Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
Identifieur interne : 001793 ( Ncbi/Checkpoint ); précédent : 001792; suivant : 001794Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia
Auteurs : Hamzah A. Mohd [Arabie saoudite] ; Ziad A. Memish [Arabie saoudite] ; Sarah H. Alfaraj [Arabie saoudite] ; Donna Mcclish [États-Unis] ; Talal Altuwaijri [Arabie saoudite] ; Marzouqah S. Alanazi [Arabie saoudite] ; Saleh A. Aloqiel [Arabie saoudite] ; Ahmed M. Alenzi [Arabie saoudite] ; Fahad Bafaqeeh [Arabie saoudite] ; Amal M. Mohamed [Arabie saoudite] ; Kamel Aldosari [Arabie saoudite] ; Sameeh Ghazal [Arabie saoudite]Source :
- Travel Medicine and Infectious Disease [ 1477-8939 ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Arabie saoudite (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Humains, Infection croisée (virologie), Infection croisée (épidémiologie), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Mâle, Orientation vers un spécialiste, Rayons X, Réaction de polymérisation en chaine en temps réel, Thorax (imagerie diagnostique), Valeur prédictive des tests, Études cas-témoins.
- MESH :
- diagnostic : Infections à coronavirus.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- imagerie diagnostique : Thorax.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- mortalité : Infections à coronavirus.
- virologie : Infection croisée, Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infection croisée, Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Orientation vers un spécialiste, Rayons X, Réaction de polymérisation en chaine en temps réel, Valeur prédictive des tests, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Case-Control Studies, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (virology), Cross Infection (epidemiology), Cross Infection (virology), Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Predictive Value of Tests, Real-Time Polymerase Chain Reaction, Referral and Consultation, Saudi Arabia (epidemiology), Thorax (diagnostic imaging), X-Rays.
- MESH :
- diagnosis : Coronavirus Infections.
- diagnostic imaging : Thorax.
- epidemiology : Coronavirus Infections, Cross Infection, Saudi Arabia.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- mortality : Coronavirus Infections.
- virology : Coronavirus Infections, Cross Infection.
- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Real-Time Polymerase Chain Reaction, Referral and Consultation, X-Rays.
Abstract
A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections.
Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory symptoms and tested negative for MERS-CoV on RT-PCR.
None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%).
None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility.
Url:
DOI: 10.1016/j.tmaid.2016.09.008
PubMed: 27671972
PubMed Central: 7110705
Affiliations:
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Memish</name><affiliation wicri:level="1"><nlm:aff id="aff1">Infectious Diseases Division, Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infectious Diseases Division, Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alfaraj, Sarah H" sort="Alfaraj, Sarah H" uniqKey="Alfaraj S" first="Sarah H." last="Alfaraj">Sarah H. Alfaraj</name><affiliation wicri:level="1"><nlm:aff id="aff3">Infection Control Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Infection Control Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Mcclish, Donna" sort="Mcclish, Donna" uniqKey="Mcclish D" first="Donna" last="Mcclish">Donna Mcclish</name><affiliation wicri:level="2"><nlm:aff id="aff4">Department of Biostatistics at Virginia Commonwealth University, Richmond, VA, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biostatistics at Virginia Commonwealth University, Richmond, VA</wicri:regionArea><placeName><region type="state">Virginie</region></placeName></affiliation></author><author><name sortKey="Altuwaijri, Talal" sort="Altuwaijri, Talal" uniqKey="Altuwaijri T" first="Talal" last="Altuwaijri">Talal Altuwaijri</name><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Surgery, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Surgery, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alanazi, Marzouqah S" sort="Alanazi, Marzouqah S" uniqKey="Alanazi M" first="Marzouqah S." last="Alanazi">Marzouqah S. Alanazi</name><affiliation wicri:level="1"><nlm:aff id="aff6">Emergency Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Emergency Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aloqiel, Saleh A" sort="Aloqiel, Saleh A" uniqKey="Aloqiel S" first="Saleh A." last="Aloqiel">Saleh A. Aloqiel</name><affiliation wicri:level="1"><nlm:aff id="aff7">Pediatric Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Pediatric Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Alenzi, Ahmed M" sort="Alenzi, Ahmed M" uniqKey="Alenzi A" first="Ahmed M." last="Alenzi">Ahmed M. Alenzi</name><affiliation wicri:level="1"><nlm:aff id="aff8">Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Bafaqeeh, Fahad" sort="Bafaqeeh, Fahad" uniqKey="Bafaqeeh F" first="Fahad" last="Bafaqeeh">Fahad Bafaqeeh</name><affiliation wicri:level="1"><nlm:aff id="aff9">Critical Care Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Critical