A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice
Identifieur interne : 002321 ( Ncbi/Checkpoint ); précédent : 002320; suivant : 002322A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice
Auteurs : Entao Li [République populaire de Chine] ; Hang Chi [République populaire de Chine] ; Pei Huang [République populaire de Chine] ; Feihu Yan [République populaire de Chine] ; Ying Zhang [République populaire de Chine] ; Chuanyu Liu [République populaire de Chine] ; Zhenshan Wang [République populaire de Chine] ; Guohua Li [République populaire de Chine] ; Shengnan Zhang [République populaire de Chine] ; Ruo Mo [République populaire de Chine] ; Hongli Jin [République populaire de Chine] ; Hualei Wang [République populaire de Chine] ; Na Feng [République populaire de Chine] ; Jianzhong Wang [République populaire de Chine] ; Yuhai Bi [République populaire de Chine] ; Tiecheng Wang [République populaire de Chine] ; Weiyang Sun [République populaire de Chine] ; Yuwei Gao [République populaire de Chine] ; Yongkun Zhao [République populaire de Chine] ; Songtao Yang [République populaire de Chine] ; Xianzhu Xia [République populaire de Chine]Source :
- Viruses [ 1999-4915 ] ; 2019.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV), a new coronavirus that has been causing severe and fatal acute respiratory illnesses in humans since its outbreak in 2012, has raised public fear worldwide. The development of prophylactics and therapeutics is urgently needed to prevent and control MERS-CoV infections. In this study, a bacterium (
Url:
DOI: 10.3390/v11090799
PubMed: 31470645
PubMed Central: 6784119
Affiliations:
- République populaire de Chine
- Dongbei, Guangdong, Jilin
- Changchun, Jiangmen, Pékin
- Université de Jilin
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PMC:6784119Le document en format XML
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<author><name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name>
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<author><name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name>
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<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A Novel Bacterium-Like Particle Vaccine Displaying the MERS-CoV Receptor-Binding Domain Induces Specific Mucosal and Systemic Immune Responses in Mice</title>
<author><name sortKey="Li, Entao" sort="Li, Entao" uniqKey="Li E" first="Entao" last="Li">Entao Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642</wicri:regionArea>
<placeName><settlement type="city">Jiangmen</settlement>
<region type="province">Guangdong</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chi, Hang" sort="Chi, Hang" uniqKey="Chi H" first="Hang" last="Chi">Hang Chi</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huang, Pei" sort="Huang, Pei" uniqKey="Huang P" first="Pei" last="Huang">Pei Huang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-viruses-11-00799">Animal Science and Technology College, Jilin Agricultural University, Changchun 130118, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Animal Science and Technology College, Jilin Agricultural University, Changchun 130118</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yan, Feihu" sort="Yan, Feihu" uniqKey="Yan F" first="Feihu" last="Yan">Feihu Yan</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-viruses-11-00799">College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040</wicri:regionArea>
<wicri:noRegion>Harbin 150040</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Chuanyu" sort="Liu, Chuanyu" uniqKey="Liu C" first="Chuanyu" last="Liu">Chuanyu Liu</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-viruses-11-00799">Animal Science and Technology College, Jilin Agricultural University, Changchun 130118, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Animal Science and Technology College, Jilin Agricultural University, Changchun 130118</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Zhenshan" sort="Wang, Zhenshan" uniqKey="Wang Z" first="Zhenshan" last="Wang">Zhenshan Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-viruses-11-00799">Animal Science and Technology College, Jilin Agricultural University, Changchun 130118, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Animal Science and Technology College, Jilin Agricultural University, Changchun 130118</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Guohua" sort="Li, Guohua" uniqKey="Li G" first="Guohua" last="Li">Guohua Li</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af6-viruses-11-00799">College of Animal Science and Technology, Shihezi University, Shihezi 832003, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Animal Science and Technology, Shihezi University, Shihezi 832003</wicri:regionArea>
<wicri:noRegion>Shihezi 832003</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhang, Shengnan" sort="Zhang, Shengnan" uniqKey="Zhang S" first="Shengnan" last="Zhang">Shengnan Zhang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af5-viruses-11-00799">College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040</wicri:regionArea>
