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The novel MER transposon-derived miRNAs in human genome.

Identifieur interne : 001D53 ( PubMed/Corpus ); précédent : 001D52; suivant : 001D54

The novel MER transposon-derived miRNAs in human genome.

Auteurs : Kung Ahn ; Jeong-An Gim ; Hong-Seok Ha ; Kyudong Han ; Heui-Soo Kim

Source :

Gene [ 1879-0038 ] ; 2013.

RBID : pubmed:22926102

English descriptors

KwdEn :
- Chromosomes, Human, Pair 17 (genetics), Chromosomes, Human, Pair 8 (genetics), DNA Transposable Elements (physiology), DNA, Intergenic (genetics), Genome, Human (physiology), HEK293 Cells, HeLa Cells, Humans, Inverted Repeat Sequences (physiology), MicroRNAs (genetics).
MESH :
- chemical , genetics : DNA, Intergenic, MicroRNAs.
- chemical , physiology : DNA Transposable Elements.
- genetics : Chromosomes, Human, Pair 17, Chromosomes, Human, Pair 8.
- physiology : Genome, Human, Inverted Repeat Sequences.
- HEK293 Cells, HeLa Cells, Humans.

Abstract

MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.

DOI: 10.1016/j.gene.2012.08.028
PubMed: 22926102

Links to Exploration step

pubmed:22926102

Le document en format XML

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<author><name sortKey="Ahn, Kung" sort="Ahn, Kung" uniqKey="Ahn K" first="Kung" last="Ahn">Kung Ahn</name>
<affiliation><nlm:affiliation>Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Gim, Jeong An" sort="Gim, Jeong An" uniqKey="Gim J" first="Jeong-An" last="Gim">Jeong-An Gim</name>
</author>
<author><name sortKey="Ha, Hong Seok" sort="Ha, Hong Seok" uniqKey="Ha H" first="Hong-Seok" last="Ha">Hong-Seok Ha</name>
</author>
<author><name sortKey="Han, Kyudong" sort="Han, Kyudong" uniqKey="Han K" first="Kyudong" last="Han">Kyudong Han</name>
</author>
<author><name sortKey="Kim, Heui Soo" sort="Kim, Heui Soo" uniqKey="Kim H" first="Heui-Soo" last="Kim">Heui-Soo Kim</name>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The novel MER transposon-derived miRNAs in human genome.</title>
<author><name sortKey="Ahn, Kung" sort="Ahn, Kung" uniqKey="Ahn K" first="Kung" last="Ahn">Kung Ahn</name>
<affiliation><nlm:affiliation>Department of Biological Sciences, College of Natural Sciences, Pusan National University, Busan 609-735, Republic of Korea.</nlm:affiliation>
</affiliation>
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<author><name sortKey="Gim, Jeong An" sort="Gim, Jeong An" uniqKey="Gim J" first="Jeong-An" last="Gim">Jeong-An Gim</name>
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<author><name sortKey="Ha, Hong Seok" sort="Ha, Hong Seok" uniqKey="Ha H" first="Hong-Seok" last="Ha">Hong-Seok Ha</name>
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<author><name sortKey="Han, Kyudong" sort="Han, Kyudong" uniqKey="Han K" first="Kyudong" last="Han">Kyudong Han</name>
</author>
<author><name sortKey="Kim, Heui Soo" sort="Kim, Heui Soo" uniqKey="Kim H" first="Heui-Soo" last="Kim">Heui-Soo Kim</name>
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<series><title level="j">Gene</title>
<idno type="eISSN">1879-0038</idno>
<imprint><date when="2013" type="published">2013</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Chromosomes, Human, Pair 17 (genetics)</term>
<term>Chromosomes, Human, Pair 8 (genetics)</term>
<term>DNA Transposable Elements (physiology)</term>
<term>DNA, Intergenic (genetics)</term>
<term>Genome, Human (physiology)</term>
<term>HEK293 Cells</term>
<term>HeLa Cells</term>
<term>Humans</term>
<term>Inverted Repeat Sequences (physiology)</term>
<term>MicroRNAs (genetics)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Intergenic</term>
<term>MicroRNAs</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>DNA Transposable Elements</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Chromosomes, Human, Pair 17</term>
<term>Chromosomes, Human, Pair 8</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Genome, Human</term>
<term>Inverted Repeat Sequences</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>HEK293 Cells</term>
<term>HeLa Cells</term>
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<front><div type="abstract" xml:lang="en">MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.</div>
</front>
</TEI>
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<DateCompleted><Year>2013</Year>
<Month>02</Month>
<Day>01</Day>
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<DateRevised><Year>2012</Year>
<Month>12</Month>
<Day>03</Day>
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<JournalIssue CitedMedium="Internet"><Volume>512</Volume>
<Issue>2</Issue>
<PubDate><Year>2013</Year>
<Month>Jan</Month>
<Day>10</Day>
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<Title>Gene</Title>
<ISOAbbreviation>Gene</ISOAbbreviation>
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<ArticleTitle>The novel MER transposon-derived miRNAs in human genome.</ArticleTitle>
<Pagination><MedlinePgn>422-8</MedlinePgn>
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<ELocationID EIdType="pii" ValidYN="Y">S0378-1119(12)01013-X</ELocationID>
<Abstract><AbstractText>MicroRNAs (miRNAs) are small RNA molecules (~20-30 nucleotides) that generally act in gene silencing and translational repression through the RNA interference pathway. They generally originate from intergenic genomic regions, but some are found in genomic regions that have been characterized such as introns, exons, and transposable elements (TE). To identify the miRNAs that are derived from palindromic MERs, we analyzed MER paralogs in human genome. The structures of the palindromic MERs were similar to the hairpin structure of miRNA in humans. Three miRNAs derived from MER96 located on chromosome 3, and MER91C paralogs located on chromosome 8 and chromosome 17 were identified in HeLa, HCT116, and HEK293 cell lines. The interactions between these MER-derived miRNAs and AGO1, AGO2, and AGO3 proteins were validated by immunoprecipitation assays. The data suggest that miRNAs derived from transposable elements could widely affect various target genes in the human genome.</AbstractText>
<CopyrightInformation>Crown Copyright © 2012. Published by Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ahn</LastName>
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<NlmUniqueID>7706761</NlmUniqueID>
<ISSNLinking>0378-1119</ISSNLinking>
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<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
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The novel MER transposon-derived miRNAs in human genome.

The novel MER transposon-derived miRNAs in human genome.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki