Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia.
Identifieur interne : 000F33 ( PubMed/Curation ); précédent : 000F32; suivant : 000F34Predictors of MERS-CoV infection: A large case control study of patients presenting with ILI at a MERS-CoV referral hospital in Saudi Arabia.
Auteurs : Hamzah A. Mohd [Arabie saoudite] ; Ziad A. Memish [Arabie saoudite] ; Sarah H. Alfaraj [Arabie saoudite] ; Donna Mcclish [États-Unis] ; Talal Altuwaijri [Arabie saoudite] ; Marzouqah S. Alanazi [Arabie saoudite] ; Saleh A. Aloqiel [Arabie saoudite] ; Ahmed M. Alenzi [Arabie saoudite] ; Fahad Bafaqeeh [Arabie saoudite] ; Amal M. Mohamed [Arabie saoudite] ; Kamel Aldosari [Arabie saoudite] ; Sameeh Ghazal [Arabie saoudite]Source :
- Travel medicine and infectious disease [ 1873-0442 ]
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Arabie saoudite (épidémiologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (isolement et purification), Femelle, Humains, Infection croisée (virologie), Infection croisée (épidémiologie), Infections à coronavirus (diagnostic), Infections à coronavirus (mortalité), Infections à coronavirus (virologie), Infections à coronavirus (épidémiologie), Mâle, Orientation vers un spécialiste, Rayons X, Réaction de polymérisation en chaine en temps réel, Thorax (imagerie diagnostique), Valeur prédictive des tests, Études cas-témoins.
- MESH :
- diagnostic : Infections à coronavirus.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- imagerie diagnostique : Thorax.
- isolement et purification : Coronavirus du syndrome respiratoire du Moyen-Orient.
- mortalité : Infections à coronavirus.
- virologie : Infection croisée, Infections à coronavirus.
- épidémiologie : Arabie saoudite, Infection croisée, Infections à coronavirus.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Orientation vers un spécialiste, Rayons X, Réaction de polymérisation en chaine en temps réel, Valeur prédictive des tests, Études cas-témoins.
English descriptors
- KwdEn :
- Adult, Case-Control Studies, Coronavirus Infections (diagnosis), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (virology), Cross Infection (epidemiology), Cross Infection (virology), Female, Humans, Male, Middle Aged, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (isolation & purification), Predictive Value of Tests, Real-Time Polymerase Chain Reaction, Referral and Consultation, Saudi Arabia (epidemiology), Thorax (diagnostic imaging), X-Rays.
- MESH :
- diagnosis : Coronavirus Infections.
- diagnostic imaging : Thorax.
- epidemiology : Coronavirus Infections, Cross Infection, Saudi Arabia.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- isolation & purification : Middle East Respiratory Syndrome Coronavirus.
- mortality : Coronavirus Infections.
- virology : Coronavirus Infections, Cross Infection.
- Adult, Case-Control Studies, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Real-Time Polymerase Chain Reaction, Referral and Consultation, X-Rays.
Abstract
A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections.
