High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Identifieur interne : 000015 ( Pmc/Curation ); précédent : 000014; suivant : 000016High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014
Auteurs : Elmoubasher A. B. A. Farag [Qatar] ; Chantal B. E. M. Reusken [Pays-Bas] ; Bart L. Haagmans [Qatar] ; Khaled A. Mohran [Qatar] ; V. Stalin Raj [Pays-Bas] ; Suzan D. Pas [Pays-Bas] ; Jolanda Voermans [Pays-Bas] ; Saskia L. Smits [Pays-Bas] ; Gert-Jan Godeke [Pays-Bas] ; Mohd. M. Al-Hajri [Qatar] ; Farhoud H. Alhajri [Qatar] ; Hamad E. Al-Romaihi [Qatar] ; Hazem Ghobashy [Qatar] ; Mamdouh M. El-Maghraby [Qatar] ; Ahmed M. El-Sayed [Qatar] ; Mohamed H. J. Al Thani [Qatar] ; Salih Al-Marri [Qatar] ; Marion P. G. Koopmans [Pays-Bas]Source :
- Infection Ecology & Epidemiology [ 2000-8686 ] ; 2015.
Abstract
Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.
Url:
DOI: 10.3402/iee.v5.28305
PubMed: 26183160
PubMed Central: 4505336
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<author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E." last="Al-Romaihi">Hamad E. Al-Romaihi</name>
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<author><name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014</title>
<author><name sortKey="Farag, Elmoubasher A B A" sort="Farag, Elmoubasher A B A" uniqKey="Farag E" first="Elmoubasher A. B. A." last="Farag">Elmoubasher A. B. A. Farag</name>
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<author><name sortKey="Reusken, Chantal B E M" sort="Reusken, Chantal B E M" uniqKey="Reusken C" first="Chantal B. E. M." last="Reusken">Chantal B. E. M. Reusken</name>
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<author><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name>
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<author><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name>
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<author><name sortKey="Voermans, Jolanda" sort="Voermans, Jolanda" uniqKey="Voermans J" first="Jolanda" last="Voermans">Jolanda Voermans</name>
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<author><name sortKey="Smits, Saskia L" sort="Smits, Saskia L" uniqKey="Smits S" first="Saskia L." last="Smits">Saskia L. Smits</name>
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<author><name sortKey="Godeke, Gert Jan" sort="Godeke, Gert Jan" uniqKey="Godeke G" first="Gert-Jan" last="Godeke">Gert-Jan Godeke</name>
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<author><name sortKey="Al Hajri, Mohd M" sort="Al Hajri, Mohd M" uniqKey="Al Hajri M" first="Mohd. M." last="Al-Hajri">Mohd. M. Al-Hajri</name>
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<author><name sortKey="Alhajri, Farhoud H" sort="Alhajri, Farhoud H" uniqKey="Alhajri F" first="Farhoud H." last="Alhajri">Farhoud H. Alhajri</name>
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<author><name sortKey="Al Romaihi, Hamad E" sort="Al Romaihi, Hamad E" uniqKey="Al Romaihi H" first="Hamad E." last="Al-Romaihi">Hamad E. Al-Romaihi</name>
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<author><name sortKey="Ghobashy, Hazem" sort="Ghobashy, Hazem" uniqKey="Ghobashy H" first="Hazem" last="Ghobashy">Hazem Ghobashy</name>
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<author><name sortKey="El Maghraby, Mamdouh M" sort="El Maghraby, Mamdouh M" uniqKey="El Maghraby M" first="Mamdouh M." last="El-Maghraby">Mamdouh M. El-Maghraby</name>
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<author><name sortKey="El Sayed, Ahmed M" sort="El Sayed, Ahmed M" uniqKey="El Sayed A" first="Ahmed M." last="El-Sayed">Ahmed M. El-Sayed</name>
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<author><name sortKey="Al Thani, Mohamed H J" sort="Al Thani, Mohamed H J" uniqKey="Al Thani M" first="Mohamed H. J." last="Al Thani">Mohamed H. J. Al Thani</name>
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<author><name sortKey="Al Marri, Salih" sort="Al Marri, Salih" uniqKey="Al Marri S" first="Salih" last="Al-Marri">Salih Al-Marri</name>
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<author><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name>
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<front><div type="abstract" xml:lang="en"><p>Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.</p>
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</TEI>
<pmc article-type="brief-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Ecol Epidemiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Infect Ecol Epidemiol</journal-id>
<journal-id journal-id-type="publisher-id">IEE</journal-id>
<journal-title-group><journal-title>Infection Ecology & Epidemiology</journal-title>
</journal-title-group>
<issn pub-type="epub">2000-8686</issn>
<publisher><publisher-name>Co-Action Publishing</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26183160</article-id>
<article-id pub-id-type="pmc">4505336</article-id>
<article-id pub-id-type="publisher-id">28305</article-id>
<article-id pub-id-type="doi">10.3402/iee.v5.28305</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Short Communication</subject>
</subj-group>
</article-categories>
<title-group><article-title>High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Farag</surname>
<given-names>Elmoubasher A. B. A.</given-names>
</name>
<degrees>MPH</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="corresp" rid="cor2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reusken</surname>
