A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations
Identifieur interne : 002165 ( Ncbi/Checkpoint ); précédent : 002164; suivant : 002166A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations
Auteurs : Weiling Li [États-Unis] ; Lin Lin [États-Unis] ; Raunaq Malhotra [États-Unis] ; Lei Yang [États-Unis] ; Raj Acharya [États-Unis] ; Mary Poss [États-Unis]Source :
- PLoS Computational Biology [ 1553-734X ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- genetics : Continental Population Groups, Endogenous Retroviruses, Genome, Human, Genome, Viral, Proviruses.
- methods : Genetics, Population, Genomics.
- Algorithms, Humans, Molecular Epidemiology, Software.
Abstract
Human Endogenous Retrovirus type K (HERV-K) is the only HERV known to be insertionally polymorphic; not all individuals have a retrovirus at a specific genomic location. It is possible that HERV-Ks contribute to human disease because people differ in both number and genomic location of these retroviruses. Indeed viral transcripts, proteins, and antibody against HERV-K are detected in cancers, auto-immune, and neurodegenerative diseases. However, attempts to link a polymorphic HERV-K with any disease have been frustrated in part because population prevalence of HERV-K provirus at each polymorphic site is lacking and it is challenging to identify closely related elements such as HERV-K from short read sequence data. We present an integrated and computationally robust approach that uses whole genome short read data to determine the occupation status at all sites reported to contain a HERV-K provirus. Our method estimates the proportion of fixed length genomic sequence (
Url:
DOI: 10.1371/journal.pcbi.1006564
PubMed: 30921327
PubMed Central: 6456218
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000F89
- to stream Pmc, to step Curation: 000F89
- to stream Pmc, to step Checkpoint: 000425
- to stream PubMed, to step Corpus: 000592
- to stream PubMed, to step Curation: 000592
- to stream PubMed, to step Checkpoint: 000697
- to stream Ncbi, to step Merge: 002165
- to stream Ncbi, to step Curation: 002165
Links to Exploration step
PMC:6456218Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations</title>
<author><name sortKey="Li, Weiling" sort="Li, Weiling" uniqKey="Li W" first="Weiling" last="Li">Weiling Li</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Lin, Lin" sort="Lin, Lin" uniqKey="Lin L" first="Lin" last="Lin">Lin Lin</name>
<affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Department of Statistics, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Statistics, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Malhotra, Raunaq" sort="Malhotra, Raunaq" uniqKey="Malhotra R" first="Raunaq" last="Malhotra">Raunaq Malhotra</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name>
<affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Department of Biology, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Acharya, Raj" sort="Acharya, Raj" uniqKey="Acharya R" first="Raj" last="Acharya">Raj Acharya</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>School of Informatics, Computing and Engineering, Indiana University, Bloomington, IN, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Informatics, Computing and Engineering, Indiana University, Bloomington, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poss, Mary" sort="Poss, Mary" uniqKey="Poss M" first="Mary" last="Poss">Mary Poss</name>
<affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Department of Biology, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30921327</idno>
<idno type="pmc">6456218</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456218</idno>
<idno type="RBID">PMC:6456218</idno>
<idno type="doi">10.1371/journal.pcbi.1006564</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000F89</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F89</idno>
<idno type="wicri:Area/Pmc/Curation">000F89</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F89</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000425</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000425</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:30921327</idno>
<idno type="wicri:Area/PubMed/Corpus">000592</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000592</idno>
<idno type="wicri:Area/PubMed/Curation">000592</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000592</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000697</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000697</idno>
