High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Identifieur interne : 000015 ( Pmc/Curation ); précédent : 000014; suivant : 000016High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Auteurs : Elmoubasher A. B. A. Farag [Qatar] ; Chantal B. E. M. Reusken [Pays-Bas] ; Bart L. Haagmans [Qatar] ; Khaled A. Mohran [Qatar] ; V. Stalin Raj [Pays-Bas] ; Suzan D. Pas [Pays-Bas] ; Jolanda Voermans [Pays-Bas] ; Saskia L. Smits [Pays-Bas] ; Gert-Jan Godeke [Pays-Bas] ; Mohd. M. Al-Hajri [Qatar] ; Farhoud H. Alhajri [Qatar] ; Hamad E. Al-Romaihi [Qatar] ; Hazem Ghobashy [Qatar] ; Mamdouh M. El-Maghraby [Qatar] ; Ahmed M. El-Sayed [Qatar] ; Mohamed H. J. Al Thani [Qatar] ; Salih Al-Marri [Qatar] ; Marion P. G. Koopmans [Pays-Bas]Source :
- Infection Ecology & Epidemiology [ 2000-8686 ] ; 2015.
Abstract
Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.
Url:
DOI: 10.3402/iee.v5.28305
PubMed: 26183160
PubMed Central: 4505336
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000015
Links to Exploration step
PMC:4505336Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014</title><author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A. B. A." last="Farag">Elmoubasher A. B. A. Farag</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B. E. M." last="Reusken">Chantal B. E. M. Reusken</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Mohran, Khaled A" sort="Mohran, Khaled A" uniqKey="Mohran K" first="Khaled A." last="Mohran">Khaled A. Mohran</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Pas, Suzan D" sort="Pas, Suzan D" uniqKey="Pas S" first="Suzan D." last="Pas">Suzan D. Pas</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Voermans, Jolanda" sort="Voermans, Jolanda" uniqKey="Voermans J" first="Jolanda" last="Voermans">Jolanda Voermans</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Godeke, Gert Jan" sort="Godeke, Gert Jan" uniqKey="Godeke G" first="Gert-Jan" last="Godeke">Gert-Jan Godeke</name><affiliation wicri:level="1"><nlm:aff id="AF0004">Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea></affiliation></author><author><name sortKey="Al Hajri, Mohd M" sort="Al Hajri, Mohd M" uniqKey="Al Hajri M" first="Mohd. M." last="Al-Hajri">Mohd. M. Al-Hajri</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Alhajri, Farhoud H" sort="Alhajri, Farhoud H" uniqKey="Alhajri F" first="Farhoud H." last="Alhajri">Farhoud H. Alhajri</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E." last="Al-Romaihi">Hamad E. Al-Romaihi</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="El Maghraby, Mamdouh M" sort="El Maghraby, Mamdouh M" uniqKey="El Maghraby M" first="Mamdouh M." last="El-Maghraby">Mamdouh M. El-Maghraby</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="El Sayed, Ahmed M" sort="El Sayed, Ahmed M" uniqKey="El Sayed A" first="Ahmed M." last="El-Sayed">Ahmed M. El-Sayed</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Al Thani, Mohamed H J" sort="Al Thani, Mohamed H J" uniqKey="Al Thani M" first="Mohamed H. J." last="Al Thani">Mohamed H. J. Al Thani</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Al Marri, Salih" sort="Al Marri, Salih" uniqKey="Al Marri S" first="Salih" last="Al-Marri">Salih Al-Marri</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26183160</idno><idno type="pmc">4505336</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505336</idno><idno type="RBID">PMC:4505336</idno><idno type="doi">10.3402/iee.v5.28305</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000015</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000015</idno><idno type="wicri:Area/Pmc/Curation">000015</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000015</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014</title><author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A. B. A." last="Farag">Elmoubasher A. B. A. Farag</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B. E. M." last="Reusken">Chantal B. E. M. Reusken</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Mohran, Khaled A" sort="Mohran, Khaled A" uniqKey="Mohran K" first="Khaled A." last="Mohran">Khaled A. Mohran</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Pas, Suzan D" sort="Pas, Suzan D" uniqKey="Pas S" first="Suzan D." last="Pas">Suzan D. Pas</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Voermans, Jolanda" sort="Voermans, Jolanda" uniqKey="Voermans J" first="Jolanda" last="Voermans">Jolanda Voermans</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation></author><author><name sortKey="Godeke, Gert