Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: An analysis of ATP-induced ribonucleotide reductase R1 hexamerization data
Identifieur interne : 000724 ( Ncbi/Curation ); précédent : 000723; suivant : 000725Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: An analysis of ATP-induced ribonucleotide reductase R1 hexamerization data
Auteurs : Tomas Radivoyevitch [États-Unis]Source :
- Biology Direct [ 1745-6150 ] ; 2009.
Descripteurs français
- KwdFr :
- Adénosine triphosphate (métabolisme), Domaine catalytique, Dynamique non linéaire, Humains, Modèles biologiques, Multimérisation de protéines, Méthode des moindres carrés, Nucléotide désoxyadenylique (métabolisme), Nucléotide désoxyguanylique (métabolisme), Nucléotides thymidyliques (métabolisme), Ribonucleotide reductases (), Ribonucleotide reductases (antagonistes et inhibiteurs), Ribonucleotide reductases (métabolisme), Simulation numérique, Sous-unités de protéines, Spécificité du substrat.
- MESH :
- antagonistes et inhibiteurs : Ribonucleotide reductases.
- métabolisme : Adénosine triphosphate, Nucléotide désoxyadenylique, Nucléotide désoxyguanylique, Nucléotides thymidyliques, Ribonucleotide reductases.
- Domaine catalytique, Dynamique non linéaire, Humains, Modèles biologiques, Multimérisation de protéines, Méthode des moindres carrés, Ribonucleotide reductases, Simulation numérique, Sous-unités de protéines, Spécificité du substrat.
English descriptors
- KwdEn :
- Adenosine Triphosphate (metabolism), Catalytic Domain, Computer Simulation, Deoxyadenine Nucleotides (metabolism), Deoxyguanine Nucleotides (metabolism), Humans, Least-Squares Analysis, Models, Biological, Nonlinear Dynamics, Protein Multimerization, Protein Subunits, Ribonucleotide Reductases (antagonists & inhibitors), Ribonucleotide Reductases (chemistry), Ribonucleotide Reductases (metabolism), Substrate Specificity, Thymine Nucleotides (metabolism).
- MESH :
- chemical , antagonists & inhibitors : Ribonucleotide Reductases.
- chemical , chemistry : Ribonucleotide Reductases.
- chemical , metabolism : Adenosine Triphosphate, Deoxyadenine Nucleotides, Deoxyguanine Nucleotides, Ribonucleotide Reductases, Thymine Nucleotides.
- Catalytic Domain, Computer Simulation, Humans, Least-Squares Analysis, Models, Biological, Nonlinear Dynamics, Protein Multimerization, Protein Subunits, Substrate Specificity.
Abstract
Ribonucleotide reductase is the main control point of dNTP production. It has two subunits, R1, and R2 or p53R2. R1 has 5 possible catalytic site states (empty or filled with 1 of 4 NDPs), 5 possible
Thousands of ATP-induced R1 hexamerization models with up to three (
The analysis presented suggests that three
This article was reviewed by Ossama Kashlan
Url:
DOI: 10.1186/1745-6150-4-50
PubMed: 20003203
PubMed Central: 2799446
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PMC:2799446Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Automated mass action model space generation and analysis methods for two-reactant combinatorially complex equilibriums: An analysis of ATP-induced ribonucleotide reductase R1 hexamerization data</title>
<author><name sortKey="Radivoyevitch, Tomas" sort="Radivoyevitch, Tomas" uniqKey="Radivoyevitch T" first="Tomas" last="Radivoyevitch">Tomas Radivoyevitch</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106</wicri:regionArea>
<wicri:noRegion>Ohio 44106</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Biology Direct</title>
<idno type="eISSN">1745-6150</idno>
<imprint><date when="2009">2009</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenosine Triphosphate (metabolism)</term>
<term>Catalytic Domain</term>
<term>Computer Simulation</term>
<term>Deoxyadenine Nucleotides (metabolism)</term>
<term>Deoxyguanine Nucleotides (metabolism)</term>
<term>Humans</term>
<term>Least-Squares Analysis</term>
<term>Models, Biological</term>
<term>Nonlinear Dynamics</term>
<term>Protein Multimerization</term>
<term>Protein Subunits</term>
<term>Ribonucleotide Reductases (antagonists & inhibitors)</term>