<idno type="wicri:Area/Ncbi/Merge">002165</idno>
<idno type="wicri:Area/Ncbi/Curation">002165</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002165</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations</title>
<author><name sortKey="Li, Weiling" sort="Li, Weiling" uniqKey="Li W" first="Weiling" last="Li">Weiling Li</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Lin, Lin" sort="Lin, Lin" uniqKey="Lin L" first="Lin" last="Lin">Lin Lin</name>
<affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Department of Statistics, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Statistics, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Malhotra, Raunaq" sort="Malhotra, Raunaq" uniqKey="Malhotra R" first="Raunaq" last="Malhotra">Raunaq Malhotra</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name>
<affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Department of Biology, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
<author><name sortKey="Acharya, Raj" sort="Acharya, Raj" uniqKey="Acharya R" first="Raj" last="Acharya">Raj Acharya</name>
<affiliation wicri:level="4"><nlm:aff id="aff001"><addr-line>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The School of Electrical Engineering and Computer Science, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="aff004"><addr-line>School of Informatics, Computing and Engineering, Indiana University, Bloomington, IN, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>School of Informatics, Computing and Engineering, Indiana University, Bloomington, IN</wicri:regionArea>
<placeName><region type="state">Indiana</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Poss, Mary" sort="Poss, Mary" uniqKey="Poss M" first="Mary" last="Poss">Mary Poss</name>
<affiliation wicri:level="4"><nlm:aff id="aff003"><addr-line>Department of Biology, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biology, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="aff005"><addr-line>Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
<settlement type="city">University Park (Pennsylvanie)</settlement>
</placeName>
<orgName type="university">Université d'État de Pennsylvanie</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">PLoS Computational Biology</title>
<idno type="ISSN">1553-734X</idno>
<idno type="eISSN">1553-7358</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term>
<term>Continental Population Groups (genetics)</term>
<term>Endogenous Retroviruses (genetics)</term>
<term>Genetics, Population (methods)</term>
<term>Genome, Human (genetics)</term>
<term>Genome, Viral (genetics)</term>
<term>Genomics (methods)</term>
<term>Humans</term>
<term>Molecular Epidemiology</term>
<term>Proviruses (genetics)</term>
<term>Software</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Algorithmes</term>
<term>Génome humain (génétique)</term>
<term>Génome viral (génétique)</term>
<term>Génomique ()</term>
<term>Génétique des populations ()</term>
<term>Humains</term>
<term>Logiciel</term>
<term>Populations d'origine continentale (génétique)</term>
<term>Provirus (génétique)</term>
<term>Rétrovirus endogènes (génétique)</term>
<term>Épidémiologie moléculaire</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Continental Population Groups</term>
<term>Endogenous Retroviruses</term>
<term>Genome, Human</term>
<term>Genome, Viral</term>
<term>Proviruses</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Génome humain</term>
<term>Génome viral</term>
<term>Populations d'origine continentale</term>
<term>Provirus</term>
<term>Rétrovirus endogènes</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genetics, Population</term>
<term>Genomics</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Algorithms</term>
<term>Humans</term>
<term>Molecular Epidemiology</term>
<term>Software</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Algorithmes</term>
<term>Génomique</term>
<term>Génétique des populations</term>
<term>Humains</term>
<term>Logiciel</term>
