Current and future developments in the treatment of virus-induced hypercytokinemia
Identifieur interne : 001927 ( Ncbi/Checkpoint ); précédent : 001926; suivant : 001928Current and future developments in the treatment of virus-induced hypercytokinemia
Auteurs : Jonathan P. Wong [Canada] ; Satya Viswanathan [Canada] ; Ming Wang [République populaire de Chine] ; Lun-Quan Sun [République populaire de Chine] ; Graeme C. Clark [Royaume-Uni] ; Riccardo V. D'Elia [Royaume-Uni]Source :
- Future Medicinal Chemistry [ 1756-8919 ] ; 2017.
Descripteurs français
- KwdFr :
- Animaux, Antiviraux (), Antiviraux (pharmacologie), Antiviraux (usage thérapeutique), Cytokines (antagonistes et inhibiteurs), Cytokines (immunologie), Cytokines (sang), Dengue (), Dengue (anatomopathologie), Dengue (immunologie), Dengue (sang), Fièvre hémorragique à virus Ebola (), Fièvre hémorragique à virus Ebola (anatomopathologie), Fièvre hémorragique à virus Ebola (immunologie), Fièvre hémorragique à virus Ebola (sang), Grippe chez les oiseaux (), Grippe chez les oiseaux (anatomopathologie), Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (sang), Humains, Inflammation (), Inflammation (anatomopathologie), Inflammation (immunologie), Oiseaux (immunologie), Oiseaux (virologie).
- MESH :
- anatomopathologie : Dengue, Fièvre hémorragique à virus Ebola, Grippe chez les oiseaux, Inflammation.
- antagonistes et inhibiteurs : Cytokines.
- immunologie : Cytokines, Dengue, Fièvre hémorragique à virus Ebola, Grippe chez les oiseaux, Inflammation, Oiseaux.
- pharmacologie : Antiviraux.
- sang : Cytokines, Dengue, Fièvre hémorragique à virus Ebola, Grippe chez les oiseaux.
- usage thérapeutique : Antiviraux.
- virologie : Oiseaux.
- Animaux, Antiviraux, Dengue, Fièvre hémorragique à virus Ebola, Grippe chez les oiseaux, Humains, Inflammation.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Birds (immunology), Birds (virology), Cytokines (antagonists & inhibitors), Cytokines (blood), Cytokines (immunology), Dengue (blood), Dengue (complications), Dengue (immunology), Dengue (pathology), Hemorrhagic Fever, Ebola (blood), Hemorrhagic Fever, Ebola (complications), Hemorrhagic Fever, Ebola (immunology), Hemorrhagic Fever, Ebola (pathology), Humans, Inflammation (complications), Inflammation (immunology), Inflammation (pathology), Inflammation (prevention & control), Influenza in Birds (blood), Influenza in Birds (complications), Influenza in Birds (immunology), Influenza in Birds (pathology).
- MESH :
- chemical , antagonists & inhibitors : Cytokines.
- chemical , blood : Cytokines.
- chemical , chemistry : Antiviral Agents.
- chemical , immunology : Cytokines.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents.
- blood : Dengue, Hemorrhagic Fever, Ebola, Influenza in Birds.
- complications : Dengue, Hemorrhagic Fever, Ebola, Inflammation, Influenza in Birds.
- immunology : Birds, Dengue, Hemorrhagic Fever, Ebola, Inflammation, Influenza in Birds.
- pathology : Dengue, Hemorrhagic Fever, Ebola, Inflammation, Influenza in Birds.
- prevention & control : Inflammation.
- virology : Birds.
- Animals, Humans.
Abstract
Emerging pathogenic viruses such as Ebola and Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) can cause acute infections through the evasion of the host's antiviral immune responses and by inducing the upregulation of inflammatory cytokines. This immune dysregulation, termed a cytokine storm or hypercytokinemia, is potentially fatal and is a significant underlying factor in increased mortality of infected patients. The prevalence of global outbreaks in recent years has offered opportunities to study the progression of various viral infections and have provided an improved understanding of hypercytokinemia associated with these diseases. However, despite this increased knowledge and the study of the infections caused by a range of emerging viruses, the therapeutic options still remain limited. This review aims to explore alternative experimental strategies for treating hypercytokinemia induced by the Ebola, avian influenza and Dengue viruses; outlining their modes of action, summarizing their preclinical assessments and potential clinical applications.