<wicri:noRegion>Harbin 150040</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mo, Ruo" sort="Mo, Ruo" uniqKey="Mo R" first="Ruo" last="Mo">Ruo Mo</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-viruses-11-00799">Animal Science and Technology College, Jilin Agricultural University, Changchun 130118, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Animal Science and Technology College, Jilin Agricultural University, Changchun 130118</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
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<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jin, Hongli" sort="Jin, Hongli" uniqKey="Jin H" first="Hongli" last="Jin">Hongli Jin</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="af7-viruses-11-00799">College of Veterinary Medicine, Jilin University, Changchun 130062, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>College of Veterinary Medicine, Jilin University, Changchun 130062</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
<orgName type="university">Université de Jilin</orgName>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Hualei" sort="Wang, Hualei" uniqKey="Wang H" first="Hualei" last="Wang">Hualei Wang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
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<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="af7-viruses-11-00799">College of Veterinary Medicine, Jilin University, Changchun 130062, China</nlm:aff>
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<wicri:regionArea>College of Veterinary Medicine, Jilin University, Changchun 130062</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
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<region type="groupement">Dongbei</region>
</placeName>
<orgName type="university">Université de Jilin</orgName>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Feng, Na" sort="Feng, Na" uniqKey="Feng N" first="Na" last="Feng">Na Feng</name>
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<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
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<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Jianzhong" sort="Wang, Jianzhong" uniqKey="Wang J" first="Jianzhong" last="Wang">Jianzhong Wang</name>
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<placeName><settlement type="city">Changchun</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name>
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<wicri:regionArea>CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Tiecheng" sort="Wang, Tiecheng" uniqKey="Wang T" first="Tiecheng" last="Wang">Tiecheng Wang</name>
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<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
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</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
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<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Sun, Weiyang" sort="Sun, Weiyang" uniqKey="Sun W" first="Weiyang" last="Sun">Weiyang Sun</name>
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<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
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<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name>
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<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Songtao" sort="Yang, Songtao" uniqKey="Yang S" first="Songtao" last="Yang">Songtao Yang</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name>
<affiliation wicri:level="1"><nlm:aff id="af2-viruses-11-00799">Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af3-viruses-11-00799">Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Key Laboratory of Jilin Province for Zoonosis Prevention and Control, Changchun 130000</wicri:regionArea>
<placeName><settlement type="city">Changchun</settlement>
<region type="province">Jilin</region>
<region type="groupement">Dongbei</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Viruses</title>
<idno type="eISSN">1999-4915</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV), a new coronavirus that has been causing severe and fatal acute respiratory illnesses in humans since its outbreak in 2012, has raised public fear worldwide. The development of prophylactics and therapeutics is urgently needed to prevent and control MERS-CoV infections. In this study, a bacterium (<italic>Lactococcus lactis</italic>
)-like particle (BLP) vaccine displaying the MERS-CoV receptor-binding domain (RBD) was developed, and gram-positive enhancer matrix (GEM) particles were used as substrates to externally bind to the MERS-CoV RBD through a protein anchor (PA). The designs included different numbers of lysin motif (LysM) repeats in the PAs linked by linkers (RBD-linker-PA2 (RLP<sub>2</sub>
), RBD-linker-PA3 (RLP<sub>3</sub>
) and RBD-PA3 (RP<sub>3</sub>
)), and three LysM repeats and a linker in the fusion proteins increased the binding activity to the RBD. The specific immune responses were tested by intranasally immunizing mice with RLP<sub>3</sub>
-GEM with or without the adjuvant GEL01. The results showed that GEL01-adjuvanted RLP<sub>3</sub>