<term>Épidémiologie moléculaire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Human Endogenous Retrovirus type K (HERV-K) is the only HERV known to be insertionally polymorphic; not all individuals have a retrovirus at a specific genomic location. It is possible that HERV-Ks contribute to human disease because people differ in both number and genomic location of these retroviruses. Indeed viral transcripts, proteins, and antibody against HERV-K are detected in cancers, auto-immune, and neurodegenerative diseases. However, attempts to link a polymorphic HERV-K with any disease have been frustrated in part because population prevalence of HERV-K provirus at each polymorphic site is lacking and it is challenging to identify closely related elements such as HERV-K from short read sequence data. We present an integrated and computationally robust approach that uses whole genome short read data to determine the occupation status at all sites reported to contain a HERV-K provirus. Our method estimates the proportion of fixed length genomic sequence (<italic>k-mers</italic>
) from whole genome sequence data matching a reference set of <italic>k-mers</italic>
unique to each HERV-K locus and applies mixture model-based clustering of these values to account for low depth sequence data. Our analysis of 1000 Genomes Project Data (KGP) reveals numerous differences among the five KGP super-populations in the prevalence of individual and co-occurring HERV-K proviruses; we provide a visualization tool to easily depict the proportion of the KGP populations with any combination of polymorphic HERV-K provirus. Further, because HERV-K is insertionally polymorphic, the genome burden of known polymorphic HERV-K is variable in humans; this burden is lowest in East Asian (EAS) individuals. Our study identifies population-specific sequence variation for HERV-K proviruses at several loci. We expect these resources will advance research on HERV-K contributions to human diseases.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hayward, A" uniqKey="Hayward A">A Hayward</name>
</author>
<author><name sortKey="Grabherr, M" uniqKey="Grabherr M">M Grabherr</name>
</author>
<author><name sortKey="Jern, P" uniqKey="Jern P">P Jern</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feschotte, C" uniqKey="Feschotte C">C Feschotte</name>
</author>
<author><name sortKey="Gilbert, C" uniqKey="Gilbert C">C Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stoye, Jp" uniqKey="Stoye J">JP Stoye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gifford, R" uniqKey="Gifford R">R Gifford</name>
</author>
<author><name sortKey="Tristem, M" uniqKey="Tristem M">M Tristem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weiss, Ra" uniqKey="Weiss R">RA Weiss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jern, P" uniqKey="Jern P">P Jern</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lower, R" uniqKey="Lower R">R Löwer</name>
</author>
<author><name sortKey="Lower, J" uniqKey="Lower J">J Löwer</name>
</author>
<author><name sortKey="Kurth, R" uniqKey="Kurth R">R Kurth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bannert, N" uniqKey="Bannert N">N Bannert</name>
</author>
<author><name sortKey="Kurth, R" uniqKey="Kurth R">R Kurth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moyes, D" uniqKey="Moyes D">D Moyes</name>
</author>
<author><name sortKey="Griffiths, Dj" uniqKey="Griffiths D">DJ Griffiths</name>
</author>
<author><name sortKey="Venables, Pj" uniqKey="Venables P">PJ Venables</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subramanian, Rp" uniqKey="Subramanian R">RP Subramanian</name>
</author>
<author><name sortKey="Wildschutte, Jh" uniqKey="Wildschutte J">JH Wildschutte</name>
</author>
<author><name sortKey="Russo, C" uniqKey="Russo C">C Russo</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wildschutte, Jh" uniqKey="Wildschutte J">JH Wildschutte</name>
</author>
<author><name sortKey="Williams, Zh" uniqKey="Williams Z">ZH Williams</name>
</author>
<author><name sortKey="Montesion, M" uniqKey="Montesion M">M Montesion</name>
</author>
<author><name sortKey="Subramanian, Rp" uniqKey="Subramanian R">RP Subramanian</name>
</author>
<author><name sortKey="Kidd, Jm" uniqKey="Kidd J">JM Kidd</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kurth, R" uniqKey="Kurth R">R Kurth</name>
</author>
<author><name sortKey="Bannert, N" uniqKey="Bannert N">N Bannert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Treangen, Tj" uniqKey="Treangen T">TJ Treangen</name>
</author>
<author><name sortKey="Salzberg, Sl" uniqKey="Salzberg S">SL Salzberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belshaw, R" uniqKey="Belshaw R">R Belshaw</name>
</author>
<author><name sortKey="Watson, J" uniqKey="Watson J">J Watson</name>
