Current and future developments in the treatment of virus-induced hypercytokinemia.
Identifieur interne : 000E03 ( PubMed/Corpus ); précédent : 000E02; suivant : 000E04Current and future developments in the treatment of virus-induced hypercytokinemia.
Auteurs : Jonathan P. Wong ; Satya Viswanathan ; Ming Wang ; Lun-Quan Sun ; Graeme C. Clark ; Riccardo V. D'EliaSource :
- Future medicinal chemistry [ 1756-8927 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Antiviral Agents (chemistry), Antiviral Agents (pharmacology), Antiviral Agents (therapeutic use), Birds (immunology), Birds (virology), Cytokines (antagonists & inhibitors), Cytokines (blood), Cytokines (immunology), Dengue (blood), Dengue (complications), Dengue (immunology), Dengue (pathology), Hemorrhagic Fever, Ebola (blood), Hemorrhagic Fever, Ebola (complications), Hemorrhagic Fever, Ebola (immunology), Hemorrhagic Fever, Ebola (pathology), Humans, Inflammation (complications), Inflammation (immunology), Inflammation (pathology), Inflammation (prevention & control), Influenza in Birds (blood), Influenza in Birds (complications), Influenza in Birds (immunology), Influenza in Birds (pathology).
- MESH :
- chemical , antagonists & inhibitors : Cytokines.
- chemical , blood : Cytokines.
- chemical , chemistry : Antiviral Agents.
- chemical , immunology : Cytokines.
- chemical , pharmacology : Antiviral Agents.
- chemical , therapeutic use : Antiviral Agents.
- blood : Dengue, Hemorrhagic Fever, Ebola, Influenza in Birds.
- complications : Dengue, Hemorrhagic Fever, Ebola, Inflammation, Influenza in Birds.
- immunology : Birds, Dengue, Hemorrhagic Fever, Ebola, Inflammation, Influenza in Birds.
- pathology : Dengue, Hemorrhagic Fever, Ebola, Inflammation, Influenza in Birds.
- prevention & control : Inflammation.
- virology : Birds.
- Animals, Humans.
Abstract
Emerging pathogenic viruses such as Ebola and Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) can cause acute infections through the evasion of the host's antiviral immune responses and by inducing the upregulation of inflammatory cytokines. This immune dysregulation, termed a cytokine storm or hypercytokinemia, is potentially fatal and is a significant underlying factor in increased mortality of infected patients. The prevalence of global outbreaks in recent years has offered opportunities to study the progression of various viral infections and have provided an improved understanding of hypercytokinemia associated with these diseases. However, despite this increased knowledge and the study of the infections caused by a range of emerging viruses, the therapeutic options still remain limited. This review aims to explore alternative experimental strategies for treating hypercytokinemia induced by the Ebola, avian influenza and Dengue viruses; outlining their modes of action, summarizing their preclinical assessments and potential clinical applications.
DOI: 10.4155/fmc-2016-0181
PubMed: 28128003
Links to Exploration step
pubmed:28128003Le document en format XML
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Wong</name><affiliation><nlm:affiliation>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Viswanathan, Satya" sort="Viswanathan, Satya" uniqKey="Viswanathan S" first="Satya" last="Viswanathan">Satya Viswanathan</name><affiliation><nlm:affiliation>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><affiliation><nlm:affiliation>College of Veterinary Medicine, China Agriculture University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Lun Quan" sort="Sun, Lun Quan" uniqKey="Sun L" first="Lun-Quan" last="Sun">Lun-Quan Sun</name><affiliation><nlm:affiliation>Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsa, China.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Graeme C" sort="Clark, Graeme C" uniqKey="Clark G" first="Graeme C" last="Clark">Graeme C. 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Wong</name><affiliation><nlm:affiliation>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Viswanathan, Satya" sort="Viswanathan, Satya" uniqKey="Viswanathan S" first="Satya" last="Viswanathan">Satya Viswanathan</name><affiliation><nlm:affiliation>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Ming" sort="Wang, Ming" uniqKey="Wang M" first="Ming" last="Wang">Ming Wang</name><affiliation><nlm:affiliation>College of Veterinary Medicine, China Agriculture University, Beijing, China.</nlm:affiliation></affiliation></author><author><name sortKey="Sun, Lun Quan" sort="Sun, Lun Quan" uniqKey="Sun L" first="Lun-Quan" last="Sun">Lun-Quan Sun</name><affiliation><nlm:affiliation>Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsa, China.</nlm:affiliation></affiliation></author><author><name sortKey="Clark, Graeme C" sort="Clark, Graeme C" uniqKey="Clark G" first="Graeme C" last="Clark">Graeme C. 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D'Elia</name><affiliation><nlm:affiliation>CBR Division, Defence Science & Technology Laboratory, Porton Down, Salisbury, UK.