<term>Ribonucleotide Reductases (chemistry)</term>
<term>Ribonucleotide Reductases (metabolism)</term>
<term>Substrate Specificity</term>
<term>Thymine Nucleotides (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adénosine triphosphate (métabolisme)</term>
<term>Domaine catalytique</term>
<term>Dynamique non linéaire</term>
<term>Humains</term>
<term>Modèles biologiques</term>
<term>Multimérisation de protéines</term>
<term>Méthode des moindres carrés</term>
<term>Nucléotide désoxyadenylique (métabolisme)</term>
<term>Nucléotide désoxyguanylique (métabolisme)</term>
<term>Nucléotides thymidyliques (métabolisme)</term>
<term>Ribonucleotide reductases ()</term>
<term>Ribonucleotide reductases (antagonistes et inhibiteurs)</term>
<term>Ribonucleotide reductases (métabolisme)</term>
<term>Simulation numérique</term>
<term>Sous-unités de protéines</term>
<term>Spécificité du substrat</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Ribonucleotide Reductases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Ribonucleotide Reductases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Adenosine Triphosphate</term>
<term>Deoxyadenine Nucleotides</term>
<term>Deoxyguanine Nucleotides</term>
<term>Ribonucleotide Reductases</term>
<term>Thymine Nucleotides</term>
</keywords>
<keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Ribonucleotide reductases</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adénosine triphosphate</term>
<term>Nucléotide désoxyadenylique</term>
<term>Nucléotide désoxyguanylique</term>
<term>Nucléotides thymidyliques</term>
<term>Ribonucleotide reductases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Catalytic Domain</term>
<term>Computer Simulation</term>
<term>Humans</term>
<term>Least-Squares Analysis</term>
<term>Models, Biological</term>
<term>Nonlinear Dynamics</term>
<term>Protein Multimerization</term>
<term>Protein Subunits</term>
<term>Substrate Specificity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Domaine catalytique</term>
<term>Dynamique non linéaire</term>
<term>Humains</term>
<term>Modèles biologiques</term>
<term>Multimérisation de protéines</term>
<term>Méthode des moindres carrés</term>
<term>Ribonucleotide reductases</term>
<term>Simulation numérique</term>
<term>Sous-unités de protéines</term>
<term>Spécificité du substrat</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Ribonucleotide reductase is the main control point of dNTP production. It has two subunits, R1, and R2 or p53R2. R1 has 5 possible catalytic site states (empty or filled with 1 of 4 NDPs), 5 possible <italic>s</italic>
-site states (empty or filled with ATP, dATP, dTTP or dGTP), 3 possible <italic>a</italic>
-site states (empty or filled with ATP or dATP), perhaps two possible <italic>h</italic>
-site states (empty or filled with ATP), and all of this is folded into an R1 monomer-dimer-tetramer-hexamer equilibrium where R1 j-mers can be bound by variable numbers of R2 or p53R2 dimers. Trillions of RNR complexes are possible as a result. The problem is to determine which are needed in models to explain available data. This problem is intractable for 10 reactants, but it can be solved for 2 and is here for R1 and ATP.</p>
</sec>
<sec><title>Results</title>
<p>Thousands of ATP-induced R1 hexamerization models with up to three (<italic>s</italic>
, <italic>a </italic>
and <italic>h</italic>
) ATP binding sites per R1 subunit were automatically generated via hypotheses that complete dissociation constants are infinite and/or that binary dissociation constants are equal. To limit the model space size, it was assumed that <italic>s</italic>
-sites are always filled in oligomers and never filled in monomers, and to interpret model terms it was assumed that <italic>a</italic>
-sites fill before <italic>h</italic>
-sites. The models were fitted to published dynamic light scattering data. As the lowest Akaike Information Criterion (AIC) of the 3-parameter models was greater than the lowest of the 2-parameter models, only models with up to 3 parameters were fitted. Models with sums of squared errors less than twice the minimum were then partitioned into two groups: those that contained no occupied <italic>h</italic>