</author>
<author><name sortKey="Katzourakis, A" uniqKey="Katzourakis A">A Katzourakis</name>
</author>
<author><name sortKey="Howe, A" uniqKey="Howe A">A Howe</name>
</author>
<author><name sortKey="Woolven Allen, J" uniqKey="Woolven Allen J">J Woolven-Allen</name>
</author>
<author><name sortKey="Burt, A" uniqKey="Burt A">A Burt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Medstrand, P" uniqKey="Medstrand P">P Medstrand</name>
</author>
<author><name sortKey="Mager, Dl" uniqKey="Mager D">DL Mager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hughes, Jf" uniqKey="Hughes J">JF Hughes</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belshaw, R" uniqKey="Belshaw R">R Belshaw</name>
</author>
<author><name sortKey="Dawson, Ala" uniqKey="Dawson A">ALA Dawson</name>
</author>
<author><name sortKey="Woolven Allen, J" uniqKey="Woolven Allen J">J Woolven-Allen</name>
</author>
<author><name sortKey="Redding, J" uniqKey="Redding J">J Redding</name>
</author>
<author><name sortKey="Burt, A" uniqKey="Burt A">A Burt</name>
</author>
<author><name sortKey="Tristem, M" uniqKey="Tristem M">M Tristem</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marchi, E" uniqKey="Marchi E">E Marchi</name>
</author>
<author><name sortKey="Kanapin, A" uniqKey="Kanapin A">A Kanapin</name>
</author>
<author><name sortKey="Magiorkinis, G" uniqKey="Magiorkinis G">G Magiorkinis</name>
</author>
<author><name sortKey="Belshaw, R" uniqKey="Belshaw R">R Belshaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shin, W" uniqKey="Shin W">W Shin</name>
</author>
<author><name sortKey="Lee, J" uniqKey="Lee J">J Lee</name>
</author>
<author><name sortKey="Son, S Y" uniqKey="Son S">S-Y Son</name>
</author>
<author><name sortKey="Ahn, K" uniqKey="Ahn K">K Ahn</name>
</author>
<author><name sortKey="Kim H, S" uniqKey="Kim H ">-S Kim H</name>
</author>
<author><name sortKey="Han, K" uniqKey="Han K">K Han</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Groger, V" uniqKey="Groger V">V Gröger</name>
</author>
<author><name sortKey="Cynis, H" uniqKey="Cynis H">H Cynis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Young, Gr" uniqKey="Young G">GR Young</name>
</author>
<author><name sortKey="Stoye, Jp" uniqKey="Stoye J">JP Stoye</name>
</author>
<author><name sortKey="Kassiotis, G" uniqKey="Kassiotis G">G Kassiotis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ryan, Fp" uniqKey="Ryan F">FP Ryan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Volkman, He" uniqKey="Volkman H">HE Volkman</name>
</author>
<author><name sortKey="Stetson, Db" uniqKey="Stetson D">DB Stetson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Magiorkinis, G" uniqKey="Magiorkinis G">G Magiorkinis</name>
</author>
<author><name sortKey="Belshaw, R" uniqKey="Belshaw R">R Belshaw</name>
</author>
<author><name sortKey="Katzourakis, A" uniqKey="Katzourakis A">A Katzourakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lower, R" uniqKey="Lower R">R Löwer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hohn, O" uniqKey="Hohn O">O Hohn</name>
</author>
<author><name sortKey="Hanke, K" uniqKey="Hanke K">K Hanke</name>
</author>
<author><name sortKey="Bannert, N" uniqKey="Bannert N">N Bannert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hughes, Jf" uniqKey="Hughes J">JF Hughes</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hughes, Jf" uniqKey="Hughes J">JF Hughes</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Romanish, Mt" uniqKey="Romanish M">MT Romanish</name>
</author>
<author><name sortKey="Cohen, Cj" uniqKey="Cohen C">CJ Cohen</name>
</author>
<author><name sortKey="Mager, Dl" uniqKey="Mager D">DL Mager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kamp, C" uniqKey="Kamp C">C Kamp</name>
</author>
<author><name sortKey="Hirschmann, P" uniqKey="Hirschmann P">P Hirschmann</name>
</author>
<author><name sortKey="Voss, H" uniqKey="Voss H">H Voss</name>
</author>
<author><name sortKey="Huellen, K" uniqKey="Huellen K">K Huellen</name>
</author>
<author><name sortKey="Vogt, Ph" uniqKey="Vogt P">PH Vogt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kidd, Jm" uniqKey="Kidd J">JM Kidd</name>
</author>
<author><name sortKey="Graves, T" uniqKey="Graves T">T Graves</name>
</author>
<author><name sortKey="Newman, Tl" uniqKey="Newman T">TL Newman</name>
</author>
<author><name sortKey="Fulton, R" uniqKey="Fulton R">R Fulton</name>
</author>