-GEM increased the systemic humoral, cellular and local mucosal immune responses in the mouse model, especially in the intestinal tract. The above results indicate that the MERS-CoV BLP product has the potential to be developed into a promising mucosal candidate vaccine to protect against MERS-CoV infections.</p>
</div>
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</biblStruct>
<biblStruct><analytic><author><name sortKey="Vialle, R" uniqKey="Vialle R">R. Vialle</name>
</author>
<author><name sortKey="Dupuis, L" uniqKey="Dupuis L">L. Dupuis</name>
</author>
<author><name sortKey="Deville, S" uniqKey="Deville S">S. Deville</name>
</author>
<author><name sortKey="Bertrand, F" uniqKey="Bertrand F">F. Bertrand</name>
</author>
<author><name sortKey="Gaucheron, J" uniqKey="Gaucheron J">J. Gaucheron</name>
</author>
<author><name sortKey="Aucouturier, J" uniqKey="Aucouturier J">J. Aucouturier</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
<region><li>Dongbei</li>
<li>Guangdong</li>
<li>Jilin</li>
</region>
<settlement><li>Changchun</li>
<li>Jiangmen</li>
<li>Pékin</li>
</settlement>
<orgName><li>Université de Jilin</li>
</orgName>
</list>
<tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Li, Entao" sort="Li, Entao" uniqKey="Li E" first="Entao" last="Li">Entao Li</name>
</region>
<name sortKey="Bi, Yuhai" sort="Bi, Yuhai" uniqKey="Bi Y" first="Yuhai" last="Bi">Yuhai Bi</name>
<name sortKey="Chi, Hang" sort="Chi, Hang" uniqKey="Chi H" first="Hang" last="Chi">Hang Chi</name>
<name sortKey="Chi, Hang" sort="Chi, Hang" uniqKey="Chi H" first="Hang" last="Chi">Hang Chi</name>
<name sortKey="Feng, Na" sort="Feng, Na" uniqKey="Feng N" first="Na" last="Feng">Na Feng</name>
<name sortKey="Feng, Na" sort="Feng, Na" uniqKey="Feng N" first="Na" last="Feng">Na Feng</name>
<name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name>
<name sortKey="Gao, Yuwei" sort="Gao, Yuwei" uniqKey="Gao Y" first="Yuwei" last="Gao">Yuwei Gao</name>
<name sortKey="Huang, Pei" sort="Huang, Pei" uniqKey="Huang P" first="Pei" last="Huang">Pei Huang</name>
<name sortKey="Huang, Pei" sort="Huang, Pei" uniqKey="Huang P" first="Pei" last="Huang">Pei Huang</name>
<name sortKey="Jin, Hongli" sort="Jin, Hongli" uniqKey="Jin H" first="Hongli" last="Jin">Hongli Jin</name>
<name sortKey="Jin, Hongli" sort="Jin, Hongli" uniqKey="Jin H" first="Hongli" last="Jin">Hongli Jin</name>
<name sortKey="Li, Entao" sort="Li, Entao" uniqKey="Li E" first="Entao" last="Li">Entao Li</name>
<name sortKey="Li, Guohua" sort="Li, Guohua" uniqKey="Li G" first="Guohua" last="Li">Guohua Li</name>
<name sortKey="Li, Guohua" sort="Li, Guohua" uniqKey="Li G" first="Guohua" last="Li">Guohua Li</name>
<name sortKey="Liu, Chuanyu" sort="Liu, Chuanyu" uniqKey="Liu C" first="Chuanyu" last="Liu">Chuanyu Liu</name>
<name sortKey="Liu, Chuanyu" sort="Liu, Chuanyu" uniqKey="Liu C" first="Chuanyu" last="Liu">Chuanyu Liu</name>
<name sortKey="Mo, Ruo" sort="Mo, Ruo" uniqKey="Mo R" first="Ruo" last="Mo">Ruo Mo</name>
<name sortKey="Mo, Ruo" sort="Mo, Ruo" uniqKey="Mo R" first="Ruo" last="Mo">Ruo Mo</name>
<name sortKey="Sun, Weiyang" sort="Sun, Weiyang" uniqKey="Sun W" first="Weiyang" last="Sun">Weiyang Sun</name>
<name sortKey="Sun, Weiyang" sort="Sun, Weiyang" uniqKey="Sun W" first="Weiyang" last="Sun">Weiyang Sun</name>
<name sortKey="Wang, Hualei" sort="Wang, Hualei" uniqKey="Wang H" first="Hualei" last="Wang">Hualei Wang</name>
<name sortKey="Wang, Hualei" sort="Wang, Hualei" uniqKey="Wang H" first="Hualei" last="Wang">Hualei Wang</name>
<name sortKey="Wang, Jianzhong" sort="Wang, Jianzhong" uniqKey="Wang J" first="Jianzhong" last="Wang">Jianzhong Wang</name>
<name sortKey="Wang, Tiecheng" sort="Wang, Tiecheng" uniqKey="Wang T" first="Tiecheng" last="Wang">Tiecheng Wang</name>
<name sortKey="Wang, Tiecheng" sort="Wang, Tiecheng" uniqKey="Wang T" first="Tiecheng" last="Wang">Tiecheng Wang</name>
<name sortKey="Wang, Zhenshan" sort="Wang, Zhenshan" uniqKey="Wang Z" first="Zhenshan" last="Wang">Zhenshan Wang</name>
<name sortKey="Wang, Zhenshan" sort="Wang, Zhenshan" uniqKey="Wang Z" first="Zhenshan" last="Wang">Zhenshan Wang</name>
<name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name>
<name sortKey="Xia, Xianzhu" sort="Xia, Xianzhu" uniqKey="Xia X" first="Xianzhu" last="Xia">Xianzhu Xia</name>
<name sortKey="Yan, Feihu" sort="Yan, Feihu" uniqKey="Yan F" first="Feihu" last="Yan">Feihu Yan</name>
<name sortKey="Yang, Songtao" sort="Yang, Songtao" uniqKey="Yang S" first="Songtao" last="Yang">Songtao Yang</name>
<name sortKey="Yang, Songtao" sort="Yang, Songtao" uniqKey="Yang S" first="Songtao" last="Yang">Songtao Yang</name>
<name sortKey="Zhang, Shengnan" sort="Zhang, Shengnan" uniqKey="Zhang S" first="Shengnan" last="Zhang">Shengnan Zhang</name>
<name sortKey="Zhang, Shengnan" sort="Zhang, Shengnan" uniqKey="Zhang S" first="Shengnan" last="Zhang">Shengnan Zhang</name>
<name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name>
<name sortKey="Zhang, Ying" sort="Zhang, Ying" uniqKey="Zhang Y" first="Ying" last="Zhang">Ying Zhang</name>
<name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name>
<name sortKey="Zhao, Yongkun" sort="Zhao, Yongkun" uniqKey="Zhao Y" first="Yongkun" last="Zhao">Yongkun Zhao</name>
</country>
</tree>
</affiliations>
</record>
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