Jan" sort="Godeke, Gert Jan" uniqKey="Godeke G" first="Gert-Jan" last="Godeke">Gert-Jan Godeke</name><affiliation wicri:level="1"><nlm:aff id="AF0004">Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea></affiliation></author><author><name sortKey="Al Hajri, Mohd M" sort="Al Hajri, Mohd M" uniqKey="Al Hajri M" first="Mohd. M." last="Al-Hajri">Mohd. M. Al-Hajri</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Alhajri, Farhoud H" sort="Alhajri, Farhoud H" uniqKey="Alhajri F" first="Farhoud H." last="Alhajri">Farhoud H. Alhajri</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E." last="Al-Romaihi">Hamad E. Al-Romaihi</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="El Maghraby, Mamdouh M" sort="El Maghraby, Mamdouh M" uniqKey="El Maghraby M" first="Mamdouh M." last="El-Maghraby">Mamdouh M. El-Maghraby</name><affiliation wicri:level="1"><nlm:aff id="AF0003">Animal Resources Department-Ministry of Environment, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Animal Resources Department-Ministry of Environment, Doha</wicri:regionArea></affiliation></author><author><name sortKey="El Sayed, Ahmed M" sort="El Sayed, Ahmed M" uniqKey="El Sayed A" first="Ahmed M." last="El-Sayed">Ahmed M. El-Sayed</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Al Thani, Mohamed H J" sort="Al Thani, Mohamed H J" uniqKey="Al Thani M" first="Mohamed H. J." last="Al Thani">Mohamed H. J. Al Thani</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Al Marri, Salih" sort="Al Marri, Salih" uniqKey="Al Marri S" first="Salih" last="Al-Marri">Salih Al-Marri</name><affiliation wicri:level="1"><nlm:aff id="AF0001">Supreme Council of Health, Doha, Qatar</nlm:aff><country xml:lang="fr">Qatar</country><wicri:regionArea>Supreme Council of Health, Doha</wicri:regionArea></affiliation></author><author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name><affiliation wicri:level="1"><nlm:aff id="AF0002">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="AF0004">Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven</wicri:regionArea></affiliation></author></analytic><series><title level="j">Infection Ecology & Epidemiology</title><idno type="eISSN">2000-8686</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Mackay, Im" uniqKey="Mackay I">IM Mackay</name></author><author><name sortKey="Arden, Ke" uniqKey="Arden K">KE Arden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Al Dhahiry, Sh" uniqKey="Al Dhahiry S">SH Al Dhahiry</name></author><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Galiano, M" uniqKey="Galiano M">M Galiano</name></author><author><name sortKey="Myers, R" uniqKey="Myers R">R Myers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alagaili, An" uniqKey="Alagaili A">AN Alagaili</name></author><author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name></author><author><name sortKey="Mishra, N" uniqKey="Mishra N">N Mishra</name></author><author><name sortKey="Kapoor, V" uniqKey="Kapoor V">V Kapoor</name></author><author><name sortKey="Sameroff, Sc" uniqKey="Sameroff S">SC Sameroff</name></author><author><name sortKey="De Wit, E" uniqKey="De Wit E">E de Wit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Memish, Z" uniqKey="Memish Z">Z Memish</name></author><author><name sortKey="Cotton, M" uniqKey="Cotton M">M Cotton</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Watson, S" uniqKey="Watson S">S Watson</name></author><author><name sortKey="Alsahafi, A" uniqKey="Alsahafi A">A Alsahafi</name></author><author><name sortKey="Al Rabeeah, A" uniqKey="Al Rabeeah A">A Al Rabeeah</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Eckerle, I" uniqKey="Eckerle I">I Eckerle</name></author><author><name sortKey="Bleicker, T" uniqKey="Bleicker T">T Bleicker</name></author><author><name sortKey="Zaki, A" uniqKey="Zaki A">A Zaki</name></author><author><name sortKey="Landt, O" uniqKey="Landt O">O Landt</name></author><author><name sortKey="Eschbach Bludau, M" uniqKey="Eschbach Bludau M">M Eschbach-Bludau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Farag, E" uniqKey="Farag E">E Farag</name></author><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Lamers, Mm" uniqKey="Lamers M">MM Lamers</name></author><author><name sortKey="Pas, Sd" uniqKey="Pas S">SD Pas</name></author><author><name sortKey="Voermans, J" uniqKey="Voermans J">J Voermans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smits, Sl" uniqKey="Smits S">SL Smits</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author><author><name