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Future medicinal chemistry</title><idno type="eISSN">1756-8927</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (chemistry)</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (therapeutic use)</term><term>Birds (immunology)</term><term>Birds (virology)</term><term>Cytokines (antagonists & inhibitors)</term><term>Cytokines (blood)</term><term>Cytokines (immunology)</term><term>Dengue (blood)</term><term>Dengue (complications)</term><term>Dengue (immunology)</term><term>Dengue (pathology)</term><term>Hemorrhagic Fever, Ebola (blood)</term><term>Hemorrhagic Fever, Ebola (complications)</term><term>Hemorrhagic Fever, Ebola (immunology)</term><term>Hemorrhagic Fever, Ebola (pathology)</term><term>Humans</term><term>Inflammation (complications)</term><term>Inflammation (immunology)</term><term>Inflammation (pathology)</term><term>Inflammation (prevention & control)</term><term>Influenza in Birds (blood)</term><term>Influenza in Birds (complications)</term><term>Influenza in Birds (immunology)</term><term>Influenza in Birds (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Inflammation</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Birds</term><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Inflammation</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dengue</term><term>Hemorrhagic Fever, Ebola</term><term>Inflammation</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Inflammation</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Birds</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Emerging pathogenic viruses such as Ebola and Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) can cause acute infections through the evasion of the host's antiviral immune responses and by inducing the upregulation of inflammatory cytokines. This immune dysregulation, termed a cytokine storm or hypercytokinemia, is potentially fatal and is a significant underlying factor in increased mortality of infected patients. The prevalence of global outbreaks in recent years has offered opportunities to study the progression of various viral infections and have provided an improved understanding of hypercytokinemia associated with these diseases. However, despite this increased knowledge and the study of the infections caused by a range of emerging viruses, the therapeutic options still remain limited. This review aims to explore alternative experimental strategies for treating hypercytokinemia induced by the Ebola, avian influenza and Dengue viruses; outlining their modes of action, summarizing their preclinical assessments and potential clinical applications.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28128003</PMID><DateCompleted><Year>2017</Year><Month>08</Month><Day>14</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1756-8927</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>02</Month></PubDate></JournalIssue><Title>Future medicinal chemistry</Title><ISOAbbreviation>Future Med Chem</ISOAbbreviation></Journal><ArticleTitle>Current and future developments in the treatment of virus-induced hypercytokinemia.</ArticleTitle><Pagination><MedlinePgn>169-178</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4155/fmc-2016-0181</ELocationID><Abstract><AbstractText>Emerging pathogenic viruses such as Ebola and Middle Eastern Respiratory Syndrome coronavirus (MERS-CoV) can cause acute infections through the evasion of the host's antiviral immune responses and by inducing the upregulation of inflammatory cytokines. This immune dysregulation, termed a cytokine storm or hypercytokinemia, is potentially fatal and is a significant underlying factor in increased mortality of infected patients. The prevalence of global outbreaks in recent years has offered opportunities to study the progression of various viral infections and have provided an improved understanding of hypercytokinemia associated with these diseases. However, despite this increased knowledge and the study of the infections caused by a range of emerging viruses, the therapeutic options still remain limited. This review aims to explore alternative experimental strategies for treating hypercytokinemia induced by the Ebola, avian influenza and Dengue viruses; outlining their modes of action, summarizing their preclinical assessments and potential clinical applications.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wong</LastName><ForeName>Jonathan P</ForeName><Initials>JP</Initials><AffiliationInfo><Affiliation>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Viswanathan</LastName><ForeName>Satya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Defence Research & Development Canada, Suffield Research Centre, Ralston, Alberta, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ming</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>College of Veterinary Medicine, China Agriculture University, Beijing, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Lun-Quan</ForeName><Initials>LQ</Initials><AffiliationInfo><Affiliation>Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsa, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clark</LastName><ForeName>Graeme C</ForeName><Initials>GC</Initials><AffiliationInfo><Affiliation>CBR Division, Defence Science & Technology Laboratory, Porton Down, Salisbury, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>D'Elia</LastName><ForeName>Riccardo V</ForeName><Initials>RV</Initials><AffiliationInfo><Affiliation>CBR Division, Defence Science & Technology Laboratory, Porton Down, Salisbury, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>01</Month><Day>27</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Future Med Chem</MedlineTA><NlmUniqueID>101511162</NlmUniqueID><ISSNLinking>1756-8919</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001717" MajorTopicYN="N">Birds</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003715" MajorTopicYN="N">Dengue</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019142" MajorTopicYN="N">Hemorrhagic Fever, Ebola</DescriptorName><QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005585" 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