-site terms (508 models) and those that contained at least one (1580 models). Normalized AIC densities of these two groups of models differed significantly in favor of models that did not include an <italic>h</italic>
-site term (Kolmogorov-Smirnov p < 1 × 10<sup>-15</sup>
); consistent with this, 28 of the top 30 models (ranked by AICs) did not include an <italic>h</italic>
-site term and 28/30 > 508/2088 with p < 2 × 10<sup>-15</sup>
. Finally, 99 of the 2088 models did not have any terms with ATP/R1 ratios >1.5, but of the top 30, there were 14 such models (14/30 > 99/2088 with p < 3 × 10<sup>-16</sup>
), i.e. the existence of R1 hexamers with >3 <italic>a</italic>
-sites occupied by ATP is also not supported by this dataset.</p>
</sec>
<sec><title>Conclusion</title>
<p>The analysis presented suggests that three <italic>a</italic>
-sites may not be occupied by ATP in R1 hexamers under the conditions of the data analyzed. If <italic>a</italic>
-sites fill before <italic>h</italic>
-sites, this implies that the dataset analyzed can be explained without the existence of an <italic>h</italic>
-site.</p>
</sec>
<sec><title>Reviewers</title>
<p>This article was reviewed by Ossama Kashlan <italic>(nominated by Philip Hahnfeldt)</italic>
, Bin Hu <italic>(nominated by William Hlavacek) </italic>
and Rainer Sachs.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Radivoyevitch, T" uniqKey="Radivoyevitch T">T Radivoyevitch</name>
</author>
<author><name sortKey="Loparo, Ka" uniqKey="Loparo K">KA Loparo</name>
</author>
<author><name sortKey="Jackson, Rc" uniqKey="Jackson R">RC Jackson</name>
</author>
<author><name sortKey="Sedwick, Wd" uniqKey="Sedwick W">WD Sedwick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manegold, C" uniqKey="Manegold C">C Manegold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kroep, Jr" uniqKey="Kroep J">JR Kroep</name>
</author>
<author><name sortKey="Van Moorsel, Cj" uniqKey="Van Moorsel C">CJ Van Moorsel</name>
</author>
<author><name sortKey="Veerman, G" uniqKey="Veerman G">G Veerman</name>
</author>
<author><name sortKey="Voorn, Da" uniqKey="Voorn D">DA Voorn</name>
</author>
<author><name sortKey="Schultz, Rm" uniqKey="Schultz R">RM Schultz</name>
</author>
<author><name sortKey="Worzalla, Jf" uniqKey="Worzalla J">JF Worzalla</name>
</author>
<author><name sortKey="Tanzer, Lr" uniqKey="Tanzer L">LR Tanzer</name>
</author>
<author><name sortKey="Merriman, Rl" uniqKey="Merriman R">RL Merriman</name>
</author>
<author><name sortKey="Pinedo, Hm" uniqKey="Pinedo H">HM Pinedo</name>
</author>
<author><name sortKey="Peters, Gj" uniqKey="Peters G">GJ Peters</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shewach, Ds" uniqKey="Shewach D">DS Shewach</name>
</author>
<author><name sortKey="Reynolds, Kk" uniqKey="Reynolds K">KK Reynolds</name>
</author>
<author><name sortKey="Hertel, L" uniqKey="Hertel L">L Hertel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Lohman, Gj" uniqKey="Lohman G">GJ Lohman</name>
</author>
<author><name sortKey="Stubbe, J" uniqKey="Stubbe J">J Stubbe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferrandina, G" uniqKey="Ferrandina G">G Ferrandina</name>
</author>
<author><name sortKey="Mey, V" uniqKey="Mey V">V Mey</name>
</author>
<author><name sortKey="Nannizzi, S" uniqKey="Nannizzi S">S Nannizzi</name>
</author>
<author><name sortKey="Ricciardi, S" uniqKey="Ricciardi S">S Ricciardi</name>
</author>
<author><name sortKey="Petrillo, M" uniqKey="Petrillo M">M Petrillo</name>
</author>
<author><name sortKey="Ferlini, C" uniqKey="Ferlini C">C Ferlini</name>
</author>
<author><name sortKey="Danesi, R" uniqKey="Danesi R">R Danesi</name>
</author>
<author><name sortKey="Scambia, G" uniqKey="Scambia G">G Scambia</name>
</author>
<author><name sortKey="Del Tacca, M" uniqKey="Del Tacca M">M Del Tacca</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohtaka, K" uniqKey="Ohtaka K">K Ohtaka</name>