<author><name sortKey="Hayden, Hs" uniqKey="Hayden H">HS Hayden</name>
</author>
<author><name sortKey="Malig, M" uniqKey="Malig M">M Malig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cohen, Cj" uniqKey="Cohen C">CJ Cohen</name>
</author>
<author><name sortKey="Lock, Wm" uniqKey="Lock W">WM Lock</name>
</author>
<author><name sortKey="Mager, Dl" uniqKey="Mager D">DL Mager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simmons, W" uniqKey="Simmons W">W Simmons</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wildschutte, Jh" uniqKey="Wildschutte J">JH Wildschutte</name>
</author>
<author><name sortKey="Ram, D" uniqKey="Ram D">D Ram</name>
</author>
<author><name sortKey="Subramanian, R" uniqKey="Subramanian R">R Subramanian</name>
</author>
<author><name sortKey="Stevens, Vl" uniqKey="Stevens V">VL Stevens</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kassiotis, G" uniqKey="Kassiotis G">G Kassiotis</name>
</author>
<author><name sortKey="Stoye, Jp" uniqKey="Stoye J">JP Stoye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johanning, Gl" uniqKey="Johanning G">GL Johanning</name>
</author>
<author><name sortKey="Malouf, Gg" uniqKey="Malouf G">GG Malouf</name>
</author>
<author><name sortKey="Zheng, X" uniqKey="Zheng X">X Zheng</name>
</author>
<author><name sortKey="Esteva, Fj" uniqKey="Esteva F">FJ Esteva</name>
</author>
<author><name sortKey="Weinstein, Jn" uniqKey="Weinstein J">JN Weinstein</name>
</author>
<author><name sortKey="Wang Johanning, F" uniqKey="Wang Johanning F">F Wang-Johanning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhardwaj, N" uniqKey="Bhardwaj N">N Bhardwaj</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hanke, K" uniqKey="Hanke K">K Hanke</name>
</author>
<author><name sortKey="Hohn, O" uniqKey="Hohn O">O Hohn</name>
</author>
<author><name sortKey="Bannert, N" uniqKey="Bannert N">N Bannert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trela, M" uniqKey="Trela M">M Trela</name>
</author>
<author><name sortKey="Nelson, Pn" uniqKey="Nelson P">PN Nelson</name>
</author>
<author><name sortKey="Rylance, Pb" uniqKey="Rylance P">PB Rylance</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Antony, Jm" uniqKey="Antony J">JM Antony</name>
</author>
<author><name sortKey="Deslauriers, Am" uniqKey="Deslauriers A">AM Deslauriers</name>
</author>
<author><name sortKey="Bhat, Rk" uniqKey="Bhat R">RK Bhat</name>
</author>
<author><name sortKey="Ellestad, Kk" uniqKey="Ellestad K">KK Ellestad</name>
</author>
<author><name sortKey="Power, C" uniqKey="Power C">C Power</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tugnet, N" uniqKey="Tugnet N">N Tugnet</name>
</author>
<author><name sortKey="Rylance, P" uniqKey="Rylance P">P Rylance</name>
</author>
<author><name sortKey="Roden, D" uniqKey="Roden D">D Roden</name>
</author>
<author><name sortKey="Trela, M" uniqKey="Trela M">M Trela</name>
</author>
<author><name sortKey="Nelson, P" uniqKey="Nelson P">P Nelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Lee, M H" uniqKey="Lee M">M-H Lee</name>
</author>
<author><name sortKey="Henderson, L" uniqKey="Henderson L">L Henderson</name>
</author>
<author><name sortKey="Tyagi, R" uniqKey="Tyagi R">R Tyagi</name>
</author>
<author><name sortKey="Bachani, M" uniqKey="Bachani M">M Bachani</name>
</author>
<author><name sortKey="Steiner, J" uniqKey="Steiner J">J Steiner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Douville, Rn" uniqKey="Douville R">RN Douville</name>
</author>
<author><name sortKey="Nath, A" uniqKey="Nath A">A Nath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trombetta, B" uniqKey="Trombetta B">B Trombetta</name>
</author>
<author><name sortKey="Fantini, G" uniqKey="Fantini G">G Fantini</name>
</author>
<author><name sortKey="D Tanasio, E" uniqKey="D Tanasio E">E D’Atanasio</name>
</author>
<author><name sortKey="Sellitto, D" uniqKey="Sellitto D">D Sellitto</name>
</author>
<author><name sortKey="Cruciani, F" uniqKey="Cruciani F">F Cruciani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nex, Ba" uniqKey="Nex B">BA Nexø</name>
</author>
<author><name sortKey="Villesen, P" uniqKey="Villesen P">P Villesen</name>
</author>
<author><name sortKey="Nissen, Kk" uniqKey="Nissen K">KK Nissen</name>
</author>
<author><name sortKey="Lindegaard, Hm" uniqKey="Lindegaard H">HM Lindegaard</name>
</author>
<author><name sortKey="Rossing, P" uniqKey="Rossing P">P Rossing</name>
</author>
