The novel MER transposon-derived miRNAs in human genome.
Identifieur interne : 001D53 ( PubMed/Corpus ); précédent : 001D52; suivant : 001D54The novel MER transposon-derived miRNAs in human genome.
Auteurs : Kung Ahn ; Jeong-An Gim ; Hong-Seok Ha ; Kyudong Han ; Heui-Soo KimSource :
- Gene [ 1879-0038 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : DNA, Intergenic, MicroRNAs.
- chemical , physiology : DNA Transposable Elements.
- genetics : Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 8.
- physiology : Genome, Human, Inverted Repeat Sequences.
- HEK293 Cells, HeLa Cells, Humans.
Abstract
MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.
DOI: 10.1016/j.gene.2012.08.028
PubMed: 22926102
Links to Exploration step
pubmed:22926102Le document en format XML
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<affiliation><nlm:affiliation>Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Gim, Jeong An" sort="Gim, Jeong An" uniqKey="Gim J" first="Jeong-An" last="Gim">Jeong-An Gim</name>
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<author><name sortKey="Ha, Hong Seok" sort="Ha, Hong Seok" uniqKey="Ha H" first="Hong-Seok" last="Ha">Hong-Seok Ha</name>
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<author><name sortKey="Han, Kyudong" sort="Han, Kyudong" uniqKey="Han K" first="Kyudong" last="Han">Kyudong Han</name>
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<author><name sortKey="Kim, Heui Soo" sort="Kim, Heui Soo" uniqKey="Kim H" first="Heui-Soo" last="Kim">Heui-Soo Kim</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The novel MER transposon-derived miRNAs in human genome.</title>
<author><name sortKey="Ahn, Kung" sort="Ahn, Kung" uniqKey="Ahn K" first="Kung" last="Ahn">Kung Ahn</name>
<affiliation><nlm:affiliation>Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation>
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<author><name sortKey="Ha, Hong Seok" sort="Ha, Hong Seok" uniqKey="Ha H" first="Hong-Seok" last="Ha">Hong-Seok Ha</name>
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<author><name sortKey="Han, Kyudong" sort="Han, Kyudong" uniqKey="Han K" first="Kyudong" last="Han">Kyudong Han</name>
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<author><name sortKey="Kim, Heui Soo" sort="Kim, Heui Soo" uniqKey="Kim H" first="Heui-Soo" last="Kim">Heui-Soo Kim</name>
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<series><title level="j">Gene</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosomes, Human, Pair 17 (genetics)</term>
<term>Chromosomes, Human, Pair 8 (genetics)</term>
<term>DNA Transposable Elements (physiology)</term>
<term>DNA, Intergenic (genetics)</term>
<term>Genome, Human (physiology)</term>
<term>HEK293 Cells</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Inverted Repeat Sequences (physiology)</term>
<term>MicroRNAs (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Intergenic</term>
<term>MicroRNAs</term>
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<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>DNA Transposable Elements</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 17</term>
<term>Chromosomes, Human, Pair 8</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Genome, Human</term>
<term>Inverted Repeat Sequences</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>HEK293 Cells</term>
<term>HeLa Cells</term>
<term>Humans</term>
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<front><div type="abstract" xml:lang="en">MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.</div>
</front>
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<Title>Gene</Title>
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<ArticleTitle>The novel MER transposon-derived miRNAs in human genome.</ArticleTitle>
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<Abstract><AbstractText>MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.</AbstractText>
<CopyrightInformation>Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
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