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Overexpression of truncated Nmd3p inhibits protein synthesis in yeast.

Identifieur interne : 000026 ( Ncbi/Curation ); précédent : 000025; suivant : 000027

Overexpression of truncated Nmd3p inhibits protein synthesis in yeast.

Auteurs : J P Belk [États-Unis] ; F. He ; A. Jacobson

Source :

RBID : pubmed:10445880

Descripteurs français

English descriptors

Abstract

The yeast NMD3 gene was identified in a two-hybrid screen using the nonsense-mediated mRNA decay factor, Upf1p, as bait. NMD3 was shown to encode an essential, highly conserved protein that associated principally with free 60S ribosomal subunits. Overexpression of a truncated form of Nmd3p, lacking 100 C-terminal amino acids and most of its Upf1p-interacting domain, had dominant-negative effects on both cell growth and protein synthesis and promoted the formation of polyribosome half-mers. These effects were eliminated by truncation of an additional 100 amino acids from Nmd3p. Overexpression of the nmd3delta100 allele also led to increased synthesis and destabilization of some ribosomal protein mRNAs, and increased synthesis and altered processing of 35S pre-rRNA. Our data suggest that Nmd3p has a role in the formation, function, or maintenance of the 60S ribosomal subunit and may provide a link for Upf1p to 80S monosomes.

DOI: 10.1017/s1355838299990027
PubMed: 10445880

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Le document en format XML

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<term>Cell Division (genetics)</term>
<term>Cloning, Molecular</term>
<term>Fungal Proteins (genetics)</term>
<term>Fungal Proteins (metabolism)</term>
<term>Fungal Proteins (physiology)</term>
<term>Galactose (pharmacology)</term>
<term>Gene Expression Regulation, Fungal</term>
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<term>Molecular Sequence Data</term>
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<term>RNA, Messenger (metabolism)</term>
<term>RNA, Ribosomal (genetics)</term>
<term>RNA, Ribosomal (metabolism)</term>
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<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins</term>
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<term>Time Factors</term>
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<term>ARN messager (métabolisme)</term>
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<term>ARN ribosomique (métabolisme)</term>
<term>Biosynthèse des protéines</term>
<term>Clonage moléculaire</term>
<term>Division cellulaire (génétique)</term>
<term>Données de séquences moléculaires</term>
<term>Facteurs temps</term>
<term>Galactose (pharmacologie)</term>
<term>Gènes dominants</term>
<term>Inhibiteurs de la synthèse protéique (métabolisme)</term>
<term>Modèles génétiques</term>
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<term>Protéines de Saccharomyces cerevisiae</term>
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<term>Polyribosomes</term>
<term>Protein Synthesis Inhibitors</term>
<term>RNA Helicases</term>
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<term>Models, Genetic</term>
<term>Molecular Sequence Data</term>
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<term>Sequence Homology, Amino Acid</term>
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<term>Facteurs temps</term>
<term>Gènes dominants</term>
<term>Modèles génétiques</term>
<term>Protéines de Saccharomyces cerevisiae</term>
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<term>Régulation de l'expression des gènes fongiques</term>
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<div type="abstract" xml:lang="en">The yeast NMD3 gene was identified in a two-hybrid screen using the nonsense-mediated mRNA decay factor, Upf1p, as bait. NMD3 was shown to encode an essential, highly conserved protein that associated principally with free 60S ribosomal subunits. Overexpression of a truncated form of Nmd3p, lacking 100 C-terminal amino acids and most of its Upf1p-interacting domain, had dominant-negative effects on both cell growth and protein synthesis and promoted the formation of polyribosome half-mers. These effects were eliminated by truncation of an additional 100 amino acids from Nmd3p. Overexpression of the nmd3delta100 allele also led to increased synthesis and destabilization of some ribosomal protein mRNAs, and increased synthesis and altered processing of 35S pre-rRNA. Our data suggest that Nmd3p has a role in the formation, function, or maintenance of the 60S ribosomal subunit and may provide a link for Upf1p to 80S monosomes.</div>
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