Epigenomic k-mer dictionaries: shedding light on how sequence composition influences in vivo nucleosome positioning.
Identifieur interne : 001123 ( Ncbi/Checkpoint ); précédent : 001122; suivant : 001124Epigenomic k-mer dictionaries: shedding light on how sequence composition influences in vivo nucleosome positioning.
Auteurs : Raffaele Giancarlo [États-Unis] ; Simona E. Rombo [États-Unis] ; Filippo Utro [États-Unis]Source :
- Bioinformatics (Oxford, England) [ 1367-4811 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Nucleosomes.
- genetics : Chromatin Assembly and Disassembly.
- methods : Sequence Analysis, DNA.
- Animals, Epigenomics, Genome, Humans.
Abstract
Information-theoretic and compositional analysis of biological sequences, in terms of k-mer dictionaries, has a well established role in genomic and proteomic studies. Much less so in epigenomics, although the role of k-mers in chromatin organization and nucleosome positioning is particularly relevant. Fundamental questions concerning the informational content and compositional structure of nucleosome favouring and disfavoring sequences with respect to their basic building blocks still remain open.
DOI: 10.1093/bioinformatics/btv295
PubMed: 26007227
Affiliations:
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