<given-names>Chantal B. E. M.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
<xref ref-type="corresp" rid="cor2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Haagmans</surname>
<given-names>Bart L.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="corresp" rid="cor2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Mohran</surname>
<given-names>Khaled A.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="AF0003">3</xref>
<xref ref-type="corresp" rid="cor2">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Raj</surname>
<given-names>V. Stalin</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pas</surname>
<given-names>Suzan D.</given-names>
</name>
<degrees>Msc</degrees>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Voermans</surname>
<given-names>Jolanda</given-names>
</name>
<degrees>Bsc</degrees>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smits</surname>
<given-names>Saskia L.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="AF0002">2</xref>
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<contrib contrib-type="author"><name><surname>Godeke</surname>
<given-names>Gert-Jan</given-names>
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<degrees>Bsc</degrees>
<xref ref-type="aff" rid="AF0004">4</xref>
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<contrib contrib-type="author"><name><surname>Al-Hajri</surname>
<given-names>Mohd. M.</given-names>
</name>
<degrees>ABCM</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
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<contrib contrib-type="author"><name><surname>Alhajri</surname>
<given-names>Farhoud H.</given-names>
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<degrees>Bsc</degrees>
<xref ref-type="aff" rid="AF0003">3</xref>
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<given-names>Hamad E.</given-names>
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<degrees>ABCM</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
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<given-names>Hazem</given-names>
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<degrees>PhD</degrees>
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<given-names>Ahmed M.</given-names>
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<given-names>Mohamed H. J.</given-names>
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<xref ref-type="aff" rid="AF0001">1</xref>
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<given-names>Salih</given-names>
</name>
<degrees>ABFM</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
</contrib>
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<given-names>Marion P. G.</given-names>
</name>
<degrees>PhD</degrees>
<role>Prof</role>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="aff" rid="AF0004">4</xref>
</contrib>
</contrib-group>
<aff id="AF0001"><label>1</label>
Supreme Council of Health, Doha, Qatar</aff>
<aff id="AF0002"><label>2</label>
Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</aff>
<aff id="AF0003"><label>3</label>
Animal Resources Department-Ministry of Environment, Doha, Qatar</aff>
<aff id="AF0004"><label>4</label>
Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands</aff>
<author-notes><corresp id="cor1"><label>*</label>
Correspondence to: Chantal B. E. M. Reusken, Viroscience department, ErasmusMC, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands, Email: <email xlink:href="c.reusken@erasmusmc.nl">c.reusken@erasmusmc.nl</email>
; Mohd. M. Al-Hajri, Supreme Council of Health, P.O. Box 42, Doha, Qatar, Email: <email xlink:href="malhajri1@sch.gov.qa">malhajri1@sch.gov.qa</email>
</corresp>
<corresp id="cor2"><label>†</label>
These authors contributed equally to the manuscript.</corresp>
<fn><p>Responsible Editor: Elas Jourdain, INRA, Centre de Recherche de Clermont-Ferrand/Theix, Saint Genès Champanelle, France.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>15</day>
<month>7</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>5</volume>
<elocation-id content-type="doi">10.3402/iee.v5.28305</elocation-id>
<history><date date-type="received"><day>21</day>
<month>4</month>
<year>2015</year>
</date>
<date date-type="rev-recd"><day>22</day>
<month>6</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>22</day>
<month>6</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>© 2015 Elmoubasher A. B. A. Farag et al.</copyright-statement>
<copyright-year>2015</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Two of the earliest Middle East respiratory syndrome (MERS) cases were men who had visited the Doha central animal market and adjoining slaughterhouse in Qatar. We show that a high proportion of camels presenting for slaughter in Qatar show evidence for nasal MERS-CoV shedding (62/105). Sequence analysis showed the circulation of at least five different virus strains at these premises, suggesting that this location is a driver of MERS-CoV circulation and a high-risk area for human exposure. No correlation between RNA loads and levels of neutralizing antibodies was observed, suggesting limited immune protection and potential for reinfection despite previous exposure.</p>
</abstract>
<kwd-group><kwd>zoonoses</kwd>
<kwd>camels</kwd>
<kwd>MERS-CoV</kwd>
<kwd>respiratory infections</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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