ; Salih Al-Marri [Qatar] ; Marion P. G. Koopmans [Pays-Bas]Source :
- Infection Ecology & Epidemiology [ 2000-8686 ] ; 2015.
Abstract
Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.
Url:
DOI: 10.3402/iee.v5.28305
PubMed: 26183160
PubMed Central: 4505336
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B. A." last="Farag">Elmoubasher A. B. A. Farag</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B. E. M." last="Reusken">Chantal B. E. M. Reusken</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Mohran, Khaled A" sort="Mohran, Khaled A" uniqKey="Mohran K" first="Khaled A." last="Mohran">Khaled A. Mohran</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Pas, Suzan D" sort="Pas, Suzan D" uniqKey="Pas S" first="Suzan D." last="Pas">Suzan D. Pas</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Voermans, Jolanda" sort="Voermans, Jolanda" uniqKey="Voermans J" first="Jolanda" last="Voermans">Jolanda Voermans</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Godeke, Gert Jan" sort="Godeke, Gert Jan" uniqKey="Godeke G" first="Gert-Jan" last="Godeke">Gert-Jan Godeke</name><affiliation wicri:level="1"><nlm:aff id="AF0004">Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Al Hajri, Mohd M" sort="Al Hajri, Mohd M" uniqKey="Al Hajri M" first="Mohd. M." last="Al-Hajri">Mohd. M. Al-Hajri</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Alhajri, Farhoud H" sort="Alhajri, Farhoud H" uniqKey="Alhajri F" first="Farhoud H." last="Alhajri">Farhoud H. Alhajri</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E." last="Al-Romaihi">Hamad E. Al-Romaihi</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="El Maghraby, Mamdouh M" sort="El Maghraby, Mamdouh M" uniqKey="El Maghraby M" first="Mamdouh M." last="El-Maghraby">Mamdouh M. El-Maghraby</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="El Sayed, Ahmed M" sort="El Sayed, Ahmed M" uniqKey="El Sayed A" first="Ahmed M." last="El-Sayed">Ahmed M. El-Sayed</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Al Thani, Mohamed H J" sort="Al Thani, Mohamed H J" uniqKey="Al Thani M" first="Mohamed H. J." last="Al Thani">Mohamed H. J. Al Thani</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Al Marri, Salih" sort="Al Marri, Salih" uniqKey="Al Marri S" first="Salih" last="Al-Marri">Salih Al-Marri</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea><wicri:noRegion>Doha</wicri:noRegion></affiliation></author><author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name><affiliation wicri:level="3"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author></analytic><series><title level="j">Infection Ecology & Epidemiology</title><idno type="eISSN">2000-8686</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mackay, Im" uniqKey="Mackay I">IM Mackay</name></author><author><name sortKey="Arden, Ke" uniqKey="Arden K">KE Arden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Al Dhahiry, Sh" uniqKey="Al Dhahiry S">SH Al Dhahiry</name></author><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name></author><author><name sortKey="Myers, R" uniqKey="Myers R">R 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sortKey="Shehata, Mm" uniqKey="Shehata M">MM Shehata</name></author><author><name sortKey="Perera, Rapm" uniqKey="Perera R">RAPM Perera</name></author><author><name sortKey="Zeid, Da" uniqKey="Zeid D">DA Zeid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author><author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name></author><author><name sortKey="Aljassim, Ra" uniqKey="Aljassim R">RA AlJassim</name></author><author><name sortKey="Kayali, G" uniqKey="Kayali G">G Kayali</name></author><author><name sortKey="Siu, Ly" uniqKey="Siu L">LY Siu</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Younan, M" uniqKey="Younan M">M Younan</name></author><author><name sortKey="Liljander, A" uniqKey="Liljander A">A Liljander</name></author><author><name sortKey="Said, My" uniqKey="Said M">MY Said</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author><author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author><author><name sortKey="Alhammadi, Ma" uniqKey="Alhammadi M">MA Alhammadi</name></author><author><name sortKey="Siu, Ly" uniqKey="Siu L">LY Siu</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author><author><name sortKey="Chu, Dkw" uniqKey="Chu D">DKW Chu</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Perera, Rapm" uniqKey="Perera R">RAPM Perera</name></author><author><name sortKey="Alhammadi, Ma" uniqKey="Alhammadi M">MA Alhammadi</name></author><author><name sortKey="Ng, H" uniqKey="Ng H">H Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saif, Lj" uniqKey="Saif L">LJ Saif</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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