DOI: 10.1016/j.tmaid.2016.09.008
PubMed: 27671972
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<front><div type="abstract" xml:lang="en">A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections.</div>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A case control study to better characterize the clinical features, laboratory, and radiological abnormalities associated with MERS-CoV infection in order to help with early identification of this syndrome from other respiratory infections.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Eighty patients admitted to a hospital in Riyadh, diagnosed with MERS-CoV infection based on RT-PCR were matched on age, sex, and the presence of a co-morbid condition on a basis of 1:2 to other patients admitted with respiratory symptoms and tested negative for MERS-CoV on RT-PCR.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">None of the reported MERS-CoV presenting symptoms was significantly associated with being infected with MERS-CoV. On the other hand, WBC count was significantly lower in patients with confirmed MERS-CoV infection (median 5.7 vs 9.3, P: 0.0004). Neutrophil count was as well significantly lower in MERS-CoV patients (median 3.7 vs 6.7, P: 0.0001). Both AST, and ALT values were significantly higher in MERS-CoV infected group (AST median 42 vs 36, P: 0.03, and ALT median 33 vs 28, P: 0.003). Overall our MERS-CoV mortality rate was (10%) below the national figure of (40%).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">None of the presenting symptoms are specific for MERS-CoV infection. And out of all the investigations WBC, neutrophil counts, AST and ALT values have some predictive utility.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Ltd. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mohd</LastName>
<ForeName>Hamzah A</ForeName>
<Initials>HA</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Division, Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: dr.hmohd@gmail.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Memish</LastName>
<ForeName>Ziad A</ForeName>
<Initials>ZA</Initials>
<AffiliationInfo><Affiliation>Infectious Diseases Division, Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. Electronic address: zmemish@yahoo.com.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alfaraj</LastName>
<ForeName>Sarah H</ForeName>
<Initials>SH</Initials>
<AffiliationInfo><Affiliation>Infection Control Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: alfarajsa@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McClish</LastName>
<ForeName>Donna</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Department of Biostatistics at Virginia Commonwealth University, Richmond, VA, USA. Electronic address: donna.mcclish@vcuhealth.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Altuwaijri</LastName>
<ForeName>Talal</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Department of Surgery, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: altuwaijrit@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alanazi</LastName>
<ForeName>Marzouqah S</ForeName>
<Initials>MS</Initials>
<AffiliationInfo><Affiliation>Emergency Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: Alanazima@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aloqiel</LastName>
<ForeName>Saleh A</ForeName>
<Initials>SA</Initials>
<AffiliationInfo><Affiliation>Pediatric Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: aloqiels@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Alenzi</LastName>
<ForeName>Ahmed M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Department of Medicine, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: alenezia@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bafaqeeh</LastName>
<ForeName>Fahad</ForeName>
<Initials>F</Initials>
<AffiliationInfo><Affiliation>Critical Care Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: bafaqeehf@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mohamed</LastName>
<ForeName>Amal M</ForeName>
<Initials>AM</Initials>
<AffiliationInfo><Affiliation>Nursing Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: mohameda@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Aldosari</LastName>
<ForeName>Kamel</ForeName>
<Initials>K</Initials>
<AffiliationInfo><Affiliation>Pathology and Laboratory Department, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: aldosaryk@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Ghazal</LastName>
<ForeName>Sameeh</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Medical Affairs, Prince Mohamed Bin Abdulaziz Hospital, Ministry of Health, Riyadh, Saudi Arabia. Electronic address: ghazals@pmah.med.sa.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>09</Month>
<Day>24</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Netherlands</Country>
<MedlineTA>Travel Med Infect Dis</MedlineTA>
<NlmUniqueID>101230758</NlmUniqueID>
<ISSNLinking>1477-8939</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003428" MajorTopicYN="N">Cross Infection</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D065207" MajorTopicYN="N">Middle East Respiratory Syndrome Coronavirus</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000302" MajorTopicYN="Y">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011237" MajorTopicYN="N">Predictive Value of Tests</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D060888" MajorTopicYN="N">Real-Time Polymerase Chain Reaction</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012017" MajorTopicYN="N">Referral and Consultation</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012529" MajorTopicYN="N">Saudi Arabia</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013909" MajorTopicYN="N">Thorax</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014965" MajorTopicYN="N">X-Rays</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Coronavirus</Keyword>
<Keyword MajorTopicYN="Y">MERS-CoV</Keyword>
<Keyword MajorTopicYN="Y">Middle East Respirator Syndrome</Keyword>
<Keyword MajorTopicYN="Y">Mortality</Keyword>
<Keyword MajorTopicYN="Y">Predictors</Keyword>
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<Month>08</Month>
<Day>30</Day>
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<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>09</Month>
<Day>14</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>09</Month>
<Day>16</Day>
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<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>10</Month>
<Day>25</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>5</Month>
<Day>4</Day>
<Hour>6</Hour>
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