</author>
<author><name sortKey="Kohya, N" uniqKey="Kohya N">N Kohya</name>
</author>
<author><name sortKey="Sato, K" uniqKey="Sato K">K Sato</name>
</author>
<author><name sortKey="Kitajima, Y" uniqKey="Kitajima Y">Y Kitajima</name>
</author>
<author><name sortKey="Ide, T" uniqKey="Ide T">T Ide</name>
</author>
<author><name sortKey="Mitsuno, M" uniqKey="Mitsuno M">M Mitsuno</name>
</author>
<author><name sortKey="Miyazaki, K" uniqKey="Miyazaki K">K Miyazaki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Flanagan, Sa" uniqKey="Flanagan S">SA Flanagan</name>
</author>
<author><name sortKey="Robinson, Bw" uniqKey="Robinson B">BW Robinson</name>
</author>
<author><name sortKey="Krokosky, Cm" uniqKey="Krokosky C">CM Krokosky</name>
</author>
<author><name sortKey="Shewach, Ds" uniqKey="Shewach D">DS Shewach</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, A" uniqKey="Muller A">A Muller</name>
</author>
<author><name sortKey="Fishel, R" uniqKey="Fishel R">R Fishel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leung, Wk" uniqKey="Leung W">WK Leung</name>
</author>
<author><name sortKey="Kim, Jj" uniqKey="Kim J">JJ Kim</name>
</author>
<author><name sortKey="Kim, Jg" uniqKey="Kim J">JG Kim</name>
</author>
<author><name sortKey="Graham, Dy" uniqKey="Graham D">DY Graham</name>
</author>
<author><name sortKey="Sepulveda, Ar" uniqKey="Sepulveda A">AR Sepulveda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakata, B" uniqKey="Nakata B">B Nakata</name>
</author>
<author><name sortKey="Wang, Yq" uniqKey="Wang Y">YQ Wang</name>
</author>
<author><name sortKey="Yashiro, M" uniqKey="Yashiro M">M Yashiro</name>
</author>
<author><name sortKey="Nishioka, N" uniqKey="Nishioka N">N Nishioka</name>
</author>
<author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name>
</author>
<author><name sortKey="Ohira, M" uniqKey="Ohira M">M Ohira</name>
</author>
<author><name sortKey="Ishikawa, T" uniqKey="Ishikawa T">T Ishikawa</name>
</author>
<author><name sortKey="Nishino, H" uniqKey="Nishino H">H Nishino</name>
</author>
<author><name sortKey="Hirakawa, K" uniqKey="Hirakawa K">K Hirakawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hartmann, A" uniqKey="Hartmann A">A Hartmann</name>
</author>
<author><name sortKey="Zanardo, L" uniqKey="Zanardo L">L Zanardo</name>
</author>
<author><name sortKey="Bocker Edmonston, T" uniqKey="Bocker Edmonston T">T Bocker-Edmonston</name>
</author>
<author><name sortKey="Blaszyk, H" uniqKey="Blaszyk H">H Blaszyk</name>
</author>
<author><name sortKey="Dietmaier, W" uniqKey="Dietmaier W">W Dietmaier</name>
</author>
<author><name sortKey="Stoehr, R" uniqKey="Stoehr R">R Stoehr</name>
</author>
<author><name sortKey="Cheville, Jc" uniqKey="Cheville J">JC Cheville</name>
</author>
<author><name sortKey="Junker, K" uniqKey="Junker K">K Junker</name>
</author>
<author><name sortKey="Wieland, W" uniqKey="Wieland W">W Wieland</name>
</author>
<author><name sortKey="Knuechel R Rueschoff, J" uniqKey="Knuechel R Rueschoff J">J Knuechel R Rueschoff</name>
</author>
<author><name sortKey="Hofstaedter, F" uniqKey="Hofstaedter F">F Hofstaedter</name>
</author>
<author><name sortKey="Fishel, R" uniqKey="Fishel R">R Fishel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ichikawa, Y" uniqKey="Ichikawa Y">Y Ichikawa</name>
</author>
<author><name sortKey="Lemon, Sj" uniqKey="Lemon S">SJ Lemon</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Franklin, B" uniqKey="Franklin B">B Franklin</name>
</author>
<author><name sortKey="Watson, P" uniqKey="Watson P">P Watson</name>
</author>
<author><name sortKey="Knezetic, Ja" uniqKey="Knezetic J">JA Knezetic</name>
</author>
<author><name sortKey="Bewtra, C" uniqKey="Bewtra C">C Bewtra</name>
</author>
<author><name sortKey="Lynch, Ht" uniqKey="Lynch H">HT Lynch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simpkins, Sb" uniqKey="Simpkins S">SB Simpkins</name>
</author>
<author><name sortKey="Bocker, T" uniqKey="Bocker T">T Bocker</name>
