The novel MER transposon-derived miRNAs in human genome.
Identifieur interne : 000990 ( Ncbi/Checkpoint ); précédent : 000989; suivant : 000991The novel MER transposon-derived miRNAs in human genome.
Auteurs : Kung Ahn [Corée du Sud] ; Jeong-An Gim ; Hong-Seok Ha ; Kyudong Han ; Heui-Soo KimSource :
- Gene [ 1879-0038 ] ; 2013.
Descripteurs français
- KwdFr :
- ADN intergénique (génétique), Cellules HEK293, Cellules HeLa, Chromosomes humains de la paire 17 (génétique), Chromosomes humains de la paire 8 (génétique), Génome humain (physiologie), Humains, Séquences répétées inversées (physiologie), microARN (génétique), Éléments transposables d'ADN (physiologie).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Intergenic, MicroRNAs.
- chemical , physiology : DNA Transposable Elements.
- genetics : Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 8.
- physiology : Genome, Human, Inverted Repeat Sequences.
- HEK293 Cells, HeLa Cells, Humans.
Abstract
MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.
DOI: 10.1016/j.gene.2012.08.028
PubMed: 22926102
Affiliations:
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pubmed:22926102Le document en format XML
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<term>Genome, Human (physiology)</term>
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<term>Inverted Repeat Sequences</term>
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<front><div type="abstract" xml:lang="en">MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.</div>
</front>
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<name sortKey="Han, Kyudong" sort="Han, Kyudong" uniqKey="Han K" first="Kyudong" last="Han">Kyudong Han</name>
<name sortKey="Kim, Heui Soo" sort="Kim, Heui Soo" uniqKey="Kim H" first="Heui-Soo" last="Kim">Heui-Soo Kim</name>
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