sortKey="Pas, Sd" uniqKey="Pas S">SD Pas</name></author><author><name sortKey="Reusken, C" uniqKey="Reusken C">C Reusken</name></author><author><name sortKey="Mohran, Ka" uniqKey="Mohran K">KA Mohran</name></author><author><name sortKey="Farag, E" uniqKey="Farag E">E Farag</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cb" uniqKey="Reusken C">CB Reusken</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Muller, Ma" uniqKey="Muller M">MA Muller</name></author><author><name sortKey="Gutierrez, C" uniqKey="Gutierrez C">C Gutierrez</name></author><author><name sortKey="Godeke, Gj" uniqKey="Godeke G">GJ Godeke</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reusken, Cbem" uniqKey="Reusken C">CBEM Reusken</name></author><author><name sortKey="Farag, Eaba" uniqKey="Farag E">EABA Farag</name></author><author><name sortKey="Haagmans, Bl" uniqKey="Haagmans B">BL Haagmans</name></author><author><name sortKey="Mohran, Ka" uniqKey="Mohran K">KA Mohran</name></author><author><name sortKey="Godeke, G J" uniqKey="Godeke G">G-J Godeke</name></author><author><name sortKey="Raj, Vs" uniqKey="Raj V">VS Raj</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Dkw" uniqKey="Chu D">DKW Chu</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Gomaa, Mm" uniqKey="Gomaa M">MM Gomaa</name></author><author><name sortKey="Shehata, Mm" uniqKey="Shehata M">MM Shehata</name></author><author><name sortKey="Perera, Rapm" uniqKey="Perera R">RAPM Perera</name></author><author><name sortKey="Zeid, Da" uniqKey="Zeid D">DA Zeid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author><author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name></author><author><name sortKey="Aljassim, Ra" uniqKey="Aljassim R">RA AlJassim</name></author><author><name sortKey="Kayali, G" uniqKey="Kayali G">G Kayali</name></author><author><name sortKey="Siu, Ly" uniqKey="Siu L">LY Siu</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corman, Vm" uniqKey="Corman V">VM Corman</name></author><author><name sortKey="Jores, J" uniqKey="Jores J">J Jores</name></author><author><name sortKey="Meyer, B" uniqKey="Meyer B">B Meyer</name></author><author><name sortKey="Younan, M" uniqKey="Younan M">M Younan</name></author><author><name sortKey="Liljander, A" uniqKey="Liljander A">A Liljander</name></author><author><name sortKey="Said, My" uniqKey="Said M">MY Said</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author><author><name sortKey="Perera, Ra" uniqKey="Perera R">RA Perera</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P Wang</name></author><author><name sortKey="Alhammadi, Ma" uniqKey="Alhammadi M">MA Alhammadi</name></author><author><name sortKey="Siu, Ly" uniqKey="Siu L">LY Siu</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hemida, Mg" uniqKey="Hemida M">MG Hemida</name></author><author><name sortKey="Chu, Dkw" uniqKey="Chu D">DKW Chu</name></author><author><name sortKey="Poon, Llm" uniqKey="Poon L">LLM Poon</name></author><author><name sortKey="Perera, Rapm" uniqKey="Perera R">RAPM Perera</name></author><author><name sortKey="Alhammadi, Ma" uniqKey="Alhammadi M">MA Alhammadi</name></author><author><name sortKey="Ng, H" uniqKey="Ng H">H Ng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saif, Lj" uniqKey="Saif L">LJ Saif</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Ecol Epidemiol</journal-id><journal-id journal-id-type="iso-abbrev">Infect Ecol Epidemiol</journal-id><journal-id journal-id-type="publisher-id">IEE</journal-id><journal-title-group><journal-title>Infection Ecology & Epidemiology</journal-title></journal-title-group><issn pub-type="epub">2000-8686</issn><publisher><publisher-name>Co-Action Publishing</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26183160</article-id><article-id pub-id-type="pmc">4505336</article-id><article-id pub-id-type="publisher-id">28305</article-id><article-id pub-id-type="doi">10.3402/iee.v5.28305</article-id><article-categories><subj-group subj-group-type="heading"><subject>Short Communication</subject></subj-group></article-categories><title-group><article-title>High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Farag</surname><given-names>Elmoubasher A. B. A.</given-names></name><degrees>MPH</degrees><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="corresp" rid="cor2">†</xref></contrib><contrib contrib-type="author"><name><surname>Reusken</surname><given-names>Chantal B. E. M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="AF0002">2</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="corresp" rid="cor2">†</xref></contrib><contrib contrib-type="author"><name><surname>Haagmans</surname><given-names>Bart L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="corresp" rid="cor2">†</xref></contrib><contrib contrib-type="author"><name><surname>Mohran</surname><given-names>Khaled A.