</author>
<author><name sortKey="Swisher, Em" uniqKey="Swisher E">EM Swisher</name>
</author>
<author><name sortKey="Mutch, Dg" uniqKey="Mutch D">DG Mutch</name>
</author>
<author><name sortKey="Gersell, Dj" uniqKey="Gersell D">DJ Gersell</name>
</author>
<author><name sortKey="Kovatich, Aj" uniqKey="Kovatich A">AJ Kovatich</name>
</author>
<author><name sortKey="Palazzo, Jp" uniqKey="Palazzo J">JP Palazzo</name>
</author>
<author><name sortKey="Fishel, R" uniqKey="Fishel R">R Fishel</name>
</author>
<author><name sortKey="Goodfellow, Pj" uniqKey="Goodfellow P">PJ Goodfellow</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leung, Sy" uniqKey="Leung S">SY Leung</name>
</author>
<author><name sortKey="Chan, Tl" uniqKey="Chan T">TL Chan</name>
</author>
<author><name sortKey="Chung, Lp" uniqKey="Chung L">LP Chung</name>
</author>
<author><name sortKey="Chan, As" uniqKey="Chan A">AS Chan</name>
</author>
<author><name sortKey="Fan, Yw" uniqKey="Fan Y">YW Fan</name>
</author>
<author><name sortKey="Hung, Kn" uniqKey="Hung K">KN Hung</name>
</author>
<author><name sortKey="Kwong, Wk" uniqKey="Kwong W">WK Kwong</name>
</author>
<author><name sortKey="Ho, Jw" uniqKey="Ho J">JW Ho</name>
</author>
<author><name sortKey="Yuen, St" uniqKey="Yuen S">ST Yuen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thelander, L" uniqKey="Thelander L">L Thelander</name>
</author>
<author><name sortKey="Reichard, P" uniqKey="Reichard P">P Reichard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name>
</author>
<author><name sortKey="Arakawa, H" uniqKey="Arakawa H">H Arakawa</name>
</author>
<author><name sortKey="Yamaguchi, T" uniqKey="Yamaguchi T">T Yamaguchi</name>
</author>
<author><name sortKey="Shiraishi, K" uniqKey="Shiraishi K">K Shiraishi</name>
</author>
<author><name sortKey="Fukuda, S" uniqKey="Fukuda S">S Fukuda</name>
</author>
<author><name sortKey="Matsui, K" uniqKey="Matsui K">K Matsui</name>
</author>
<author><name sortKey="Takei, Y" uniqKey="Takei Y">Y Takei</name>
</author>
<author><name sortKey="Nakamura, Y" uniqKey="Nakamura Y">Y Nakamura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakano, K" uniqKey="Nakano K">K Nakano</name>
</author>
<author><name sortKey="Balint, E" uniqKey="Balint E">E Balint</name>
</author>
<author><name sortKey="Ashcroft, M" uniqKey="Ashcroft M">M Ashcroft</name>
</author>
<author><name sortKey="Vousden, Kh" uniqKey="Vousden K">KH Vousden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, Ij" uniqKey="Feng I">IJ Feng</name>
</author>
<author><name sortKey="Radivoyevitch, T" uniqKey="Radivoyevitch T">T Radivoyevitch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kashlan, Ob" uniqKey="Kashlan O">OB Kashlan</name>
</author>
<author><name sortKey="Scott, Cp" uniqKey="Scott C">CP Scott</name>
</author>
<author><name sortKey="Lear, Jd" uniqKey="Lear J">JD Lear</name>
</author>
<author><name sortKey="Cooperman, Bs" uniqKey="Cooperman B">BS Cooperman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ihaka, R" uniqKey="Ihaka R">R Ihaka</name>
</author>
<author><name sortKey="Gentleman, R" uniqKey="Gentleman R">R Gentleman</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Akaike, H" uniqKey="Akaike H">H Akaike</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burnham, Kp" uniqKey="Burnham K">KP Burnham</name>
</author>
<author><name sortKey="Anderson, Dr" uniqKey="Anderson D">DR Anderson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Radivoyevitch, T" uniqKey="Radivoyevitch T">T Radivoyevitch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, H" uniqKey="Xu H">H Xu</name>
</author>
<author><name sortKey="Faber, C" uniqKey="Faber C">C Faber</name>
</author>
<author><name sortKey="Uchiki, T" uniqKey="Uchiki T">T Uchiki</name>
</author>
<author><name sortKey="Fairman, Jw" uniqKey="Fairman J">JW Fairman</name>
</author>
<author><name sortKey="Racca, J" uniqKey="Racca J">J Racca</name>
</author>
<author><name sortKey="Dealwis, C" uniqKey="Dealwis C">C Dealwis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rofougaran, R" uniqKey="Rofougaran R">R Rofougaran</name>