<author><name sortKey="Petersen, T" uniqKey="Petersen T">T Petersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bhardwaj, N" uniqKey="Bhardwaj N">N Bhardwaj</name>
</author>
<author><name sortKey="Montesion, M" uniqKey="Montesion M">M Montesion</name>
</author>
<author><name sortKey="Roy, F" uniqKey="Roy F">F Roy</name>
</author>
<author><name sortKey="Coffin, Jm" uniqKey="Coffin J">JM Coffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fukunaga, K" uniqKey="Fukunaga K">K Fukunaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ciuffi, A" uniqKey="Ciuffi A">A Ciuffi</name>
</author>
<author><name sortKey="Ronen, K" uniqKey="Ronen K">K Ronen</name>
</author>
<author><name sortKey="Brady, T" uniqKey="Brady T">T Brady</name>
</author>
<author><name sortKey="Malani, N" uniqKey="Malani N">N Malani</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Berry, Cc" uniqKey="Berry C">CC Berry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Witherspoon, Dj" uniqKey="Witherspoon D">DJ Witherspoon</name>
</author>
<author><name sortKey="Xing, J" uniqKey="Xing J">J Xing</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Watkins, Ws" uniqKey="Watkins W">WS Watkins</name>
</author>
<author><name sortKey="Batzer, Ma" uniqKey="Batzer M">MA Batzer</name>
</author>
<author><name sortKey="Jorde, Lb" uniqKey="Jorde L">LB Jorde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sudmant, Ph" uniqKey="Sudmant P">PH Sudmant</name>
</author>
<author><name sortKey="Rausch, T" uniqKey="Rausch T">T Rausch</name>
</author>
<author><name sortKey="Gardner, Ej" uniqKey="Gardner E">EJ Gardner</name>
</author>
<author><name sortKey="Handsaker, Re" uniqKey="Handsaker R">RE Handsaker</name>
</author>
<author><name sortKey="Abyzov, A" uniqKey="Abyzov A">A Abyzov</name>
</author>
<author><name sortKey="Huddleston, J" uniqKey="Huddleston J">J Huddleston</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lin, L" uniqKey="Lin L">L Lin</name>
</author>
<author><name sortKey="Chan, C" uniqKey="Chan C">C Chan</name>
</author>
<author><name sortKey="West, M" uniqKey="West M">M West</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Escobar, Md" uniqKey="Escobar M">MD Escobar</name>
</author>
<author><name sortKey="West, M" uniqKey="West M">M West</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ishwaran, H" uniqKey="Ishwaran H">H Ishwaran</name>
</author>
<author><name sortKey="James, Lf" uniqKey="James L">LF James</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X Wang</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benjamini, Y" uniqKey="Benjamini Y">Y Benjamini</name>
</author>
<author><name sortKey="Hochberg, Y" uniqKey="Hochberg Y">Y Hochberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bostock, M" uniqKey="Bostock M">M Bostock</name>
</author>
<author><name sortKey="Ogievetsky, V" uniqKey="Ogievetsky V">V Ogievetsky</name>
</author>
<author><name sortKey="Heer, J" uniqKey="Heer J">J Heer</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Indiana</li>
<li>Pennsylvanie</li>
</region>
<settlement><li>University Park (Pennsylvanie)</li>
</settlement>
<orgName><li>Université d'État de Pennsylvanie</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Li, Weiling" sort="Li, Weiling" uniqKey="Li W" first="Weiling" last="Li">Weiling Li</name>
</region>
<name sortKey="Acharya, Raj" sort="Acharya, Raj" uniqKey="Acharya R" first="Raj" last="Acharya">Raj Acharya</name>
<name sortKey="Acharya, Raj" sort="Acharya, Raj" uniqKey="Acharya R" first="Raj" last="Acharya">Raj Acharya</name>
<name sortKey="Lin, Lin" sort="Lin, Lin" uniqKey="Lin L" first="Lin" last="Lin">Lin Lin</name>
<name sortKey="Malhotra, Raunaq" sort="Malhotra, Raunaq" uniqKey="Malhotra R" first="Raunaq" last="Malhotra">Raunaq Malhotra</name>
<name sortKey="Poss, Mary" sort="Poss, Mary" uniqKey="Poss M" first="Mary" last="Poss">Mary Poss</name>
<name sortKey="Poss, Mary" sort="Poss, Mary" uniqKey="Poss M" first="Mary" last="Poss">Mary Poss</name>
<name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002165 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 002165 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:6456218 |texte= A computational framework to assess genome-wide distribution of polymorphic human endogenous retrovirus-K In human populations }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:30921327" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a MersV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |