Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity.
Identifieur interne : 000311 ( Ncbi/Curation ); précédent : 000310; suivant : 000312Assessment of synthetic peptides of severe acute respiratory syndrome coronavirus recognized by long-lasting immunity.
Auteurs : S. Shichijo [Japon] ; N. Keicho ; H T Long ; T. Quy ; N C Phi ; L D Ha ; V V Ban ; S. Itoyama ; C-J Hu ; N. Komatsu ; T. Kirikae ; F. Kirikae ; S. Shirasawa ; M. Kaji ; T. Fukuda ; M. Sata ; T. Kuratsuji ; K. Itoh ; T. SasazukiSource :
- Tissue antigens [ 0001-2815 ] ; 2004.
Descripteurs français
- KwdFr :
- MESH :
- immunologie : Immunité, Peptides, Système immunitaire, Sérum, Virus du SRAS.
- sang : Immunoglobuline G.
- Humains, Rhéologie, Test ELISA.
English descriptors
- KwdEn :
- MESH :
- chemical , blood : Immunoglobulin G.
- immunology : Immune System, Immunity, Peptides, SARS Virus, Serum.
- Enzyme-Linked Immunosorbent Assay, Humans, Rheology.
Abstract
In order to determine highly immunogenic severe acute respiratory syndrome coronavirus (SARS-CoV) epitope peptides capable of inducing long-lasting immunity, we first screened immunoglobulin-G (IgG) antibodies reactive to 197 different overlapping 15-mers from the SARS-CoV proteins in the sera of three infected patients. Forty-two peptides among them were reactive to the sera from all three patients. Consequently, we tested for the reactivity of these 42 peptides to patients' sera (n = 45) at 6-month post-infection. The significantly higher levels of IgG antibodies specific to three (S791, M207 and N161) of 42 peptides were detectable in the post-infection sera from 23 (51%), 27 (60%) and 19 (42%) of 45 patients, respectively. These three peptides, recognized by their long-lasting immunity, may provide a better understanding of the immunogenicity of SARS-CoV.
DOI: 10.1111/j.1399-0039.2004.00314.x
PubMed: 15496204
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Quy</name></author><author><name sortKey="Phi, N C" sort="Phi, N C" uniqKey="Phi N" first="N C" last="Phi">N C Phi</name></author><author><name sortKey="Ha, L D" sort="Ha, L D" uniqKey="Ha L" first="L D" last="Ha">L D Ha</name></author><author><name sortKey="Ban, V V" sort="Ban, V V" uniqKey="Ban V" first="V V" last="Ban">V V Ban</name></author><author><name sortKey="Itoyama, S" sort="Itoyama, S" uniqKey="Itoyama S" first="S" last="Itoyama">S. Itoyama</name></author><author><name sortKey="Hu, C J" sort="Hu, C J" uniqKey="Hu C" first="C-J" last="Hu">C-J Hu</name></author><author><name sortKey="Komatsu, N" sort="Komatsu, N" uniqKey="Komatsu N" first="N" last="Komatsu">N. Komatsu</name></author><author><name sortKey="Kirikae, T" sort="Kirikae, T" uniqKey="Kirikae T" first="T" last="Kirikae">T. Kirikae</name></author><author><name sortKey="Kirikae, F" sort="Kirikae, F" uniqKey="Kirikae F" first="F" last="Kirikae">F. 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Sasazuki</name></author></analytic><series><title level="j">Tissue antigens</title><idno type="ISSN">0001-2815</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Immune System (immunology)</term><term>Immunity (immunology)</term><term>Immunoglobulin G (blood)</term><term>Peptides (immunology)</term><term>Rheology</term><term>SARS Virus (immunology)</term><term>Serum (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains</term><term>Immunité (immunologie)</term><term>Immunoglobuline G (sang)</term><term>Peptides (immunologie)</term><term>Rhéologie</term><term>Système immunitaire (immunologie)</term><term>Sérum (immunologie)</term><term>Test ELISA</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Immunoglobulin G</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Immunité</term><term>Peptides</term><term>Système immunitaire</term><term>Sérum</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Immune System</term><term>Immunity</term><term>Peptides</term><term>SARS Virus</term><term>Serum</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Immunoglobuline G</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Enzyme-Linked Immunosorbent Assay</term><term>Humans</term><term>Rheology</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Rhéologie</term><term>Test ELISA</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In order to determine highly immunogenic severe acute respiratory syndrome coronavirus (SARS-CoV) epitope peptides capable of inducing long-lasting immunity, we first screened immunoglobulin-G (IgG) antibodies reactive to 197 different overlapping 15-mers from the SARS-CoV proteins in the sera of three infected patients. Forty-two peptides among them were reactive to the sera from all three patients. Consequently, we tested for the reactivity of these 42 peptides to patients' sera (n = 45) at 6-month post-infection. The significantly higher levels of IgG antibodies specific to three (S791, M207 and N161) of 42 peptides were detectable in the post-infection sera from 23 (51%), 27 (60%) and 19 (42%) of 45 patients, respectively. These three peptides, recognized by their long-lasting immunity, may provide a better understanding of the immunogenicity of SARS-CoV.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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