</author>
<author><name sortKey="Vodnala, M" uniqKey="Vodnala M">M Vodnala</name>
</author>
<author><name sortKey="Hofer, A" uniqKey="Hofer A">A Hofer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roach, Ls" uniqKey="Roach L">LS Roach</name>
</author>
<author><name sortKey="Song, H" uniqKey="Song H">H Song</name>
</author>
<author><name sortKey="Ismagilov, Rf" uniqKey="Ismagilov R">RF Ismagilov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Song, H" uniqKey="Song H">H Song</name>
</author>
<author><name sortKey="Ismagilov, Rf" uniqKey="Ismagilov R">RF Ismagilov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huebner, A" uniqKey="Huebner A">A Huebner</name>
</author>
<author><name sortKey="Olguin, Lf" uniqKey="Olguin L">LF Olguin</name>
</author>
<author><name sortKey="Bratton, D" uniqKey="Bratton D">D Bratton</name>
</author>
<author><name sortKey="Whyte, G" uniqKey="Whyte G">G Whyte</name>
</author>
<author><name sortKey="Huck, Wt" uniqKey="Huck W">WT Huck</name>
</author>
<author><name sortKey="De Mello, Aj" uniqKey="De Mello A">AJ de Mello</name>
</author>
<author><name sortKey="Edel, Jb" uniqKey="Edel J">JB Edel</name>
</author>
<author><name sortKey="Abell, C" uniqKey="Abell C">C Abell</name>
</author>
<author><name sortKey="Hollfelder, F" uniqKey="Hollfelder F">F Hollfelder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huebner, A" uniqKey="Huebner A">A Huebner</name>
</author>
<author><name sortKey="Bratton, D" uniqKey="Bratton D">D Bratton</name>
</author>
<author><name sortKey="Whyte, G" uniqKey="Whyte G">G Whyte</name>
</author>
<author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name>
</author>
<author><name sortKey="Demello, Aj" uniqKey="Demello A">AJ Demello</name>
</author>
<author><name sortKey="Abell, C" uniqKey="Abell C">C Abell</name>
</author>
<author><name sortKey="Hollfelder, F" uniqKey="Hollfelder F">F Hollfelder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Atkinson, Ac" uniqKey="Atkinson A">AC Atkinson</name>
</author>
<author><name sortKey="Donev, An" uniqKey="Donev A">AN Donev</name>
</author>
<author><name sortKey="Tobias, Rd" uniqKey="Tobias R">RD Tobias</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hucka, M" uniqKey="Hucka M">M Hucka</name>
</author>
<author><name sortKey="Finney, A" uniqKey="Finney A">A Finney</name>
</author>
<author><name sortKey="Sauro, Hm" uniqKey="Sauro H">HM Sauro</name>
</author>
<author><name sortKey="Bolouri, H" uniqKey="Bolouri H">H Bolouri</name>
</author>
<author><name sortKey="Doyle, Jc" uniqKey="Doyle J">JC Doyle</name>
</author>
<author><name sortKey="Kitano, H" uniqKey="Kitano H">H Kitano</name>
</author>
<author><name sortKey="Arkin, Ap" uniqKey="Arkin A">AP Arkin</name>
</author>
<author><name sortKey="Bornstein, Bj" uniqKey="Bornstein B">BJ Bornstein</name>
</author>
<author><name sortKey="Bray, D" uniqKey="Bray D">D Bray</name>
</author>
<author><name sortKey="Cornish Bowden, A" uniqKey="Cornish Bowden A">A Cornish-Bowden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Le Novere, N" uniqKey="Le Novere N">N Le Novere</name>
</author>
<author><name sortKey="Bornstein, B" uniqKey="Bornstein B">B Bornstein</name>
</author>
<author><name sortKey="Broicher, A" uniqKey="Broicher A">A Broicher</name>
</author>
<author><name sortKey="Courtot, M" uniqKey="Courtot M">M Courtot</name>
</author>
<author><name sortKey="Donizelli, M" uniqKey="Donizelli M">M Donizelli</name>
</author>
<author><name sortKey="Dharuri, H" uniqKey="Dharuri H">H Dharuri</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Sauro, H" uniqKey="Sauro H">H Sauro</name>
</author>
<author><name sortKey="Schilstra, M" uniqKey="Schilstra M">M Schilstra</name>
</author>
<author><name sortKey="Shapiro B Snoep, Jl" uniqKey="Shapiro B Snoep J">JL Shapiro B Snoep</name>
</author>
<author><name sortKey="Hucka, M" uniqKey="Hucka M">M Hucka</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
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