Url:
DOI: 10.4155/fmc-2016-0181
PubMed: 28128003
PubMed Central: 7079716
Affiliations:
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PMC:7079716Le document en format XML
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Wong</name><affiliation wicri:level="1"><nlm:aff id="aff1">Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Viswanathan, Satya" sort="Viswanathan, Satya" uniqKey="Viswanathan S" first="Satya" last="Viswanathan">Satya Viswanathan</name><affiliation wicri:level="1"><nlm:aff id="aff1">Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta</wicri:regionArea><wicri:noRegion>Alberta</wicri:noRegion></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><affiliation wicri:level="3"><nlm:aff id="aff2">College of Veterinary Medicine, China Agriculture University, Beijing, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Veterinary Medicine, China Agriculture University, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Sun, Lun Quan" sort="Sun, Lun Quan" uniqKey="Sun L" first="Lun-Quan" last="Sun">Lun-Quan Sun</name><affiliation wicri:level="1"><nlm:aff id="aff3">Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsa, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsa</wicri:regionArea><wicri:noRegion>Changsa</wicri:noRegion></affiliation><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Clark, Graeme C" sort="Clark, Graeme C" uniqKey="Clark G" first="Graeme C" last="Clark">Graeme C. 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(immunologie)</term><term>Cytokines (sang)</term><term>Dengue ()</term><term>Dengue (anatomopathologie)</term><term>Dengue (immunologie)</term><term>Dengue (sang)</term><term>Fièvre hémorragique à virus Ebola ()</term><term>Fièvre hémorragique à virus Ebola (anatomopathologie)</term><term>Fièvre hémorragique à virus Ebola (immunologie)</term><term>Fièvre hémorragique à virus Ebola (sang)</term><term>Grippe chez les oiseaux ()</term><term>Grippe chez les oiseaux (anatomopathologie)</term><term>Grippe chez les oiseaux (immunologie)</term><term>Grippe chez les oiseaux (sang)</term><term>Humains</term><term>Inflammation ()</term><term>Inflammation (anatomopathologie)</term><term>Inflammation (immunologie)</term><term>Oiseaux (immunologie)</term><term>Oiseaux (virologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Dengue</term><term>Fièvre hémorragique à virus Ebola</term><term>Grippe chez les oiseaux</term><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Inflammation</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cytokines</term><term>Dengue</term><term>Fièvre hémorragique à virus Ebola</term><term>Grippe chez les oiseaux</term><term>Inflammation</term><term>Oiseaux</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Birds</term><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Inflammation</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Inflammation</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cytokines</term><term>Dengue</term><term>Fièvre hémorragique à virus Ebola</term><term>Grippe chez les oiseaux</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Oiseaux</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Birds</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Antiviraux</term><term>Dengue</term><term>Fièvre hémorragique à virus Ebola</term><term>Grippe chez les oiseaux</term><term>Humains</term><term>Inflammation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Emerging pathogenic viruses such as Ebola and Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) can cause acute infections through the evasion of the host's antiviral immune responses and by inducing the upregulation of inflammatory cytokines. This immune dysregulation, termed a cytokine storm or hypercytokinemia, is potentially fatal and is a significant underlying factor in increased mortality of infected patients. The prevalence of global outbreaks in recent years has offered opportunities to study the progression of various viral infections and have provided an improved understanding of hypercytokinemia associated with these diseases. However, despite this increased knowledge and the study of the infections caused by a range of emerging viruses, the therapeutic options still remain limited. This review aims to explore alternative experimental strategies for treating hypercytokinemia induced by the Ebola, avian influenza and Dengue viruses; outlining their modes of action, summarizing their preclinical assessments and potential clinical applications.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sanchez, A" uniqKey="Sanchez A">A Sanchez</name></author><author><name sortKey="Geisbert, Tw" uniqKey="Geisbert T">TW Geisbert</name></author><author><name sortKey="Feldman, H" uniqKey="Feldman H">H Feldman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Majumder, Ms" uniqKey="Majumder M">MS Majumder</name></author><author><name sortKey="Rivers, C" uniqKey="Rivers C">C Rivers</name></author><author><name sortKey="Lofgren, E" uniqKey="Lofgren E">E Lofgren</name></author><author><name sortKey="Fisman, D" uniqKey="Fisman D">D 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D" uniqKey="Olagnier D">D Olagnier</name></author><author><name sortKey="Amatore, D" uniqKey="Amatore D">D Amatore</name></author><author><name sortKey="Castiello, L" uniqKey="Castiello L">L Castiello</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><settlement><li>Pékin</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Wong, Jonathan P" sort="Wong, Jonathan P" uniqKey="Wong J" first="Jonathan P" last="Wong">Jonathan P. Wong</name></noRegion><name sortKey="Viswanathan, Satya" sort="Viswanathan, Satya" uniqKey="Viswanathan S" first="Satya" last="Viswanathan">Satya Viswanathan</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name></noRegion><name sortKey="Sun, Lun Quan" sort="Sun, Lun Quan" uniqKey="Sun L" first="Lun-Quan" last="Sun">Lun-Quan Sun</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Clark, Graeme C" sort="Clark, Graeme C" uniqKey="Clark G" first="Graeme C" last="Clark">Graeme C. Clark</name></noRegion><name sortKey="D Elia, Riccardo V" sort="D Elia, Riccardo V" uniqKey="D Elia R" first="Riccardo V" last="D'Elia">Riccardo V. D'Elia</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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