Care Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Mohamed, Amal M" sort="Mohamed, Amal M" uniqKey="Mohamed A" first="Amal M." last="Mohamed">Amal M. Mohamed</name><affiliation wicri:level="1"><nlm:aff id="aff10">Nursing Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Nursing Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Aldosari, Kamel" sort="Aldosari, Kamel" uniqKey="Aldosari K" first="Kamel" last="Aldosari">Kamel Aldosari</name><affiliation wicri:level="1"><nlm:aff id="aff11">Pathology and Laboratory Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Pathology and Laboratory Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Ghazal, Sameeh" sort="Ghazal, Sameeh" uniqKey="Ghazal S" first="Sameeh" last="Ghazal">Sameeh Ghazal</name><affiliation wicri:level="1"><nlm:aff id="aff12">Medical Affairs, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Medical Affairs, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Travel Medicine and Infectious Disease</title><idno type="ISSN">1477-8939</idno><idno type="eISSN">1873-0442</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Coronavirus Infections (diagnosis)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (mortality)</term><term>Coronavirus Infections (virology)</term><term>Cross Infection (epidemiology)</term><term>Cross Infection (virology)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (isolation & purification)</term><term>Predictive Value of Tests</term><term>Real-Time Polymerase Chain Reaction</term><term>Referral and Consultation</term><term>Saudi Arabia (epidemiology)</term><term>Thorax (diagnostic imaging)</term><term>X-Rays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Arabie saoudite (épidémiologie)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification)</term><term>Femelle</term><term>Humains</term><term>Infection croisée (virologie)</term><term>Infection croisée (épidémiologie)</term><term>Infections à coronavirus (diagnostic)</term><term>Infections à coronavirus (mortalité)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle</term><term>Orientation vers un spécialiste</term><term>Rayons X</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Thorax (imagerie diagnostique)</term><term>Valeur prédictive des tests</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Thorax</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term><term>Saudi Arabia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Thorax</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infection croisée</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Cross Infection</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Arabie saoudite</term><term>Infection croisée</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Real-Time Polymerase Chain Reaction</term><term>Referral and Consultation</term><term>X-Rays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Orientation vers un spécialiste</term><term>Rayons X</term><term>Réaction de polymérisation en chaine en temps réel</term><term>Valeur prédictive des tests</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><sec><title>Background</title><p>A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections.</p></sec><sec><title>Methods</title><p>Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory symptoms and tested negative for MERS-CoV on RT-PCR.</p></sec><sec><title>Results</title><p>None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%).</p></sec><sec><title>Conclusions</title><p>None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Boheemena, S" uniqKey="Boheemena S">S. 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Mohd</name></noRegion><name sortKey="Alanazi, Marzouqah S" sort="Alanazi, Marzouqah S" uniqKey="Alanazi M" first="Marzouqah S." last="Alanazi">Marzouqah S. Alanazi</name><name sortKey="Aldosari, Kamel" sort="Aldosari, Kamel" uniqKey="Aldosari K" first="Kamel" last="Aldosari">Kamel Aldosari</name><name sortKey="Alenzi, Ahmed M" sort="Alenzi, Ahmed M" uniqKey="Alenzi A" first="Ahmed M." last="Alenzi">Ahmed M. Alenzi</name><name sortKey="Alfaraj, Sarah H" sort="Alfaraj, Sarah H" uniqKey="Alfaraj S" first="Sarah H." last="Alfaraj">Sarah H. Alfaraj</name><name sortKey="Aloqiel, Saleh A" sort="Aloqiel, Saleh A" uniqKey="Aloqiel S" first="Saleh A." last="Aloqiel">Saleh A. Aloqiel</name><name sortKey="Altuwaijri, Talal" sort="Altuwaijri, Talal" uniqKey="Altuwaijri T" first="Talal" last="Altuwaijri">Talal Altuwaijri</name><name sortKey="Bafaqeeh, Fahad" sort="Bafaqeeh, Fahad" uniqKey="Bafaqeeh F" first="Fahad" last="Bafaqeeh">Fahad Bafaqeeh</name><name sortKey="Ghazal, Sameeh" sort="Ghazal, Sameeh" uniqKey="Ghazal S" first="Sameeh" last="Ghazal">Sameeh Ghazal</name><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Memish, Ziad A" sort="Memish, Ziad A" uniqKey="Memish Z" first="Ziad A." last="Memish">Ziad A. Memish</name><name sortKey="Mohamed, Amal M" sort="Mohamed, Amal M" uniqKey="Mohamed A" first="Amal M." last="Mohamed">Amal M. Mohamed</name></country><country name="États-Unis"><region name="Virginie"><name sortKey="Mcclish, Donna" sort="Mcclish, Donna" uniqKey="Mcclish D" first="Donna" last="Mcclish">Donna Mcclish</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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