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="AF0003">3</xref><xref ref-type="corresp" rid="cor2">†</xref></contrib><contrib contrib-type="author"><name><surname>Raj</surname><given-names>V. Stalin</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Pas</surname><given-names>Suzan D.</given-names></name><degrees>Msc</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Voermans</surname><given-names>Jolanda</given-names></name><degrees>Bsc</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Smits</surname><given-names>Saskia L.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Godeke</surname><given-names>Gert-Jan</given-names></name><degrees>Bsc</degrees><xref ref-type="aff" rid="AF0004">4</xref></contrib><contrib contrib-type="author"><name><surname>Al-Hajri</surname><given-names>Mohd. M.</given-names></name><degrees>ABCM</degrees><xref ref-type="aff" rid="AF0001">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Alhajri</surname><given-names>Farhoud H.</given-names></name><degrees>Bsc</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>Al-Romaihi</surname><given-names>Hamad E.</given-names></name><degrees>ABCM</degrees><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Ghobashy</surname><given-names>Hazem</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>El-Maghraby</surname><given-names>Mamdouh M.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="AF0003">3</xref></contrib><contrib contrib-type="author"><name><surname>El-Sayed</surname><given-names>Ahmed M.</given-names></name><degrees>ABCM</degrees><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Al Thani</surname><given-names>Mohamed H. J.</given-names></name><degrees>ABCM</degrees><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Al-Marri</surname><given-names>Salih</given-names></name><degrees>ABFM</degrees><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Koopmans</surname><given-names>Marion P. G.</given-names></name><degrees>PhD</degrees><role>Prof</role><xref ref-type="aff" rid="AF0002">2</xref><xref ref-type="aff" rid="AF0004">4</xref></contrib></contrib-group><aff id="AF0001"><label>1</label>Supreme Council of Health, Doha, Qatar</aff><aff id="AF0002"><label>2</label>Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</aff><aff id="AF0003"><label>3</label>Animal Resources Department-Ministry of Environment, Doha, Qatar</aff><aff id="AF0004"><label>4</label>Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</aff><author-notes><corresp id="cor1"><label>*</label>Correspondence to: Chantal B. E. M. Reusken, Viroscience department, ErasmusMC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands, Email: <email xlink:href="c.reusken@erasmusmc.nl">c.reusken@erasmusmc.nl</email>; Mohd. M. Al-Hajri, Supreme Council of Health, P.O. Box 42, Doha, Qatar, Email: <email xlink:href="malhajri1@sch.gov.qa">malhajri1@sch.gov.qa</email></corresp><corresp id="cor2"><label>†</label>These authors contributed equally to the manuscript.</corresp><fn><p>Responsible Editor: Elas Jourdain, INRA, Centre de Recherche de Clermont-Ferrand/Theix, Saint Genès Champanelle, France.</p></fn></author-notes><pub-date pub-type="epub"><day>15</day><month>7</month><year>2015</year></pub-date><pub-date pub-type="collection"><year>2015</year></pub-date><volume>5</volume><elocation-id content-type="doi">10.3402/iee.v5.28305</elocation-id><history><date date-type="received"><day>21</day><month>4</month><year>2015</year></date><date date-type="rev-recd"><day>22</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>22</day><month>6</month><year>2015</year></date></history><permissions><copyright-statement>© 2015 Elmoubasher A. B. A. Farag et al.</copyright-statement><copyright-year>2015</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.</p></abstract><kwd-group><kwd>zoonoses</kwd><kwd>camels</kwd><kwd>MERS-CoV</kwd><kwd>respiratory infections</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000015 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 000015 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Pmc
|étape= Curation
|type= RBID
|clé= PMC:4505336
|texte= High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:26183160" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |