Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
Identifieur interne : 001130 ( Ncbi/Checkpoint ); précédent : 001129; suivant : 001131Prediction and biochemical analysis of putative cleavage sites of the 3C-like protease of Middle East respiratory syndrome coronavirus
Auteurs : Andong Wu [République populaire de Chine] ; Yi Wang [République populaire de Chine] ; Cong Zeng [République populaire de Chine] ; Xingyu Huang [République populaire de Chine] ; Shan Xu [République populaire de Chine] ; Ceyang Su [République populaire de Chine] ; Min Wang [République populaire de Chine] ; Yu Chen [République populaire de Chine] ; Deyin Guo [République populaire de Chine]Source :
- Virus Research [ 0168-1702 ] ; 2015.
Descripteurs français
- KwdFr :
- Alignement de séquences, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (enzymologie), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Cysteine endopeptidases (), Cysteine endopeptidases (génétique), Cysteine endopeptidases (métabolisme), Humains, Infections à coronavirus (virologie), Maturation post-traductionnelle des protéines, Modèles moléculaires, Peptides (génétique), Peptides (métabolisme), Phylogénie, Spécificité du substrat, Séquence d'acides aminés.
- MESH :
- enzymologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient, Cysteine endopeptidases, Peptides.
- métabolisme : Cysteine endopeptidases, Peptides.
- virologie : Infections à coronavirus.
- Alignement de séquences, Coronavirus du syndrome respiratoire du Moyen-Orient, Cysteine endopeptidases, Humains, Maturation post-traductionnelle des protéines, Modèles moléculaires, Phylogénie, Spécificité du substrat, Séquence d'acides aminés.
English descriptors
- KwdEn :
- Amino Acid Sequence, Coronavirus Infections (virology), Cysteine Endopeptidases (chemistry), Cysteine Endopeptidases (genetics), Cysteine Endopeptidases (metabolism), Humans, Middle East Respiratory Syndrome Coronavirus (chemistry), Middle East Respiratory Syndrome Coronavirus (classification), Middle East Respiratory Syndrome Coronavirus (enzymology), Middle East Respiratory Syndrome Coronavirus (genetics), Models, Molecular, Peptides (genetics), Peptides (metabolism), Phylogeny, Protein Processing, Post-Translational, Sequence Alignment, Substrate Specificity.
- MESH :
- chemical , chemistry : Cysteine Endopeptidases.
- chemical , genetics : Cysteine Endopeptidases, Peptides.
- chemical , metabolism : Cysteine Endopeptidases, Peptides.
- chemistry : Middle East Respiratory Syndrome Coronavirus.
- classification : Middle East Respiratory Syndrome Coronavirus.
- enzymology : Middle East Respiratory Syndrome Coronavirus.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Amino Acid Sequence, Humans, Models, Molecular, Phylogeny, Protein Processing, Post-Translational, Sequence Alignment, Substrate Specificity.
Abstract
A prediction method of coronaviral 3CLpro cleavage sites was proposed to balance the accuracy and false positives. Three of the nine putative non-canonical cleavage sites were verified, which are located upstream to nsp4. All 11 canonical cleavage sites of MERS-CoV 3CLpro were confirmed and the Michaelis constants were calculated.
Url:
DOI: 10.1016/j.virusres.2015.05.018
PubMed: 26036787
PubMed Central: 7114542
Affiliations:
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PMC:7114542Le document en format XML
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<term>Cysteine Endopeptidases (genetics)</term>
<term>Cysteine Endopeptidases (metabolism)</term>
<term>Humans</term>
<term>Middle East Respiratory Syndrome Coronavirus (chemistry)</term>
<term>Middle East Respiratory Syndrome Coronavirus (classification)</term>
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<term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term>
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<keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term>
<term>Cysteine endopeptidases</term>
<term>Peptides</term>
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<term>Protein Processing, Post-Translational</term>
<term>Sequence Alignment</term>
<term>Substrate Specificity</term>
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<term>Maturation post-traductionnelle des protéines</term>
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<front><div type="abstract" xml:lang="en"><title>Highlights</title>
<p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label>
<p id="par0005">A prediction method of coronaviral 3CLpro cleavage sites was proposed to balance the accuracy and false positives.</p>
</list-item>
<list-item id="lsti0010"><label>•</label>
<p id="par0010">Three of the nine putative non-canonical cleavage sites were verified, which are located upstream to nsp4.</p>
</list-item>
<list-item id="lsti0015"><label>•</label>
<p id="par0015">All 11 canonical cleavage sites of MERS-CoV 3CLpro were confirmed and the Michaelis constants were calculated.</p>
</list-item>
</list>
</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Assiri, A" uniqKey="Assiri A">A. Assiri</name>
</author>
<author><name sortKey="Mcgeer, A" uniqKey="Mcgeer A">A. McGeer</name>
</author>
<author><name sortKey="Perl, T M" uniqKey="Perl T">T.M. Perl</name>
</author>
<author><name sortKey="Price, C S" uniqKey="Price C">C.S. Price</name>
</author>
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<affiliations><list><country><li>République populaire de Chine</li>
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<region><li>Hubei</li>
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<settlement><li>Wuhan</li>
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<orgName><li>Université de Wuhan</li>
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